CLUSTAL W(1.81) multiple sequence alignment ENSRNOP00000051338/1-1380 MGTEAGEGITFSVPPILSAGFCPIPEGGSCRRGGGAATAAEGEPSLQPLLMPPPPPPPGS ENSP00000351908/1-1374 MSTEADEGITFSVPPFAPSGFCTIPEGGICRR-GGAAAVGEGEEH------QLPPPPPGS ENSCPOP00000003829/1-1326 ----------------------------------------------------PPPPPAGA ENSMUSP00000093485/1-1380 MGTEAGEGITFSVPPFASVGFCTIPEGGSCRRGGGAATAAEGEPSLQPLLVPPPPPPPGS XP_004871536.1/1-1374 MGTEAGEGITFSVPPLASSGFCTFPEGGSCRK-GGAATVAEGEPS-----AVPPPPPPGS ****.*: ENSRNOP00000051338/1-1380 FWNVESAAAPGTSCPTTAPGSSATRGRGNSGSGGGRRTTVAYVINEASQGQLVVAESEAL ENSP00000351908/1-1374 FWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEAL ENSCPOP00000003829/1-1326 FWNVDS-AAPGPGCPAAAPGSNAARCRGNSSSGGGRRTTVAYVINEASQGQLVVAESEAL ENSMUSP00000093485/1-1380 FWNVESAAAPGTSCPTTAPGSSATRGRGNSGSGGGRRTTVAYVINEASQGQLVVAESEAL XP_004871536.1/1-1374 FWNVDSAAAPGPGCP-TAPGSSATRCRGNSASAGGRRTTVAYVINEASQGQLVVAESEAL ****:* **** .** ::..*.*:* **.* ..*.************************* ENSRNOP00000051338/1-1380 QSLREACEAVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRE ENSP00000351908/1-1374 QSLREACETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRE ENSCPOP00000003829/1-1326 QSLREACEAVGATLETLHFGKLDFGETAVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRE ENSMUSP00000093485/1-1380 QSLREACEAVGATLETLHFGKLDFGETAVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRE XP_004871536.1/1-1374 QSLREACETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRE ********:******************:******************************** ENSRNOP00000051338/1-1380 SFSMANNIILYCDTNSDSLQSLKEIICQKNTVCTGNYTFIPYMVTPHNKVYCCDSSFMKG ENSP00000351908/1-1374 SFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKG ENSCPOP00000003829/1-1326 SFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYTFIPYMVSPHNKVYCCDSSFMKG ENSMUSP00000093485/1-1380 SFSMANNIILYCDTNSDSLQSLKEIICQKNTVCTGNYTFIPYMVTPHNKVYCCDSSFMKG XP_004871536.1/1-1374 SFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYSFIPYMVTPHNKVYCCDSSFMKG *******************************:*****:*:***::*************** ENSRNOP00000051338/1-1380 LTELMQPNFELLLGPICLPLVDRFVQLLKVAQASSSQYFRESILNDIRKARNLYTGKELA ENSP00000351908/1-1374 LTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELA ENSCPOP00000003829/1-1326 LTELMQPNFELLLGPICLPLMDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELA ENSMUSP00000093485/1-1380 LTELMQPNFELLLGPICLPLVDRFVQLLKVAQASSSQYFRESILSDIRKARNLYTGKELA XP_004871536.1/1-1374 LTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELA ********************:***:*******************.*************** ENSRNOP00000051338/1-1380 AELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKF ENSP00000351908/1-1374 AELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKF ENSCPOP00000003829/1-1326 AELTRIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKF ENSMUSP00000093485/1-1380 AELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKF XP_004871536.1/1-1374 AELTRIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHLHVKF ***:*************************************************** **** ENSRNOP00000051338/1-1380 HYAFALNRRNLPGDRAKALDIMIPMVQSEEQVASDMYCLVGRIYKDMFLDSNFTDTESRD ENSP00000351908/1-1374 HYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRD ENSCPOP00000003829/1-1326 HYAFALNRRNLPGDRAKALDIMIPMVESKGQVASDMYCLVGRIYKDMFLDSNFTDTESRD ENSMUSP00000093485/1-1380 HYAFALNRRNLPGDRAKALDIMIPMVQSEEQVASDMYCLVGRIYKDMFLDSNFTDTESRD XP_004871536.1/1-1374 HYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRD **************************:*: ****************************** ENSRNOP00000051338/1-1380 HGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQ ENSP00000351908/1-1374 HGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQ ENSCPOP00000003829/1-1326 HGASWYKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQ ENSMUSP00000093485/1-1380 HGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQ XP_004871536.1/1-1374 