CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000004797/1-1336 MYRAGEPVKRPPLGPVPPRLRSVEVARGRAGYGFTLAGQAPCVLSGVIRGSPADFVGLRA XP_004847422.1/1-1415 MYRAGEPAKRLPPGPAPPCMRSVEVARGRAGYGFTLSGQAPCVLSGVLRGSPADFVGLRA ENSP00000339381/1-1447 MFRAGEASKRPLPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRA ENSMUSP00000084970/1-1451 MYRAGEPGKRQP-GPAPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRA ENSRNOP00000045065/1-1387 MYRAGEPGKRQS-GPAPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRA *:****. ** ** ** :****************:******** *:************ ENSCPOP00000004797/1-1336 GDQIFTINEINVKKASHEDVVKLIGKCSGVLRLVIGEGAGHPEACSSDDEGGLCEGKGWL XP_004847422.1/1-1415 GDQIFAINEINVKRASHEDVVKLIGKCSGVLRLVIGEGSGHPEACSSDDEGGVWEGRGWL ENSP00000339381/1-1447 GDQILAVNEINVKKASHEDVVKLIGKCSGVLHMVIAEGVGRFESCSSDEEGGLYEGKGWL ENSMUSP00000084970/1-1451 GDQILAINEINVKKASHEDVVKLIGKCSGVLHMVIAEGTSHVESCSSDEEGGLYEGKGWL ENSRNOP00000045065/1-1387 GDQILAINEINVKKASHEDVVKLIGKCSGVLRMVISEGSSHVEPSSSDEEGGLCEGKGWL ****:::******:*****************::**.** .: *..***:***: **:*** ENSCPOP00000004797/1-1336 RPKLDSKALGINRAERVVEEMQSGGIFSMIFENPSLCMSTPEPSQGKQRSLSESASVRLE XP_004847422.1/1-1415 RPKLDSKALGINRAERVVEEMQSGGIFSMIFENPSLCSSGLEPLKGKQRSLSESAATWPE ENSP00000339381/1-1447 KPKLDSKALGINRAERVVEEMQSGGIFNMIFENPSLCASNSEPLKLKQRSLSESAATRFD ENSMUSP00000084970/1-1451 RPKLDSKALGINRAERVVEEVQSGGIFNMIFESSSLCASGPEPLKLKQRSLSESAALRLD ENSRNOP00000045065/1-1387 RPKLDSKALGINRAERVVEEVQSGGIFNMIFESPSLCASGSEPLKLKQRSLSESAALRLD :*******************:******.****..*** * ** : *********: : ENSCPOP00000004797/1-1336 ---GSPNAVQTGLLSKEELVRVIHDDSVFSAGPENLDSFALDASILNVAMVVGYLGSIEL XP_004847422.1/1-1415 ---DSPSAVHPGLLSTEEVARMIHDD-VFSTGPENPDSFVLDASILNVAMVVGYLGSIEL ENSP00000339381/1-1447 VGHESINNPNPNMLSKEEISKVIHDDSVFSIGLESHDDFALDASILNVAMIVGYLGSIEL ENSMUSP00000084970/1-1451 AGQAGLCAPHPSMLSKEDISKVINDDSVFTVGLDSHDDFGLDASILNVAMVVGYLGSIEL ENSRNOP00000045065/1-1387 VGQDSLCTPHPSMLSKEEISKVINDDSVFTVGLDNHDDFGLDASILNVAMVVGYLGSIEL . :..:**.*:: ::*:** **: * :. *.* **********:********* ENSCPOP00000004797/1-1336 PSTSCNLESDSLQAIRGCMRRLRAEQKIHSLVTMKVMHDRVLLCSDKACVVAEYPAEKLA XP_004847422.1/1-1415 PSTSSNLESDSLQAIRGCMRRLRAEQKIHSLVTMKVMHDRVLLCSDKACVVAEYPAEKLA ENSP00000339381/1-1447 PSTSSNLESDSLQAIRGCMRRLRAEQKIHSLVTMKIMHDCVQLSTDKAGVVAEYPAEKLA ENSMUSP00000084970/1-1451 PSTSSNLEHDSLQAIRGCMRRLRAEQKIHSLVTMKVMHDCVQLVTDRAGVVAEYPAEKLA ENSRNOP00000045065/1-1387 PSTSSNLEHDSLQAIRGCMRRLRAEQKIHSLVTMKVMHDCVQLVTDRAGVVAEYPAEKLA ****.