CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000044898/1-1456 -------MKKKSVYNQNVGDQECDDMEGEENSNTADASGLLYSEADRCPICLSCLLGKEV ENSRNOP00000007003/1-1417 -------MKKKPVYNQSVGDQESEDAEGEENRNNADTSGLLYSEVDRCPICLSCLLGKEV ENSP00000358374/1-1463 -------MKKKTVCTLNMGDKKYEDMEGEENGDNTISTGLLYSEADRCPICLNCLLEKEV ENSCPOP00000004572/1-1390 ETLSQGEMKKKTVYTLHMGDQEHEDMEGEASRNNTAIAGLLYSEADRCPICLNYLLEKEV XP_004863250.1/1-800 -------MKKKTVCTVHMGDQEYEDTEGEGSRNNTAATGLLYSEADRCPICLTCLLEKEV ****.* . :**:: :* *** . :.: :******.*******. ** *** ENSMUSP00000044898/1-1456 GFPESCNHVFCMACILKWAEILASCPIDRKPFQAVFELSAFEGCAKIQVKRRLRETEDKE ENSRNOP00000007003/1-1417 GFPESCNHVFCMACILKWAEILASCPIDRKPFQAVFELRAFEGCAKIQVKRRSRELDDKE ENSP00000358374/1-1463 GFPESCNHVFCMTCILKWAETLASCPIDRKPFQAVFKFSALEGYVKVQVKKQLRETKDKK ENSCPOP00000004572/1-1390 GFPESCNHVFCMTCILKWAETLASCPIDRKPFQAVFKFSALEGCIKVQVKRQLRETKDNK XP_004863250.1/1-800 GFPESCNHVFCMTCILKWAETLASCPIDRKPFQAVFKFSALDGCIKVQVKRQLRDTKEKK ************:******* ***************:: *::* *:***:: *: .::: ENSMUSP00000044898/1-1456 NQRSFKKQLFYHESSKGNKRKRNTIREDLLCERSDGLKVLYRNIS-NKMDGKKNATVKTN ENSRNOP00000007003/1-1417 NEESFKKQLVYHESSKSDKRKGNTVREDLLCERSDDLKVLYRNFSNNKMGGKKNATVKTN ENSP00000358374/1-1463 NENSFEKQVSCHENSKSCIRRKAIVREDLLSAKVCDLKWIHRNSLYSETGGKKNAAIKIN ENSCPOP00000004572/1-1390 NESCFKKQLSCHARPEGCIRKKAVIREDLLSARFYDLTLLYRNSSYNKMGGKKNAAIKID XP_004863250.1/1-800 NEISLKKQLSCHERSEGFLRKKA-IREDLLSARFYDLTLIHRNASYHKTGGKKNAAIKID *: .::**: * .:. *: :*****. : .*. ::** : .*****::* : ENSMUSP00000044898/1-1456 KVQRSNQCTDSCIRNEMSSVFSCGSHSWGPR-THRASCTESIEVNEISALIRQKRQELEL ENSRNOP00000007003/1-1417 KVQRLNQCTDSCVRSDMPSVSSCDGHSWGPR-TYRVSCTESIEVNEINALIRQKRQELEL ENSP00000358374/1-1463 KPQRSNWSTNQCFRNFFSNMFSSVSHSGESSFTYRAYCTEFIEASEISALIRQKRHELEL ENSCPOP00000004572/1-1390 KTRRSNQCTSYCFRNFFSNLFSSGSYNGESSFTCRAYCTEFIEVNEISALIRQKRQELEL XP_004863250.1/1-800 KPRRSNQCTSYCFRNFFSNIFSSGSHNGDSSFTRRAYCTEFMAVNEISALIGQKRQELEL * :* * .*. *.*. :..: *. .:. . * *. *** : ..**.*** ***:**** ENSMUSP00000044898/1-1456 SWFPNTLPGNG-RVGSVPWSVETAFLSLASSGLPRTVFPASTTSLEHFGTSHKGYALAHT ENSRNOP00000007003/1-1417 SWFPNTLPGNG-RVGSVPWSVETAVLPLVSSVLPRTIFPASTMSLENFGTSHKGYALAHT ENSP00000358374/1-1463 SWFPDTLPGIG-RIGFIPWNVETEVLPLISSVLPRTIFPTSTISFEHFGTSCKGYALAHT ENSCPOP00000004572/1-1390 SWFPDSLPGIGSRIGFIPWNVEAEVLPLISSVLPRTVFPTSILSLENFDSSCKGYALAHT XP_004863250.1/1-800 SWFPDSLPGIG-RIGFIPWNVEAEVLPLISYVLPRTIFPTSTISLENFGPPCKGYALAHT ****::*** * *:* :**.