HGASWYKKAFESEPTLQSGINYAVLLLAAGHQFETSFELRKVGVKLSSLLGKKGNLEKLQ *****:****************************:************************* ENSRNOP00000051338/1-1380 SYWEVGFFLGASVLANDHLRVIQASEKLFRLKTPAWYLKSIVETILIYKHFVKLTTEQPT ENSP00000351908/1-1374 SYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPV ENSCPOP00000003829/1-1326 SYWEVGFFLGASVLANDHLRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTAEQPV ENSMUSP00000093485/1-1380 SYWEVGFFLGASVLANDHLRVIQASEKLFRLKTPAWYLKSIVETILIYKHFVKLTTEQPS XP_004871536.1/1-1374 SYWEVGFFLGASVLANDHLRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPV ******************:**********:*************************:*** ENSRNOP00000051338/1-1380 AKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLP ENSP00000351908/1-1374 AKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLP ENSCPOP00000003829/1-1326 AKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLP ENSMUSP00000093485/1-1380 AKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLP XP_004871536.1/1-1374 AKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLP ************************************************************ ENSRNOP00000051338/1-1380 DDKKGIHEWNFNASSVRGVRISRYNDVGILLFLNYNSNNKPLHFCSEVHLGRFFEMVNTI ENSP00000351908/1-1374 DDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTI ENSCPOP00000003829/1-1326 DDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTI ENSMUSP00000093485/1-1380 DDKKGIHEWNFGASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKRFFEMVNTI XP_004871536.1/1-1374 DDKKGIHEWNFSASSIRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKRFFEMVNTI ***********.***:*** **:::: :*:: :**:: ::**:*:* :******** ENSRNOP00000051338/1-1380 TEEKGRGAEEGDCEGDSLEYDYEHDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPE ENSP00000351908/1-1374 TEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPE ENSCPOP00000003829/1-1326 TEEKGRSVEEGDCDSDSLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPE ENSMUSP00000093485/1-1380 TEEKGRGAEDGDCEGDSLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPE XP_004871536.1/1-1374 TEEKGRSVEEGDCEGDSLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPE ******..*:***:.* ******:************************************ ENSRNOP00000051338/1-1380 RDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPL ENSP00000351908/1-1374 RDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPL ENSCPOP00000003829/1-1326 RDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPL ENSMUSP00000093485/1-1380 RDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPL XP_004871536.1/1-1374 RDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPL ************************************************************ ENSRNOP00000051338/1-1380 KDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGIN ENSP00000351908/1-1374 KDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGIN ENSCPOP00000003829/1-1326 KDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGIN ENSMUSP00000093485/1-1380 KDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGIN XP_004871536.1/1-1374 KDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGIN ************************************************************ ENSRNOP00000051338/1-1380 PCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFK ENSP00000351908/1-1374 PCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFK ENSCPOP00000003829/1-1326 PCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTMIEMATGKPPFYELGEPQAAMFK ENSMUSP00000093485/1-1380 PCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFK XP_004871536.1/1-1374 PCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFK *************************************:********************** ENSRNOP00000051338/1-1380 VGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSV ENSP00000351908/1-1374 VGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSA ENSCPOP00000003829/1-1326 VGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLTDEFLKVSSKKKKTQPKLSV ENSMUSP00000093485/1-1380 VGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLIDEFLKVSSKKKKTQPKLSA XP_004871536.1/1-1374 VGMFKVHPEIPESMSGEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSA ***************.