CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000039707/1-1009 MAAIKALQEWCRQQCEGYRDVSITNMTTSFRDGLAFCAILHRHRPDLINFSALRKENIYE ENSRNOP00000031199/1-1014 MAAIKALQEWCRQQCEGYRDVSITNMTTSFRDGLAFCAILHRHRPDLINFNALRKENIYE ENSP00000297508/1-904 MAAIRALQQWCRQQCEGYRDVNICNMTTSFRDGLAFCAILHRHRPDLINFSALKKENIYE ENSCPOP00000004883/1-976 MAAIKALQQWCRQQCEGYRDVDITNMTTSFRDGLAFCAILHRHRPDLINYSALRKENIYE XP_004840399.1/1-985 MAAIKALQQWCRQQCEGYRGVDITNMTTSFRDGLAFCAILHRHRPDLINYSALRKENIYE ****:***:**********.*.* *************************:.**:****** ENSMUSP00000039707/1-1009 NNKLAFQVAEEQLGIPALLDAEDMVALKVPDRLSILTYVSQYYNYFHGRSPIGGMAGIKR ENSRNOP00000031199/1-1014 NNKLAFQVAEEQLGIPALLDAEDMVALKIPDRLSILTYVSQYYNYFHGRSPIGGMAGMKR ENSP00000297508/1-904 NNKLAFRVAEEHLGIPALLDAEDMVALKVPDRLSILTYVSQYYNYFHGRSPIGGMAGVKR ENSCPOP00000004883/1-976 NNKLAFSVAEEHLGIPALLDAEDMVALKVPDRLSILTYVSQYYNYFHGRSPIGGMAGIKR XP_004840399.1/1-985 NNKLAFSVAEEQLGIPALLDAEDMVALKVPDRLSILTYVSQYYNYFHGRSPIGGMAGIKR ****** ****:****************:****************************:** ENSMUSP00000039707/1-1009 PSSDSTEELSG-KKGLSQPAKLPSPAQTQRSPLSPARTNPVVQRNEGGSQRPSPKAAPGT ENSRNOP00000031199/1-1014 PSSDSTEELSGKKKVPSQPAKLSSPVPTQRLPLSPARTNPVVQRNEGVSERPSPKAAPGT ENSP00000297508/1-904 ASEDSEEEPSG-KKAPVQAAKLPSPAPARKPPLSPAQTNPVVQRRNEGAGGPPPKTDQAL ENSCPOP00000004883/1-976 PPSDPEEEPSG-KKAPSTPAKLPSSAPAQALPAPAARTSSMAQRMDGG-----PKAAQTV XP_004840399.1/1-985 PPSDPEEEPSG-KKTPSMPAKLPSPVPGRVLPLSEGRTSSVVQRKDGGPEGPLPKAGQTL ...*. ** ** ** .***.*.. : * . .:*..:.** : **: ENSMUSP00000039707/1-1009 AGSSVSSICGVCGKHVHLVQRHLADGRLYHRSCFRCKQCSSTLHSGAYRATGEPGVFVCT ENSRNOP00000031199/1-1014 VGSSVSSICGVCGKHVHLVQRHLADGRLYHRSCFRCKQCSSTLHSGAYRATGEPGVFVCT ENSP00000297508/1-904 AGSLVSSTCGVCGKHVHLVQRHLADGRLYHRSCFRCKQCSCTLHSGAYKATGEPGTFVCT ENSCPOP00000004883/1-976 AGSAVSSTCAVCGKHVHLVQRHLVDGRLYHRSCFKCKQCSSTLRSGAYRATGEPGIYVCT XP_004840399.1/1-985 AGSAVSSICGVCGKHVHLVQRHLVDGRLYHRSCFRCKQCFSTLRSGAYRAAGEPGIFICT .** *** *.*************.**********:**** .**:****:*:**** ::** ENSMUSP00000039707/1-1009 HHSSEVTSVSPKSSNLASRKPGGVTADTRPFGVSWTVQEANGEG-TPLRVRTAAWEHAGG ENSRNOP00000031199/1-1014 HHSSEAVSVSPKLSNLASRQPGGGIADTRPIGVSQKVLETNGEA-TPLRARTAAWEHAGG ENSP00000297508/1-904 SHLPAAASASPKLTGLVPRQPGAMGVDSRTSCSPQKAQEAN-------KARPSAWEPAAG ENSCPOP00000004883/1-976 SHHSRATSANTALPALTSKQPAATPVDAGAPSVLQKTQEMNGLREAAPKAQPVAHRPVVG XP_004840399.1/1-985 SHHSKATSGKAAVLGVPSRQP----VDSGPPTILRKAQEMNGQGDAPLKAHPAVQQPAGD * . ..