CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000004757/1-1434 TFKSGLCSSRPGSDDKHTARP--FPVGPRDGGGNMAAAGALERSFLELSGAERERLRQFR XP_004851868.1/1-1402 ----------------------------------MAAAGALERSFLELSGAERERLRRFR ENSP00000367721/1-1436 MLHLSAAPPAPPPEVTATARPCLCSVGRRGDGGKMAAAGALERSFVELSGAERERPRHFR ENSMUSP00000059289/1-1402 ----------------------------------MAAAGSLERSFVELSGAERERPRHFR ENSRNOP00000036307/1-1379 ----------------------------------MAAAGSLERSFVELSGAERERPRHFR *****:*****:********* *:** ENSCPOP00000004757/1-1434 EFTVCGLGTSSAAPGAVKYSESAGGFYYVESGKLFSVTRNRFIHWKTCGDTVELVEESLD XP_004851868.1/1-1402 EFTVCVLGSAGVAPGAVKYSESAGGFYYVESGKLFAVTRNRFIHWKTSGDTVELVEESLD ENSP00000367721/1-1436 EFTVCSIGTANAVAGAVKYSESAGGFYYVESGKLFSVTRNRFIHWKTSGDTLELMEESLD ENSMUSP00000059289/1-1402 EFTVCDIGTASAAFGTVKYSESAGGFYYVESGKLFSITRNRFIHWKTSGDTLELVEESLD ENSRNOP00000036307/1-1379 EFTVCDLGTANAAFGAVKYSESAGGFYYVESGKLFSITRNRFIHWKTSGDTLELVEESLD ***** :*::... *:*******************::**********.***:**:***** ENSCPOP00000004757/1-1434 INLLNNAVRLKFQNCSILPGGVYVVETQTHVIIMILTNQTVHRLLLLHPSRMYRSELVTE XP_004851868.1/1-1402 INLLNNAVRVKFQNCSILPGGVYVTETQAHVIVLLLTNQSVHRLLLPHPSRMYRSELVTE ENSP00000367721/1-1436 INLLNNAIRLKFQNCSVLPGGVYVSETQNRVIILMLTNQTVHRLLLPHPSRMYRSELVVD ENSMUSP00000059289/1-1402 LNLLNNAVRLKFQNYNILPGGVHVSETQNHVIILILTNQTVHRLILPHPSRMYRSELVTE ENSRNOP00000036307/1-1379 LNLLNNAVRLKFQNYSLLPGGVHVSETQNHVIILILTNHTVHRLILPHPSRMYRSELVTE :******:*:**** .:*****:* *** :**:::***::****:* ***********.: ENSCPOP00000004757/1-1434 SQMQSIFTDIGKVDFRDPCSYQLIPAVPGLSPHAAASAAWLSSDGEALFALPSAAGGIFI XP_004851868.1/1-1402 SQMQSIFTDIGKVDFRDPCSYQLIPTVPGLSPHAAASAAWLSSDGEALFALPSAAGGVFI ENSP00000367721/1-1436 SQMQSIFTDIGKVDFTDPCNYQLIPAVPGISPNSTASTAWLSSDGEALFALPCASGGIFV ENSMUSP00000059289/1-1402 SQMQSIFTDIGKVDFRDPCNSQLIPSVPGLSPGSTTSAAWLSSDGEALFALPSASGGIFV ENSRNOP00000036307/1-1379 SQMQSIFTDIGKVDFKDPCNYQLIPTVPGLSPSSTTSAAWLSSDGEALFALPSASGGIFV *************** ***. ****:***:** :::*:**************.*:**:*: ENSCPOP00000004757/1-1434 LKLSPYDRPGTLAVVELKQSSVMQRLLTGWMPTAIRGDQGPSDRALSLAVHCVEHDAFLF XP_004851868.1/1-1402 LKLPPYDRPGTVAVVELKQSSVMQRLLTGWMPTAIRGEQGPSDRALSLAVHCAEHDAFLF ENSP00000367721/1-1436 LKLPPYDIPGMVSVVELKQSSVMQRLLTGWMPTAIRGDQSPSDRPLSLAVHCVEHDAFIF ENSMUSP00000059289/1-1402 LKLPPYDVPGIASVVELKQSSVMQRLLTGWMPTAIRGDHGPSDRALSLAVHCVEHDAFIF ENSRNOP00000036307/1-1379 LKLPPYDIPGIASVVELKQSSVMQRLLTGWMPTAIRGDHGPSDRALSLAVHCVEHDAFIF ***.