CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000003983/1-950 MHRAVDPPGARAAREAFALGGLSCSGAWSSCPPHPPPRSAWLPGGRCSASIGQPPIPAPL XP_004857511.1/1-1660 MHRAVDPPGARAAREAFALGGLSCSGAWSSCPPHPLPRSAWLPGGRCSASIGQPPLPAPP ENSP00000254846/1-1682 MHRAVDPPGARAAREAFALGGLSCAGAWSSCPPHPPPRSAWLPGGRCSASIGQPPLPAPL ENSMUSP00000091620/1-1641 MHRAVDPPGARSAREAFALGGLSCAGAWSSCPPHPPPRSSWLPGGRCSASVGQPPLSAPL ENSRNOP00000060247/1-1340 ------------------------------------------------------------ ENSCPOP00000003983/1-950 PPSHGSSSGHPNKPYYAPGTPTPRPLHGKLESLHGCVQALLRDPVQPGLWEQLGQLYESE XP_004857511.1/1-1660 PPSHGSSSAHPNKPYYAPGTPTPRPLHGKLESLHGCVQALLREPAQPGLWEQLGQLYESE ENSP00000254846/1-1682 PPSHGSSSGHPSKPYYAPGAPTPRPLHGKLESLHGCVQALLREPAQPGLWEQLGQLYESE ENSMUSP00000091620/1-1641 PPSHGSSSGHPNKPYYAPGTPTPRPLHGKLESLHGCVQALLREPAQPGLWEQLGQLYESE ENSRNOP00000060247/1-1340 ------------------------------------------------------------ ENSCPOP00000003983/1-950 HDSEEATRCYHSALRYGGSFAELGPRIGRLQQAQLWNFHAGSCQHRAKVLPPLEQVWNLL XP_004857511.1/1-1660 HDSEEAIRCYHSALRYGGSFAELGPRIGRLQQTQLWNFHAGSCQHRAKVLPPLEQVWNLL ENSP00000254846/1-1682 HDSEEATRCYHSALRYGGSFAELGPRIGRLQQAQLWNFHTGSCQHRAKVLPPLEQVWNLL ENSMUSP00000091620/1-1641 HDSEEAVCCYHRALRYGGSFAELGPRIGRLQQAQLWNFHAGSCQHRAKVLPPLEQVWNLL ENSRNOP00000060247/1-1340 ------------------------------------------------------------ ENSCPOP00000003983/1-950 HLEHKRNYGAKRGGPPVKRAAEPPVVQPVPPATLSGPSGEEGLSPGGKRRRGCSSEQTGL XP_004857511.1/1-1660 HLEHKRNYGTKRGGPPVKRAAEPPVVQPVPPAALSGPSGEEGLSPGGKRRRGCSSEQTGL ENSP00000254846/1-1682 HLEHKRNYGAKRGGPPVKRAAEPPVVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGL ENSMUSP00000091620/1-1641 HLEHKRNYGAKRGGPPVKRSAEPPVVQPMPPAALSGPSGEEGLSPGGKRRRGCSSEQAGL ENSRNOP00000060247/1-1340 -----------RG-----------------------PSSEE------------------- ** **.** ENSCPOP00000003983/1-950 PPGLPL-----PPPPLPPPPPPPPPSLSCLAASPPFQLTKPGLWNTLHGDSWAPERKGSG XP_004857511.1/1-1660 PPGLPL--------PPPPLPPPPPPPLSGLVTSPPFQLNKPGLWSTLHGDAWGPERKGSG ENSP00000254846/1-1682 PPGLPL--PPPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSA ENSMUSP00000091620/1-1641 PPGLPLPPPPPPPPPPPPPPPPPPPPLPGLAISPPFQLTKPGLWNTLHGDAWGPERKGSA ENSRNOP00000060247/1-1340 ------------------------------------------------------------ ENSCPOP00000003983/1-950 PPERQEQRHSLPHPYPYPAPAYATHPPPSHRLVPAAPPGPGPRPPGAESHGCLLTTRPPG XP_004857511.1/1-1660 PPERQEQRHLLSHSYPYPAPAYTTH-PPSHRLVPTAPPGPGPRPPGAESHGCLPATRPPG ENSP00000254846/1-1682 PPERQEQRHSLPHPYPYPAPAYTAH-PPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPG ENSMUSP00000091620/1-1641 PPERQEQRHSMPHSYPYPAPAYSAH-PPSHRLVPNTPLGPGPRPPGAESHGCLPATRPPG ENSRNOP00000060247/1-1340 -----EQRHSLPHPHPYPAPAYTAH-PPSHRLGPATPLGPGPRPPGAESHGCLPATRPPG **** :.