* .. : .::* .*: . .. * * :.:. . . . . ENSMUSP00000039707/1-1009 NTTAKGFVQTELKPPSTS--QVHVGSSAGPKLPTITVTTTSVTSKALTHVTNSSPIGWSS ENSRNOP00000031199/1-1014 NRAAKGFVQTELTPPATS--RVHVGSPAGPRLPMSTVTTTSANSKATTHVTNSSPVGWSS ENSP00000297508/1-904 NSPARASVPAAPNPAATSATSVHVRSPARP--SESRLAPTPTEGKVRPRVTNSSPMGWSS ENSCPOP00000004883/1-976 NTTAKGFARITSEPPASTV-PIQVGSPAGPRLPANPVASLLEHSTASTHVTGRSPMGRTS XP_004840399.1/1-985 NAAVKGFAQTTSEPPATTC-PIRVGSPAGSRLPTSPVASHLEHNRAGTRVTNSSPMGWTS * ..:. . *.::: ::* *.* . . ::. . . .:**. **:* :* ENSMUSP00000039707/1-1009 PAQSSPANFNSRPVVSPSARNTHLPGSQGQTASK--GVKTQLNLNSESSNTAVTPAWTSS ENSRNOP00000031199/1-1014 SAQSSTGTSGSRPVVSPSALGAHLSVPQGQAASK--GVKTQLNSSTDSSSTAPTPAWTSS ENSP00000297508/1-904 AAP-CTAAAASHPAVPPSAPDPRPATPQGGGAPRVAAPQTTLSSSSTSAATVDPPAWTPS ENSCPOP00000004883/1-976 HAQ-YPATNSSRSA--PSIPEPCPATPQGLGPPRVSTSVTKLGLNSASPGAADPPAWTPS XP_004840399.1/1-985 LAQ-SPVANSSRSA--PSVPDPCPAMPQGQGTPQVSAALTKLASNSASPGAVDPPAWTPS * . *:.. ** . . .** ..: * * .: *. :. .****.* ENSMUSP00000039707/1-1009 ASKTQQAREKFFQTPPSAPAPASAPAPAP-TSKVPTVVTVPTSKVPNVVTAPTSKVP--T ENSRNOP00000031199/1-1014 SSRTQQAREKFFHNLSPAPAPAPASSSSSHASRVPTVVTAPSGKVSPLVNTSTSKVPSAT ENSP00000297508/1-904 ASRTQQARNKFFQTSAVPPG---------------------------------------- ENSCPOP00000004883/1-976 ATRTQQARERFFQSPAAPT----------------------------------------- XP_004840399.1/1-985 ATRTQQARQRFFQSPAAPR----------------------------------------- :::*****::**:. . . ENSMUSP00000039707/1-1009 VVTVPTSKVPTVVSAPTSKVPTVVSAPTSKVPTVVNSTNSRVTTVVNAPTSKVPTVVSAT ENSRNOP00000031199/1-1014 VVTVPTSKASTVVTAPTSKAPTVVTVPISKAPTVVTAPTSKVSTVVTVPTSKASTVVTAP ENSP00000297508/1-904 ------------------------------------------------------------ ENSCPOP00000004883/1-976 ------------------------------------------------------------ XP_004840399.1/1-985 ------------------------------------------------------------ ENSMUSP00000039707/1-1009 NGRVPTVVTAHTGRVPAVMNTSASKVSPVVDAPAQESSREQALSVLRKALPALTGSGTQA ENSRNOP00000031199/1-1014 TSKASTVVTVPTGRGHVVVNTSASKVSGVVDNPAQESSREQALSVLRKALPGLTRAGSQA ENSP00000297508/1-904 --------TSLSGRGPTPSLV-----------LSKDSSKEQARNFLKQALSALEEAGAPA ENSCPOP00000004883/1-976 --------SGPVGQTPAPANA-----------PFRDSSREQALSFLKKALSGVEAAGAQA XP_004840399.1/1-985 --------SGPASRTPAPTDT-----------PFRDSSREQALSFLKKTLPGREAGGAQA : .: . . ::**:*** ..*:::*.. .