CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000037409/1-1441 MAAAAAAAAAAAAAAMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPP ENSRNOP00000031549/1-1444 -MATVAAAAAAAVAAMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPP ENSP00000311513/1-1441 -----MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPP ENSCPOP00000004730/1-1433 ------ATAAAAAAAMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPP XP_004869726.1/1-1436 -----MATAAAAAAAMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPP *:****.*.********************************************* ENSMUSP00000037409/1-1441 PDIGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMS ENSRNOP00000031549/1-1444 PDIGHGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMS ENSP00000311513/1-1441 PDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMS ENSCPOP00000004730/1-1433 PDVGHGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMS XP_004869726.1/1-1436 PDVGHGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMS **:*:******************************************************* ENSMUSP00000037409/1-1441 VECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRM ENSRNOP00000031549/1-1444 VECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRM ENSP00000311513/1-1441 VECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRM ENSCPOP00000004730/1-1433 VECKLALLKYLCECQFDDNLKFKNIINEEDADAMRLQPIGRDKDGLMYWYQLDQDHNVRM XP_004869726.1/1-1436 VECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRM ********************************:*************************** ENSMUSP00000037409/1-1441 YIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQEDSSRESPTLEDEET ENSRNOP00000031549/1-1444 YIEEQDDQDGSSWKCIVRNRNELAETLALLRAQIDPVLLKNSSQQEDPSRESPTLEDEET ENSP00000311513/1-1441 YIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEET ENSCPOP00000004730/1-1433 YIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPALEDEET XP_004869726.1/1-1436 YIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNCSQQDNSSRESPTLEDEET ******************************:**********.***::.*****:****** ENSMUSP00000037409/1-1441 KKDEETPKQEASKENEKTGADERSVDSGKCSAASALEEPAVKTEKADEKELAKLPVIVKL ENSRNOP00000031549/1-1444 KKDEETPKQEASRGNEKTEADERSMDSRKRSAANALEGPAVKIEKADEKELVKLPVIVKL ENSP00000311513/1-1441 KKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKL ENSCPOP00000004730/1-1433 KKEEETPKQGFFVCFILLCFEERQVDSVNHSTAYFLEETIVKIEKDDEKELTKLPIIVKL XP_004869726.1/1-1436 KKEEETPKQEEQKETKKTK-EERPVDSVNHSTASVLEETIFQVEKDDEKELIKLPVIVKL **:****** :*: :* : *:* ** . .: ** ***** ***:**** ENSMUSP00000037409/1-1441 EKPLPETEEKKIIREESDSFKENVKPIKVEAKECRADPKDLKGSLERLGSQEPERADFGS ENSRNOP00000031549/1-1444 EKPVPETEDKKIIREESDSFKENVKPIKVEAKECRVDPKDLKGSLERLGSQEPERADFGS ENSP00000311513/1-1441 EKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGG ENSCPOP00000004730/1-1433 EKSLSESEEKKIIKEENDSFKENIKPIKVEVKECRSDPKDIKGSMEKVGAPEPERLEFGG XP_004869726.1/1-1436 EKSLPESEEKKIIKEESDSFKENIKPIKVEVKECRTDPKDSKGSMEKVGAQEPERLEFGG **.:.*.*:****:**.******:******.**** **** *.