CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000004574/1-1618 MERPTTSKSENHEP-KNVICEESKPVKVTTNQTLKARNDKSVKEIGSSSRNHES------ XP_004869298.1/1-1663 METPKTSKSENHEP-KNVICEESKPVKVITNQTLKARNDKSVKEIGSSPSNRNSSKKTKQ ENSP00000257177/1-1645 MEESKTLKSENHEPKKNVICEESKAVQVIGNQTLKARNDKSVKEIENSSPNRNSSKKNKQ ENSMUSP00000095538/1-1648 MEEPKTSKNENHEPKKNIICEESKAVKIISNQTLKPRNDKS--EIGTSSLNRNSSKKTKQ ENSRNOP00000030200/1-1073 ------------------------------------------------------------ ENSCPOP00000004574/1-1618 ------------------------------RDQSHAKQKNYPNSPVKAEKIPAT-SQAKL XP_004869298.1/1-1663 NDTCVEKTEVKSWKVNAASVPGPKDLGLVLRDQSHCKGKKLPNSPVKAEKIPSSTSQAKL ENSP00000257177/1-1645 NDICIEKTEVKSCKVNAANLPGPKDLGLVLRDQSHCKAKKFPNSPVKAEK--ATISQAKS ENSMUSP00000095538/1-1648 NDICIEKTEAKSCKVNAASVPGPKDLGLVHRDQSHCKMKKLPNSPMKAQK--GS-SQTKL ENSRNOP00000030200/1-1073 ------------------------------------------------------------ ENSCPOP00000004574/1-1618 EK-PSLQAKAEKTPKPPNLPVKAEKAPFSPAAAAATKALSAQRKSEKVSSSHIKSEKVAS XP_004869298.1/1-1663 EKAPNLQAKVEKVPKSPNLPAKAEKVPCSTATAAAGKSLSSQRKAEKAPSSQMKSEKVAN ENSP00000257177/1-1645 EKATSLQAKAEKSPKSPN-----------------------SVKAEKASSYQMKSEKVPS ENSMUSP00000095538/1-1648 EKTPSLQTKAEKVPKSPNLPVKAEKAPCTTAEATTEKALNSQRKEENTPTSQMKLQKTPR ENSRNOP00000030200/1-1073 ------------------------------------------------------------ ENSCPOP00000004574/1-1618 VSSADPEKVSSLLLKENKRQTELQQTAS------SSANKVNIETVQREKSALERLSQSQK XP_004869298.1/1-1663 VSAVDPEKVPSLLLKENKRQTELQQTGKKNPSSFTSVNKVNIETIQREKSALEKLPQSQK ENSP00000257177/1-1645 -SPAEAEKGPSLLLKDMRQKTELQQIGKKIPSSFTSVDKVNIEAVGGEKCALQNSPRSQK ENSMUSP00000095538/1-1648 -SPLEPENVPSLLLKENVKQTESQQTGKKLTSSFVSMDKRKSEALQGEKSALENSSLSQK ENSRNOP00000030200/1-1073 ------------------------------------------------------------ ENSCPOP00000004574/1-1618 QQTRTDNNGDSDDSASGIEDVLDDSSKYKLEPLSLEKSSEVDYFVNAAVLN-SGIWYERS XP_004869298.1/1-1663 QQTRTDNNGDSDDSASGIEDMSDDSRKMKNDESNKENSSEMGYLENATVIDESALTPEQR ENSP00000257177/1-1645 QQTCTDNTGDSDDSASGIEDVSDDLSKMKNDESNKENSSEMDYLENATVIDESALTPEQR ENSMUSP00000095538/1-1648 QQTQTDNIADSDDSASGIEDTADDLSKMKSEESNKENSSEMDYLENATVIDESALTPEQR ENSRNOP00000030200/1-1073 ------------------------------------------------------------ ENSCPOP00000004574/1-1618 