*: * ENSMUSP00000039707/1-1009 PNRSFP------------------------------------------------------ ENSRNOP00000031199/1-1014 PSRSSP------------------------------------------------------ ENSP00000297508/1-904 PGRPSP------------------------------------------------------ ENSCPOP00000004883/1-976 PGKVPPWGSPASTPYAAALSSLEPSKACPGQSRALNKALRGGVPVLLDLASRTYEVPEVG XP_004840399.1/1-985 ASRSSP------------------------------------------------------ ..: * ENSMUSP00000039707/1-1009 ---------------------------------------------ATSSVLVTLPKNEVP ENSRNOP00000031199/1-1014 ---------------------------------------------ATSSVLITLPKNEVP ENSP00000297508/1-904 ---------------------------------------------ATAAVPSSQPKTEAP ENSCPOP00000004883/1-976 AHHPWGAPSSCWGVRPGSWLQVRLWGSCLEGAHGPSHAWYLLLTHRSSPAMNSCPKTEGP XP_004840399.1/1-985 ---------------------------------------------ATSPAVNSCPQTEAP ::.. : *:.* * ENSMUSP00000039707/1-1009 QKVPSDK-LSALTTQTPNFTIKLEPSAPVNVGNT---AVFLQAGKKSPSISPRVGKTSVG ENSRNOP00000031199/1-1014 PKVPSAK-LSHSTTQAFSPTPKMEPTAPLSVGSTSWTSVSLQAGKKSPGISPGIGKTSAV ENSP00000297508/1-904 QASPLAKPLQSSSPRVLGLPSRMEPPAPLSTSSTSQASALPPAGRRNLAESSGVGRVGAG ENSCPOP00000004883/1-976 KAVPSGKPLQSDAPHTLSSTSRTEPSARLSVGST------SQVG-KSPATSSGVIKEGTG XP_004840399.1/1-985 KTALSANPSQPTIPHTLHSTSRPEPSAHLSVGNTSQASGLSQMG-RTSAVSSGLGRAGIG : . .:. . : **.* :....* * :. . *. : : . ENSMUSP00000039707/1-1009 SRPQAEVAGVKGPGP--------ISQEGQEEGPEGWRARLKPVDKKTPAGRSLEQKEP-V ENSRNOP00000031199/1-1014 SRPQAEVKGTSGPGP--------TSQEGQEEGPEGWRARLKPVDKSIPSARALEQKEP-V ENSP00000297508/1-904 SRPKPEAPMAKGKSTTLTQDMSTSLQEGQEDGPAGWRANLKPVDRRSPAERTLKPKEPRA ENSCPOP00000004883/1-976 SRLKPEAPTAKGPST--------SPQQSQEDGPEGWRARLKPVEKKPPAGRAQEPKEPRV XP_004840399.1/1-985 SRLKPEAPTAKDAGT-------SSPQESQEGGPEGWRARLKPVDKKPPAERAREPKGPRV ** :.*. ... .. *:.** ** ****.****:: *: *: : * * . ENSMUSP00000039707/1-1009 LAEPRIGD------TSRKASSSSDSSVHITLTSIQHKRKPCPAGSGPSPAA--LSPSPSH ENSRNOP00000031199/1-1014 LAEPRAGD------TPRKASSSSDSSIHITLTPIQQKRTPCLADSGSSLAA--PSP-PSR ENSP00000297508/1-904 LAEPRAGE------APRKVSGSFAGSVHITLTPVRPDRTPRPASPGPSLPA--RSPSPPR ENSCPOP00000004883/1-976 PAEPKAGEAPVAPRTPVQVSGHVQVGVQITLTPVQPEQTLAHAGPGTKLPE--ASPSSSS XP_004840399.1/1-985 LAEPKAGDVPVSPRAPMQASGSFQGGARTTLTPVQPQQTPGHTGQGLRLPAASPSPSPSP ***: *: :. :.