*:*: : **** :**. ENSMUSP00000037409/1-1441 NIK-SQDIIEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSATPTKEVLK ENSRNOP00000031549/1-1444 NIKSSQDITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGHLCKSATPTKECLK ENSP00000311513/1-1441 NIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLK ENSCPOP00000004730/1-1433 NVKSSQDITEKSPEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEVLK XP_004869726.1/1-1436 NVRSSQDITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLK *:: *::* ***.********************************* ****.***** ** ENSMUSP00000037409/1-1441 DDIKQEEETCKRVSTISALSHEGKQLVNGEINDDKVIPNFKTEQMEIQLCDTKEDSASIP ENSRNOP00000031549/1-1444 DDVKQEEETCKRVSTISALSHEGKQLMNGEMNDDKVTASLKTEQLETQLCHTKEDSSSIP ENSP00000311513/1-1441 DEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYS-P ENSCPOP00000004730/1-1433 DEIKQEEETCKRISTITALSHDGKQLVNGEVSDEKITPNVRTEQIETKCLDTKEDMYSNF XP_004869726.1/1-1436 DEIKQEEETCKRISTVTTLSHDGKQLVNGEVNDEKVTSNVKTEQIETKFSDTKEDICSSL *::*********:**:::*.*:****:***:.*::: ...:** :* : .***: * ENSMUSP00000037409/1-1441 AKDGNACMEGNGTECLNSVITSTKTSELEKEA-PLGKGIDSSVPDIESLSQKARLEEPGL ENSRNOP00000031549/1-1444 AKDGSAGLEGSGVECLNSVLTSTKTSELEKEV-SLGKAVDGSASDVESHSQKGRGEEPGP ENSP00000311513/1-1441 SKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDP ENSCPOP00000004730/1-1433 SKDRSVIMEGNGAECLNSVITSTKTQELEKEVTLLGKTADSSVSVLETHSQKGLLEELSL XP_004869726.1/1-1436 SKDRSVIMEGNGAECLNSVLTSTKIHDLEIEVVPLGKVEDSAGSVVGTHSQKGLLEEPGL :** . **.*.*.****:** * :** *. * * *.: . : ***. ** . ENSMUSP00000037409/1-1441 LNMDMPLEPSEKATDLSLKPTLSATEPCSTKVEEKAPRSKSENHTPGIECLERVEKAKKT ENSRNOP00000031549/1-1444 PNMDMPLEPSEKTTDLSLKSTLSATESCPTKIEEKAPKSKGENHTAGIECLEKVEKAKKT ENSP00000311513/1-1441 PEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKT ENSCPOP00000004730/1-1433 PEMETPFESSEITKDLSLKTASSAPEACTIKIEEKSPKSKKDNLPPTLECLEKLGKSKKT XP_004869726.1/1-1436 PEMETSLKSSEIAKDLSLKTALSATESCTIKIEEKPPKSKKDNHPPILESLEKVEKSKKT :*: .:..** :.*** *.: *:.*.*. * ***.*::* :: .. :*.**:: *:*** ENSMUSP00000037409/1-1441 SIDKDIQKLSPIPEEVVRGALESEKSGPCEVAETPLPLSMAGAKEKQTSEKKDVDC-SRG ENSRNOP00000031549/1-1444 SVDKDIQRLSPIPEEVVRGPLESEESGLCEVAETPLPLEMTGAKEKQTSEKKGVDCLSRG ENSP00000311513/1-1441 FLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTS ENSCPOP00000004730/1-1433 FLDKDTQRLSPIPEEIPKSTIESEKQASPEAAENSL-SKMTGHCEKLILEKEGVECQSIS XP_004869726.1/1-1436 FLDKDTQRLSPIPEEVPKSTIESEKPGSPGAAENSPPSKMTDHCEKLASEKEGVECQSIS :*** *:*******: :..:***: . .**.. .: . ** **: *:* * . ENSMUSP00000037409/1-1441 SSESQSLENASPEILKEDSESSREEVAKLDNAQTSGMEDTSETKGSVQKNKFKYKLVSER ENSRNOP00000031549/1-1444 SSEGQSLENASPDILRENSESSRVEMAKLDNAQTSGVEDTSQTKGSVQKNKCKYKLVSEG ENSP00000311513/1-1441 TVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEE ENSCPOP00000004730/1-1433 SVEG--LEKTDPEIIKEDSESMKVEMDNLDNTQTSSLGKPSETKDSVQKSKFKYKLVPEE XP_004869726.1/1-1436 SVEG--LEKTAPDILTEDSDSMKVEMDNLDNTQTSGLGDPSETKDSVQRSKFKYKLVPEE : . :::. : : *:*: : *: :***:***.: ..*:**.*:*:.* *****.