CLUSTAL W(1.81) multiple sequence alignment ENSP00000263736/1-995 MSSLPRRAKVQVQDVVLKDEFSSFSELSSASEEDDKEDSAWEPQKKVPRSRKQPPPKESK ENSCPOP00000004296/1-846 ------------------------------------------------------------ XP_004839448.1/1-987 -MSLPRRAKIQVQTTVSKDEFSYFSELSSASEEDDKEDSVWEPQKKVPRARKQPAAKESK ENSMUSP00000092810/1-981 MPSLRKRVKIQAENAEPKDECSFFSELSSGSEEDNKEDSIWEPQKKVPRNRRQPASKGSK ENSRNOP00000065410/1-1016 MPSLRKRTKIQTENAEPRDECSSFSELSSGSEEDNKEDSIWEPQKKVLRNRRRPASKGSK ENSP00000263736/1-995 PKRMPRVKKNAPQISDGSEVVVVKEELNSSVAIADTALEDRKNKLDTVQTLKTAKTKQKC ENSCPOP00000004296/1-846 ------------------------------------------------------------ XP_004839448.1/1-987 PKRMPRGKKNITLKSGGSEGVAVKEELNRSIAIADVDLEE--NKLNTAQTLKTAKTKQKN ENSMUSP00000092810/1-981 RKQGPRAKKSSQQVDDESKDVAVKEELNSPVAIVDADLEEKSHKLQTTKTLKTAAKKQKK ENSRNOP00000065410/1-1016 RKQGPRVKKSAQQVHDISKDVAVKEELNSPVAIVNANLEEENQKLHTTNTLKTAAKKQKN ENSP00000263736/1-995 AAQPHTVRRTKKLKVEEETSKASNLEGESNSSETPSTSTVWGGTCKKEENDDDFTFGQSA ENSCPOP00000004296/1-846 -----------------------------DGAEIPSTSTMGEGVCKKEESEDDFTFGQSP XP_004839448.1/1-987 SAQ-----RMKKLKVDEETSEVSNLAGESNSTEIPSTSTMVEGVCKKEENEDDFTFGQSP ENSMUSP00000092810/1-981 PVP----RAKKRLKVDEETSQASPLEGGGSNVETPSTSACGNV-CKKEESEDSFTFGQSP ENSRNOP00000065410/1-1016 AGH----GAKKRLKVDEETNQASPFEGGESNVEAPSTSEDRDM-CKK-ESEDSFTFEQSP .. * **** *** *.:*.*** **. ENSP00000263736/1-995 LKKIKTETYPQGQPVKFPANANSTKEEVEMNWDMVQVLSERTNIEPWVCANIIRLFNDDN ENSCPOP00000004296/1-846 LKRMKTETCPQGQPVKFPGSANTIKEEVEMNWDIVQVLSERTNIELWVCANIIRLFNDDN XP_004839448.1/1-987 LKRMKTEMCPQGQPVKFPASANTIKEEVEMNWDIVQVLSERTNIELWVCANIIRLFNDDN ENSMUSP00000092810/1-981 VKRIRTESCPQGRPARVPDGVSDIKEEVEMNWDVVQVLSERTNIEPWVCANIIRLFNDDN ENSRNOP00000065410/1-1016 LKRIKTESCPQGRPARVP-GASDIKEEVEMNWDIVQVLSERTNIEPWICANIIRLFNDDN :*:::** ***:*.:.* ... *********:*********** *:************ ENSP00000263736/1-995 TIPFIIRYRKELINNLDADSLREVQQTLEELRAVAKKVHSTIQKIKKEGKMSECLLKAML ENSCPOP00000004296/1-846 TIPFIVRYRKELINNLDADSLREVRQTLEELRMVAKKVHSTIQKIKKEGKMSECLLKALL XP_004839448.1/1-987 TIPFIVRYRKELINNLDADSLREVRQTLEELRAIAKKVHSTIQKIKKEGKMSECLLKALL ENSMUSP00000092810/1-981 TIPFIVRYRKELINNLDADFLREVRQTLDELRDVAKKVHSRIQKIKKEGKMSECLLQALL ENSRNOP00000065410/1-1016 TIPFIVRYRKELINNLDADFLREVRQTLDELRDVAKKVHSRIQKIKKEGKMSECLLQALL *****:************* ****:***:*** :****** ***************:*:* ENSP00000263736/1-995 NCKTFEELEHVSAPYKTGSKGTKAQRARQLGLEGAARALLEKPGELSLLSYIRPDVKGLS ENSCPOP00000004296/1-846 NCRSFEELEHVSAPYKSGSKGTKAQRAKQLGLEAAAKTLLENPGQLNLLSYIRSDVKGLS XP_004839448.1/1-987 NCKSFEELEHVSAPYKTGSKGTKAQRAKQLGLETAAWTLLENPGKLNLLSYIRPDVKGLS ENSMUSP00000092810/1-981 NCKTFEELEHVSAPYKMGSKGTKAQRAKQLGLEGAAWTLLENPGQLNLLSYIKPDVKGLS ENSRNOP00000065410/1-1016 NCKTFEELEHVSAPYKMGSKGTKAQRAKQLGLEGAAWTLLENPGQLNLPSYIRPDVKGLS **::************ **********:***** ** :***:**:*.* ***:.