**: .*.* * ****:**:* *:*:*... ******** ENSMUSP00000044898/1-1456 QGGGEKKQTSGTSNTRGSRRKPAATAPTRRSTRNTRAETVSQSQKSPVSNYSECDAPGNS ENSRNOP00000007003/1-1417 QGGGEKKQTSGTSNTRGSRRKPATTAPTRRSTRNTRVETVSPSQKSPVPNYSECDAPGNS ENSP00000358374/1-1463 QEGEEKKQTSGTSNTRGSRRKPAMTTPTRRSTRNTRAETASQSQRSPISDNSGCDAPGNS ENSCPOP00000004572/1-1390 QEGEEKKQTSGASNTRGSRRKPAAT-PTRRSTRNTKTETVNQSQRSPTSNNSGCDAPGNS XP_004863250.1/1-800 QEGEEKKQTSGTSNTRGTRRKPAAT-PTRRSTRNTKAETVSQSQISPTSNNSGCDAPGNN * * *******:*****:***** * *********:.**.. ** ** .: * ******. ENSMUSP00000044898/1-1456 NSSVSISPPAESEKQTRQAPKRKSVRRGRKPPLLKKKLRRSVPPAEKSSS-DSVEEETVD ENSRNOP00000007003/1-1417 NSSVSISPPAESEKQTRQAPKRKSVRRGRKPPSLKKKPRKSLPPAEKTTSSDSVEEDTVD ENSP00000358374/1-1463 NPSLSVPSSAESEKQTRQAPKRKSVRRGRKPPLLKKKLRSSVAAPEKSSSNDSVDEETAE ENSCPOP00000004572/1-1390 NPSVSVLSPAESEKQTRQAPKRKCVRRGRKPPVLKKKLRRSVPPPEKSSSNDSIEEEIVE XP_004863250.1/1-800 NPSVSVFSPAESEKQTRQAPKRKSVRRGRKPPVLKKKLRRSVPPPEKSSSSDSVEEETLE *.*:*: ..**************.******** **** * *:...**::* **::*: : ENSMUSP00000044898/1-1456 SDTPPVLEKEQQSCVESS-SICSVQTDEENHLH--LESCSEQTEEN-EQANNHEIEEQTE ENSRNOP00000007003/1-1417 SDTPPVLEKEQQSCVESS-SICSIQTDEENHLAKCLESCDEQTEEN-EQTKNHEIEEQTE ENSP00000358374/1-1463 SDTSPVLEKEHQPDVDSS-NICTVQTHVENQSANCLKSCNEQIEESEKHTANYDTEERVG ENSCPOP00000004572/1-1390 SDAAAVLEKEQQSDVEES-NICSVQTDTENQSADCLKSCNEQMEENEECKENHDIEQKVG XP_004863250.1/1-800 SDAPPVLEKEQQSDVEESTNIFSVQTDVENQSAKCLKSCSEQIEEN-ECKENHDVEEKVE **:..*****:*. *:.* .* ::**. **: *:**.** **. : *:: *::. ENSMUSP00000044898/1-1456 SLNSESCTQDPPGLVG--------EDTGIEAKEFCADHDISPDTSLRGRDSAEHQEQLSG ENSRNOP00000007003/1-1417 ILNSESCTQYPPVLVG--------EDSGIEAKELCVDNDVSTDSSLKGSDPLENQEQGSG ENSP00000358374/1-1463 SSSSESCAQDLPVLVGEEGEVKKLENTGIEANVLCLESEISENILEKGGDPLEKQDQISG ENSCPOP00000004572/1-1390 SSYSESCTDNPPMLVGE--ENKKPENITMEANVLNSECEISKDTFEKGSDPLKNQDQMSE XP_004863250.1/1-800 SSYSGSCTDDPPVLVRE-GEEDKPENTGVEADILNLKSEISKDIFEKESDPLESQDQI-- * **:: * ** *: :**. : . ::* : : *. : *:* ENSMUSP00000044898/1-1456 SSESEVQALVCTESPPEGSPTCPPSDIE-HQPVSSPLGEVSDNTTPVVSDERAEESLTVE ENSRNOP00000007003/1-1417 SSGSEVQASVCTESPPEDFLTCPPSDIEGHQPVSGPLGEVSENATPVLSDERAE------ ENSP00000358374/1-1463 LSQSEVKTDVCTVHLPNDFPTCLTSESKVYQPVSCPLSDLSENVESVVNEEKIT------ ENSCPOP00000004572/1-1390 SEGK----TVIYSNPPSDFLSCSGSEIEVPHHVSSLLSEIPENIESEVNEQKVI------ XP_004863250.1/1-800 ------------------------------------------------------------ ENSMUSP00000044898/1-1456 STDLNDERTGESLTVESTDLNDSAVNIEAFVESPKMESCEGETAQGLDRHCVPSSDSELP ENSRNOP00000007003/1-1417 ----------DSLMVGNADLNDSVENTEAFVMSPKVESSEGEITHGLNRHCIPSSDTELP ENSP00000358374/1-1463 ----------ESSLVEITEHKDFTLKTEELIESPKLESSEGEIIQTVDRQSVKSPEVQLL ENSCPOP00000004572/1-1390 ----------ESRTVGIIDHQDSTVKIEESIEIPKLESSESEIILTVDRKTVETSEIQLL XP_004863250.1/1-800 ------------------------------------------------------------ ENSMUSP00000044898/1-1456 EHIQTENTEIIPACEHIQTENTEIIPACEHIQTENTEIIPVCGTLENENSDAVQDCEDNL ENSRNOP00000007003/1-1417 ELIQTENTEIIPT----------------------------CGTLENESSGAVQGCEDTL ENSP00000358374/1-1463 GHVETEDVEIIAT----------------------------CDTFGNEDFNNIQDSENNL ENSCPOP00000004572/1-1390 GHSETWDTEKAT-----------------------------CETAENGNFNSTQDSEDNL XP_004863250.1/1-800 ------------------------------------------------------------ ENSMUSP00000044898/1-1456 LKHNLDNSQSDKFLEETTESLVEHPIHAELPHKEVDQSEKHFSEDNNESVPMECDSFCSD ENSRNOP00000007003/1-1417 LKHNLDNTQLDNSLEEKTDSLVEHPIHAELPHKEVEQSEKHFSEDNNETVPMECDSFCSD ENSP00000358374/1-1463 LKNNLLNTKLEKSLEEKNESLTEHPRSTELPKTHIEQIQKHFSEDNNEMIPMECDSFCSD ENSCPOP00000004572/1-1390 VKN--LNTKLDKPLEEKSD-----PKSLELLNTHIEQIEKHFSEDNNEMVPMECDSLCSD XP_004863250.1/1-800 ------------------------------------------------------------ ENSMUSP00000044898/1-1456 QNESEVESSANTDSKQLSENSVPHSSEDKL-SSDPAVEKVETVAQPAES---LVDKAPKP ENSRNOP00000007003/1-1417 QNESEVESSANTDPKQLSENSVTHSSDNKL-SSDPVVENVETVAQPAES---LVDKAPKP ENSP00000358374/1-1463 QNESEVEPSVNADLKQMNENSVTHCSENNMPSSDLADEKVETVSQPSESPKDTIDKTKKP ENSCPOP00000004572/1-1390 QNESEIESSVSTDSKQLIENTVVHSSENSMPFSNPVNEKIETLSQTSENASDTVDKSKKP XP_004863250.1/1-800 ------------------------------------------------------------ ENSMUSP00000044898/1-1456 RTRRSRFHSPSTTWSPNKDAAQEKRRAQSPSPKRETVVESQSSQSPSPKRESARGRRKSR ENSRNOP00000007003/1-1417 RTRRSRFHSPSTTWSPNKDAAQEKRRAQSPSPKRETAVESKSSQSPSPKRESARGRRKSR ENSP00000358374/1-1463 RTRRSRFHSPSTTWSPNKDTPQEKKRPQSPSPRRETGKESRKSQSPSPKNESARGRKKSR ENSCPOP00000004572/1-1390 RTRRSRFHSPSTTWSPNKDTAQEKKRSQSPSPKRETGKESRKSRSPSPKKESARGRRKSR XP_004863250.1/1-800 ------------------------------------------------------------ ENSMUSP00000044898/1-1456 SLSPKKDVARERR--QSRSPKRENAREAKRSESGSPRRDTSRENQRSQSRVKDSSSREKS ENSRNOP00000007003/1-1417 