CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000028187/1-1581 MAVSRVLSLLATVASMALVIQETHFAAGADMGSCYDGVGRAQRCLPEFENAAFGRRAEAS ENSRNOP00000013172/1-1580 MAVSGILSRLATVVCVALVMLKAHCATGAGMGSCYDGAGRAQRCLPEFENAAFGRRAEAS ENSP00000354360/1-1575 MAAAALLLGLALLAPR---------AAGAGMGACYDGAGRPQRCLPVFENAAFGRLAQAS ENSCPOP00000003965/1-1507 ------------------------------------------------------------ XP_004849653.1/1-1573 --MAAVVLGLALALAL---------VGAAGADGCYDGAGRARRCRPEFENVAFGRRAAAS ENSMUSP00000028187/1-1581 HTCGRP-PEDFCPHVGAPGAGLQCQRCDDADPGRRHDASYLTDFHSPDDSTWWQSPSMAF ENSRNOP00000013172/1-1580 HTCGQP-PEDFCPHVGAPGAGPQCQRCDDADPRRRHDASYLTDFHSPDDSTWWQSPSMAF ENSP00000354360/1-1575 HTCGSP-PEDFCPHVGAAGAGAHCQRCDAADPQRHHNASYLTDFHSQDESTWWQSPSMAF ENSCPOP00000003965/1-1507 ------------------GAGTQCQRCDAADPARHHNASYLTDFHNPDDSTWWQSPSMAF XP_004849653.1/1-1573 HTCGSPEAEDFCPHVRAPGAGTQCQRCDAADPGRHHNASYLTDFHSPDDSTWWQSPSMAF *** :***** *** *:*:********. *:*********** ENSMUSP00000028187/1-1581 GVQYPTSVNLTLSLGKAYEITYVRLKFHTSRPESFAIYKRTYASGPWEPYQYYSASCQKT ENSRNOP00000013172/1-1580 GVQYPTSVNLTLHLGKAYEITYVRLKFHTSRPESFAIYKRTHTGGPWEPYQYYSASCQKT ENSP00000354360/1-1575 GVQYPTSVNITLRLGKAYEITYVRLKFHTSRPESFAIYKRSRADGPWEPYQFYSASCQKT ENSCPOP00000003965/1-1507 GVQHPTSVNITLRLGKAYEISYVRLKFHTSRPESFAIYKRSRPGGPWEPYQFYSASCQRT XP_004849653.1/1-1573 GVQYPTSVTLTLRLGKAYEISYVRLKFHTSRPESFAIYKRSHEDGPWEPYQYYSASCHKT ***:****.:** *******:*******************: .*******:*****::* ENSMUSP00000028187/1-1581 YGRPEGHYLRPGEDERVAFCTSEFSDISPLNGGNVAFSTLEGRPSAYNFEESPVLQEWVT ENSRNOP00000013172/1-1580 YGHPEGHYLRPGEDERVAFCTSEFSDISPLNGGNVAFSTLEGRPSAYNFEESPVLQEWVT ENSP00000354360/1-1575 YGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPGLQEWVT ENSCPOP00000003965/1-1507 YGRPEGHSLRPGDDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYSFEDSPGLQDWVT XP_004849653.1/1-1573 YGQPEGLYLRPGDEERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPGLQDWVT **:*** ****::****************.****************.