CLUSTAL W(1.81) multiple sequence alignment ENSP00000321706/1-1058 MDLGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSAAAHS ENSMUSP00000099558/1-1058 MDLGPLNICEEMTILHGGFLMAEQLFHPKALVQLTKSDWEHVGQPIVEALKEISSATAHS ENSRNOP00000010187/1-1058 MDLGPLNICEEMTILHGGFLMAEQLFHPKALEQLTKSDWEHVGQPIVEALKEISSATAHS ENSCPOP00000003885/1-1047 -----------MTILHGGFLLAEQLYRPKALAELTKSDWEHVGQPIVEALREICSATVHS XP_004857161.1/1-1058 MDLGPFNICEEMTILHGGFLLAEQLYCPKALAELIKSDWEHVGQPIVEALREICSATVHS *********:****: **** :* *****:**:******:**.**:.** ENSP00000321706/1-1058 QPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELLKSLE ENSMUSP00000099558/1-1058 QPFAWKKKALIIIWTKVLQPSPVSPSDTDTRWQEDVFFSVGNMIPTINHTVLFELLKSLE ENSRNOP00000010187/1-1058 QPFAWKKKALIIIWAKVLQPSPVSPSDTDTRWQEDVFFSVGNMIPTINHTVLFELLKSLE ENSCPOP00000003885/1-1047 QPLAWKKKALIIIWAKVLQPYPPTSPDTETRWQEDVFFSVGNMIPTINHTVLFELLKSLE XP_004857161.1/1-1058 QPLAWKKKALIIIWAKVLQPCPLTPLDTETRWQEDVFFSVGNMIPTINHTVLFELLKSLK **:***********:***** * :. **:******:**************:********: ENSP00000321706/1-1058 ASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQDPLLS ENSMUSP00000099558/1-1058 ASGLFIQLLMALPTTIGRSELQSFLEHMTVDTSSKDVAFFLDVWWEMMKHKGDQQDPLLS ENSRNOP00000010187/1-1058 ASGLFIQLLMALPTTIGRSELQSFLEHMTIDTSSKDVAFFLDVWWEMMKHKGDEQDPLLS ENSCPOP00000003885/1-1047 ASGLFIQLLMALPTTICRAELERFLEHMTIDTSSKDVAFFLDVWWEMMKHKGNQQDPLLS XP_004857161.1/1-1058 ASGLFVQLLMALPTTICCTELERFLEHMTIDTSSKDVAFFLDVWWEMMKHKGNQQDPLLS *****:********** :**: ****:*:***::***********:*****. ****** ENSP00000321706/1-1058 QFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRKCCAL ENSMUSP00000099558/1-1058 QFRTMAHKYLPSSDEFSHPPKRFKSDPDVGPTMPLLAMLLNGLKQIQKRILSLGMKCCAL ENSRNOP00000010187/1-1058 QFRTMAHKYLPSSDEFSHPPKRFKSDPDVGPTMPLLAMLLNGLKQIQKRILSLGMKCCAL ENSCPOP00000003885/1-1047 HFRTMAHKYLSSTDEFSHPPKRFKSDPDVCPTLPLLAMLLKGLKQIQKRILGLGMKCCAL XP_004857161.1/1-1058 HFRIMAHKYLSSSDEFSHPPKRFKSDPDVCPTLPLLAMLLNGLKQIQKRILCLEMKCCAL :* ******.: ***.*****::****. **:*******.**.***.*** ***** ENSP00000321706/1-1058 ANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEAERDV ENSMUSP00000099558/1-1058 ANLADMLSVFALLEDDTQEVSATVYLDKLATVISVWNSDTQNPYHRQALADKVKEAERDV ENSRNOP00000010187/1-1058 ANLADMLSVFALMEDDTQEVSATVYLDKLATVISVWNSDTQNPYHQQALADKVKEAERDV ENSCPOP00000003885/1-1047 ANLADMLTVFALVEEDPQEVSATVYLDKLATVISVWNSDAQNPYHQQALVEKVKEAERDI XP_004857161.1/1-1058 ANLADMLTVFALREDDPQEVSATMYLDKLATVISMWNLDTQNPYHQQALVEKVKEAERDI *******:**** *:*.******:**********:** *:*****:***.:********: ENSP00000321706/1-1058 SLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFSQNAT ENSMUSP00000099558/1-1058 SLTSLAKLPSETVFMGFELMYNLLQEWGAELQDMLNSSQGTNYDTYRLCDSLTSFSQNLE ENSRNOP00000010187/1-1058 SLTSLAKLPSETVFMGFELMYNLLQEWGTELQDMLNSSQGTNYDTYRLCDSLTSFSQNLE ENSCPOP00000003885/1-1047 SLTSLAKLPSETIFLGFEFMHSLLREWGEELQVLLNSSQGINYDSYRLCDSLTSFSQNLK XP_004857161.1/1-1058 SLTSLAKLPSETIFLGFEFMHSLLQEWGEELQVLLNSIQGINYDSYRLCDSLTSFSQNLK ************:*:* *::: **:*** *** :*.