************************ ******************. ENSRNOP00000051338/1-1380 LAARANKYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKADPFSFKTRAKSCGEKDGKGI ENSP00000351908/1-1374 LSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGI ENSCPOP00000003829/1-1326 LLPISAEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGEKDVKGI ENSMUSP00000093485/1-1380 LSTGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKADPFSFKARAKSCGEKDGKGI XP_004871536.1/1-1374 LSVGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGEKDVKGI * : :********************************.******:*******:* *** ENSRNOP00000051338/1-1380 RTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKVVRNLMESL ENSP00000351908/1-1374 RTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESL ENSCPOP00000003829/1-1326 RTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMECL ENSMUSP00000093485/1-1380 RTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKVVRNLMESL XP_004871536.1/1-1374 RTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKVVRNLMESL ***************************************************:******.* ENSRNOP00000051338/1-1380 AQGPEEPKLKWEHITTLISSLREFVRSTDRKIIATTLSRLKLELDFDSHGISQVQVVLFG ENSP00000351908/1-1374 AQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFG ENSCPOP00000003829/1-1326 AQGAEEPKLKWEHITTLIVSLREFVRSTDRKIIASTLSKLKLELDFDSHGISQVQVVLFG ENSMUSP00000093485/1-1380 AQGAEEPKLKWEHITTLISSLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFG XP_004871536.1/1-1374 AQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFG ***.************** ***************:***:********************* ENSRNOP00000051338/1-1380 FQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADPEDLD ENSP00000351908/1-1374 FQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLD ENSCPOP00000003829/1-1326 FQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADPEDLD ENSMUSP00000093485/1-1380 FQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADPEDLD XP_004871536.1/1-1374 FQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADPEDLD ******************************************************* **** ENSRNOP00000051338/1-1380 VDDEHEESPSNQTARRPQPVAEDAVATSGVSTLSSTVSHDSQNAHRSLNVQLGRMKMETN ENSP00000351908/1-1374 VEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETN ENSCPOP00000003829/1-1326 VEEEHEEPPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLSVQLGRMKIETN ENSMUSP00000093485/1-1380 VEDEHEELSSNQTVRRPQAITEDAVATSGVSTLSSTVSHDSQNAHRSLNVQLGRMKIETN XP_004871536.1/1-1374 VEDEHEEPPSNQTVRRPQAIIEDAVATSGVSTLSSTVSHDSQSAHRTLNVQLGRMKIETN *:::*** .****.****.: *********************.***:*.*******:*** ENSRNOP00000051338/1-1380 RLLEELVRKEKELQALLHQAIEEKDQEIKHLRLKSQPIDTPGFPVCHLNAPGTAIEDSEL ENSP00000351908/1-1374 RLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSEL ENSCPOP00000003829/1-1326 RLLEELVQKEKELQAFLHQAIEEKEQEIKHLKLKYQPIDIPELLVCHPNPPHRNTDNSEL ENSMUSP00000093485/1-1380 RLLEELVRKERELQALLHQAIEEKDQEIRHLKLKSQPIDIPGFPVCHLNSPGTTTEDSEL XP_004871536.1/1-1374 RLLEELVRKEKELQALLHQAIEEKDQEIKHLKLKSQPIDIPGLPVCHPNSPGTTTKDSEL *******:**:****:**:*****:***:**:** ***: * : * * *.. .:*** ENSRNOP00000051338/1-1380 TGWLRENGADEDTISRFLAEDYTLVDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKG ENSP00000351908/1-1374 TDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQ ENSCPOP00000003829/1-1326 TDWLRQNGADEDTISRFLDEKYTLVDVLYYVTRDDLKYLRLRGGMLCTLWKAIIDFRNK- ENSMUSP00000093485/1-1380 PGWLRENGADEDTISRFLAEDYTLVDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKC XP_004871536.1/1-1374 TDWLRENGADEDTISRFLAEDYTLVDVLYYVTRDDLKCLRIRGGMLCTLWKAIIDFRDKC ..*** ************ *.***:************ **:****************:* ENSRNOP00000051338/1-1380 - ENSP00000351908/1-1374 T ENSCPOP00000003829/1-1326 - ENSMUSP00000093485/1-1380 - XP_004871536.1/1-1374 T