*.:*******::* **.*** * :* *************** :***** ENSCPOP00000003983/1-950 SDLRESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGITTTTTSSSSSSSSSTGLRGVE XP_004857511.1/1-1660 SDLRESRVQRSRMDSSVSPAATIACVPYAPSRPPGLPGI--TTSSSSSSSSSGTSLRGVE ENSP00000254846/1-1682 SDLRESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPG---TTTSSSSSSSSNTGLRGVE ENSMUSP00000091620/1-1641 SDLRESRVQRSRMDSSVSPAASTACVPYAPSRPPGLPGT--SSSSSSSSSSNNTGLRGVE ENSRNOP00000060247/1-1340 SDLRESRVQRSRMDSSVSPAASTACVPYAPSRPPGLPG-----TSSSSSSSNNTGLRGVE *********************: *************** :*******..*.***** ENSCPOP00000003983/1-950 SSPGLPGADHYQTPALEVSSHQGRLGPLAHSSRKPFPAAPTATSHLPLPPGPSTPPPLHC XP_004857511.1/1-1660 LSPGLPGADHYQTHSLEVSSHQGRLGPSAHSSRKPFSAAPTATPHLPLPPGPTSPPPPPC ENSP00000254846/1-1682 PNPGIPGADHYQTPALEVS-HHGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPC ENSMUSP00000091620/1-1641 PSPGIPGADHYQNPALEISPHQARLGPSAHSSRKPFLTAPAATPHLSLPPGTPSSPPPPC ENSRNOP00000060247/1-1340 PSPGIPGADHYQNPALEIAPHQARLGPSAHSSRKPFLTAPAAAPHLSLPSGTPSSPPPPC .**:*******. :**:: *:.**** ******** **:*:.**.**.*..:.** * ENSCPOP00000003983/1-950 PRLLRPPPPPSWLKGPACRGAREDGEILEELFFGAEGPPRPPPPSLPPREGFLGPPAPRF XP_004857511.1/1-1660 PRLFRPPPPPSWVKGPACRSAREDGEILEELFFGAEGPSRPPPPALPPREGFLGPPAPRF ENSP00000254846/1-1682 PRLLRPPPPPAWLKGPACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRF ENSMUSP00000091620/1-1641 PRLLRPPPPPAWMKGSACRAAREDGEILGELFFGAEGPPRPPPPPLPHRDGFLGPPNPRF ENSRNOP00000060247/1-1340 PRLLRPPPPPAWMKGSACRSAREDGEILGELFFGAEGPPRPPPPPLPHRDGFLGPPNPRF ***:******:*:**.***.******** *****:***.**.**.** *:****** .** ENSCPOP00000003983/1-950 SVGTQDSHTPPTPPATSSSSSSSHSS----SHSSSPTGPVPFSPPPYLPRSGEPLPQPPS XP_004857511.1/1-1660 SVGTQDSHPPPTPPATSSSSSSNSNHNHNHSHSSSPNGPVPFSPPPYLSRSIEPLPRPPS ENSP00000254846/1-1682 SVGTQDSHTPPTPPTPTTSSSNSNSG----SHSSSPAGPVSFPPPPYLARSIDPLPRPPS ENSMUSP00000091620/1-1641 SVGTQDSHNPPIPPTTTSSSSSSN------SHSSSPTGPVPFPPPSYLARSIDPLPRPSS ENSRNOP00000060247/1-1340 SVGTQDSHTPPTPPTTTSSSSSSSSSN---SHSSSPTGPVPFPPPPYLARSIDPLPRPSS ******** ** **:.::***.. ****** ***.*.**.**.** :***:*.* ENSCPOP00000003983/1-950 PTLSPQDAPLPPLTLALPPVPPSSCHQNTSGSFRHSESPRPGVSFPKTPEVEPGPLPGPL XP_004857511.1/1-1660 PTLSPQDPPLAPLTLALPPAPPSSCHQNTSGSFRHSESPRPRVSFPKTPEVEPGPLPGPL ENSP00000254846/1-1682 PAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPL ENSMUSP00000091620/1-1641 PTLSPQDPPLPPLTLALPPAPPSSCHQNTSGSFRRSESPRPRVSFPKTPEVGQGPPPGPV ENSRNOP00000060247/1-1340 PTLSSQDPPLPPLTLALPPAPPSSCHQNTSGSFRRSESPRPRVSFPKTPEVGQGPPPGSL *: ..**.** ********.**************:.