VNFKQVLETMLQNLVFKLFARSPEYTNCRYLCKLCLIHIENIQGAHKHIKEKRHKKNILE XP_004869298.1/1-1663 LGLKQAEERLERDHIFRLEKRSPEYTNCRYLCKLCLIHIENIQGAHKHIKEKRHKKNILE ENSP00000257177/1-1645 LGLKQAEERLERDHIFRLEKRSPEYTNCRYLCKLCLIHIENIQGAHKHIKEKRHKKNILE ENSMUSP00000095538/1-1648 LGLKQAEERLERDHIFRLEKRSPEYTNCRYLCKLCLIHIENIQGAHKHIKEKRHKKNILE ENSRNOP00000030200/1-1073 ------------------------------------------------------------ ENSCPOP00000004574/1-1618 KQEESELRSLSPPSSAHLAALSVAVVEIAKEQGITDEDLKARQEIVEEMSKVITTFLPEC XP_004869298.1/1-1663 KQEESELRSLPPPSPAHLAALSVAIVEVAKEQGITDDDLKARLEIVEEMSKVITAFLPEC ENSP00000257177/1-1645 KQEESELRSLPPPSPAHLAALSVAVIELAKEHGITDDDLRVRQEIVEEMSKVITTFLPEC ENSMUSP00000095538/1-1648 KQEESELRSLPSPSSAHLAALSVAVVELAKEQGITDDDLRIRQDIVEEMSKVIMTFLPEC ENSRNOP00000030200/1-1073 ------------------------------EQGITDDDLRIRQDIVEEMSKVIVTFLP-- *:****:**: * :********* :*** ENSCPOP00000004574/1-1618 SLRLYGSSLTKFALKSSDVNIDIKFPSTMNHPDLLIQVLGIYKPPVLYVDVESDFHAKVP XP_004869298.1/1-1663 SLRLYGSSLTKFALTSSDVNIDIKFPSTMNHPDLLIQVLGIFKKNVLYVDVESDFHAKVP ENSP00000257177/1-1645 SLRLYGSSLTRFALKSSDVNIDIKFPPKMNHPDLLIKVLGILKKNVLYVDVESDFHAKVP ENSMUSP00000095538/1-1648 SLRLYGSSLTKFALKSSDVNIDIKFPPKMNHPDLLIQVLGILKKSALYIDVESDFHAKVP ENSRNOP00000030200/1-1073 ---------------------------------------------ALYVDVESDFHAKVP .**:*********** ENSCPOP00000004574/1-1618 VVICKDRKRSGLLCRVSAGNDTACLTTDLLAALGKMEPVFTPLVLAFRYWAKLCYIDSQT XP_004869298.1/1-1663 VVVCKDRK-SGLLCRVSAGNDSACLTTDLLAALSKMEPVFTPLVLAFRYWAKLCYIDSQT ENSP00000257177/1-1645 VVVCRDRK-SGLLCRVSAGNDMACLTTDLLTALGKIEPVFIPLVLAFRYWAKLCYIDSQT ENSMUSP00000095538/1-1648 VVVCKDRK-SALLCRVSAGNDMACLTTDLLAALGKVEPVFTPLVLAFRYWAKLCYIDSQT ENSRNOP00000030200/1-1073 VVVCKDRK-SGLLCRVSAGNDMACLTTDLLAALGKVEPVFTPLVLAFRYWA--------- **:*:*** *.********** ********:**.*:**** ********** ENSCPOP00000004574/1-1618 DGGIPSYCFVLMTMFFLQQRKPPILPCLLGSWIEGFDPKRMDDFQLKGIVEEKFVKWEYK XP_004869298.1/1-1663 DGGIPSYCFALMAMFFLQQRKPPILPCLLGSWIEGFDPKRMDDFQLKGIVEEKFVKWEYK ENSP00000257177/1-1645 DGGIPSYCFALMVMFFLQQRKPPLLPCLLGSWIEGFDPKRMDDFQLKGIVEEKFVKWECN ENSMUSP00000095538/1-1648 DGGIPSYCFALMVMFFLQQRKPPLLPCLLGSWIEGFDPKRMDDFQLKGIVEEKFVKWEYN ENSRNOP00000030200/1-1073 ------------------------------------------------------------ ENSCPOP00000004574/1-1618 