* ** .**:************* ENSP00000321706/1-1058 LYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMDRHME ENSMUSP00000099558/1-1058 LYLDTTNMPKEEREVVSELAECVRDFLRKTSRMLNDKGLEDITASIAMAIIEQKMDRHME ENSRNOP00000010187/1-1058 LYLDTASLPKEEREVVLELAKCVRDFLRKTSRMLNDKGLEDITASIAMAIIEQKMDRYME ENSCPOP00000003885/1-1047 LYMDTTSLTKEERQVVSDLAECVRDFLRKTSRVLNNKGFEDITASIAMAIIEQKMDRHMD XP_004857161.1/1-1058 LYLDTTNLSKEERQVVSELAECVKDFLRKTSRVLNNKGFEDITASIAMAIIEQKMDRHME **:: :.:.**:*:** :**:**:******* :*:::.:**********:*:*****:*: ENSP00000321706/1-1058 VCYIFASEKKWAFSDEWVACLGSNRALFRQPDLVLRLLETVIDVSTADRAIPESQIRQVI ENSMUSP00000099558/1-1058 MCYIFASEKKWAFSDEWVACLVNNRSLFREPDLVLSLLETVMEVISSDRVIPQPQIKQVI ENSRNOP00000010187/1-1058 MCYIFASEKKWAFSDEWVACLVNNRCLFREPDLVLSLLETVMEVINSNRVIPQTHIKQVI ENSCPOP00000003885/1-1047 MCYIFASEKKWAFTDEWVSCLVNNRALFREPDLVLRLLETVMEVTMTDRAIPQSQIKQVI XP_004857161.1/1-1058 MCYIFASEKKWVFTDEWVSCLVNNRALFREPDLVLRLFETVMEVSMTDRAIPQSQIKQVI :**********.*:****:** .**.***:***** *:***::* ::*.**:.:*:*** ENSP00000321706/1-1058 HLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQSASEQ ENSMUSP00000099558/1-1058 CLTLECYEDLSLPDKNKVLSGVLHYLGPKGLSDRLSDYLEGFQEDLNTTFNQLAQSTSEQ ENSRNOP00000010187/1-1058 CLTLECYEDLSLPDKNKVLSGVLHYLGPKGLSDRLSNYLEGFQEDLNTTFNQLAQSTSEQ ENSCPOP00000003885/1-1047 CLILECYADLSLPDKNKVLSGVLRCWGRKGLSDRLLPYLDSFQEELNMMFNQLAQSTSEQ XP_004857161.1/1-1058 SLILVCYADLSLLDKNKVLSGVLHCWGRKGLSERLLPYLESFQEDLNTMFNQLTQSTSEQ * * ** **** .*****:*:*: * ****::* *::.***:** ****:**:*** ENSP00000321706/1-1058 GLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEEQGPNSSA ENSMUSP00000099558/1-1058 GLAKAVASVAHLVILNPEVVVKKMCSLAVTNLGTHRFLAQILTAFPALKFTEEQGANPCT ENSRNOP00000010187/1-1058 GLAKAVASVAHLVILNPEVVVKKMCSLAVTNLGTHRFLAQILTAFPALKFTEEQGPNPYT ENSCPOP00000003885/1-1047 GLAKAVASVARMIILHPEVTVKKMCSMAVVNLGTQKFLAQILTAFPALRFTEEQGPNPST XP_004857161.1/1-1058 GLAKAVASVARLVILHPEITVKKMCSIAVVNLGTQRFLAQILTAFPALRFTEEQGPNPST **********:::*::**:.******:**.****::************:*.****.*. : ENSP00000321706/1-1058 TFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFVLPFL ENSMUSP00000099558/1-1058 SFMVSCLKETVWTKFSTPKEEKQFLELVSCLTNPVKPQGIPVAALLEPDEVLKEFVLPFL ENSRNOP00000010187/1-1058 SFMVSCLKETVWTKFSTPKEEKQFLELVSCLMNPVKPQGIPIAALLEPDEVLKEFVLPFL ENSCPOP00000003885/1-1047 TFVVSCLKETVWTKFSTPKEEKQFLELLSGLMNPVKPQGIPVAALLEPDEVLKEFVLPFL XP_004857161.1/1-1058 TFVVSCLRETVWTKFSTPKEEKQFLELLSCLMSPVKPQGIPVAALLEPDEVLKEFVLPFL :*:****:**** **************:. * .********:****************** ENSP00000321706/1-1058 RLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPKEKRC ENSMUSP00000099558/1-1058 MLDMEEVGLSLKLFIQTLEANAGLEEYWLQTCSPFPLLFSLCQLLDSFSKFWQLPREKRY ENSRNOP00000010187/1-1058 MLDMEEVGLSLKLFIQTLEANAGLEEYWLQTCSPFPLLFSLCQLLDSFSKFWQLPREKRY ENSCPOP00000003885/1-1047 ALDAAEVDISLKIFIQTLEVNVGLEEYWLQPCSPFPLIFSLCQLLDSFSKYWQLPPEKRC XP_004857161.1/1-1058 ALDAVEVDLSLKIFIQTLEANAGLEEYWLQTCSPFPLIFSLCRLLDSFNKYWQLPQEKRC ** **.:**::******.