CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000004563/1-1339 PVTMTVDELVFFVNGRKVVEKNADPETTLLAYLRTHDLRVGLSGTKLGCGEGGCGACTVM XP_004839314.1/1-1334 --MTVVDELVFFVNGKKVVEKNADPETTLLAYLRR---KLGLSGTKLGCGEGGCGACTVM ENSP00000368727/1-1333 ---MTADKLVFFVNGRKVVEKNADPETTLLAYLRR---KLGLSGTKLGCGEGGCGACTVM ENSMUSP00000024866/1-1335 MTRTTVDELVFFVNGKKVVEKNADPETTLLVYLRR---KLGLCGTKLGCGEGGCGACTVM ENSRNOP00000009634/1-1331 ---MTADELVFFVNGKKVVEKNADPETTLLVYLRR---KLGLCGTKLGCGEGGCGACTVM ..*:*******:**************.*** ::**.***************** ENSCPOP00000004563/1-1339 ISKFDHFQNKVVHYSVNACLAPICSLHHMAVTTVEGIGSTKTRLHPVQERIAKSHGSQCG XP_004839314.1/1-1334 ISKYDNLQNKVIHYSVNACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCG ENSP00000368727/1-1333 LSKYDRLQNKIVHFSANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCG ENSMUSP00000024866/1-1335 ISKYDRLQNKIVHFSVNACLTPICSLHHVAVTTVEGIGNTK-KLHPVQERIAKSHGSQCG ENSRNOP00000009634/1-1331 ISKYDRLQNKIVHFSVNACLAPICSLHHVAVTTVEGIGNTQ-KLHPVQERIARSHGSQCG :**:*.:***::*:*.****:*******:*********.*: :*********:******* ENSCPOP00000004563/1-1339 FCTPGIVMSMYTLLRNQPTPTIEEIEDAFQGNLCRCTGYRPILQGFRTFSQNGGCCGGNR XP_004839314.1/1-1334 FCTPGIVMSMYTLLRNQPEPTIEEIEDAFQGNLCRCTGYRPILQGFRTFSQNGGCCGGNG ENSP00000368727/1-1333 FCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDG ENSMUSP00000024866/1-1335 FCTPGIVMSMYTLLRNKPEPTVEEIENAFQGNLCRCTGYRPILQGFRTFAKDGGCCGGSG ENSRNOP00000009634/1-1331 FCTPGIVMSMYTLLRNQPEPTVEEIENAFQGNLCRCTGYRPILQGFRTFAKDGGCCGGSG ****************:* **:****:**********************:::******. ENSCPOP00000004563/1-1339 DNPNCCMNQKKDETLTLSQSLFKPEDFTPLDPSQEPIFPPELLRLKDAPRKQLRFQGERV XP_004839314.1/1-1334 DNPNCCMNQKKDRTITLSPPLFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFQGERV ENSP00000368727/1-1333 NNPNCCMNQKKDHSVSLSPSLFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFEGERV ENSMUSP00000024866/1-1335 NNPNCCMSQTKDQTIAPSSSLFNPEDFKPLDPTQEPIFPPELLRLKDTPRKTLRFEGERV ENSRNOP00000009634/1-1331 NNPNCCMNQTKDQTVSLSPSLFNPEDFKPLDPTQEPIFPPELLRLKDTPQKKLRFEGERV :******.*.**.::: * .**:**:*.****:**************:*:* ***:**** ENSCPOP00000004563/1-1339 TWIQASTLQELLDLKAQYPDAKLVVGNTEIGIEMKFKNMLYPMIVCPTWICELTSVEHGP XP_004839314.1/1-1334 TWIQASTLQELLDLKARYPDAKLVVGNTEIGIEMKFKNMLYPMIICPAWIPELTSVEHGP ENSP00000368727/1-1333 TWIQASTLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGP ENSMUSP00000024866/1-1335 TWIQVSTMEELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPLIICPAWILELTSVAHGP ENSRNOP00000009634/1-1331 TWIQASTMEELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPLIVCPAWIPELNSVVHGP ****.**::*******::**********************:*:*:**:** **.** *** ENSCPOP00000004563/1-1339 DGITFGAACSLSCMEKVLHDAIAELPDHKTEVFKGVLEQLRWFAGKQIKSVASIGGNIIN XP_004839314.1/1-1334 EGITFGAACSLSCMEKVLGDAIAELPAQKTEVFKGVLEQLRWFAGKQIKYVASIGGNIIT ENSP00000368727/1-1333 DGISFGAACPLSIVEKTLVDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIIT ENSMUSP00000024866/1-1335 EGISFGAACPLSLVESVLADAIATLPEQRTEVFRGVMEQLRWFAGKQVKSVASIGGNIIT ENSRNOP00000009634/1-1331 EGISFGASCPLSLVESVLAEEIAKLPEQKTEVFRGVMEQLRWFAGKQVKSVASIGGNIIT :**:***:*.