CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000004743/1-1122 MDKLRIIFLEDSGSLDFTRRLARLSLFTTAVILLLSASFIPSSLGGTEKELRLVDGENRC XP_004869589.1/1-1161 MDKFRIMFPEDSGSADFRRHLVHLSPFTIAVVSLLSVSLITSCLGGTGKELRLVDGENKC ENSP00000352071/1-1156 MSKLRMVLLEDSGSADFRRHFVNLSPFTITVVLLLSACFVTSSLGGTDKELRLVDGENKC ENSMUSP00000108160/1-1159 MGGHRMVLLGGAGSPGCKR-FVHLGFFVVAVSSLLSASAVTNAPGEMKKELRLAGGENNC ENSRNOP00000058828/1-1120 MGKNRMVLLGGAGSPGYKG-FVHLGFFVVAVSSLLSVSAVTQAPEGRKKELRLAGGENNC *. *::: .:** . :..*. *. :* ***.. :... *****..***.* ENSCPOP00000004743/1-1122 SGRVEIKVQEEWGTVCNHGWGMEEVAVVCSQLRCPTLVTATGWTNSSGGAGRIWMDHVSC XP_004869589.1/1-1161 SGRVEVKVQEDWGTVCSHDWGMEEVSVICDQLGCPTAVKAPGWTNSSAGSGRIWMDHVSC ENSP00000352071/1-1156 SGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMDHVSC ENSMUSP00000108160/1-1159 SGRVELKIHDKWGTVCSNGWSMNEVSVVCQQLGCPTSIKALGWANSSAGSGYIWMDKVSC ENSRNOP00000058828/1-1120 SGRVELKIHEKWGTVCGNGWSMNEVSVVCQQLGCPTLIKAPGWANASAGSGDIWMDKVSC *****:*:::.*****.:.*.*: *:*:*.** *** :.* **:*:*.*:* ****:*** ENSCPOP00000004743/1-1122 RGNESALWDCNHSGWGKA-NCTHQQDAGVTCSDGSELEMRLVN-GRGRCSGRLEIKFQGR XP_004869589.1/1-1161 RGNESALWECNHNGWGIQ-NCTHQQDAGVTCSDGSELELRLVN-GDNRCSGRVEVKFQGQ ENSP00000352071/1-1156 RGNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTR-GGNMCSGRIEIKFQGR ENSMUSP00000108160/1-1159 TGNESALWDCKHDGWGKH-NCTHEKDAGVTCSDGSNLEMRLVNSAGHRCLGRVEIKFQGK ENSRNOP00000058828/1-1120 TGNESALWDCKHEGWGKH-NCTHEQDAGVTCADGSNLEMRLVNSGDNRCSGRVEIKFQGK *******:*:*.*** ****::******:***:**:**.. . * **:*:****: ENSCPOP00000004743/1-1122 WGTVCDDHFYMEDASVVCNQLQCQTAVGFAGSTKFGSGSGPIWLDDLECHGNESTLWSCK XP_004869589.1/1-1161 WGTVCDDQFYMDDASVVCNQLKCGGAISFSGSAKFGAGSGPIWLDDVSCHGNESALWYCG ENSP00000352071/1-1156 WGTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCK ENSMUSP00000108160/1-1159 WGTVCDDNFSKDHASVICKQLGCGSAISFSGSAKLGAGSGPIWLDDLACNGNESALWDCK ENSRNOP00000058828/1-1120 WGTVCDDNFSKDHASVICKQLGCGSAISFSGSAKLGAGSGQIWLDDLACNGNESAIWDCK *******:* :.***:*.** * *:.*:**:::* *** **:**: *:****::* * ENSCPOP00000004743/1-1122 HNGWGKNNCGHSEDVGVICLEGADMGMRLVDGGVTNCSGRLEVKFQGEWGTVCEHHWDIE XP_004869589.1/1-1161 HRGWGSHNCAHGEDVGVICLEGADMGLRLAG-GVSKCSGRLEVKFQGEWGTVCDNGWDSS ENSP00000352071/1-1156 HQGWGKHNCDHAEDAGVICSKGADLSLRLVD-GVTECSGRLEVRFQGEWGTICDDGWDSY ENSMUSP00000108160/1-1159 HRGWGKHNCDHAEDVGVICLEGADLSLRLVD-GVSRCSGRLEVRFQGEWGTVCDDNWDLR ENSRNOP00000058828/1-1120 HRGWGRHNCDHAEDVGVICLDGADLSLRLVD-GVSKCSGRLEVRFQGEWGTVCDDSWDRR *.