*** ** :************************::.****.*******.*****:* ENSCPOP00000004757/1-1434 ALCQDHKLRMWSYKDQMCLMVADMLDYVPVNKDLRLMAGTGHRLRLAYSPSLGLYLGAYV XP_004851868.1/1-1402 ALCQDHKLRMWSCKDQMCLMVVDMLEYVPVNKDFRHTAGAGHRLRLAYSPSLGLYLGAYV ENSP00000367721/1-1436 ALCQDHKLRMWSYKEQMCLMVADMLEYVPVKKDLRLTAGTGHKLRLAYSPTMGLYLGIYM ENSMUSP00000059289/1-1402 ALCQDHKLRMWSYKDQMCLMVADMLEYVPVNKDLRLTAGTGHKLRLAYSPSMGLYLGIYM ENSRNOP00000036307/1-1379 ALCQDHKLRMWSYKDQMCLMVADMLEYVPVNKDLRLTAGTGHKLRLAYSPSMGLYLGIYM ************ *:******.***:****:**:* **:**:*******::***** *: ENSCPOP00000004757/1-1434 HAPQRGQFCIFQLVSTENNRYSLDHIASLFTSQETLVDFALTPTDVWALWHDAENQTIVK XP_004851868.1/1-1402 HAPKQGQFCIFQLVSTESNRYSLDHISSLFTSQETLVDFALTPTDVWALWHDAENQTIVK ENSP00000367721/1-1436 HAPKRGQFCIFQLVSTESNRYSLDHISSLFTSQETLIDFALTSTDIWALWHDAENQTVVK ENSMUSP00000059289/1-1402 HAPKRGQFCVFQLVSTENNRYSLDHISSLFTSQETLVDFALTSTDIWALWHDAENQTIVK ENSRNOP00000036307/1-1379 HAPKRGQFCIFQLVSTESSRYSLDHISSLFTSQETLVDFALTSTDIWALWHDAENQTIVK ***::****:*******..*******:*********:*****.**:***********:** ENSCPOP00000004757/1-1434 YINFEHNVAGQWNPVFLQPLPEEELVIRDDQDPREIYLRSLFTPGRFINGALCKALQIFC XP_004851868.1/1-1402 YINFEHNVAGQWNPVFIQPLPEEELVIRDDQDPREIYLRSLFTPGRFISGALCKALQIFC ENSP00000367721/1-1436 YINFEHNVAGQWNPVFMQPLPEEEIVIRDDQDPREMYLQSLFTPGQFTNEALCKALQIFC ENSMUSP00000059289/1-1402 YINFEHNVAGQWNPVFMQPLPEEEIVIRDDQDPREMYLRSLFTPGHFINAALCKALQIFC ENSRNOP00000036307/1-1379 YINFEHNVAGQWNPVFMQSLPEEEIVIRDDQDPR-----------------------IFC ****************:*.*****:********* *** ENSCPOP00000004757/1-1434 RGTERNLDLSWNELKKEVTLAVESELHGSVTEYEFSQQDFRNLQHEFWSKFYACCLQYQE XP_004851868.1/1-1402 RGTERNLDLSWNELKKEVTLAVENELHSSVTEYEFSQQDFRNLQQEFWSKFYACCLQYQE ENSP00000367721/1-1436 RGTERNLDLSWSELKKEVTLAVENELQGSVTEYEFSQEEFRNLQQEFWCKFYACCLQYQE ENSMUSP00000059289/1-1402 RGTERNLDLSWNELKKEITLAVENELQGSVTEYEFSQDEFRTLQQEFWCKFYACVLQYQE ENSRNOP00000036307/1-1379 RGTERNLDLSWSELKKEITLAVENELQGSVTEYEFSQDEFRTLQQEFWCKFYACCLQYQE ***********.*****:*****.**:.*********::**.**:***.***** ***** ENSCPOP00000004757/1-1434 ALSQPLALLLNPHTNMLCLLKKGYISFLLPTSLVDHLYLLPEENFLTEDETAISDDMEVA XP_004851868.1/1-1402 ALSQPLALLLNPHTNMLCLLKKGYLSFLLPTSLVDHLYLLPEENFLTEDETAISDDVEVA ENSP00000367721/1-1436 ALSHPLALHLNPHTNMVCLLKKGYLSFLIPSSLVDHLYLLPYENLLTEDETTISDDVDIA ENSMUSP00000059289/1-1402 ALSHPLALHLNPVTNMVCLLKKGYLSFLVPSSLVDHLYLLPDEHLLTEDETTISDDADVA