** :*..* : :* ** ::****:**:**********:* ***:*****. ENSCPOP00000004563/1-1339 ASPISDLNPVFMASGAKLTLVSKGTRRTVRMDHTFFPGYRRTLLSPEEILFSIEIPYSKE XP_004839314.1/1-1334 ASPISDLNPVFMASGAKLMLVSKGTRRTVRMDHTFFPGYRKTLLSPEEILFSIEIPYSRE ENSP00000368727/1-1333 ASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTLLSPEEILLSIEIPYSRE ENSMUSP00000024866/1-1335 ASPISDLNPVLMASRAKLTLASRGTKRTVWMDHTFFPGYRRTLLSPEEILVSIVIPYSRK ENSRNOP00000009634/1-1331 ASPISDLNPVFMASGAKLTLVSRGTRRTVRMDHTFFPGYRKTLLRPEEILLSIEIPYSKE **********:*** *** *.*:**:*** **********:*** *****.** ****:: ENSCPOP00000004563/1-1339 GEFFSAFKQASRREDDIAKVTCGMRVLFKPGTTEVKELSLCYGGMANRTISALKTTQKQL XP_004839314.1/1-1334 GEFFSAFKQASRREDDIAKVTCGMRVLFKPGTTEVMEMSLCYGGMANRTISALMTTQKQL ENSP00000368727/1-1333 GEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQL ENSMUSP00000024866/1-1335 GEFFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQELSLCFGGMADRTVSALKTTPKQL ENSRNOP00000009634/1-1331 GEFFSAFKQASRREDDIAKVTSGMRVLFKPGTIEVQELSLCFGGMADRTISALKTTPKQL **:******************.********** ** *::**:****:**:*** ** :** ENSCPOP00000004563/1-1339 SKSWNEELLQDVCRELAEELRLEPDAPGGMVDFRRTLTLSFFFKFYLTVLQKLGKVNPED XP_004839314.1/1-1334 SKSWNEELLQNVCKELAEELHLEHNAPGGMVDFRRTLTLSFFFKFYLTVLQKLGKGNPED ENSP00000368727/1-1333 SKLWKEELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQENLED ENSMUSP00000024866/1-1335 SKSWNEELLQDVCAGLAEELHLAPDAPGGMVEFRRTLTLSFFFKFYLTVLQKLGRADLEG ENSRNOP00000009634/1-1331 SKSWNEELLQSVCAGLAEELHLAPDAPGGMVEFRRTLTLSFFFKFYLTVLQKLGRADLED ** *:*****.** *****:* :******:** *******************: : *. ENSCPOP00000004563/1-1339 KCGTLDPTFASATLLFQKDPPANVQLFQEVPPGQSEEDMVGRPLPHLAAHMQASGEAVYC XP_004839314.1/1-1334 KCGTLDPTFASATLLFHKDPPANVQLFQEVPPGQSEEDMVGRPLTHLAANMQASGEAVYC ENSP00000368727/1-1333 KCGKLDPTFASATLLFQKDPPADVQLFQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYC ENSMUSP00000024866/1-1335 MCGKLDPTFASATLLFQKDPPANVQLFQEVPKGQSEEDMVGRPMPHLAADMQASGEAVYC ENSRNOP00000009634/1-1331 MCGKLDPTFASATLLFQKDPPANVQLFQEVPKDQSEEDMVGRPLPHLAANMQASGEAVYC **.************:*****:******** .**********:.****.********** ENSCPOP00000004563/1-1339 DDIPRYENELSLRLVTSTRAHAKILSIDTSEAQKVPGFVCFLSAEDIPGSNVTGLFDDET XP_004839314.1/1-1334 DDIPRYENELSLRLVTSTRAHAKILSIDTSEAQKVPGFVCFLSADDIPGSNITGLFNDET ENSP00000368727/1-1333 DDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITGICNDET ENSMUSP00000024866/1-1335 DDIPRYENELSLRLVTSTRAHAKIMSIDTSEAKKVPGFVCFLTSEDVPGSNITGIFNDET ENSRNOP00000009634/1-1331 DDIPRYENELSLRLVTSTRAHAKITSIDTSEAKKVPGFVCFLTAEDVPNSNATGLFNDET ************************ *******:********::::*:*.