*** **************************:*** * * :*:* *********** ENSCPOP00000004797/1-1336 FSAVCPDDRRFFGLVTMQTNDDGSLAQGEEGALRTSCHVFMVDPDLFHHKIHQGIARRFG XP_004847422.1/1-1415 FSAVCPDDRRFFGLVTMQMNDDGSLAPGEECALRTSCHVFMVDPDLFHHKIHQGIARRFG ENSP00000339381/1-1447 FSAVCPDDRRFFGLVTMQTNDDGSLAQEEEGALRTSCHVFMVDPDLFNHKIHQGIARRFG ENSMUSP00000084970/1-1451 FSAVCPDDRRFFGLVTMQTNDDGGLAQEDEGALRTSCHVFMVDPDLFHHKIHQGIARRFG ENSRNOP00000045065/1-1387 FSAVCPDDRRFFGLVTMQTNDDGCLAQEDEGALRTSCHVFMVDPDLFHHKIHQGIARRFG ****************** **** ** :* ****************:************ ENSCPOP00000004797/1-1336 FMCTADPDTSGCLEFPASSLPVLQFISILYRDMGEFIEGVRARAFLDGDADAHQNNSTSS XP_004847422.1/1-1415 FACTADPDTSGCLEFPASSLPVLQFVSVLYRDMGELIEGVRARAFLDGDVDAQQNNSTSS ENSP00000339381/1-1447 FECTADPDTNGCLEFPASSLPVLQFISVLYRDMGELIEGMRARAFLDGDADAHQNNSTSS ENSMUSP00000084970/1-1451 FACTADPDTSGCLEFPASSLPVLQFISVLYRDMGELIEGVRARAFLDGDADAHQNNSTSS ENSRNOP00000045065/1-1387 FACTADPDTSGCLEFPASSLPVLQFISVLYRDMGELIEGVRARAFLDGDADAHQNNSTSS * *******.***************:*:*******:***:*********.**:******* ENSCPOP00000004797/1-1336 NSDSGIGNFNQEEKSNRVLVVDLGGGLSRHGPGSSASWEGAGARSSQSWAASWSRSFCHS XP_004847422.1/1-1415 NSDSGIGNFAQEEKSNRVLVVDLGGASSRHGPGSGGGWEGTGARSSQPGAGSWTRALSLD ENSP00000339381/1-1447 NSDSGIGNFHQEEKSNRVLVVDLGGSSSRHGPG-GSAWDGVGGRGAQPWGAPWTGPFCPD ENSMUSP00000084970/1-1451 NSDSGIGNFNQEEKSNRVLVVDLGGGSSRHGQGSSPGWESGGGRGSQPWSAPWNGAFCHD ENSRNOP00000045065/1-1387 NSDSGIGNFNQEEKSNRVLVVDLGGGSSRHGQGSSPGWESVSGRGSQPWSAPWNGTFCHD ********* ***************. **** * . .*:. ..*.:*. ...*. .:. . ENSCPOP00000004797/1-1336 PEGCASFEAGPQADRLRDLSKHLGPASHTEGTPASLWSSVPPSKRGSASTSCGLSQRWLP XP_004847422.1/1-1415 PEGGALLEAGSHTDRLWDLSKPLGPASLGEGAPASLRSSVPPSKRGAAGSSCGLGQRWLP ENSP00000339381/1-1447 PEGSPPFEAAHQTDRFWDLNKHLGPASPVEVPPASLRSSVPPSKRGTVGAGCGFNQRWLP ENSMUSP00000084970/1-1451 SEAGSPLETSPNTDRFWDLTKHSGPVSHMEVPPATLRSSIPPSKRGAAGSSCGFNQRWLP ENSRNOP00000045065/1-1387 SEAGSPLETSPNTDRFWDLTKHSGPVFHMEVPPATLRSSIPPSKRGATGSSCGFNQRWLP .*. . :*:. ::**: **.* **. * .**:* **:******:..:.**:.***** ENSCPOP00000004797/1-1336 VHVLQEWQCGHASDQESYTDSTDGWSSVNCGTLPPPMSKIPADRYRVEGSFMQAPLSAQK XP_004847422.1/1-1415 VHVLQEWQCGHASDQESYTDSTDGWSSVNCGTLPPPMSKIPADRYRVEGSFVQAPLSTQK ENSP00000339381/1-1447 VHVLREWQCGHTSDQDSYTDSTDGWSSINCGTLPPPMSKIPADRYRVEGSFAQPPLNAPK ENSMUSP00000084970/1-1451 VHVLQEWQCGHASDQESYTDSTDGWSSVNCGTLPPPMSKIPADRYRVEGSFAQAPLSTQK ENSRNOP00000045065/1-1387 VHVLQEWQCGHASDQESYTDSTDGWSSVNCGTLPPPMSKIPADRYRVEGSFAQAPLSTQK ****:******:***:***********:*********************** *.