*. ******.******:****:*** *.*:**** *** ENSP00000321706/1-1058 LSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKSFFEG ENSMUSP00000099558/1-1058 LTLDSKDLVTHILELLCEIVLANTETFSPDTWAKSLSWLHRKLDQLDWTVGLRLKNFFEG ENSRNOP00000010187/1-1058 LTLDSKDLVTHILELLCEIVLANIETFSPDTWAKSLSWLHRKLDQLDWTVGLRLKDFFEG ENSCPOP00000003885/1-1047 LSLEGKDLVIHILELLCETVLANVETFSPDTWIKSLSWLHRKLEQLDWTVGLRLKNFFEG XP_004857161.1/1-1058 LSLEGKDLVIHILELLCEIVLANAETFSPDTWIKSLSWLHRKLEQLDWTVGPRLKNFFEG *:*: ***. ******** * ** ******.* **********:******* ***.**** ENSP00000321706/1-1058 HFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLLVVDV ENSMUSP00000099558/1-1058 HFKCEVPATLFDICKLSEAQWTSQVHEGYGPGTGLLAWMECCSVSSSISDQMLSLLVMDV ENSRNOP00000010187/1-1058 HFKCEVPATLFEICKLSEAQWTSQAHEGYGPGTGLLAWMECCSISNSVTEQMLSLLVVNV ENSCPOP00000003885/1-1047 HFKCEVPATLFEICKLSEAEWTSQSYPGYGPGTGLLAWMECCCISSGLSEQMFSLLMVDV XP_004857161.1/1-1058 HFKCEVPATLFEICKLSEAEWTSQAYPGYGPGTGLLAWMECCCISSGISEQMFSLLVVDV ***********:****** :**** : ***.***********.:*..::::*:***:::* ENSP00000321706/1-1058 GNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQFVPLL ENSMUSP00000099558/1-1058 GNPEEVRLFSKGFLVALVQVMPWCSPQEWQYLQQLTRKLLEKQLLHVPYSLEYIQFVPLL ENSRNOP00000010187/1-1058 GNPEEVRLFSKGFLVALVQVMPWCSPQEWQYLQQLTRKLLEKQLLHVPYSLEYVQFVPLL ENSCPOP00000003885/1-1047 GNPEEVRLFSKGFLVALVQVMPWCSPQEWQCLYQLTRRLLEKQLLHVPYSLEYIQFVPLL XP_004857161.1/1-1058 GNPEEVRLFSKGFLVALVQVMPWCSPQEWQCFYQLTRRLLEKQLLHVPYSLEYIQFVPLL ****************************** : ****:***************:****** ENSP00000321706/1-1058 NLKPFAQELQLSVLFLRTFQFLCSHSCRDWLPLEGWNHVVKLLCGSLTRLLDSVRAIQAA ENSMUSP00000099558/1-1058 NLKPFAQELQLSVLSLRVFQFLCSQSCCNWLPLDGWSHVVKLLCNSLTSVLDAVRLMQSV ENSRNOP00000010187/1-1058 NLRPFAQELQLSVLSLRAFQFLCSQSCCNWLPLDGWSHVVKLLCSSLTSVLDAVRLIQSV ENSCPOP00000003885/1-1047 NLKPFAQELQLSVLFLRAFQFLCSQSCRNWLPMEGWNHVVRLLCGSLTSLLDSVRLIQPV XP_004857161.1/1-1058 NLKPFAQELQLSVLFLRAFQFLCSQSCCDWLPMEGWTHTVRLLCGSLTNLLDAVRLIQPV **:*********** **.******:** :***::**.*.*:***.*** :**:** :*.. ENSP00000321706/1-1058 GPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLSKTNP ENSMUSP00000099558/1-1058 GPWAQGQEGDLTQETLFVYTQMFCHVLHIMAMLPQEVCEPLYVLALEILTCYETLSKSNP ENSRNOP00000010187/1-1058 GPWAQGQEGDLTQETLFVYTQMFCHVLHIMAMLPQEVCEPLYVLALEILTCYETLSKTNP ENSCPOP00000003885/1-1047 GPWAQGQDQNLTQETLFVYTQVFCHILHIMAMLPQEVCEPLYVLALEVLTCYETLSKTNS XP_004857161.1/1-1058 GPWAQGQDQDLTQETLFVYTQVFCHVLHIMAMLPQEVCEPLYVLALEVLTCYETLSKTNP ***.** : :****:******:*** ******* ************ *********:*. ENSP00000321706/1-1058 SVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF ENSMUSP00000099558/1-1058 SVSSLLQKVDEQRFLKSIAKNISPEERRQTLLQKINNF ENSRNOP00000010187/1-1058 SVSSLLQKVDEQRFLKSIAKNISPEERRQTLLQKINNF ENSCPOP00000003885/1-1047 SVSALLQKVNEQRFLKSIAENISPEERRQTLLQKISNF XP_004857161.1/1-1058 SVSSLLQKVNEQHFLKSIAENISPKERRQTLLQKISNF ***:***:..**:******:.*.*:*********:..*