****** ENSP00000263736/1-995 TLQDIEIGVQHILADMIAKDKDTLDFIRNLCQKRHVCIQSSLAKVSSKKVNEKDVDKFLL ENSCPOP00000004296/1-846 ALQDIETGVQHILADMIAKDKDTLDFIRKLCQNRYICIQSSLAKVSSKKVNEKDVDKFQL XP_004839448.1/1-987 ALQDIETGVQHILADMIAKDKDTLDFIRKLCQNRYICIQSSLAKVSSKKVNEKDVDKFQL ENSMUSP00000092810/1-981 ELNDIETGVQHILADMIAKDKDTLDFIRGLCKHRYICIQSSLAKVSSKKVNEKEVDKFQL ENSRNOP00000065410/1-1016 ELKDIETGVQHILADMIAKDKDTLDFIRDLCKHRYICIQSSLAKVSSKKVNEKEVDKFQL *:*** ********************* **::*::*****************:**** * ENSP00000263736/1-995 YQHFSCNIRNIHHHQILAINRGENLKVLTVKVNISDGVKDEFCRWCIQNRWRPRSFARPE ENSCPOP00000004296/1-846 YQNFSCNIRNIQHHQILAINRGENLKILTVKVNISDGIKNEFCRWCIQNRWRPHGFARPE XP_004839448.1/1-987 YQNFSCNIRNIQHHQILAINRGENLKILTVKVNISDGIKNEFCRWCIQNRWRPRGFARPE ENSMUSP00000092810/1-981 YQNFSCNIRTIHHHQILAINRGENLKILTVKVNISDGVKNEFCRWCIQNRWRPRGFARPE ENSRNOP00000065410/1-1016 YQNFSCNIRNIHHHQILAINRGENLKILTVKVNISDGVKNEFCRWCIQNRWRPRGFARPE **:******.*:**************:**********:*:*************:.***** ENSP00000263736/1-995 LMKILYNSLNDSFKRLIYPLLCREFRAKLTSDAEKESVMMFGRNLRQLLLTSPVPGRTLM ENSCPOP00000004296/1-846 LMKILHNSLDDSFKRLIYPLLCREFRAKLTSDAEKESVMMFGRNLRQLLLTSPVPGRTLM XP_004839448.1/1-987 LMKILHNSLDDSFKRLIYPLLCRDFRAKLTSDAEKESVMMFGRNLRQLLLTSPVPGRTLM ENSMUSP00000092810/1-981 LMKILHNSLDDSFKRLIVPLLCREFRAKLTSDAEKQSVMMFGQNLRQLLLTSPVPGRTLM ENSRNOP00000065410/1-1016 LMKILHNSLDDSFKRLIVPLLCRELRAKLTSDAEKQSVMMFGQNLRQLLLTSPVPGRTLM *****:***:******* *****::**********:******:***************** ENSP00000263736/1-995 GVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREAEKIKTLLLNFNCSTVVIGNGTA ENSCPOP00000004296/1-846 GVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREAEKIKRLLLNFNCSTVVIGNGTA XP_004839448.1/1-987 GVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREAEKIKRLLLNFNCSTVVIGNGTA ENSMUSP00000092810/1-981 GVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREAEKIKRLLLHFNCRTVVIGNGTA ENSRNOP00000065410/1-1016 GVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREAEKIKRLLLNFNCNTVVIGNGTA ****************************************** ***:*** ********* ENSP00000263736/1-995 CRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGLDPNLRSAVSIAR ENSCPOP00000004296/1-846 CRETEAYFADLIMKNYFAPLDVVYCIVSEAGTSIYSVSPEANKEMPGLDPNVRSAVSIAR XP_004839448.1/1-987 CRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGLDPNLRSAVSIAR ENSMUSP00000092810/1-981 CRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGLDPNLRSAVSIAR ENSRNOP00000065410/1-1016 CRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGLDPNLRSAVSIAR *******************************:*******************:******** ENSP00000263736/1-995 RVQDPLAELVKIEPKHIGVGMYQ------------------------------------H ENSCPOP00000004296/1-846 RVQDPLAELVKIEPKHIGVGMYQ------------------------------------H XP_004839448.1/1-987 RVQDPLAELVKIEPKHIGVGMYQ------------------------------------H