*** :** *.**.**** .***:.:**.. **:.*******:*******:*:. ** ENSCPOP00000004743/1-1122 DAAVVCKQLGCPTTVIAMGRINASEGSGNIWLDRVACKGHESALWYCGHEEWGKHFCNHH XP_004869589.1/1-1161 DASVVCKQLGCPTVVTPMGRANASEGSGNILLDSVACDGHESAIWYCKHHEWGRHFCHHN ENSP00000352071/1-1156 DAAVACKQLGCPTAVTAIGRVNASKGFGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHN ENSMUSP00000108160/1-1159 DASVVCKQLGCPTAISAIGRVNASEGSGQIWLDNISCEGHEATLWECKHQEWGKHYCHHR ENSRNOP00000058828/1-1120 DASVVCKQLGCPTAITAIGRVNASEGSGPIWLDSISCEGHEPALWECKHQEWGKHYCNHK **:*.********.: .:** ***:* * * ** ::*.***.::* * *.***:*:*:*. ENSCPOP00000004743/1-1122 EDVGVTCSDGSDLELRLIGGGSRCAGVVEVEIQKIVGKVCNRVWTLQEADIACKQLGCGS XP_004869589.1/1-1161 EDAGVTCSDGSDLDLRLTGGGSRCAGTVEVEIQKLAGKVCDRGWTIKEADIICRQLGCGS ENSP00000352071/1-1156 EDAGVTCSDGSDLELRLRGGGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGS ENSMUSP00000108160/1-1159 EDAGVTCSDGADLELRLVGGGSRCAGIVEVEIQKLTGKMCSRGWTLADADVVCRQLGCGS ENSRNOP00000058828/1-1120 EDAGVTCSDGADLELRLVGGGSRCAGMVEVEIQKLTGKVCSRGWTLTDADVVCRQLGCGS **.*******:**:*** ******** ******:: **:*.* * : :**: *:****** ENSCPOP00000004743/1-1122 AVETSSIMYS--KTKPSKVWLEVVNCNGNETSLWDCKNSQWSEETCS-YGEAKVTCSAHR XP_004869589.1/1-1161 AVQTSAKLYS--KTETAKTWLEIRSCQGNETSLWDCKNWQWGGQDCP-SEGAQVTCSAHR ENSP00000352071/1-1156 ALKTSYQVYS--KIQATNTWLFLSSCNGNETSLWDCKNWQWGGLTCDHYEEAKITCSAHR ENSMUSP00000108160/1-1159 ALQTQAKIYS--KTGATNTWLFPGSCNGNETTFWQCKNWQWGGLSCDNFEEAKVTCSGHR ENSRNOP00000058828/1-1120 ALQTQSKIYSKTKTEATNTWLFPGSCSGNETSLWQCKNWQWGGLSCDHFEEAQVTCSGHR *::*. :** * .::.** .*.****::*:*** **. * *::***.** ENSCPOP00000004743/1-1122 EPRLVDGNMPCSGRVEVKHADKWGSVCDSDFSLEAASVLCRELQCGSVISILGGAYFGEG XP_004869589.1/1-1161 EPRLVDGDIPCSGRVEVKHGDRWGSVCDSDFSLEAASVLCRELQCGSAISILGGAHFGEG ENSP00000352071/1-1156 EPRLVGGDIPCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGGAHFGEG ENSMUSP00000108160/1-1159 EPRLVGGEIPCSGRVEVKHGDVWGSVCDFDLSLEAASVVCRELQCGTVVSILGGAHFGEG ENSRNOP00000058828/1-1120 KPRLVGGEIPCSGRVEVKHGDTWGSVCDFDLSLEAAGVVCRELQCGTVVSILGGAHFGEG :****.*::**********.* ***:** *:*****.*:*******:.:******:**** ENSCPOP00000004743/1-1122 KGQIWTEEFQCKGSESHLSLCPLAPRQDGTCDHSREVGVICSRYTEIRLVDGKSSCEGRV XP_004869589.1/1-1161 KGQIWAEEFQCEGHESHLSLCPLAHGQDGTCGHSRDVGVVCSRYTEMRLANGKSSCEGRV ENSP00000352071/1-1156 NGQIWAEEFQCEGHESHLSLCPVAPRPEGTCSHSRDVGVVCSRYTEIRLVNGKTPCEGRV ENSMUSP00000108160/1-1159 SGQIWGEEFQCSGDESHLSLCSVAPPLDRTCTHSRDVSVVCSRYIDIRLAGGESSCEGRV ENSRNOP00000058828/1-1120 SGQIWGEEFQCSGDESHLSLCSVAPPLDRTCSHSRDVSIVCSRYIDIRLADGKSSCEGRV .