**:** **:*** ENSMUSP00000028187/1-1581 STDILISLDRLNTFGDDIFKDPRVLQSYYYAVSDFSVGGRCKCNGHASECEPNAAGQLAC ENSRNOP00000013172/1-1580 STDLLISLDRLNTFGDDIFKDPRVLQSYYYAVSDFSVGGRCKCNGHASACGPNEAGQLAC ENSP00000354360/1-1575 STELLISLDRLNTFGDDIFKDPKVLQSYYYAVSDFSVGGRCKCNGHASECGPDVAGQLAC ENSCPOP00000003965/1-1507 STELLVSLDRLNTFGDDIFGDPRVLRSYYYAVSDLSVGGRCKCNGHASECGPDAAGQLVC XP_004849653.1/1-1573 STELLVSLDRLNTFGDDIFRDPRVLQSYYYAVSDFSVGGRCKCNGHASECSPDAAGRLVC **::*:************* **:**:********:************* * *: **:*.* ENSMUSP00000028187/1-1581 RCQHNTTGVDCERCLPFFQDRPWARGTAEDANECLPCNCSGHSEECTFDRELYRSTGHGG ENSRNOP00000013172/1-1580 HCQHNTTGVDCERCLPFFQDRPWARGTAEDANECLPCNCSGHSEECTFDRELYRSTGHGG ENSP00000354360/1-1575 RCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHGG ENSCPOP00000003965/1-1507 RCQHHTAGADCERCLPFFRDRPWARATARTANECLPCNCSGRSENCTFDLELFRSTGHGG XP_004849653.1/1-1573 RCQHNTTGANCERCLPFFQDRPWARGTAQAANECLPCSCSGRSKDCTFDLELFRSTGRGG :***:*:*.:********:******.**. *:*****.***:*::**** **:****:** ENSMUSP00000028187/1-1581 HCQRCRDHTTGPHCERCEKNYYRWSPKTPCQPCDCHPAGSLSLQCDNSGVCPCKPTVTGW ENSRNOP00000013172/1-1580 HCQRCRDHTAGPHCEHCEKNYYRWDPKTPCQPCDCHPAGSLSLQCDNSGTCPCKLTVTGW ENSP00000354360/1-1575 RCHHCRDHTAGPHCERCQENFYHWDPRMPCQPCDCQSAGSLHLQCDDTGTCACKPTVTGW ENSCPOP00000003965/1-1507 HCHGCRDHTAGPHCERCEENFYRWDARAPCQPCDCHPAGSLRLQCDASGSCPCKPLVTGW XP_004849653.1/1-1573 RCHHCLDHTAGPHCERCEENFYRWDQRAPCRPCDCHPAGSWRLQCDASGTCPCKPSVTGW :*: * ***:*****:*::*:*:*. : **:****:.*** **** :* *.** **** ENSMUSP00000028187/1-1581 KCDRCLPGFHSLSEGGCRPCACNVAGSLGTCDPRSGNCPCKENVEGSLCDRCRPGTFNLQ ENSRNOP00000013172/1-1580 KCDRCLPGFHSLSEGGCRPCTCNVAGSLGTCDPRSGNCPCKENVEGGLCDRCRPGTFNLQ ENSP00000354360/1-1575 KCDRCLPGFHSLSEGGCRPCTCNPAGSLDTCDPRSGRCPCKENVEGNLCDRCRPGTFNLQ ENSCPOP00000003965/1-1507 KCDRCLPGFHSLSEGGCRPCACSAAGSLGTCDPRSGSCPCKQKVEGSLCDRCRPGTFNLQ XP_004849653.1/1-1573 KCDRCLPGFHSLSEGGCRPCTCNAAGSLDTCDPRSGRCPCKENVEGSLCDRCRPGTFNLQ ********************:*. ****.******* ****::***.************* ENSMUSP00000028187/1-1581 PHNPVGCSSCFCYGHSKVCSPAAGFQEHHIRSDFRHGAGGWQIRSMGVSKRPLQWSQSGL ENSRNOP00000013172/1-1580 PHNPAGCSSCFCYGHSKVCAPASGFQEHHIRSDFRHGADGWQARSTEVSERPLQWSQSGI ENSP00000354360/1-1575 PHNPAGCSSCFCYGHSKVCASTAQFQVHHILSDFHQGAEGWWARSVGGSEHPPQWSPNGV ENSCPOP00000003965/1-1507 LHNPAGCSSCFCYGHSKACTAAAGFQAHHVLSSLRHGAGAWRVRSTGGAEHPARWSPGGV XP_004849653.1/1-1573 PHNPAGCSSCFCYGHSKVCTATAGFQVHHVFSSLRQGAGAWRARGTGGAEQPARWSPGGV ***.