SSSATEKNSIAEENKAKADQPKDDTKKTETVNQSNAMKEKHGKSPLTLETPNQVSLGQLW XP_004869298.1/1-1663 SSSATEKNSIAEENKAKADQPKDDTKKTETDNQSNAMKEKHGKSPLTLETPNQVSLGQLW ENSP00000257177/1-1645 SSSATEKNSIAEENKAKADQPKDDTKKTETDNQSNAMKEKHGKSPLALETPNRVSLGQLW ENSMUSP00000095538/1-1648 SSSATEKNLIADENKAKADEPKDDTKKTETDNQSNAAKAKHGKSPLTLEAPNQVPLGQLW ENSRNOP00000030200/1-1073 ------------------------------------------KSPLTLEAPNQVPLGQLW ****:**:**:*.***** ENSCPOP00000004574/1-1618 LELLKFYTLDFALEEYVICVRIQDILTRENKNWPKRRIAIEVDPFSVKRNVARSLNSQLV XP_004869298.1/1-1663 LELLKFYTLDFALEEYVICVRIQDILTRENKNWPKRRIAIE-DPFSVKRNVARSLNSQLV ENSP00000257177/1-1645 LELLKFYTLDFALEEYVICVRIQDILTRENKNWPKRRIAIE-DPFSVKRNVARSLNSQLV ENSMUSP00000095538/1-1648 LELLKFYTLDFALEEYVICVRIQDILTRENKNWPKRRIAIE-DPFSVKRNVARSLNSQLV ENSRNOP00000030200/1-1073 LELLKFYTLDFALEEYVICVRIQDILTRENKNWPKRRIAIE-DPFSVKRNVARSLNSQLV ***************************************** ****************** ENSCPOP00000004574/1-1618 YEYVVERFRAAYRYFACPQRKGENKSTVPFKKKDKGKISNKKPVKSDNVATSCSVLLGEN XP_004869298.1/1-1663 YEYVVERFRAAYRYFACPQRKGGNKSTVHFKKKEKGKISNKKPVKSDNMGTSCSVLLGES ENSP00000257177/1-1645 YEYVVERFRAAYRYFACPQTKGGNKSTVDFKKREKGKISNKKPVKSNNMATNGCILLGET ENSMUSP00000095538/1-1648 YEYVVERFRAAYRYFACPQKKGGNKSTMDPKKKEKGKLSSKKPVKSDCSATNCCI-LGES ENSRNOP00000030200/1-1073 YEYVVERFRAAYRYFACPQRKGGNKSTVDLKKKEKGKLSNKKPVKSDCSATNGCV-LGES ******************* ** ****: **::***:*.******: .*. .: ***. ENSCPOP00000004574/1-1618 TEKINTESGQSDKHD-TECTSQRCIVKNDHLLVNELDLADHGQESSSLSVANEGTELEPK XP_004869298.1/1-1663 TEKINTERSQSDKHDDMECTSQRCINDNDHLLVNELGLADTVQESSSLSIVNEGTELEPK ENSP00000257177/1-1645 TEKINAEREQPVQCDEMDCTSQRCIIDNNNLLVNELDFADHGQDSSSLST-SKSSEIEPK ENSMUSP00000095538/1-1648 AEKIHMERGQPAKHDETEFTSQRCIVDNDSLLVNELGLANHGQDSSSLSTASGGSDLKQK ENSRNOP00000030200/1-1073 TEKVNMERGQPLKHDEMEFTSQRCIVDNDRLLVNELGLADHGQDSSSLSTGSEGSELQQK :**:: * *. : * : ****** .*: ******.:*: *:***** . .:::: * ENSCPOP00000004574/1-1618 SVKKIDGLVPLQTCFKKELGQCNCIG---SADPDESAGTDCRSNLEIENSHRIMCIDTSA XP_004869298.1/1-1663 SVKKLDGLVPSETCFKKELGQCNCIE---SPDPNESAGTDCRSNLEIETSHQIMCIDTSA ENSP00000257177/1-1645 LDKKQDDLAPSETCLKKELSQCNCIDLSKSPDPDKSTGTDCRSNLETESSHQSVCTDTSA ENSMUSP00000095538/1-1648 SAEKQGDLTPSETSLKKELSQCICIG---TPDGAESAGTDCRSNLEMDSSHQIVCNNVSA ENSRNOP00000030200/1-1073 SAEKQGDLTPSETSLKKELSQCHCTG---TPDGAGSAGTDCRSNLEMESSHQIVCNNISA :* ..