**** *****.* *******.:* : ** ***:*.::**** ::**..*::.***** ENSCPOP00000004743/1-1122 ELKVLGVWGSLCSSHWSMEDAHVLCQQLKCGVALSTPEGAHFGRGNGLVWRHTFHCKGTE XP_004869589.1/1-1161 ELKVFGVWGSLCGSHWNMEDAHVLCQQLKCGIALSTPEGAHFGREHGQAWRHIFHCNGTE ENSP00000352071/1-1156 ELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRHMFHCTGTE ENSMUSP00000108160/1-1159 ELKTLGAWGPLCSSHWDMEDAHVLCQQLKCGVAQSIPEGAHFGKGAGQVWSHMFHCTGTE ENSRNOP00000058828/1-1120 ELKTLGAWGPLCSSHWDIEDAHVLCQQLKCGVALSTPGGAHFGKGAGQVWRHKFHCTGTE ***.:*.**.**.***.:*************:* * * **:**: * * * ***.*** ENSCPOP00000004743/1-1122 EHMGDCPLTALGASLCSESQVASVICSGNQSQRLWPCNASSP-EPTVSSIPPESAVTCLE XP_004869589.1/1-1161 EHMGDCPVTALGASLCSEGQVASVICSGNQSQRLLPCNSSSL-MPTSSTSPQESAVTCLE ENSP00000352071/1-1156 QHMGDCPVTALGASLCPSEQVASVICSGNQSQTLSSCNSSSL-GPTRPTIPEESAVACIE ENSMUSP00000108160/1-1159 EHIGDCLMTALGAPTCSEGQVASVICSGNQSQTLLPCSSLSPVQTTSSTIPKESEVPCIA ENSRNOP00000058828/1-1120 EHIGDCPMTALGTPMCSDGQVASVICSGNQSHTLLPCSSSSSVQTTSSTIAKDSDVPCIA :*:*** :****:. *.. ************: * .*.: * .* .: . :* *.*: ENSCPOP00000004743/1-1122 NSQVRLVNGNSHCAGRVEIYHEGSWGTICDDSWDLGDAHVVCRQLGCGVAINATGSAHFG XP_004869589.1/1-1161 SNHIRLVDGPGRCAGRVEVYHEDSWGTICDDSWELGDAHVVCRQLGCGVAINATGSAHFG ENSP00000352071/1-1156 SGQLRLVNGGGRCAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFG ENSMUSP00000108160/1-1159 SGQLRLVGGGGRCAGRVEVYHEGSWGTVCDDNWDMTDANVVCKQLDCGVAINATGSAYFG ENSRNOP00000058828/1-1120 SGQLRLVGGGGRCAGRVEVYHEGSWGTICDDSWDLTDANVVCKQLDCGVAINATGSAYFG ..::***.* .:******:***.****:***.*:: **:***:**.** ********:** ENSCPOP00000004743/1-1122 EGTGPIWLDEIQCNGKEKHIWQCRSHGWGQHNCRHKEDAGVICSEYMSLRLTGEGSQGTC XP_004869589.1/1-1161 EGTGPIWLDEINCNGKEAHIWQCHSHGWGQHNCRHKEDAGVICSEFMSLRLAGERSRGAC ENSP00000352071/1-1156 EGTGPIWLDEMKCNGKESRIWQCHSHGWGQQNCRHKEDAGVICSEFMSLRLTSEASREAC ENSMUSP00000108160/1-1159 EGAGAIWLDEVICTGKESHIWQCHSHGWGRHNCRHKEDAGVICSEFMSLRLTNEAHKENC ENSRNOP00000058828/1-1120 EGTGDIWLDEIDCSGKESHIWQCHSHGWGRHNCRHKEDAGVVCSEFMSLRLTNEAHRVNC **:* *****: *.*** :****:*****::**********:***:*****:.* : * ENSCPOP00000004743/1-1122 SGRLEVFYNGVWGSVGRNDMSETTMGVVCKHLGCGDNGTMEPASSDKIPSRLMWVDKVQC XP_004869589.1/1-1161 AGRLEVFYSGDWGSVGRSAMSLATVGIACKQLGCGDNGTIEPASPDKRPARPMWLDEVRC ENSP00000352071/1-1156 AGRLEVFYNGAWGTVGKSSMSETTVGVVCRQLGCADKGKINPASLDKAMSIPMWVDNVQC ENSMUSP00000108160/1-1159 TGRLEVFYNGTWGSIGSSNMSPTTVGVVCRQLGCADNGTVKPIPSDKTPSRPMWVDRVQC ENSRNOP00000058828/1-1120 TGRLEVFYNGTWGSIGSSNMSPTTVGVVCRQLGCADNGTVKPTSSDKTPTRPMWTDSVQC :*******.