************.*:.:: ** **: *.:::** .* *. :::* :** .*: ENSMUSP00000028187/1-1581 LLGLRGGEELSAPKKFLGDQRLSYGQPVILTLQVPPGGSPPPIQLRLEGAGLALSLRPSS ENSRNOP00000013172/1-1580 LLGLRGGEELSAPEKFLGDQRLSYGQPLILTLQVPPGGSPPPMQLRLEGAGLSLALKPSN ENSP00000354360/1-1575 LLSPEDEEELTAPEKFLGDQRFSYGQPLILTFRVPPGDSPLPVQLRLEGTGLALSLRHSS ENSCPOP00000003965/1-1507 LLGPEE-EELTAPELFLGDQRLSYGQPLTLTFQVPPGGSLPPTQLRLEGAGLRLALKPSD XP_004849653.1/1-1573 LLGPED-EELTAPELFLGDQRLSYGQPLTLTFQVPPGGSPPPAQLRLEGAGLALALRPSS **. . ***:**: ******:*****: **::****.* * ******:** *:*: *. ENSMUSP00000028187/1-1581 LPSPQDTRQPRRVQLQFLLQETSEEAESPLPTFHFQRLLSNLTALSIWTSGQGPGHSGQV ENSRNOP00000013172/1-1580 LPSSQDTRQPGRVQLQFLLQETSEEAEPPLPAFHFQRLLSNLTTLSIWTSGQGLGHSGHV ENSP00000354360/1-1575 LSGPQDAGHPREVELRFHLQETSEDVAPPLPPFHFQRLLANLTSLRLRVS-PGPSPAGPV ENSCPOP00000003965/1-1507 QSVPQDAGQQGQAQVHFLLQETSEDTLPALPAFHFQRVLANLTALCIRTSGQGSGLSGQV XP_004849653.1/1-1573 QSAPQDAGQPGQAQLHFLLQETSEEAEPPLPAFHFQRILANLTALRIRASGQGPSSSGPA . .**: : ..:::* ******:. ..**.*****:*:***:* : .* * . :* . ENSMUSP00000028187/1-1581 LLCEVQLTSAWPQRELAPPASWVETCLCPQGYTGQFCEFCALGYKREIPHGGPYANCIPC ENSRNOP00000013172/1-1580 LLCEVHLTSARPQRGLAPPASWVETCLCPQGYTGQFCEFCALGYKREIPHGGPYTNCIPC ENSP00000354360/1-1575 FLTEVRLTSARP--GLSPPASWVEICSCPTGYTGQFCESCAPGYKREMPQGGPYASCVPC ENSCPOP00000003965/1-1507 LLSEVRLTSARAQQGRSPPATWVETCSCPQGYTGQFCEACAPGYKREMPQGGPYVNCVPC XP_004849653.1/1-1573 LLSEVRLTSARAWQGLSPPATWVETCSCPQGYMGQFCESCAPGYKRETPRGGPYASCVPC :* **:**** . :***:*** * ** ** ***** ** ***** *:****..*:** ENSMUSP00000028187/1-1581 TCNQHGTCDPNTGICLCGHHTEGPSCERCMPGFYGNAFSGRADDCQPCPCPGQSACATIP ENSRNOP00000013172/1-1580 TCNQHGTCDPNTGICLCGHHTEGPSCERCMPGFYGNAFSGHADDCQPCPCPGQSACTTIP ENSP00000354360/1-1575 TCNQHGTCDPNTGICVCSHHTEGPSCERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIP ENSCPOP00000003965/1-1507 TCNQHGTCDPSTGTCLCGHHTEGPSCERCLTGFYGNPSSGQADDCKPCPCPGQSACTAIP XP_004849653.1/1-1573 TCNQHGTCDPNTGTCLCSHHTEGPSCEHCLPGFYGNPFKGRADDCKPCPCPGQSACTAIP **********.** *:*.*********:*:.