***** ********* ** **.: ENSCPOP00000003983/1-950 SKAPQPVPPGVGDLPARGPQLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKE XP_004857511.1/1-1660 SKAPQPVPPGVGELPARGPRLFDFPSTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKE ENSP00000254846/1-1682 SKAPQPVPPGVGELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKE ENSMUSP00000091620/1-1641 SKAPQPVPPGVGELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKE ENSRNOP00000060247/1-1340 SKAPQPVPPGVGELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKE ************:******:*****.********************************** ENSCPOP00000003983/1-950 EE-QQQQEAGVVPQPPLKEPFASLQPAFPADTAPATTAATTTADATTTITTTAT------ XP_004857511.1/1-1660 EE--QQQEAGVVPPPPLKEPFASLQPPFPSDTAPTTTAATTTADATTTITTATTTAAATI ENSP00000254846/1-1682 EE-QQQHEAGVAPQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTTTTTTT------ ENSMUSP00000091620/1-1641 EEQQQQQEAGVAPPPPLKEPFASLQPPFPSDTAPATTTAAPTTATTTTTTTTT------- ENSRNOP00000060247/1-1340 EE-QQQQEAGAVPPPPLKEPFASLRSSLPSDTAPAATTAAATPTTTTTT----------- ** **:***..* **********:..:*:****::*:.: : :*** ENSCPOP00000003983/1-950 -----AAAEEEKKPPPAL-PPPPPLAKFPPPSQPQPPPPGAPPPASPASLLKSLACVLEG XP_004857511.1/1-1660 ATANATTQEEEKKPPPALPPPPPPLAKFPPPSQPQTAPPLPPPPASPASLLKSLACVLEG ENSP00000254846/1-1682 -----ATQEEEKKPPPAL-PPPPPLAKFPPPSQPQPPP---PPPPSPASLLKSLASVLEG ENSMUSP00000091620/1-1641 -----TTQEEEKKPPPAL-PPPPPLAKFPPPPQPQPPP---PPPASPASLLKSLASVLEG ENSRNOP00000060247/1-1340 -----TTQEEEKKPPPAL-PPPPPLAKFPPP--PQPPP---PPPASPASLLKSLASVLEG :: ********** ************ **..* ***.**********.**** ENSCPOP00000003983/1-950 QKYCYRGSGAAVSTRPGPVSTSQYSPGPPSGATAPPPASVAPSAQGSAQPSASLSSQFST XP_004857511.1/1-1660 QKYCYRGNGAAVSTRPGPLPTSQYSPGPPSGATAPPPTSVAPSTQGSPQPSASSSSQFST ENSP00000254846/1-1682 QKYCYRGTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSAAPSAQGSPQPSASSSSQFST ENSMUSP00000091620/1-1641 QKYCYRGTGAAVSTRPGSVPATQYSPSPASGATAPPPTSVAPSAQGSPKPSVSSSSQFST ENSRNOP00000060247/1-1340 QKYCYRGTGAAVSTRPGSVPATQYSPSPASGATAPPPTSVAPSAQGSPKPSVSSSSQFST *******.*********.:.::****.*.***** **:*.***:***.:**.* ****** ENSCPOP00000003983/1-950 SGGPWPREAPRGGEEPAPGLATPAQPPPPLR-PASLGVLKVLEEVRAVPKILVERVG--- XP_004857511.1/1-1660 SGGPWARE-HRAGEEPAPGPATSTQPPPPLPLPPARSESEVLEEISRACETLVERVGRSA ENSP00000254846/1-1682 SGGPWARE-RRAGEEPVPGPMTPTQPPPPLSLPPARSESEVLEEISRACETLVERVGRSA ENSMUSP00000091620/1-1641 SGGPWARE-HRAGEEPAPGPVTPAQLPPPLPLPPARSESEVLEEISRACETLVERVGRSA ENSRNOP00000060247/1-1340 SGGPWVRE-RRAGEEPAPGPVTPAQLPPPLPLPPARSESEVLEEISRACETLVERVGRSA ***** ** *.****.