**.: * ENSCPOP00000004797/1-1336 RDWARKAFGMQNLFGPSRNVRRTKEDKKGSKFGRGIGLAQTSQRSSARRSFRRSKRFSIT XP_004847422.1/1-1415 RDWARKAFGMQNLFGPPRNLRKTKEDRKGSRFGRGIGLVQTSQHTSARRSFGRSKRFSIT ENSP00000339381/1-1447 REWSRKAFGMQSIFGPHRNVRKTKEDKKGSKFGRGTGLTQPSQRTSARRSFGRSKRFSIT ENSMUSP00000084970/1-1451 RDWSRKAFGMQNLFGPHRNVRKTKEDKKSSKLGRGVALAQTSQRTSARRSFGRSRRFSIT ENSRNOP00000045065/1-1387 RDWSRKAFGMQNLFGPHRNVRKTKEDKKSSKLGRGVALAQTSQRTSARRSFGRSRRFSLT *:*:*******.:*** **:*:****:*.*::*** .*.*.**::****** **:***:* ENSCPOP00000004797/1-1336 RSLDDLESATVSDGELTGADLKDCVSSNSLSSNASLPSVQSCRRLRERRVASWAVSFERL XP_004847422.1/1-1415 RSLDDLESATVSDGELTGADLKDCVSSNSLSSNASLPSVQSCRRLRERRVASWAVSFERL ENSP00000339381/1-1447 RSLDDLESATVSDGELTGADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERL ENSMUSP00000084970/1-1451 RSLDDLESATVSDGELTGADLKDCISNNSLSSNASLPSVQSCRRLRERRVASWAVSFERL ENSRNOP00000045065/1-1387 RSLDDLETARLQDEELTGADLKDCISNNSLSSNASLPSVQSCRRLRERRVASWAVSFERL *******:* :.* **********:*.********************************* ENSCPOP00000004797/1-1336 LQDPVGIRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSHRAREIFSKFLCSKAT XP_004847422.1/1-1415 LQDPVGIRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSCRAREIFSKFLCSKAT ENSP00000339381/1-1447 LQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKAT ENSMUSP00000084970/1-1451 LQDPVGVRYFSDFLRKEFSEENILFWQACECFSHVPAHDKKELSYRAREIFSKFLCSKAT ENSRNOP00000045065/1-1387 LQDPVGVRYFSDFLRKEFSEENILFWQACECFSHVPAHDKKELSYRAREIFSKFLCSKAT ******:*********************** *.*********** *************** ENSCPOP00000004797/1-1336 TPVNIDSQAQLADDILNAPHPDMFKEQQLQIFNLMKFDSYTRFLKSQLYQECILAEVEGR XP_004847422.1/1-1415 TPVNIDSQAQLADDILNAPHPDMFKEQQLQIFNLMKFDSYTRFLKSQLYQECILAEVEGR ENSP00000339381/1-1447 TPVNIDSQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGR ENSMUSP00000084970/1-1451 TPVNIDSQAQLADDILNAPHPDMFKEQQLQIFNLMKFDSYTRFLKSQLYQECVLAEVEGR ENSRNOP00000045065/1-1387 TPVNIDSQAQLADDILNAPHPDMFKEQQLQIFNLMKFDSYTRFLKSQLYQECVLAEVEGR **************:*.***************************** *****:******* ENSCPOP00000004797/1-1336 ALPDAQQVPSSPASKHSIGSDHSSTSTPKKLSGKSKSGRSLNEDAGDEDSEKKRKGAFFS XP_004847422.1/1-1415 ALPDAQQVPSSPASKRSIGSDHSSASTPKKLSGKSKSGRSLNEDAGDEDSEKKRKGAFFS ENSP00000339381/1-1447 ALPDSQQVPSSPASKHSLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFS ENSMUSP00000084970/1-1451 TLPDSQQVPSSPASKHSISSDHSNVSTPKKLSGKSKSGRSLNEDVGEEDSEKKRRGAFFS ENSRNOP00000045065/1-1387 TLPDSQQVPSSPASKHSISSDHSNVSTPKKLSGKSKSGRSLNEDVGEEDSEKKRKGAFFS :***:**********:*:.