* ENSMUSP00000037409/1-1441 NSTASENTEITSERKKEGIKLTIRISSRKKKPDCPPQTVDSESKEEKAGKEEEKASVGRT ENSRNOP00000031549/1-1444 NSTASENTEITSERKKEGIKLTIRISSRKKKPDCPPQIVDSESKEEKAGKEEEKTSVGRT ENSP00000311513/1-1441 ETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRT ENSCPOP00000004730/1-1433 ETISSANTEITSERQKEGIKLTIRISSRKKKPDCPPQILEPESKQDKTEKEEEKANVGRT XP_004869726.1/1-1436 ETAASENTEITSERQKEGIKLTIRISSRKKKADCPPEILEPESKQEKTEKEEEKTNVGRT :: :* ********:****************.*.**: ::.*.*::*: *****:.**** ENSMUSP00000037409/1-1441 LRRSPRISRPTAKVAEIRVQKADKRRADGEDGVEGEPASLQTADKKDHLKKAEKDTNSKA ENSRNOP00000031549/1-1444 LRRSPRISRPTAKVAEIRDQKADKKRAEGEEGVEGETTSLQTADKKEHLKKAEKDTNSKA ENSP00000311513/1-1441 LRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKV ENSCPOP00000004730/1-1433 LRRSPRISRPTAKAAEIRDQKADKKRGEGEDEVEEDSAASQKTDKKENLQK-EKDINSKV XP_004869726.1/1-1436 LRRSPRISRPTAKAAEIRDQKADKKRGEGEDEIEEESAALQKTDKKD-LKKTEKDTNSKI *************.**** *****:*.:**: :* :.:: *.:***: *:* *** *** ENSMUSP00000037409/1-1441 SKVKPKGKVRWTGSRTRGRWKYSSNDESEGSESDKSSAALEEEEGKEGEEAVLPDDDEPC ENSRNOP00000031549/1-1444 SKVKPKGKVRWTGSRTRGRWKYSSNDESEGSESDKSSAASEEEEGKESEEAVLPDDDEPC ENSP00000311513/1-1441 SKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPC ENSCPOP00000004730/1-1433 SKVKPKGKVRWTGSRSRGKWKYSSNDESEGSDSEKSSAASEEEEEKESEDAILADDDEPC XP_004869726.1/1-1436 SKVKPKGKVRWTGSRTRGKWKYSSNDESEGSDSEKSSAASEEEVEKESEEAILADDDEPC ***************:**:************ *:***** *** **.*:*:*.****** ENSMUSP00000037409/1-1441 KKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDL ENSRNOP00000031549/1-1444 KKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDL ENSP00000311513/1-1441 KKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDL ENSCPOP00000004730/1-1433 KKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDL XP_004869726.1/1-1436 KKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDL ************************************************************ ENSMUSP00000037409/1-1441 DVALKKKERAERRKERLVYVGISIENIIPPQEPEFSEEQEEKKKDAKKSKANALERRSTR ENSRNOP00000031549/1-1444 DVALKKKERAERRKERLVYVGISIENIIPPQEPEFSEDQEEKKKDAKKSKANVLERRSTR ENSP00000311513/1-1441 DVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTR ENSCPOP00000004730/1-1433 DVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTR XP_004869726.1/1-1436 DVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKPNLLERRSTR *********************************:***:*******:****.* ******* ENSMUSP00000037409/1-1441 TRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKEN ENSRNOP00000031549/1-1444 TRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKEN ENSP00000311513/1-1441 TRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKEN ENSCPOP00000004730/1-1433 TRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKEN XP_004869726.1/1-1436 TRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISAILEEERKEN **************************************************:**:****** ENSMUSP00000037409/1-1441 KRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEEPP ENSRNOP00000031549/1-1444 KRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEEPP ENSP00000311513/1-1441 KRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPP ENSCPOP00000004730/1-1433 KRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENLDESEEDPP XP_004869726.1/1-1436 KRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENLDESEEDPP *************************************************** *****:** ENSMUSP00000037409/1-1441 SNEDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEEESEENSRDSESDFSD ENSRNOP00000031549/1-1444 SNEDSDTDFCSRRLRRHPSRPMRQSRRLRRKTQKKKYSDDDEEEEESEENSRDSESDFSD ENSP00000311513/1-1441 SNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDD-EEEESEENSRDSESDFSD ENSCPOP00000004730/1-1433 SNEDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDD-EEEESEENSRDSESDFSD XP_004869726.1/1-1436 SNDDSDTDFCSRRLRRHSSRPMRQSRRLRRKTPKKKYSDDD-EEEESEENSRDSESDCSD **:**************.************** ******** *************** ** ENSMUSP00000037409/1-1441 DFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESF ENSRNOP00000031549/1-1444 DFSDEFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESY ENSP00000311513/1-1441 DFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESY ENSCPOP00000004730/1-1433 DFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESY XP_004869726.1/1-1436 DFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESY ****:******************************************************: ENSMUSP00000037409/1-1441 MSKNSEDDELTKESKRSVRKRGRSTDDYSEAD-EDDEEEGKPSRKRLHRIETD-EESCDN ENSRNOP00000031549/1-1444 MSKNSEDDELTKESKRSIRKRGRSTGEYSEAD-EEEEEEGKPSRKRLHRIETD-EESCDS ENSP00000311513/1-1441 LSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDN ENSCPOP00000004730/1-1433 TSKNSEDDELAKDSKRSVRKRGRSTDEYSEAD--EEEEESKPSRKRLHRIETD-EESCDN XP_004869726.1/1-1436 ASKNSEDDELSKESKRSVRKRSRSTDDYSEAD-EEEEEEGKPSRKRLHRIETD-EESCDN *********:*:****:***.***.:***** ::***.************* *****. ENSMUSP00000037409/1-1441 AHGDADQPARDSQPSALPSEQESSKKPYRIESDEEEDFEN--KVGSPLDYSLVDLPSTNG ENSRNOP00000031549/1-1444 AHGDADQPARESQASVLPSEQESSKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNG ENSP00000311513/1-1441 AHGDANQPARDSQPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNG ENSCPOP00000004730/1-1433 THGDVDQHAHDSQPRVLPSAQEITKKSYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNG XP_004869726.1/1-1436 THGGADQHTHDSQPRVLPSEQESTKKPYRIESDEEEDFDNVGKVGSPLDYSLVDLPSTNG :**..:* :::**. .*** ** :**.***********:* ****************** ENSMUSP00000037409/1-1441 QSPGKAIENLMGKATEKSQTPKDNGTASASLAPNGTSGGQEVGAPEEDEDELLRVTDLVD ENSRNOP00000031549/1-1444 QSPGKAIENLMGKATEKSQTPKDNGTASANLAPNGTSGGQEVGAPEEDEDELLRVTDLVD ENSP00000311513/1-1441 QSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLVD ENSCPOP00000004730/1-1433 QSPGKAIENLIGKPPEKPQTPKDNSTTSASLASNGTS-GQEAGAPEEEEDELLRVTDLVD XP_004869726.1/1-1436 QSPGKAIENLIGKPTEKPQTPKDNSTASASLASNGTSSGQEAGAPEEEEDELLRVTDLVD **********:**..**.******.*:**.**.**** ***.*****:************ ENSMUSP00000037409/1-1441 YVCNSEQL ENSRNOP00000031549/1-1444 YVCNSEQL ENSP00000311513/1-1441 YVCNSEQL ENSCPOP00000004730/1-1433 YVCNSEQL XP_004869726.1/1-1436 YVCNSEQL ********