*.* :*.:****.** * :.* *:********* :.**: :* : ** ENSCPOP00000004574/1-1618 TSCKCKATEVASDLNDDDNLPSQELYYVFDKFILTSGKPPTIVCSICKKDGHSKNDCPED XP_004869298.1/1-1663 TSCNCKATEVASDLNDDDNLLSQELYYVFDKFILTSGKPPTIVCSICKKDGHSKNDCPED ENSP00000257177/1-1645 TSCNCKATEDASDLNDDDNLPTQELYYVFDKFILTSGKPPTIVCSICKKDGHSKNDCPED ENSMUSP00000095538/1-1648 TSCNCKATEVTSDLVDEDNLPSQELYYVFDKFILTSGKPPTIVCSICKKDGHSKNDCPED ENSRNOP00000030200/1-1073 TSCNCKATEVASDLIDDDNLPSQELYYVFDKFILTSGKPPTIVCSICKKDGHSKNDCPED ***:***** :*** *:*** :************************************** ENSCPOP00000004574/1-1618 FRKIDLKPLPPMTNRFREILDLVCKRCFVDELSPPFSEQYNREQILIGLEKFIQKEYDEK XP_004869298.1/1-1663 FRKIDLKPLPPMTNRFREILDLVCKRCF-DELSPPFSEQHNREQILIGLEKFIQKEYDEK ENSP00000257177/1-1645 FRKIDLKPLPPMTNRFREILDLVCKRCF-DELSPPCSEQHNREQILIGLEKFIQKEYDEK ENSMUSP00000095538/1-1648 FRKIDLKPLPPMTNRFREILDLVCKRCF-DELSPPCSEQHNREQILIGLEKFIQKEYDEK ENSRNOP00000030200/1-1073 FRKIDLKPLPPMTNRFREILDLVCKRCF-DELSPPCSEQHNREQILIGLEKFIQKEYDEK **************************** ****** ***:******************** ENSCPOP00000004574/1-1618 ARLCLFGSSKNGFGFRDSDLDICMTLEGHENAEKLNCKEIIENLAKILKRHPGLRNILPI XP_004869298.1/1-1663 ARLCLFGSSKNGFGFRDSDLDICMTLEGHENAEKLNCKEIIENLAKILKRHPGLRNILPI ENSP00000257177/1-1645 ARLCLFGSSKNGFGFRDSDLDICMTLEGHENAEKLNCKEIIENLAKILKRHPGLRNILPI ENSMUSP00000095538/1-1648 ARLCLFGSSKNGFGFRDSDLDICMTLEGHENAEKLNCKEIIENLAKILKRHPGLRNILPI ENSRNOP00000030200/1-1073 ARLCLFGSSKNGFGFRDSDLDICMTLEGHENAEKLNCKEIIENLAKILKRHPGLRNILPI ************************************************************ ENSCPOP00000004574/1-1618 TTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTRMLATYAAIDPRVQYLGYTMKVFAKRCD XP_004869298.1/1-1663 TTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTRMLATYAAIDPRVQYLGYTMKVFAKRCD ENSP00000257177/1-1645 TTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTRMLATYAAIDPRVQYLGYTMKVFAKRCD ENSMUSP00000095538/1-1648 TTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTRMLATYAAIDPRVQYLGYTMKVFAKRCD ENSRNOP00000030200/1-1073 TTAKVPIVKFEHRRSGLEGDISLYNTL------------------------------RCD *************************** *** ENSCPOP00000004574/1-1618 IGDASRGSLSSYAYILMVLYFLQQRKPPVIPVLQEIFDGKQIPQRMVDGWNAFFFDKTEE