SLSPKKDVSRERR--QSRSPKRENAREAKRSESGSPRRDTSRENQRSQSRVKDSSSREKS ENSP00000358374/1-1463 SQSPKKDIARERRQSQSRSPKRDTTRESRRSESLSPRRETSRENKRSQPRVKDSSPGEKS ENSCPOP00000004572/1-1390 SQSPKKD-TRERRYSHSRSPKRDSTKEGKRSESPSPKRDTCRENRRSQSKLKDTSSREKS XP_004863250.1/1-800 ------------------------------------------------------------ ENSMUSP00000044898/1-1456 RSRSRERESDREAQRRERDRERRARRWSRSRSRSRSPSRLRTKSKSSSFGRNERDNYSPR ENSRNOP00000007003/1-1417 RSRSRERESDRDAQRRDRDRERRARRWSRSRSRSRSPSRSRTKSKSSSFGRNERDTYSPR ENSP00000358374/1-1463 RSQSRERESDRDGQRRE--RERRTRKWSRSRSHSRSPSRCRTKSKSSSFGRIDRDSYSPR ENSCPOP00000004572/1-1390 -------------------RYRRTRRWSRSRSRSRSPSRSRTKSKSSSFGRNERDSYSPR XP_004863250.1/1-800 ------------------------------------------------------------ ENSMUSP00000044898/1-1456 WKERWTNDGWRCPRGNDRYRRNDSEKQNENTRNEKNDITAD-SNDPSSTDKHRSDCPSWV ENSRNOP00000007003/1-1417 WREKWTNDGWRCPRGNDRYRRNDSEKQNENTRNEKDDITADNTNDPSSTDKHRDDCPSWV ENSP00000358374/1-1463 WKGRWANDGWRCPRGNDRYRKNDPEKQNENTRKEKNDIHLD-ADDPNSADKHRNDCPNWI ENSCPOP00000004572/1-1390 WKGRWPNDTWRCPRGNDRYRRNDTEKQNENIRKEKNNINLD-ADDPNSADKHRNDCPTWV XP_004863250.1/1-800 ------------------------------------------------------------ ENSMUSP00000044898/1-1456 TEKINSGPDPRTRNPEKLKDSHWEENRNENSGNSWTKNFGPGWMSS--RGRGGRGKGAYR ENSRNOP00000007003/1-1417 TEKINSGPDPRTRNPEKLKDSHWEENRNDNSGNSWTKNFGPGWMSS--RGRGGRGKGAYR ENSP00000358374/1-1463 TEKINSGPDPRTRNPEKLKESHWEENRNENSGNSWNKNFGSGWVSNRGRGRGNRGRGTYR ENSCPOP00000004572/1-1390 TEKINSGPDPRTRNPEKLKDSHWEENRNENSGTSWNKNFGSGWMSN--RGRVNRGRGAYR XP_004863250.1/1-800 ------------------------------------------------------------ ENSMUSP00000044898/1-1456 GNFACNDQSENRWQSRTPLSGS------DSFKSAEQQPSKRKSEQELSFGTAADRSGWTS ENSRNOP00000007003/1-1417 GNFACNDQSENRWQSRTPLSGS------DSFKSVEQQPSKRKSEQELSFGTPADRSGWTS ENSP00000358374/1-1463 SSFAYKDQNENRWQNRKPLSGNSNSSGSESFKFVEQQSYKRKSEQEFSFDTPADRSGWTS ENSCPOP00000004572/1-1390 GSLAYTDQNENRWQNRKPLSGN------DSFKFVEQQAYKQKSEQEFSFDTPADRSGWTS XP_004863250.1/1-800 ------------------------------------------------------------ ENSMUSP00000044898/1-1456 ASSWAVRKTLPADVQSYYSRRGRNSSGPQSGWMRQEEETPEQDSNLKDQTN-QVDGSQLP ENSRNOP00000007003/1-1417 ASSWAVRKTLPADVQNYYSRRGRSSSGPQSAWMRQEEETPEQDSNLKDQTN-QIDGSQLP ENSP00000358374/1-1463 ASSWAVRKTLPADVQNYYSRRGRNSSGPQSGWMKQEEETSGQDSSLKDQTNQQVDGSQLP ENSCPOP00000004572/1-1390 ASSWAVRKTLPADVQNYYSRRGRNPSGQQSGWMRQEETAEQVDSNLKDQTNQQIDGSQLP