ENSMUSP00000092810/1-981 RVQDPLAELVKFDPKHIGVGMYQ------------------------------------H ENSRNOP00000065410/1-1016 RVQDPLAELVKFDPKHIGVGMYQVKQCGSCLKWKEGEIEQKKVCFSVVEKETTDSSCTEH ***********::********** * ENSP00000263736/1-995 DVSQTLLKATLDSVVEECVSFVGVDINICSEVLLRHIAGLNANRAKNIIEWREKNGPFIN ENSCPOP00000004296/1-846 DVSQTLLKATLDSVVEECVSFVGVDINICSEVLLRHIAGLNANRAKNIIEWREKNGPFIN XP_004839448.1/1-987 DVSQTLLKATLDSVVEECVSFVGVDINICSEVLLRHIAGLNTNRAKNIIEWREKNGPFIN ENSMUSP00000092810/1-981 DVSQTLLKATLDSVVEECVSFVGVDINICSEVLLRHIAGLNANRAKNIIEWREKNGPFIN ENSRNOP00000065410/1-1016 DVSQTLLKATLDSVVEECVSFVGVDINICSEVLLRHIAGLNANRAKNIIEWREKNGPFIN *****************************************:****************** ENSP00000263736/1-995 REQLKKVKGLGPKSFQQCAGFIRINQDYIRTFCS-QQTETSGQIQGVAVTSSADVEVTNE ENSCPOP00000004296/1-846 REQLKKVKGLGPKSFQQCAGFIRINQDYIRTFCS-QQTESSSQIQAVAVTSSAGAEVTNE XP_004839448.1/1-987 REQLKKVKGLGPKSFQQCAGFIRINQDYIRTFCS-QQTESLSHIQGIAVTPSAGVEVTHE ENSMUSP00000092810/1-981 REQLKKVKGLGPKSFQQCAGFVRINQDYIRTFCS-QHTDSSGQSQETAM-------VTNE ENSRNOP00000065410/1-1016 REQLKKVKGLGPKSFQQCAGFVRVNQDYIRTFCSGQHTDSSGQSQEAAM-------VTKE *********************:*:********** *:*:: .: * *: **:* ENSP00000263736/1-995 KQGKKKSKTAVNVLLKPNPLDQTCIHPESYDIAMRFLSSIGGTLYEVGKPEMQQKINSFL ENSCPOP00000004296/1-846 KQGKKKSKTTVDAILKPNPLDQTCIHPESYDIAMRFLLFIGGTLGEIGKPEMQQKINSFL XP_004839448.1/1-987 KQGKKKNKTSVDAMLKPNPLDQTCIHPESYDIAMRFLSFIGGTLCEIGKPEMKQKINSSL ENSMUSP00000092810/1-981 KLGKKKNKA--DATLIPNPLDQTCIHPESYDIAVRFLSFIGGTMCEIGKPEMQQKINVSL ENSRNOP00000065410/1-1016 KPGKKKNKA--DVALTPNPLDETCIHPESYDIAVRFLSFIGGTLYEIGKPEMQQKINSSL * ****.*: :. * *****:***********:*** ****: *:*****:**** * ENSP00000263736/1-995 EKEGMEKIAERLQTTVHTLQVIIDGLSQPESFDFRTDFDKPDFKRSIVCLEDLQIGTVLT ENSCPOP00000004296/1-846 DKEGIEKAAERLKTTVHTLQVVIDGLSQPESFDFRTDFDKPDFKRSIVCLEDLQVGTILT XP_004839448.1/1-987 EKEGIEKAAERLTTTVQTLQIVIDGLSQPESFDFRTDFDKPDFKRSIVCLEDLQVGMILT ENSMUSP00000092810/1-981 GKEGIEETAERLQTTVHTLQVIIDGLSQPKTFDIRTDFDKPDFKRSIVCLEDLQVGTVLT ENSRNOP00000065410/1-1016 GKEGIEKTAERLQTTAHTLQVIIDGLSQPKTFDIRTDFDKPDFKRSIVCLADLQVGTILT ***:*: **** **.:***::*******::**:**************** ***:* :** ENSP00000263736/1-995 GKVENATLFGIFVDIGVGKSGLIPIRNVTEAKLSKTKKRRSLGLGPGERVEVQVLNIDIP ENSCPOP00000004296/1-846 GKVENATLFGIFVDIGVGQSGLIPIRNVTEAKLSKTKKRRSLGLGPGERVEVRVLNINIP XP_004839448.1/1-987 GKVENATLFGIFVDIGVGRSGLIPIRNVTEAKLSKTKKRRSLGLGPGERVEVQVLNIDIP ENSMUSP00000092810/1-981 GKVENATLFGVFVDIGVGKAGLIPIRFITEAKLSKTKRRRSLGLGPGEKVEVKVLNVDIP ENSRNOP00000065410/1-1016 GKVENATLFGVFVDIGVGKAGLIPIRFITEAKLSKTKKRRSLGLGPGEKVEVKVLSVDIP **********:*******::****** :*********:**********:***:**.::** ENSP00000263736/1-995 RSRITLDLIRVL ENSCPOP00000004296/1-846 RSRITLDLIRVL XP_004839448.1/1-987 RSRITLDLIRVL ENSMUSP00000092810/1-981 RSRISLDLLRVL ENSRNOP00000065410/1-1016 RSRISLDLLRVL ****:***:***