XP_004869298.1/1-1663 IGDASRGSLSSYAYILMVLYFLQQRKPPVIPVLQEIFDGKQIPQRMVDGWNAFFFDKTEE ENSP00000257177/1-1645 IGDASRGSLSSYAYILMVLYFLQQRKPPVIPVLQEIFDGKQIPQRMVDGWNAFFFDKTEE ENSMUSP00000095538/1-1648 IGDASRGSLSSYAYILMVLYFLQQRKPPVIPVLQEIFDGKQIPQRMVDGWNAFFFDKTEE ENSRNOP00000030200/1-1073 IGDASRGSLSSYAYILMVLYFLQQRKPPVIPVLQEIFDGKQIPQRMVDGWNAFFFDKTEE ************************************************************ ENSCPOP00000004574/1-1618 LKKRLPSLGKNTESLGELWLGLLRFYTEEFDFKEYVISIRQKKLLTTFEKQWTSKCIAIE XP_004869298.1/1-1663 LKKRLPSLGKNTESLGELWLGLLRFYTEEFDFKEYVISIRQKKLLTTFEKQWTSKCIAIE ENSP00000257177/1-1645 LKKRLPSLGKNTESLGELWLGLLRFYTEEFDFKEYVISIRQKKLLTTFEKQWTSKCIAIE ENSMUSP00000095538/1-1648 LKKRLPSLGKNTESLGELWLGLLRFYTEEFDFKEYVISIRQKKLLTTFEKQWTSKCIAIE ENSRNOP00000030200/1-1073 LKKRLPSLGKNTESLGELWLGLLRFYTEEFDFKEYVISIRQKKLLTTFEKQWTSKCIAIE ************************************************************ ENSCPOP00000004574/1-1618 DPFDLNHNLGAGVSRKMTNFIMKAFINGRKLFGTPFYPLIGREAEYFFDSRVLTDGELAP XP_004869298.1/1-1663 DPFDLNHNLGAGVSRKMTNFIMKAFINGRKLFGTPFYPLIGREAEYFFDSRVLTDGELAP ENSP00000257177/1-1645 DPFDLNHNLGAGVSRKMTNFIMKAFINGRKLFGTPFYPLIGREAEYFFDSRVLTDGELAP ENSMUSP00000095538/1-1648 DPFDLNHNLGAGVSRKMTNFIMKAFINGRKLFGTPFYPLIGREAEYFFDSRVLTDGELAP ENSRNOP00000030200/1-1073 DPFDLNHNLGAGVSRKMTNFIMKAFINGRKLFGTPFYPLIGREAEYFFDSRVLTDGELAP ************************************************************ ENSCPOP00000004574/1-1618 NDRCCRVCGKIGHYMKDCPKRKSYIIIKIKKKFQIYYKNDSRDTHDTRDVR--------- XP_004869298.1/1-1663 NDRCCRVCGKIGHYMKDCPKRK-----RLKKKDSEEEKEGNEEDKDSRDLLDSRDLHDTR ENSP00000257177/1-1645 NDRCCRVCGKIGHYMKDCPKRKSSLLFRLKKKDSEEEKEGNEEEKDSRDVLDPRDLHDTR ENSMUSP00000095538/1-1648 NDRCCRVCGKIGHYMKDCPKRKSSLLFRLKKKDSEEEKEGNEEEKDSRDLL--------- ENSRNOP00000030200/1-1073 NDRCCRVCGKIGHYMKDCPKRK-----RLKKKDSEEEKEGNEEEKDSRDLL--------- ********************** ::*** . *:...: :*:**: ENSCPOP00000004574/1-1618 ---DPRDLRCFICGDAGHVRRECPEVKLARQRNSSVAAAQLVRNLVNAQQVAGSAQQQGD XP_004869298.1/1-1663 DFRDPRDLRCFICGDAGHVRRECPEVKLARQRNSSVAAAQLVRNLVNAQQVASSAQQQGD ENSP00000257177/1-1645 DFRDPRDLRCFICGDAGHVRRECPEVKLARQRNSSVAAAQLVRNLVNAQQVAGSAQQQGD ENSMUSP00000095538/1-1648 ---DSRDLRCFICGDAGHVRRECPEVKMARQRNSSVAAAQLVRNLVNAQQVAGSAQQQSD ENSRNOP00000030200/1-1073 ---DSRDLRCFICGDAGHVRRECPEVKMARQRNSSVAAAQLVRNLVNAQQVAGSAQQQSD *.