ENSRNOP00000036307/1-1379 ALSHPLALHLNPLTNMVCLLKKGYLSFLVPSSLVDHLYLLPDEHLLTEDETTISDDADVA ***:**** *** ***:*******:***:*:********** *::******:**** ::* ENSCPOP00000004757/1-1434 RDVMCLMKCLRMIGESVTTDMSVLMEMNCHNLQSPEKAAERILQDMIIIDIENVMEDVCS XP_004851868.1/1-1402 RDVMCLMRCLRMIGESVSTDMTVLMEMNCYSLQSPEKAAERILQDLIIIDVENVMEDVCS ENSP00000367721/1-1436 RDVICLIKCLRLIEESVTVDMSVIMEMSCYNLQSPEKAAEQILEDMITIDVENVMEDICS ENSMUSP00000059289/1-1402 RDVLCLIKCLRMIGESVTMDMAVLMETSCYNLQSPEKAAEHILEDLITIDVENVMEDICS ENSRNOP00000036307/1-1379 RDVLCLIKCLRMIGESVTMDMAVLMETSCYNLQSPEKAAEHILEDLITIDVENVMEDICS ***:**::***:* ***: **:*:** .*:.*********:**:*:* **:******:** ENSCPOP00000004757/1-1434 KLQEMRNPAHAIGLIIREIDYETDVDMETGFNPAQPLNVRLNLSQLYGSSSAAYVVCRGV XP_004851868.1/1-1402 RLQEMRNPAHAIGLVLREMDYETDVETEMGFNPAQPLNVRMNLSQLYGSSTAAFLLCRAV ENSP00000367721/1-1436 KLQEIRNPIHAIGLLIREMDYETEVEMEKGFNPAQPLNIRMNLTQLYGSNTAGYIVCRGV ENSMUSP00000059289/1-1402 KLQEIRNPVHAIGLLIREMDYETEVEMEKGFDPAQPLNVRMNLSQLYGSSTAGYIVCRGV ENSRNOP00000036307/1-1379 KLQEIRNPVHAIGLLIREMDYETEVEMEKGFDPAQPLNVRMNLSQLYGSSTAGYIVCRGV :***:*** *****::**:****:*: * **:******:*:**:*****.:*.:::**.* ENSCPOP00000004757/1-1434 HKIASTRFLICRDLLIFQQLLTRLGDTGLLGPGQLFQAQQEVLHRTAPLLLSYHLIKWAS XP_004851868.1/1-1402 HRVASTRFLICRDLLIFQQLLTRLGDTGILGPGQLFQAQQEVLHRTAPLLLSYYLIEWGT ENSP00000367721/1-1436 HKIASTRFLICRDLLILQQLLMRLGDAVIWGTGQLFQAQQDLLHRTAPLLLSYYLIKWGS ENSMUSP00000059289/1-1402 YKIASTRFLICRDLLILQQLLTRLGDAVILGAGQLFQAQQDLLHRTAPLLLSYYLIKWAS ENSRNOP00000036307/1-1379 YKIASTRFLICRDLLILQQLLTRLGDAVSTSPAERSSSSYFVIHVTRPPTEATYPLTFSG :::*************:**** ****: ...: .:. ::* * * : : : :. ENSCPOP00000004757/1-1434 QCLATDVPVDTLESNLQHLSVLELTDSGAAVACPFVSSPQTVVELFFQEVARKHIIAHLF XP_004851868.1/1-1402 QCLATDVPVDTLESNLQHLSVLELTDSGAFVANPFVSSPQTVVELFFQEVARKHIIAHLF ENSP00000367721/1-1436 ECLATDVPLDTLESNLQHLSVLELTDSGALMANRFVSSPQTIVELFFQEVARKHIISHLF ENSMUSP00000059289/1-1402 QCLATDVPVDTLESNLQHLSVLELTDSGALMANKLVSSPQTIMELFFQEVARKQIISHLF ENSRNOP00000036307/1-1379 ILICTILIKSTMESNLQHLSVLELTDSGALMANKLVSSPQTIMELFFQEVARKHIISHLF :.* : .*:***************** :* :******::**********:**:*** ENSCPOP00000004757/1-1434 SQPKAPPSQTALNWPEMITTVTNYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIHLLHP XP_004851868.1/1-1402 SQPKEPPSQAALNWPEMATTVTNYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIHLLHP ENSP00000367721/1-1436 SQPKAPLSQTGLNWPEMITAITSYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIQLLHP ENSMUSP00000059289/1-1402 SQPKAPLSQTGLNWPEMITAVTGYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIQLLHP ENSRNOP00000036307/1-1379 SQPKAPLSQTGLNWPEMVTAVTGYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIQLLHP **** * **:.