** **: :*** ENSCPOP00000004563/1-1339 VFAKDEVTCIGHIIGAVVTDTREHAQRAAQGVKITYEDLPAIITIEDAIKNNSFYKYELQ XP_004839314.1/1-1334 VFAKDKVTCIGHIIGAVVTDTREHAQRAAQGVKITYEDLPAIITIEDAIKNNSFYGSEKK ENSP00000368727/1-1333 VFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFYGPELK ENSMUSP00000024866/1-1335 VFAKDEVTCVGHIIGAVVADTPEHAHRAARGVKITYEDLPAIITIQDAIKNNSFYGPEVK ENSRNOP00000009634/1-1331 VFAKDEVTCVGHIIGAVVADTPEHAQRAARGVKITYEDLPAIITIQDAINNNSFYGSEIK *****:***:********:** **::***:*******:*******:***:***** * : ENSCPOP00000004563/1-1339 IEKGDLKKGFAEADNVVSGELYLGGQDHFYLETHCTIAVPKGESGEMELFVSTQNTMKTQ XP_004839314.1/1-1334 IEKGDLKKGFAEADNVVSGEFYIGGQDHFYLETHCTIAVPKGESGEMELFVSTQNTMKTQ ENSP00000368727/1-1333 IEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQ ENSMUSP00000024866/1-1335 IEKGDLKKGFSEADNVVSGELYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQ ENSRNOP00000009634/1-1331 IEKGDLKKGFSEADNVVSGELYIGGQEHFYLETNCTIAVPKGEAGEMELFVSTQNTMKTQ **********:*********:*:***:******:*********:**************** ENSCPOP00000004563/1-1339 NFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVLSTAVALAAHKTGRPVRCMLDRDEDM XP_004839314.1/1-1334 SFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVLSTAVALAAYKTGHPVRCMLDRDEDM ENSP00000368727/1-1333 SFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDM ENSMUSP00000024866/1-1335 SFIAKMLGVPDNRIVVRVKRMGGGFGGKETRSTLISTAVALAAYKTGRPVRCMLDRDEDM ENSRNOP00000009634/1-1331 SFVAKMLGVPDNRIVVRVKRMGGGFGGKETRSTVVSTAVALAAHKTGRPVRCMLDRDEDM .*:******* **********************::********:***:************ ENSCPOP00000004563/1-1339 LITGGRHPFLARYKVGFMKDGKIVALEVDHFSNCGNTRDLSESIMDRALFHMDNTYKIPN XP_004839314.1/1-1334 LISGGRHPFLARYKVGFMKNGKIVALEVDHFSNSGNTLDLSESIMDRALFHMDNTYLIPN ENSP00000368727/1-1333 LITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPN ENSMUSP00000024866/1-1335 LITGGRHPFLAKYKVGFMKTGTIVALEVAHFSNGGNSEDLSRSIMERAVFHMDNAYKIPN ENSRNOP00000009634/1-1331 LITGGRHPFLAKYKVGFMKTGTVVALEVAHFSNGGNTEDLSRSIMERALFHMDNAYKIPN **:********:******* *.:***** **** **: ***.***:**:***** * *** ENSCPOP00000004563/1-1339 IRGTGYLCKTNLASNTAFRGFGGPQAMLIAEYWMSEVAMTCGQPPEKVRRINMYQEGDLT XP_004839314.1/1-1334 IRGTGRLCKTNLPSNTAFRGFGGPQGMLTAEYWMTEISVTCGLPPEEVRRKNMYQEGDLT ENSP00000368727/1-1333 IRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLT ENSMUSP00000024866/1-1335 IRGTGRICKTNLPSNTAFRGFGGPQGMLIAEYWMSEVAVTCGLPAEEVRRKNMYKEGDLT ENSRNOP00000009634/1-1331 IRGTGRICKTNLPSNTAFRGFGGPQGMLIAEYWMSEVAITCGLPAEEVRRKNMYKEGDLT ***** :*****.************.** ** **:*:::*** *.*:*** *:*:***** ENSCPOP00000004563/1-1339 HFNQKLEAFTLPRCWDQCMTSAQYYARRAEVDKFNKENCWKKRGLCIIPTKFGISFSVPF XP_004839314.1/1-1334 HFNQQLEAFTLPRCWDECIASAQYHARRAEVDKFNKENCWKKRGLCIIPTKFGISFSVPF ENSP00000368727/1-1333 HFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPF ENSMUSP00000024866/1-1335 HFNQKLEGFTLPRCWDECIASSQYQARKMEVEKFNRENCWKKRGLCIIPTKFGISFTLSF ENSRNOP00000009634/1-1331 HFNQKLEGFTLPRCWDECIASSQYLARKREVEKFNRENCWKKRGLCIIPTKFGISFTLPF ****:**.