*****. *:****:**********::** ENSMUSP00000028187/1-1581 ESGDVVCTHCPPGQRGRRCESCEDGFFGDPLGLSGAPQPCRRCQCSGNVDLNAVGNCDPH ENSRNOP00000013172/1-1580 ESRDVVCTHCPPGQRGRRCESCEDGFFGDPLGLSGAPQPCRRCQCSRNVDLNAVGNCDPH ENSP00000354360/1-1575 ESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPL ENSCPOP00000003965/1-1507 ESGEVVCTHCPPGQRGRRCESCDDGFFGDPLGLSGAPQPCRRCQCNGNMDPNAIGNCDPL XP_004849653.1/1-1573 ESGEVVCTHCPRGRRGRRCESCDDGFFGDPLGLSADPQPCRQCQCSGNVDLNALGNCDPL ** :******* *:****** *:********** . ****::***. *:* **:***** ENSMUSP00000028187/1-1581 SGHCLRCLYNTTGAHCEHCREGFYGSAVATRPVDKCAPCSCDLRGSVSEK-TCNPVTGQC ENSRNOP00000013172/1-1580 SGRCLRCLHNTTGAHCEHCQEGFYGSALATRPADKCAPCSCDPRGSSSQK-TCNPATGQC ENSP00000354360/1-1575 SGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQC ENSCPOP00000003965/1-1507 SGRCLRCLHNTTGTYCERCREGFYGSALAPRPADKCTPCSCSPVGSVSEQMSCDSVTGQC XP_004849653.1/1-1573 SGRCLRCLHSTAGERCEQCLEGFYGSALASRPADKCRPCSCSRGGSVAEQMPCDPVTGQC **:*****:.*:* **:* *******:*.**.*** **** ** ::: .*:..**** ENSMUSP00000028187/1-1581 VCLPYVSGRDCSRCSPGFYDLQSGRGCQSCKCHPLGSLENKCHPKTGQCPCRPGVTGQAC ENSRNOP00000013172/1-1580 ACLPYVTGRDCSRCSPGFYDLQPGRGCQSCKCHPVGSLENKCHPKTGQCPCRPGVTGQAC ENSP00000354360/1-1575 SCLPHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQAC ENSCPOP00000003965/1-1507 PCLPHVTGRDCSLCSPGFYNLHPGRGCRSCMCHPLGSQENQCHPETGQCHCRAGVMGLAC XP_004849653.1/1-1573 ACLPHVTGRDCSLCSPGFYDLQPGRGCRSCACHPLGSQEKQCHPETGQCPCRPGVAGLAC ***:*:.**** * ***::*:.****:** ***:** *.:***:**** **.** * ** ENSMUSP00000028187/1-1581 DRCQLGFFGFSIKGCRDCRCSPLGAASSQCHENSTCVCRPGFVGYKCDRCQDNFFLADGD ENSRNOP00000013172/1-1580 DRCQLGFFGFSIKGCRDCRCSPLGAASPQCHENSTCVCRPGFVGYKCDRCQDNFFLVDGD ENSP00000354360/1-1575 DRCQLGFFGFSIKGCRACRCSPLGAASAQCHENGTCVCRPGFEGYKCDRCHDNFFLTADG ENSCPOP00000003965/1-1507 DRCQLGFFGFSIKGCRACRCSPLGATSAQCHENSTCVCRPGFVGYKCDRCQDNFFPAEGG XP_004849653.1/1-1573 DRCQPGFFGFSIKGCRACRCSPLGAALAQCHENSTCVCQPGFMGYKCDRCRDNFFPTAGG **** *********** ********: .*****.****:*** *******:**** . .. ENSMUSP00000028187/1-1581 TGCQECPTCYALVKEEAAKLKARLMLMEGWLQRSDCGSPWGPLDILQGEAPLGDVYQGHH ENSRNOP00000013172/1-1580 TGCQECPTCYALVKEEAAKLKTRLMLMEGWLQGSECGSPWGPLDILQGEAPRGDVYQGHH ENSP00000354360/1-1575 THCQQCPSCYALVKEEAAKLKARLTLTEGWLQGSDCGSPWGPLDILLGEAPRGDVYQGHH ENSCPOP00000003965/1-1507 AHCQECPPCYGLVKEEVAKLKARLALMEEWLQGSDCGYPWGPPDILQGEAPGGNGDQGHH XP_004849653.1/1-1573 TLCQECPPCYGLVEEEVAKLRTRLTLMEGWLQGSDCGSSWRPLDIPQREAPQGDSDQGHH : **:**.