**********************:************************.*****.* ENSCPOP00000004574/1-1618 QSIRTRQSSECSDSPSYSPQPQPQPFPQNSSQSAAVTQPPSQSGSQPKLGPPQQGAQASH XP_004869298.1/1-1663 QSIRTRQSSECSDSPSYS--PQPQPFPQNSSQSTAVTQPPSQSGSQPKLGPSQQGAQASH ENSP00000257177/1-1645 QSIRTRQSSECSESPSYS--PQPQPFPQNSSQSAAITQPSSQPGSQPKLGPPQQGAQPPH ENSMUSP00000095538/1-1648 QSIRTRQSSECSDSPSYS--PQPQPFPQNSPQPSALPPPPSQPGSQPKLGPPQQGGQPPH ENSRNOP00000030200/1-1073 QSIRTRQSSECSDSPSYS--PQPQPFPQNSPQPSALPPPPSQPGSQPKLGPPQQGGQPPH ************:***** **********.*.:*:. *.**.********.***.*..* ENSCPOP00000004574/1-1618 QVQMPMYNFPQSPPAQYSPMHNMGLLPMHPLQIPAPSWPIHGPVIHSAPGSAPSSIGLND XP_004869298.1/1-1663 QVQMPMYNFPQSPPAQYSPMHNMGLLPMHPLQIPAPSWPIHGPVIHSAPGSAPSSIGLND ENSP00000257177/1-1645 QVQMPLYNFPQSPPAQYSPMHNMGLLPMHPLQIPAPSWPIHGPVIHSAPGSAPSNIGLND ENSMUSP00000095538/1-1648 QVQMPLYNFPQSPPAHYSPMHSMGLLPMHPLQIPAPSWPIHGPMLHSAPGSTPSNIGLND ENSRNOP00000030200/1-1073 QVQMPLYNFPPSPPAHYSPMHGMGLLPMHPLQIPAPSWPIHGPMLHSAPGSTPSNIGLND *****:**** ****:*****.*********************::******:**.***** ENSCPOP00000004574/1-1618 PSIIFAQPAARPMAIPNSSHDGHWPRTVAPNSLLNNGAVGNSGNAEPGFRGLNPPIPWEH XP_004869298.1/1-1663 PSIIFAQPAARPMAIPSSSHDGHWPRTVAPNSLVNNGAVGSS---EPGFRGLNPPIPWEH ENSP00000257177/1-1645 PSIIFAQPAARPVAIPNTSHDGHWPRTVAPNSLVNSGAVGNS---EPGFRGLTPPIPWEH ENSMUSP00000095538/1-1648 PSIIFAQPAARPMAIPSPSHDGHWPRTVAPNSLVNNGAVGNS---EPRFRGLNPPIPWEH ENSRNOP00000030200/1-1073 PSIIFAQPAARPMAIPSSSHDGHWPRTVAPNSLVNNGAVGNS---EPRFRGLNPPIPWEH ************:***..***************:*.****.* ** ****.******* ENSCPOP00000004574/1-1618 APRPHFPLVPASWPYGLHQNFMHQGNTRFQPNKPFYTQ-DRCATRRCRERCPHPPRGNVS XP_004869298.1/1-1663 APRPHFPLVPASWPYGLHQNFMHQGNTRFQPNKPFYTQ-DRCAARRCRERCPHPPRGNVS ENSP00000257177/1-1645 APRPHFPLVPASWPYGLHQNFMHQGNARFQPNKPFYTQ-DRCATRRCRERCPHPPRGNVS ENSMUSP00000095538/1-1648 APR-HFPLVPASWPYGLHQNFMHQGNPRFQP-KPFYAQ-DRCATRRCRERCPHPPRGNVS ENSRNOP00000030200/1-1073 APRPHFPLVPASWPYGLHQNFMHQGNPRFQP-KPFYAQAERCATRRSRERCPHPPRGNVS *** **********************.**** ****:* :***:**.************* ENSCPOP00000004574/1-1618 E XP_004869298.1/1-1663 E ENSP00000257177/1-1645 E ENSMUSP00000095538/1-1648 E ENSRNOP00000030200/1-1073 E *