XP_004863250.1/1-800 ---------------------------------------------LEYQTNQQIDGSQLP *: *** *:****** ENSMUSP00000044898/1-1456 VNMMQPHMSVMQPPVNAPHPPVGVFPYPVGLPAPMMNMQRNPFTMHPPMPLHLHTGVPLM ENSRNOP00000007003/1-1417 VTMLQPHMSVMQPPVNAQHQPVGIFPYPVGVHAPMMNMQRNPFTMHPPMPLHLHTGVPLM ENSP00000358374/1-1463 INMMQPQMNVMQQQMNAQHQPMNIFPYPVGVHAPLMNIQRNPFNIHPQLPLHLHTGVPLM ENSCPOP00000004572/1-1390 VNMMQP-----------QHQPMNIFPYPVGVHAPLMNIQRHPYNIHPQLPLHLHAGVPLV XP_004863250.1/1-800 VNMMQPQVNVIPQQMNAQHQPMNIFPYPVGVHAPVMNIQRHPYNIHPQLPVHLHTGVPLV :.*:** * *:.:******: **:**:**:*:.:** :*:***:****: ENSMUSP00000044898/1-1456 QVAAPASIPQG-PPPPPPPPPSQQVSYVASQPDGKQVQGLSSASHVSNNMNTQVLPAPSA ENSRNOP00000007003/1-1417 QVA-PASIPQG-PPPPPPPPPSQQVNYIASQPDGKQVQGFPSASHVSNNMNTQVLPAPSA ENSP00000358374/1-1463 QVATPTSVSQGLPPPPPPPPPSQQVNYIASQPDGKQLQGIPSSSHVSNNMSTPVLPAPTA ENSCPOP00000004572/1-1390 QVATPPTVTQG-----------QQVNYMASQPDGKPLQGIPNASHVSNNMSTPVLPAPTA XP_004863250.1/1-800 QVAAPPTVTQGLPPPPPPPPPSQQVNYIAAQPDGKQLQGIPNASHVSNNMSTPVLPAPTA *** *.::.** ***.*:*:***** :**:..:*******.* *****:* ENSMUSP00000044898/1-1456 APANTGSVQGPSSGNTSSSSHVQASNAAVKLAES----------------KKLQIQEKAA ENSRNOP00000007003/1-1417 APANTGSVQGPSSGNTSSSSHVQAANAAVKLAES----------------KKLQIQEKAA ENSP00000358374/1-1463 APGNTGMVQGPSSGNTSSSSHSKASNAAVKLAESKVSVAVEASADSSKTDKKLQIQEKAA ENSCPOP00000004572/1-1390 APGNTGTVQGPSSGNTSSSSHSKASNAAVKLAES----------------KKLQIQEKAA XP_004863250.1/1-800 APGNTGTVQGPSSGNTSSSSHSKASNAAVKLAESKVSVTVEASADSSKTDKKLQIQEKAA **.*** ************** :*:********* ********** ENSMUSP00000044898/1-1456 QEVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCHSKSGEVNSTKVANLVKAYVDKYRYSR ENSRNOP00000007003/1-1417 QEVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCHSKSGEVNSTKVANLVKAYVDKYKYSR ENSP00000358374/1-1463 QEVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCHSKSGEVNSTKVANLVKAYVDKYKYSR ENSCPOP00000004572/1-1390 QEVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCHSKSGEVNPTKVANLVKAYVDKYRHAR XP_004863250.1/1-800 QEVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCHSKSGEVNSTKVANLVKAYVDKYKYSR *****************************************.**************:::* ENSMUSP00000044898/1-1456 ----KKALEEPGSTEKT-- ENSRNOP00000007003/1-1417 ----KKTLEEPVSTEKN-- ENSP00000358374/1-1463 KGSQKKTLEEPVSTEKNIG ENSCPOP00000004572/1-1390 KGSQKKAVEEPAGQSTA-- XP_004863250.1/1-800 KGSQKKTVEEPVSAENNVG **::*** . ..