** *.:* **** *.: . :****: . : ****** ENSCPOP00000003983/1-950 ------------------------------------------------------------ XP_004857511.1/1-1660 IDPGDTVDTADPLDSVAERLVPPAQVKEESGGVVTAAAAGPGSGKRRQKEHLKEHRRHRR ENSP00000254846/1-1682 TDPADPVDTAEPADSGTERLLPPAQAKEEAGG-VAAVS---GSCKRRQKEHQKEHRRHRR ENSMUSP00000091620/1-1641 INP---VDTADPVDSGTEPQPPPAQAKEESGG-VAVAAAGPGSGKRRQ----KEHRRHRR ENSRNOP00000060247/1-1340 INPADPVDIADPVDSGTEPQPPPAQAKEESGG-VAVAAAGPGSGKRRQ----KEHRRHRR ENSCPOP00000003983/1-950 ---------------------PK------------------------------------- XP_004857511.1/1-1660 ACKDSVGRRPREGRAKAKA--PKEKSRRVLGNLDLQSEEIQGREKVRPDLGGASKAKPPT ENSP00000254846/1-1682 ACKDSVGRRPREGRAKAKAKVPKEKSRRVLGNLDLQSEEIQGREKSRPDLGGASKAKPPT ENSMUSP00000091620/1-1641 ACRDSVGRRPREGRAKAKAKAPKEKSRRVLGNLDLQSEEIQGREKARPDVGGVSKVKTPT ENSRNOP00000060247/1-1340 TCRDSVGRRPREGRAKAKAKAPKEKSRRVLGNLDLQSEEIQGREKARPDVGGASKVKTPT ** ENSCPOP00000003983/1-950 ------------------------------------------------------------ XP_004857511.1/1-1660 APALQPVPAPSAQPTPPSAPVPGKKTREEAPGPPGVSRADMLKLRSLSEGPPKELKIRLI ENSP00000254846/1-1682 APAPPSAPAPSAQPTPPSASVPGKKAREEAPGPPGVSRADMLKLRSLSEGPPKELKIRLI ENSMUSP00000091620/1-1641 APAPPPAPAPAAQPTPPSAPVPGKKTREEAPGPPGVSRADMLKLRSLSEGPPKELKIRLI ENSRNOP00000060247/1-1340 TPAPPPAPAPSAQPTPPSAPVPGKKTREEAPGPPGVSRADMLKLRSLSEGPPKELKIRLI ENSCPOP00000003983/1-950 ------------------------------------------------------------ XP_004857511.1/1-1660 KVESGDKETFIASEVEERRLRMADLTISHCAADVVRASKNAKVKGKFRESYLSPAQSVKP ENSP00000254846/1-1682 KVESGDKETFIASEVEERRLRMADLTISHCAADVVRASRNAKVKGKFRESYLSPAQSVKP ENSMUSP00000091620/1-1641 KVESGDKETFIASEVEERRLRMADLTISHCAADVMRASKNAKVKGKFRESYLSPAQSVKP ENSRNOP00000060247/1-1340 KVESGDKETFIASEVEERRLRMADLTISHCAADVMRASKNAKVKGKFRESYLSPAQSVKP ENSCPOP00000003983/1-950 ------------------------------------CT--RNP----------------- XP_004857511.1/1-1660 KINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGL ENSP00000254846/1-1682 KINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGL ENSMUSP00000091620/1-1641 KINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGL ENSRNOP00000060247/1-1340 KINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGL ** *** ENSCPOP00000003983/1-950 -------------------------EDAWN------------------------------ XP_004857511.1/1-1660 FSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSF ENSP00000254846/1-1682 FSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSF ENSMUSP00000091620/1-1641 FSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSF ENSRNOP00000060247/1-1340 FSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSF :: *: ENSCPOP00000003983/1-950 ---------------------------TAAP----------------------------- XP_004857511.1/1-1660 QESLQEEKESEDEESEEPDSTTGTPPSSNAPDPKNHHIIKFGTNIDLSDAKRWKPQLQEL ENSP00000254846/1-1682 QESLQEEKESEDEESEEPDSTTGTPP-SSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQEL ENSMUSP00000091620/1-1641 QESLQEERESEDEESEEPDSTTGTSP-SSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQEL ENSRNOP00000060247/1-1340 QESLQEEKESEDEESEEPDSTTGTSPSSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQEL : ** ENSCPOP00000003983/1-950 ------------------------------------------------------------ XP_004857511.1/1-1660 LKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGD ENSP00000254846/1-1682 LKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGD ENSMUSP00000091620/1-1641 LKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGD ENSRNOP00000060247/1-1340 LKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGD ENSCPOP00000003983/1-950 ------------------------------------------------------------ XP_004857511.1/1-1660 CEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAG ENSP00000254846/1-1682 CEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAG ENSMUSP00000091620/1-1641 CEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAG ENSRNOP00000060247/1-1340 CEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAG ENSCPOP00000003983/1-950 ------------------------------------------------------------ XP_004857511.1/1-1660 TVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKI ENSP00000254846/1-1682 TVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKI ENSMUSP00000091620/1-1641 TVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKI ENSRNOP00000060247/1-1340 TVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKI ENSCPOP00000003983/1-950 ------------------------------------------------------------ XP_004857511.1/1-1660 SDPDLFKMIKFCLLQSMKHCQVQRESLVRGGKKIAYQGRVKDEPAYYCNECDVEVFNILF ENSP00000254846/1-1682 SDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILF ENSMUSP00000091620/1-1641 SDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILF ENSRNOP00000060247/1-1340 SDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILF ENSCPOP00000003983/1-950 ------------------------------------------------------------ XP_004857511.1/1-1660 VTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTL----------- ENSP00000254846/1-1682 VTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLVRARRARGQRR ENSMUSP00000091620/1-1641 VTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTL----------- ENSRNOP00000060247/1-1340 VTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTL----------- ENSCPOP00000003983/1-950 ----------------------------------- XP_004857511.1/1-1660 ----------------------------APTSTSR ENSP00000254846/1-1682 RALGQAAGTGFGSPAAPFPEPPPAFSPQAPASTSR ENSMUSP00000091620/1-1641 ----------------------------APASTSR ENSRNOP00000060247/1-1340 ----------------------------APASTSR