**.**:**.***::** * * *** *:** .* * ** *** *: **** ENSMUSP00000028187/1-1581 LLQETRGTFLQQMVGLEDSVKATWEQLQVLRGHVHCAQAGAQKTCIQLAELEETLQSSEE ENSRNOP00000013172/1-1580 LFQDPTGLFSHVPNPTVMTLTLTWVSVPCLLPCTDCTQPYGERHCLQRANLGHCTYHKQG ENSP00000354360/1-1575 LLPGAREAFLEQMMSLEGAVKAAREQLQRLNKGARCAQAGSQKTCTQLADLEAVLESSEE ENSCPOP00000003965/1-1507 LLPGPQDALLGQLRGLEGAVKASRERLQALIEASGCAQAGTAKTCTQLADLGATLESSQD XP_004849653.1/1-1573 LLSGARGALLEQLTGLEVAVKAAWEQLQALSQAARCTQARAGKTCTQLAELGATLESSQD *: . : ::. : : * *:*. : * * *:* .: ENSMUSP00000028187/1-1581 EVLRAASALSFLASLQKGSSTPTNWSHLASEAQILARSHRDTATKIEATSERALLASNAS ENSRNOP00000013172/1-1580 PCSESAAVMFFQANLQEGSSAPTNWGRLASEAYILTRSHRDTATKIEATVERALLASNTS ENSP00000354360/1-1575 EILHAAAILASLEIPQEGPSQPTKWSHLATEARALARSHRDTATKIAATAWRALLASNTS ENSCPOP00000003965/1-1507 EILNAASILTSLATLQDGSSQPSNWSHLAAEARALARGHRDTAAEIKTTVHRALLASNTS XP_004849653.1/1-1573 ELLHTAAALTSLTTPQDWPGQPSSWSHLATEARALARGHRDTAAKIEATARRALLTSNTS .:*: : *. .. *:.*.:**:** *:*.*****::* :* ****:**:* ENSMUSP00000028187/1-1581 YELL-KLMEGRVASEAQQELEDRYQEVQAAQTALGIAVAEALPKAEKALATVKQVIGDAA ENSRNOP00000013172/1-1580 YELLWKLLKGSVASEAQQELEERYQEVQAAQTALGIAVAEALPKAEKALATVKQVVGAAA ENSP00000354360/1-1575 YALLWNLLEGRVALETQRDLEDRYQEVQAAQKALRTAVAEVLPEAESVLATVQQVGADTA ENSCPOP00000003965/1-1507 SSLLWKLADGRAALETQHDLEDRYQEVQAAQRALGTALARELPKARRVLASVQQGTDNST XP_004849653.1/1-1573 QALLWGLEDGRVALEAQQDLEDRYQEVQAAQKALGTAVAQELPEAKRLLASVQRGIADAA ** * .* .* *:*::**:********* ** *:*. **:*. **:*:: :: ENSMUSP00000028187/1-1581 PHLGLLVTPEAMN--FQARGLSWKVKALEQKLEQKEPEVGQSVGALQVEAGRALEKMEPF ENSRNOP00000013172/1-1580 PRLGSMVTPEAMD--SQARYLGRRVKALEQKLQQNQ--AGQAVGALQVEAGRALRKVEPF ENSP00000354360/1-1575 PYLALLASPGALPQKSRAEDLGLKAKALEKTVASWQHMATEAARTLQTAAQATLRQTEPL ENSCPOP00000003965/1-1507 LLLASLATAGAPPLQSQAGDLDFRVQVLEQKVASRERAATKATRALQASVQAALQRTEPL XP_004849653.1/1-1573 PRLASPAAPAVLP---QPGDLDSKARALEQKVASRERTAREAAGTLQASARVVLQRTEPL *. .:. . :. *. :.:.**:.: . : . ::. :**. . .