****** *::*.********************************:**** ENSCPOP00000004757/1-1434 WCQVNVGSCRFMLGRCYLITGEEHKALQCFCQAASEVGKEEFLDRLIRSEDGEVASSPRL XP_004851868.1/1-1402 WCQVNVGSCRFMLGRCYLIMGEEHKALECFCQAASEVGKEEFLDRLIRSEEGEVESSPRM ENSP00000367721/1-1436 WCQVNVGSCRFMLGRCYLVTGEGQKALECFCQAASEVGKEEFLDRLIRSEDGEIVSTPRL ENSMUSP00000059289/1-1402 WCQVNVGSCRFMLGRCYLVTGEVQKALECFCQAASEVGKEEFLDRLIRSEDGEIVSTPKL ENSRNOP00000036307/1-1379 WCQVNVGSCRFMLGRCYLVTGEVQKALECFCQAASEVGKEEFLDRLIRTEDGEIVSTPKL ******************: ** :***:********************:*:**: *:*:: ENSCPOP00000004757/1-1434 QYYDKVLRLLDVVGLPELVIQLATVAITEAGDDWKGQATLRTCIFKHHLDLGHNSQAYEA XP_004851868.1/1-1402 QYYDKVLRLLDIVGLPELVIQLATAAITEAGDDWKGQATLRTCIFKHHLDLGHNSQAYEA ENSP00000367721/1-1436 QYYDKVLRLLDVIGLPELVIQLATSAITEAGDDWKSQATLRTCIFKHHLDLGHNSQAYEA ENSMUSP00000059289/1-1402 QYYDKVLRLLDVVGLPELVIQLATSAITEAGDDWKSQATLRTCIFKHHLDLGHNSQAYEA ENSRNOP00000036307/1-1379 QYYDKVLRLLDVVGLPELVIQLATSAITEAGDDWKSQATLRTCIFKHHLDLGHNSQAYEA ***********::*********** **********.************************ ENSCPOP00000004757/1-1434 LTQIPDSSRQLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLTTHNY XP_004851868.1/1-1402 LTQIPDSSRQLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLTTHNY ENSP00000367721/1-1436 LTQIPDSSRQLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLMTHNY ENSMUSP00000059289/1-1402 LTQIPDSSRQLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLMTHNY ENSRNOP00000036307/1-1379 LTQIPDSSRQLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLMTHNY ******************************************************* **** ENSCPOP00000004757/1-1434 YELLYAFHIHRHNFRKAGTVMFEYGTRLGREVRTLRGLEKQGSCYLAAINCLRLIRPEYA XP_004851868.1/1-1402 YELLYAFHIHRHNFRKAGTVMFEYGTRLGREVRTLRGLEKQGSCYLAALNCLRLIRPEYA ENSP00000367721/1-1436 YELLYAFHIYRHNYRKAGTVMFEYGMRLGREVRTLRGLEKQGNCYLAALNCLRLIRPEYA ENSMUSP00000059289/1-1402 YELLYAFHIYRHNYRKAGTVMFEYGMRLGREVRTLRGLEKQGNCYLAAINCLRLIRPEYA ENSRNOP00000036307/1-1379 YELLYAFHIYRHNYRKAGTVMFEYGMRLGREVRTLGGLEKQGNCYLAAINCLRLIRPEYA *********:***:*********** ********* ******.