* **::* . ** :*:*:.*::***.*:*.::* . ** : ** * *:* ENSCPOP00000004743/1-1122 PIGPDTLWQCTSSPWRQRLASP-AEETWITCDNKIRLKDQGKPAHCSGRVEVWHRGSWGT XP_004869589.1/1-1161 PAGPDTLWQCTSSPWRRRLASP-AEETWIVCHDKIRLKDQDHLAQCSGRVEVWHGGSWGS ENSP00000352071/1-1156 PKGPDTLWQCPSSPWEKRLASP-SEETWITCDNKIRL--QEGPTSCSGRVEIWHGGSWGT ENSMUSP00000108160/1-1159 PKGVDTLWQCPSSPWKQRQASPSSQESWIICDNKIRL--QEGHTDCSGRVEIWHKGSWGT ENSRNOP00000058828/1-1120 PKGVDTLWQCPSSPWKQRQASP-SQESWIVCDDKIRL--QEGHTDCSGRVEIWHRGSWGT * * ******.****.:* *** ::*:** *.:**** * : ******:** ****: ENSCPOP00000004743/1-1122 VCDDSWDLNDAQVVCRQLGCGEAVKALKEAAFGQGTGPIWLSQVKCRGNESSLWDCPAKQ XP_004869589.1/1-1161 VCDDSWGLSDAQVVCRQLGCGRAVVALKEAAFGRGTGPVWLSQVKCRGNESSLWDCPEGR ENSP00000352071/1-1156 VCDDSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDCPARR ENSMUSP00000108160/1-1159 VCDDSWDLNDAKVVCKQLGCGQAVKALKEAAFGPGTGPIWLNEIKCRGNESSLWDCPAKP ENSRNOP00000058828/1-1120 VCDDSWDLNDAEVACKQLGCGQAVEALKEAAFGPGTGPIWLNEMKCRGNESSLWDCPARP ******.*.**:*.*:***** *: *:*** ** ****:**.::**:********** ENSCPOP00000004743/1-1122 WGYSDCGHKEDAAVQCLPGTSESMPSE----G----HKSLVVLVIFGVILLALLIGFLTW XP_004869589.1/1-1161 WGNSDCGHKEDAAVRCLPAQISSSLGAFFFLG----HKALAVSVIFGIILLALLIGFLTW ENSP00000352071/1-1156 WGHSECGHKEDAAVNCTDISVQKTPQK-ATTGRSSRQSSFIAVGILGVVLLAIFVALFFL ENSMUSP00000108160/1-1159 WSHSDCGHKEDASIQCLPKMTSESHHG---TG----HPTLTALLVCGAILLVLLIVFLLW ENSRNOP00000058828/1-1120 WSHSDCGHKEDASVKCLPRMTLESQHG---TG----HSTLTALLVCGAILLVLLIAFLLW *. *:*******::.* . * : :: . : * :**.::: :: ENSCPOP00000004743/1-1122 ILKKRQIQRLTVFSRGEHFVHHIRYEEMNSRQKIDDLDLHASSGIL-------------- XP_004869589.1/1-1161 ILKKRQIQRLTVFSRGERSVHHIRYEEMNSNLQVDDLDLPTSFGQCILREPIAGGLRLNG ENSP00000352071/1-1156 TKKRRQRQRLAVSSRGENLVHQIQYREMNSCLNADDLDLMNSSENS---------HESAD ENSMUSP00000108160/1-1159 TLKRRQIQRLTVSSRGEVLIHQVQYQEMDS--KADDLDLLKSSENS---------NNSYD ENSRNOP00000058828/1-1120 TLKRRQTQRLTVSSRGEVLIHQVQYQEMDS--KTDDLDLLKSSGWH---------LRNLD *:** ***:* **** :*:::*.**:* : ***** * ENSCPOP00000004743/1-1122 -----------------------QDHVRK----------NIKHM XP_004869589.1/1-1161 FKVVGLISVSKYLSVFGIDKAAALRHSD-----------ENGNL ENSP00000352071/1-1156 FSAAELISVSKFLPISGMEKEAILSHTEK----------ENGNL ENSMUSP00000108160/1-1159 FNDDGLTSLSKYLPISGIKKGSFRGTLRRKMIIYNPLRLEFKKP ENSRNOP00000058828/1-1120 MTAS----------------------------------------