*.: **: ENSMUSP00000028187/1-1581 MQLRNKTTAAFTRASSAVQAAKVTVIGAETLLADLEGMKLRSPLPKEQAALKKKAGSIRT ENSRNOP00000013172/1-1580 LQLRNKTTAALTQVSSAVQAAKVTVIGAKTLLADLEGMKLRFPLPKEQAALKRKAGSIRT ENSP00000354360/1-1575 TKLHQEARAALTQASSSVQAATVTVMGARTLLADLEGMKLQFPRPKDQAALQRKADSVSD ENSCPOP00000003965/1-1507 TQLRQEATAALARASSSVQAASVTVMGAKALLADLQGMKLWFPRPKDQAALRRRAGVIRD XP_004849653.1/1-1573 MQLRQEATAALGQASSSVQAATVTVTGAKTLLADLEGMKLWFSGPEDQAELQRRVGMVRD :*:::: **: :.**:****.*** **.:*****:**** . *::** *:::.. : ENSMUSP00000028187/1-1581 RLLEDTKRKTKQAERMLGNAASLSSSTKKKSKEAELMSKDNAKLSRALLREGKQGYRHAS ENSRNOP00000013172/1-1580 RLLKDTKRKTKQAERMLGNAASLSSNSQKRSKEAELMSKENAKLARAFLREGKQNYRHAS ENSP00000354360/1-1575 RLLADTRKKTKQAERMLGNAAPLSSSAKKKGREAEVLAKDSAKLAKALLRERKQAHRRAS ENSCPOP00000003965/1-1507 RLLADTRKKTQQAERMLGNSVLLSSSTRKKSREAELLAKDGAKLARASLQDGKQGHRRAR XP_004849653.1/1-1573 QLLADGRRKTKQAERMLGNTALLSSRAREKSREAELLAKDNAKVARGSLRDGKQGHRRAS :** * ::**:********:. *** ::::.:***:::*:.**:::. *:: ** :*:* ENSMUSP00000028187/1-1581 RLASQTQATLRRASRLLLTSEAHKQELEEAKQVTSGLSTVERQIRESRISLEKDTKVLSE ENSRNOP00000013172/1-1580 RLASQTQATLRQASRLVLTSEARKQELEEAKQVASGLSTVERQIRESRISLEKDTKVLSE ENSP00000354360/1-1575 RLTSQTQATLQQASQQVLASEARRQELEEAERVGAGLSEMEQQIRESRISLEKDIETLSE ENSCPOP00000003965/1-1507 QLASQTQATFTQASQLVLTSGARRRKLEEAEQVGTGLNTVEQQIRESRISLEKDIEALSE XP_004849653.1/1-1573 QLASQTQATLQRASRLVLTSGARRQGLEETEQVGAGLSTMEQQIRESRVSLEKDVEALAE :*:******: :**: :*:* *::: ***:::* :**. :*:******:***** :.*:* ENSMUSP00000028187/1-1581 LLVKLGSLGVHQAPAQTLNETQRALESLRLQLDSHGALHHKLRQLEEESARQELQIQSFE ENSRNOP00000013172/1-1580 LLAKLGSLGTHQAPAQTLNETQQALESLRLQLDSHGSLHHKLRQLEEESARQELQIQSFE ENSP00000354360/1-1575 LLARLGSLDTHQAPAQALNETQWALERLRLQLGSPGSLQRKLSLLEQESQQQELQIQGFE ENSCPOP00000003965/1-1507 LLARLGTLDTHEAPSHALNETQQVLDSLRLQLGSQGALQGKLRLLEQESEQQRLQIQGFD XP_004849653.1/1-1573 LLAGLGSLDTHGAPGHSLNETQRALEGLRLQLGSQGALQGKLRLLEQESKQQELQIQGFN **. **:*..* **.::***** .*: *****.* *:*: ** **:** :*.****.*: ENSMUSP00000028187/1-1581 DDLAEIRADKHNLETILSSLPENCAS-- ENSRNOP00000013172/1-1580 NDLAEIRADKHNLETILSSLPENCAS-- ENSP00000354360/1-1575 SDLAEIRADKQNLEAILHSLPENCASWQ ENSCPOP00000003965/1-1507 SDLAEIRADKQNLEAILRNLPAHCAS-- XP_004849653.1/1-1573 SDLAEIRTDKQNLEAILRSLPELCAGRQ .******:**:***:** .** **.