*. . : ***.:: .:. :. * . ** .. ENSMUSP00000039707/1-1009 RKKLAVPPSLDVSADWLQPEPKKQEDGTRSCKEE--KSPTRWSRERSAVLDSGLAPPGEA ENSRNOP00000031199/1-1014 RKKLVVPPTLDVSADWLQPELKKQDDQTRSCKE---KTATWGTRESSAILDNDLVSPDEA ENSP00000297508/1-904 RRRLAVPASLDVCDNWLRPEPPGQEARVQSWKEEEKKPHLQGKPGRPLSPANVPALPGET ENSCPOP00000004883/1-976 RRRLAIPPSLDISANWLQSEPSEQEAQVQSWKE---KPHSQDKPGRPSALAGIPASPEKT XP_004840399.1/1-985 RRRLAVPPSLDVSANWLQSEPSGQDAQGRSRKEE--KPHSRDKPGRPPSPADVPASPGKS *::*.:*.:**:. :**:.* *: :* ** *. . . . . * :: ENSMUSP00000039707/1-1009 VTSPVRLHPDYIPQEELQRQLQDIESQLDALELRGVELEKRLRAAEGDASEDSLMVDWFR ENSRNOP00000031199/1-1014 VTSPVRLHPNYISQEELQRQLQDIERQLDALELRGVELEKRLRAAEGDASEDGLMVDWFR ENSP00000297508/1-904 VTSPVRLHPDYLSPEEIQRQLQDIERRLDALELRGVELEKRLRAAEGDDAEDSLMVDWFW ENSCPOP00000004883/1-976 VSSPIRLHPDYVPQ--------------DALELRGVALEQQLRAADGAAEEDDLMVAWFR XP_004840399.1/1-985 TTSPIRLHPDYVPQEEIDRQLQDIERQLDSLELKGITMEQQLRAAEGAAEEDDLMVAWFQ .:**:****:*:. *:***:*: :*::****:* **.*** ** ENSMUSP00000039707/1-1009 LIHEKQLLLRLESELMYKSKDQRLEEQQLDLQGELRRLMDKPEGLKSPQDRQREQELLSQ ENSRNOP00000031199/1-1014 LIHEKQLLLRRESELMYKSKDQCLEERQLDLQGELRRLMEKPEGLKSPQDRKREQELLNQ ENSP00000297508/1-904 LIHEKQLLLRQESELMYKSKAQRLEEQQLDIEGELRRLMAKPEALKSLQERRREQELLEQ ENSCPOP00000004883/1-976 LVHEKQLLLRQESELMYKSKTQRLEERQQDLEGELRRLMAKPEYLKTPQDQRREQELLSQ XP_004840399.1/1-985 LVHKKQLLLRLESELMYKSKAQRLEERQLDLEGELRRLMAKPEGLKSPQDRRREQELLSQ *:*:****** ********* * ***:* *::******* *** **: *:::******.* ENSMUSP00000039707/1-1009 YVNTVNDRSDIVDFLDEDRLREQEEDQMLENMIQNLG----------------------- ENSRNOP00000031199/1-1014 YVNTVNDRSDIVDNLDEDRLREQEEDQMLESMIQNLG----------------------- ENSP00000297508/1-904 YVSTVNDRSDIVDSLDEDRLREQEEDQMLRDMIEKLG----------------------- ENSCPOP00000004883/1-976 YVSTVNDRSDIVDILDEDRLREKEEDQVLQDMIQRLD----------------------- XP_004840399.1/1-985 YVSTVNDRSDIVDILDEDRLREKEEDQVLQDMIQRLGREACARQAQGRWAGQVPLQWDRP **.********** ********:****:*..**:.*. ENSMUSP00000039707/1-1009 -----------------------------------------------------------L ENSRNOP00000031199/1-1014 -----------------------------------------------------------L ENSP00000297508/1-904 -----------------------------------------------------------L ENSCPOP00000004883/1-976 -----------------------------------------------------------L XP_004840399.1/1-985 EGPRPTAQGTGSGGGWGRSGHLAGFSWCSGWAALVPAPAGLEDPGRGRPHTTSPPLSPDL * ENSMUSP00000039707/1-1009 QRKKSKSFLSKIWSSKSKSGQA- ENSRNOP00000031199/1-1014 QRKKSKSFLSKIWSSKSKSGQT- ENSP00000297508/1-904 QRKKSKFRLSKIWSPKSKSSPSQ ENSCPOP00000004883/1-976 QKKKPKFRLSKIWGTKNKGAPQ- XP_004840399.1/1-985 QKKKSKFRLSKIWGPKSKSSHPE *:**.* *****..*.*..