*******::*::*:** **: **:***:********************::.* ENSCPOP00000004563/1-1339 LNQAGALVHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPISKIYISETSTNTVPN XP_004839314.1/1-1334 LNQAGALIHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPISKIYISETSTNTVPN ENSP00000368727/1-1333 LNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPN ENSMUSP00000024866/1-1335 LNQGGALVHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIHITETSTNTVPN ENSRNOP00000009634/1-1331 LNQGGALVHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIHISETSTNTVPN ***.***:************************************ ***:*:********* ENSCPOP00000004563/1-1339 TSPTAASVSADLNGQAIYEACQTILKRLEPFKKKNPNGSWEDWVSAAYLDAVSLSATGFY XP_004839314.1/1-1334 TSPTAASVSADINGQAIYEACQTLLKRLEPFKKKNPNGSWEDWVSAAYLDAVSLSATGFY ENSP00000368727/1-1333 TSPTAASVSADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSATGFY ENSMUSP00000024866/1-1335 TSPTAASASADLNGQAIYEACQTILKRLEPFKKKNPSGSWESWVMDAYTSAVSLSATGFY ENSRNOP00000009634/1-1331 TSPTAASASADLNGQAVYEACQTILKRLEPFKKKKPNGPWEAWVMDAYTSAVSLSATGFY *******.***:****:* ****:******:***:*.*.** ** ** .:********* ENSCPOP00000004563/1-1339 KTPNLGYDPKTNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGTSLNPAIDIG XP_004839314.1/1-1334 KTPNLGYDFKTNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIG ENSP00000368727/1-1333 RTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIG ENSMUSP00000024866/1-1335 KTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIG ENSRNOP00000009634/1-1331 KTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIG :******. :****************************************:********* ENSCPOP00000004563/1-1339 QVEGAFVQGLGLFTMEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKRAI XP_004839314.1/1-1334 QVEGAFIQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKRAI ENSP00000368727/1-1333 QVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAI ENSMUSP00000024866/1-1335 QVEGAFVQGLGLFTMEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKRAI ENSRNOP00000009634/1-1331 QVEGAFVQGLGLFTMEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKRAI ******:*******:**************************** *************:** ENSCPOP00000004563/1-1339 YASKAVGEPPLFLAASIFFAIKDAIGAARAQRSDYNTKQLFRLDSPATPEKIRNACGDQF XP_004839314.1/1-1334 YASKAVGEPPLFLAASIFFAIKDAISAARAQRSDYNSKQLFRLDSPATPEKIRNACGDQF ENSP00000368727/1-1333 YASKAVGEPPLFLAASIFFAIKDAIRAARAQHTGNNVKELFRLDSPATPEKIRNACVDKF ENSMUSP00000024866/1-1335 YASKAVGEPPLFLASSIFFAIKDAIRAARAQHGDSNAKQLFQLDSPATPEKIRNACVDQF ENSRNOP00000009634/1-1331 YASKAVGEPPLFLASSIFFAIKDAIRAARAQHGD-NAKQLFQLDSPATPEKIRNACVDQF **************:********** *****: . * *:**:************** *:* ENSCPOP00000004563/1-1339 TTLCVTGTPENCKPWSLRV XP_004839314.1/1-1334 TTLCVTGTPENCQPWSLRV ENSP00000368727/1-1333 TTLCVTGVPENCKPWSVRV ENSMUSP00000024866/1-1335 TTLCATGTPENCKSWSVRI ENSRNOP00000009634/1-1331 TTLCVTGVPENCKSWSVRI ****.**.****:.**:*: