CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000004497/1-1268 EGHPRPLSALLTLSLLSSKDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE ENSMUSP00000072091/1-1344 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE ENSRNOP00000050929/1-1331 -----PARQSDFIFLVALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE ENSP00000347427/1-1332 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE XP_004857352.1/1-1309 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE * : * : :***************************************** ENSCPOP00000004497/1-1268 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT ENSMUSP00000072091/1-1344 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT ENSRNOP00000050929/1-1331 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT ENSP00000347427/1-1332 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT XP_004857352.1/1-1309 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT ************************************************************ ENSCPOP00000004497/1-1268 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR ENSMUSP00000072091/1-1344 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR ENSRNOP00000050929/1-1331 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR ENSP00000347427/1-1332 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR XP_004857352.1/1-1309 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR ************************************************************ ENSCPOP00000004497/1-1268 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR ENSMUSP00000072091/1-1344 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR ENSRNOP00000050929/1-1331 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR ENSP00000347427/1-1332 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR XP_004857352.1/1-1309 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR ************************************************************ ENSCPOP00000004497/1-1268 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKAYLSRPPTEQLLKFPFIRDQPTERQVRI ENSMUSP00000072091/1-1344 ALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI ENSRNOP00000050929/1-1331 ALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI ENSP00000347427/1-1332 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI XP_004857352.1/1-1309 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI ********************** *********:*************************** ENSCPOP00000004497/1-1268 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ ENSMUSP00000072091/1-1344 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ ENSRNOP00000050929/1-1331 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ ENSP00000347427/1-1332 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ XP_004857352.1/1-1309 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ ************************************************************ ENSCPOP00000004497/1-1268 ENKSNSEAL-----------RDPEAHIKHLLHQRQRRIEEQKEERRRVEEEQSRELLQRY ENSMUSP00000072091/1-1344 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK ENSRNOP00000050929/1-1331 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK ENSP00000347427/1-1332 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK XP_004857352.1/1-1309 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK ********* ******************************:* ** ** ENSCPOP00000004497/1-1268 MVGKEYTNQLEDIQALRLEEEQRQLEILQEYKRKQLEEQRQSERLQRQLQQEHAYLKS-- ENSMUSP00000072091/1-1344 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ ENSRNOP00000050929/1-1331 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSQK ENSP00000347427/1-1332 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL- XP_004857352.1/1-1309 LQEKEQQRRLEDIQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ : ** .:***:**** ***:** * ****************************** ENSCPOP00000004497/1-1268 --------------------------QILPGDRKPLYHYGRGINPADKPAWAREVEERTR ENSMUSP00000072091/1-1344 Q----------QQQQQQLQKQQQQQQQILPGDRKPLYHYGRGINPADKPAWAREVEERAR ENSRNOP00000050929/1-1331 -----------QQQQQQQQQQQQQQQQILPGDRKPLYHYGRGINPADKPAWAREVEERAR ENSP00000347427/1-1332 -----------QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTR XP_004857352.1/1-1309 QQQQQQQQLQKQQQQQQQQQQQQQQQQILPGDRKPLYHYGRGINPADKPAWAREVEERTR *:**************:***************:* ENSCPOP00000004497/1-1268 MNKQQSSPLAKTKPGGTGPEP----------AALSQTPPMQRPVEPQEGPHKSLVAHRVP ENSMUSP00000072091/1-1344 MNKQQNSPLAKAKPSSAGPEPPISQASPSPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVP ENSRNOP00000050929/1-1331 MNKQQNSPLAKTKPSSAGPEPPIPQASPSPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVP ENSP00000347427/1-1332 MNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVP XP_004857352.1/1-1309 MNKQQNSPLAKTKTSSTGPEPPIPQASPGPQGPLSQTPPMQRPVEPQEGPHKSLVAHRVP *****.*****:*...:**** ..*************************** ENSCPOP00000004497/1-1268 LKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDP-AIPTPTATPSARGAVIRQNSDPTSEG ENSMUSP00000072091/1-1344 LKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAAVPTPTATPSARGAVIRQNSDPTSEG ENSRNOP00000050929/1-1331 LKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAAVPTPTATPSARGAVIRQNSDPTSEG ENSP00000347427/1-1332 LKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDP-AIPAPTATPSARGAVIRQNSDPTSEG XP_004857352.1/1-1309 LKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDP-AIPTPTATPSARGAVIRQNSDPTSEG ********************************* *:*:********************** ENSCPOP00000004497/1-1268 PGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGPRPAQAVRA------------ ENSMUSP00000072091/1-1344 PGPSPNPPSWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYL ENSRNOP00000050929/1-1331 PGPSPNPPSWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYL ENSP00000347427/1-1332 PGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYL XP_004857352.1/1-1309 PGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGASRPAQAVRA------------ ********:*****************************..******** ENSCPOP00000004497/1-1268 -------------------------SNPDLRRSDSGWEHSDSVLPAAHGRLPQAGSLERN ENSMUSP00000072091/1-1344 QRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERN ENSRNOP00000050929/1-1331 QRRAERGTPKPPGPPAQPPGPPNTSSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERN ENSP00000347427/1-1332 QRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERN XP_004857352.1/1-1309 -------------------------SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERN *********.***:*******:**:********** ENSCPOP00000004497/1-1268 RSRVGASTKLDSSPVLSPGNKTKPDDHRSRPGRPASYKRAIGEDFVLLKERNLDEAPRPP ENSMUSP00000072091/1-1344 RNRVGASTKLDSSPVLSPGNKAKPEDHRSRPGRPASYKRAIGEDFVLLKERTLDEAPKPP ENSRNOP00000050929/1-1331 RNRVGASTKLDSSPVLSPGNKAKPEDHRSRPGRPA--------DFVLLKERTLDEAPKPP ENSP00000347427/1-1332 --RVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPA--------DFVLLKERTLDEAPRPP XP_004857352.1/1-1309 RNRVGASTKLDSSPVLSPGNKAKPDDHRSRPGRPA--------DFVLLKERTLDEASRPP ***.*:* ***********:**:********** ********.****.:** ENSCPOP00000004497/1-1268 KKAMDYSSSSEEVESSDDEEEEGDGEPSEGSRDTPGGRSDGDTDSVSTMVVHDVEEIAGT ENSMUSP00000072091/1-1344 KKAMDYSSSSEEVESSEEEEEEGDGEPSEGSRDTPGGR-DGDTDSVSTMVVHDVEEISGT ENSRNOP00000050929/1-1331 KKAMDYSSSSEEVESSEDEEEEGDGEPSEGSRDTPGGRSDGDTDSVSTMVVHDVEEVSGT ENSP00000347427/1-1332 KKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGT XP_004857352.1/1-1309 KKAMDYSSSSEEVESSEDDEEEGDGEPSEGSRDTPGGRSDGDTDSISTMVVHDVEEIAGS ****************:::****:* *:********** ******:**********::*: ENSCPOP00000004497/1-1268 QPPYGGGTMVVQRTPEEERSLLHADSNGYTNLPDVVQPSHSPTESSKGQSPPSKDGGSDY ENSMUSP00000072091/1-1344 QPSYGGGTMVVQRTPEEERSLLLADSNGYTNLPDVVQPSHSPTENSKGQSPPTKDGGSDY ENSRNOP00000050929/1-1331 QPSYGGGTMVVQRTPEEERSLLLADSNGYTNLPDVVQPSHSPTENSQGQSPPTKDGGGDY ENSP00000347427/1-1332 QPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDY XP_004857352.1/1-1309 QPPYGGGTMVVQRTPEEERSLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSSDY **.****************.** *********************.*:*****:***..** ENSCPOP00000004497/1-1268 QSRGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGEGARLDQLQYDVRKGSVVNV ENSMUSP00000072091/1-1344 QSRGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGEGGRLDQLQFDVRKGSVVNV ENSRNOP00000050929/1-1331 QSRGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGEGGRLDQLQFDVRKGSVVNV ENSP00000347427/1-1332 QSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNV XP_004857352.1/1-1309 QSCGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGEGARLDQLQYDVRKGSVVNV ** ***************************:*********** ******:********** ENSCPOP00000004497/1-1268 NPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGR ENSMUSP00000072091/1-1344 NPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGR ENSRNOP00000050929/1-1331 NPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGR ENSP00000347427/1-1332 NPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGR XP_004857352.1/1-1309 NPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGR ************************************************************ ENSCPOP00000004497/1-1268 RRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCG ENSMUSP00000072091/1-1344 RRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCG ENSRNOP00000050929/1-1331 RRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCG ENSP00000347427/1-1332 RRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCG XP_004857352.1/1-1309 RRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCG ************************************************************ ENSCPOP00000004497/1-1268 HYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRL ENSMUSP00000072091/1-1344 HYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRL ENSRNOP00000050929/1-1331 HYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRL ENSP00000347427/1-1332 HYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRL XP_004857352.1/1-1309 HYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRL ******************.***************************************** ENSCPOP00000004497/1-1268 KVIYGSSAGFHAVDVDSGNSYDIYIPVHIQCQITPHAIIFLPNTDGMEMLLCYEDEGVYV ENSMUSP00000072091/1-1344 KVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYV ENSRNOP00000050929/1-1331 KVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIVFLPNTDGMEMLLCYEDEGVYV ENSP00000347427/1-1332 KVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYV XP_004857352.1/1-1309 KVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYV ******************************.*******:********************* ENSCPOP00000004497/1-1268 NTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK ENSMUSP00000072091/1-1344 NTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK ENSRNOP00000050929/1-1331 NTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK ENSP00000347427/1-1332 NTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK XP_004857352.1/1-1309 NTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK ************************************************************ ENSCPOP00000004497/1-1268 FLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW ENSMUSP00000072091/1-1344 FLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW ENSRNOP00000050929/1-1331 FLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW ENSP00000347427/1-1332 FLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW XP_004857352.1/1-1309 FLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW ***********************************