****..******************: *:*******:***** ENSCPOP00000004797/1-1336 WSRSRSTGRSQKKKEPGDHGQDTLPTNGGLCRRRESQGSVSSAGSLDLPEACRTLVPEKD XP_004847422.1/1-1415 WSRSRSTGRSQKKKEPSDHTQDALPANGSLC-RRESQGSVSSTGSLDLPEACRTLVPERD ENSP00000339381/1-1447 WSRTRSTGRSQKKREHGDHADDALHANGGLC-RRESQGSVSSAGSLDLSEACRTLAPEKD ENSMUSP00000084970/1-1451 WSRSRSTGRSQKKKDHGDHAHDAPHANGGLC-RRESQGSVSSAGSLDLSEACRTSALEKD ENSRNOP00000045065/1-1387 WSRSRSTGRSQKKKDHGDHAHDALHANGGLC-RRESQGSVSSAGSLDLSEACRTSALERD ***:*********:: .** .*: :**.** **********:*****.***** . *:* ENSCPOP00000004797/1-1336 KAVKHCCIYLPDGATCVVAVKSGFSIKEILAGLCERHGINGAAVDLFLVGGDKPLVLHQD XP_004847422.1/1-1415 KAAKHCCIHLPDGTSCVVAVKSGFSIKEILSGLCERQGINGAAVDLFLVGGDKPLVLHQD ENSP00000339381/1-1447 KATKHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQD ENSMUSP00000084970/1-1451 KAAKHCCVHLPDGTSCVVAVKSGFSIKEILSGLCERHGINGAAVDLFLVGGDKPLVLHQD ENSRNOP00000045065/1-1387 KAAKHCCVHLPDGTSCVVAVKSGFSIKEILSGLCERHGINGAAVDLFLVGGDKPLVLHQD **.****::****::******:*****:**:*****:******.**************** ENSCPOP00000004797/1-1336 SSILASRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLDLGSLLVRL XP_004847422.1/1-1415 SSILASRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLDLGHLLVRL ENSP00000339381/1-1447 SSILESRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRL ENSMUSP00000084970/1-1451 SSILATRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLDLGSLLVRL ENSRNOP00000045065/1-1387 SSILATRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLDLGSLLVRL **** :*****************************************:*****. ***** ENSCPOP00000004797/1-1336 SGEKEPLDLGAPISSLDGQRVVLEERDPARGRAPTDKQKGALAKPSAAASSRPRDRSATG XP_004847422.1/1-1415 SGEKEPLDLGAPISSLDGQRVVLEERDPTRGRASTDKQKGTPAKPSAAASSGPRNHSATG ENSP00000339381/1-1447 SGEKEPLDLGAPISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNTAVNSSSRNHSATG ENSMUSP00000084970/1-1451 SGEKEPLDLGAPISSLDGQRVILEERDPSRGKVSTDKQKGAPVKQNSAVNSSPRNHLAMG ENSRNOP00000045065/1-1387 SGEKEPLDLGAPISSLDGQRVILEERDPSRGKVSTEKQKGAPVKQSSAVNSSPRNHSAMG *********************:***:**:**:..::****. .* .:*..* .*:: * * ENSCPOP00000004797/1-1336 EERTLGKSNSIKIKGENGKNARDPRLSKREESIA-----KYQKINLDEAEEFFELISKAQ XP_004847422.1/1-1415 EERTLGKSNSIKIKGENGKNARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQ ENSP00000339381/1-1447 EERTLGKSNSIKIKGENGKNARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQ ENSMUSP00000084970/1-1451 EERTLGKSNSIKIRGENGKSARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQ ENSRNOP00000045065/1-1387 EERTLGKSNSIKIRGENGKSARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQ *************:*****.************** ********************* ENSCPOP00000004797/1-1336 SNRADDQRGLLTKEDLVLPEFLRLPPGSTKLPLCTLAAG-KGFSKRPETTGHSREKASLP XP_004847422.1/1-1415 SNRADDQRGLLRKEDLVLPEFLRLPPGCTELALCSPAPA-KGFSKRPETTGHSGEKVALP ENSP00000339381/1-1447 SNRADDQRGLLRKEDLVLPEFLRLPPGSTELTLPTPAAVAKGFSKRS-ATGNGRESASQP ENSMUSP00000084970/1-1451 SNRADDQRGLLRKEDLVLPEFLRLPAGSSELALSSPPPV-KGYSKRA-VTGHGQEGAAQT ENSRNOP00000045065/1-1387 SNRADDQRGLLRKEDLVLPEFLRLPPGSSELALSSPPPV-KGFSKRA-VTSHGQEGAVQT *********** *************.*.::*.* : .. **:***. .*.:. * . . ENSCPOP00000004797/1-1336 ----------SDSPAT---------------------------------GPRGASPLGQK XP_004847422.1/1-1415 ----------SNSPTT------------SPGSAQSPGSAHSP------PGPPGATPPGQK ENSP00000339381/1-1447 GEQWEPVQESSDSPST------------------SPGSASSP------PGPPGTTPPGQK ENSMUSP00000084970/1-1451 EESY------SDSPATSPASAQSPCSAYSPGSAHSPGSAHST------PGPPGTTQPGEK ENSRNOP00000045065/1-1387 EESY------SDSPATSPASAQSPCSAYSPGSAHSPGSAHSPGSAHSTPGPPGTAQPGEK *:**:* ** *:: *:* ENSCPOP00000004797/1-1336 ---------------VQEGPTQVWRRRQSQEVEDGGIQT-EDESRADLTLVGEGDISSPN XP_004847422.1/1-1415 ---------------AQEGATQVW-RRQSREVEAGCIQT-EDESGADLTLVGEGDISSPN ENSP00000339381/1-1447 SPSGPFCTPQSPVSLAQEGTAQIW-KRQSQEVEAGGIQTVEDEHVAELTLMGEGDISSPN ENSMUSP00000084970/1-1451 -PTKPSC-----VSMVQEGTTQAW-RRLSPEMEAGGIQTVEDEQVADLTLMGEGDISSPN ENSRNOP00000045065/1-1387 -PTKPSC-----ISTVQEGTTQAW-RRLSPELEAGGIQTVEEEQVADLTLMGEGDISSPN .***.:* * :* * *:* * *** *:* *:***:********* ENSCPOP00000004797/1-1336 STLLPPPPSPQDAPGPLRPG-----------------------TSQF------------- XP_004847422.1/1-1415 STLLPPPPSPQDAPGPPRPGGGACDSRGLPVNRIFDVDLAGVATSMW--------PGPGR ENSP00000339381/1-1447 STLLPPPSTPQEVPGPSRPGSGTHGSRDLPVNRIIDVDLVTGSAPGRDGGIAGAQAGPGR ENSMUSP00000084970/1-1451 STLLPPPPTPQDTPGPPRPGGGARVSGGLPVNRIIDVDLVSGVSPGWGGSILGVQLGPRR ENSRNOP00000045065/1-1387 STLLPPPPLPQDTPGPTRPG-----------------------TSRF------------- *******. **:.*** *** :. ENSCPOP00000004797/1-1336 ----------------------------------- XP_004847422.1/1-1415 VRPA-RAPVSDRSGQSPGPRVPSKAQPGAHHATFV ENSP00000339381/1-1447 SQASGGPPTSDLPGLGPVPGEPAKPKTSAHHATFV ENSMUSP00000084970/1-1451 VKAN-GPSLPNGPGLSTIPGEPTKPKTSTHHATFV ENSRNOP00000045065/1-1387 -----------------------------------