*****:*********** ENSCPOP00000004757/1-1434 WIVQPAAGAVYDRPGTSPKRNHDGECMAAPGARQVEILELADLEKECALAHVRLVLARHD XP_004851868.1/1-1402 WIVRPAAGAVYDRPGTSPKRNHDGECTATPAARQVEILELADLEKECSLAHIRLVLARHD ENSP00000367721/1-1436 WIVQPVSGAVYDRPGASPKRNHDGECTAAPTNRQIEILELEDLEKECSLARIRLTLAQHD ENSMUSP00000059289/1-1402 WIVQPASGAVSDRPGASPKRNHDGECTAAPTNRQIEILELEDLEKEYSLARIRLTLARHD ENSRNOP00000036307/1-1379 WIVQPASGAVSDRPGASPKRNHDGECTAAPTNRQIEILELEDLEKECSLARIRLTLARHD ***:*.:*** ****:********** *:* **:***** ***** :**::**.**:** ENSCPOP00000004757/1-1434 PAAVAVAGSSSAEEMVTLLVQAGLFDTALTLCQTFKLPLTPVFEGLAFKCIRLQLGGENA XP_004851868.1/1-1402 PAAVAVAGSSSAEEMVTLLVQAGLFDTAISLCQAFRLPLTPVFEGLTFKCIRLQLAGDNA ENSP00000367721/1-1436 PSAVAVAGSSSAEEMVTLLVQAGLFDTAISLCQTFKLPLTPVFEGLAFKCIKLQFGGEAA ENSMUSP00000059289/1-1402 PSVIAIAGSSSAKEMSALLVQAGLFDTAISLCQTFTLPLTPVFEGLAFKCIKLQFGGEAA ENSRNOP00000036307/1-1379 PSAIAIAGSSSAKEMSTLLVQAGLFDTAISLCQTFKLPLTPVFEGLAFKCIKLQFGGEAA *:.:*:******:** :***********::***:* **********:****:**:.*: * ENSCPOP00000004757/1-1434 QAEAWAWLAANQLSSVVTTKESSATDEAWRLLSTYLERYKVQNNLYHQCVINKLLSHGVP XP_004851868.1/1-1402 QAEAWAWLAANQLSSVVTTKESSATDEAWRLLSTYLERYKMQNNLYHQCVINKLLSHGVP ENSP00000367721/1-1436 QAEAWAWLAANQLSSVITTKESSATDEAWRLLSTYLERYKVQNNLYHHCVINKLLSHGVP ENSMUSP00000059289/1-1402 QGEAWSWLATNQLSSVITTKESSATDEAWRLLSTYLERYKVQNNLYHHCVINKLLSHGVP ENSRNOP00000036307/1-1379 QGEAWAWLAANQLSSVITTKESSATDEAWRLLSTYLERYKVQNNLYHHCVINKLLSHGVP *.***:***:******:***********************:******:************ ENSCPOP00000004757/1-1434 LPNWLINSYKKVDAAELLRLYLKYDLLEEAVDLVSEYVDAVLGKGHQYFGIEFPLSATAP XP_004851868.1/1-1402 LPNWLINSYKKVDAAELLRLYLKYDLLEEAVDLVSEYVDAVLGKGHQYFGIEFPLSATAP ENSP00000367721/1-1436 LPNWLINSYKKVDAAELLRLYLNYDLLEEAVDLVSEYVDAVLGKGHQYFGIEFPLSATAP ENSMUSP00000059289/1-1402 LPNWLINSYKKVDAAELLRLYLNYDLLEEAVDLVSEYVDAVLGKGHQYFGIEFPLSATAP ENSRNOP00000036307/1-1379 LPNWLINSYKKVDAAELLRLYLNYDLLEEAVDLVSEYVDAVLGKGHQYFGIEYIIYSKRP **********************:*****************************: : :. * ENSCPOP00000004757/1-1434 MVWLPYSSIDQLLQALGENTANSHNIALSQKILDKLEDYQQKVDKATRDLLFRLNL XP_004851868.1/1-1402 MVWLPYSSIDQLLQALGENSANSHNLALSQKILDKLEDYQQKVDKATRDLLFRLNL ENSP00000367721/1-1436 MVWLPYSSIDQLLQALGENSANSHNIALSQKILDKLEDYQQKVDKATRDLLYRRTL ENSMUSP00000059289/1-1402 MVWLPYSSIDQLLQALGENSANSHNIILSQKILDKLEDYQQKVDKATRDLLYRRDL ENSRNOP00000036307/1-1379 GVWGPLELESQVMQALGENSANSHNIILSQKILDKLEDYQQKVDKATRDLLYRRDL ** * . .*::******:*****: ************************:* *