CLUSTAL W(1.81) multiple sequence alignment ENSP00000297440/1-855 MAALGVAEAVAAPHPAEGAETAEAVELSRALSRLLPGLEADSKPGRRRALEALRRALEEP ENSMUSP00000026975/1-853 MAAPAEAEVAAAPGL---TEAAEAAELTRALSRLLPGLETESKLGRRRALEALEQVLEEA ENSRNOP00000035454/1-851 MAAPAEAEVAAGF-----AEADEAAELTRALGRLLPGLETESKLGRRRALEALEHALEEA ENSCPOP00000003805/1-848 -----AAEAEGGASP---AELAQAADLSRVLSRLLPGLETDSKLGRRRALRGLQHVLEET XP_004840384.1/1-849 ----MAAEVERATGP---AELAEAAELSRVLGRLLPGLETDSKLGRRRALEALQHLLEDS **. . :* :*.:*:*.*.*******::** ******..*.: **:. ENSP00000297440/1-855 -GPAADPTAFQGPWARLLLPRLLRCLSDPAEGCRALAVHLLDLGLRRAARPRDALPRLLP ENSMUSP00000026975/1-853 VRPGADSAAFQGPWARLLLPRLLRLLSDPAEGCRALAAHLLDLGLRRAARPRDALPRLLP ENSRNOP00000035454/1-851 VRPGTDSAAFQGPWARLLLPRLLRLLTDPAEGCRALAAHLLDLGLRRAARPRDALPRLLP ENSCPOP00000003805/1-848 TGPSANPAAFQGPWARLLLPRLLRLLADPAEGCRALAVHLLDLGLRRAARPCDALPRLLP XP_004840384.1/1-849 AGPSADPAAFQGPWARLLLPRLLRLLSDPAEGCRALATHLLDLGLRRAARPCDALPRLLP *.::.:**************** *:**********.************* ******** ENSP00000297440/1-855 ALAARLAGPVPARRPPEACEELRLALVQLLGLAVDLCGAALAPHLDDALRALRCSLLDPF ENSMUSP00000026975/1-853 ALSARLARPELARPPPEPCEELRLALVQLLHLAVDLGGAALAPHLDDAVRALRAALLDPF ENSRNOP00000035454/1-851 ALTARLARPESTRPPPEPCEELRLALVQLLHLAVDLGGAALAPHLDDAVRALRGALLDPF ENSCPOP00000003805/1-848 ALTARLARPEPARPPLEACEELRLALVQLLGLTVRLGGVALAPHLDDAVRALRGALLDPF XP_004840384.1/1-849 ALAARLTRPEPARPPPETCEELRLALVQLLGLTVRLGGAALAPHLDDAVLALRSALLDPF **:***: * :* * *.************ *:* * *.*********: *** :***** ENSP00000297440/1-855 AAVRRESCSCAAALAQATPDHFHMQSESLIGPLMQTISHQHWKVRVAAIEATGAVIHFGN ENSMUSP00000026975/1-853 AAVRREGCECAAALARATPEHFHMQSESLIGPLMQTISHQHWKVRVAVIEATGTVIQFGS ENSRNOP00000035454/1-851 AAVRREGCECAAALARAIPEHFHMQSESLIGPLMQTISHQHWKVRVAVIEATGTVIQFGN ENSCPOP00000003805/1-848 AAVRRESCECAAALARATPDHFHMQSESLISPLMHTISHQHWKVRVAVIEATGTVIQFGN XP_004840384.1/1-849 AAVRRESCECAAALARATPDHFHMQSESLISPLMQTISHQHWKVRVAVIEATGTVIQFGN ******.*.******:* *:**********.***:************.*****:**:**. ENSP00000297440/1-855 GKSVDDVLSHFAQRLFDDVPQVRRAVASVVGGWLLCLRDRYSFFHKLIPLLLSSLNDEVP ENSMUSP00000026975/1-853 GNSVDDVLSHFAQRLFDDVPQVRQAVTSVVGGWLLNLRDRYSFLHKLTPLLLSSFSDEMP ENSRNOP00000035454/1-851 GNSVDDVLSHFAQRLFDDVPQVRQAVTSVVGGWLLNLRDRYSFFHKLTPLLLSSFSDEMP ENSCPOP00000003805/1-848 GKSVDDVLSHFAQRLFDDVTQVRQAVTSVVGGWLLALRDRYSFFHKLIPLLLSSFNDEMP XP_004840384.1/1-849 GKSIDDVLSHFAQRLFDDVCQVRQAVTSVVGGWLLALRDRYSFFHKLIPLLLSSVSDEMP *:*:*************** ***:**:******** *******:*** ******..**:* ENSP00000297440/1-855 EVRQLAASLWEDVGLQWQKENEEDLKDKLDFAPPTPPHYPPHERRPVLGCRELVFRNLSK ENSMUSP00000026975/1-853 EIRQTATSLWEKVGLQWQQENEADLKDKLDFASPPPPNYPEHESRPGLGCRELVFRNLSK ENSRNOP00000035454/1-851 EVRQTATSLWEKVGLQWQEENEADLKDKLDFASPPPPNYPEHESRPGLGCRELVFRNLSK ENSCPOP00000003805/1-848 ETRQLATSLWEKVGLQWQEENEADLKDKLDFASPPPPHYPQGEHRPVLGCRELVFRNLSK XP_004840384.1/1-849 EIRQLATSLWEKVGLQWQEENEADLKDKLDFALPPPPHYPQQESRPVLGCRELVFRNLSK * ** *:****.******:*** ********* *.**:** * ** ************* ENSP00000297440/1-855 ILPALCHDITDWVVGTRVKSAQLLPVLLLHAEDHATQHLEVVLRTLFQACTDEEAAVVQS ENSMUSP00000026975/1-853 VLPAICHDITDWVVGTRVKAAQLLPVLLLHAEDHITQHLEIVLRTLHQACTDEEKAVVGS ENSRNOP00000035454/1-851 VLPAICHDITDWVVGTRLKAAQLLPVLLLHAEDHITQHLEIVLRTLHQACTDEEKAVVSS ENSCPOP00000003805/1-848 ILPAICHDITDWVVGTRVKSAQLLPVLLLHAEDHITQHLEIILRTLQRACADEEAAVVSS XP_004840384.1/1-849 VLPAICHDITDWVVGTRVKSAQLLPVLLLHAEDHITQHLEIILRTLQQACADEEPAVVSS :***:************:*:************** *****::**** :**:*** *** * ENSP00000297440/1-855 CTRSAELVGTFVSPEVFLKLILSTLKKTPSASGLLVLASAMRGCPREALQPHLAAIATEL ENSMUSP00000026975/1-853 CIRAAELIGTFVSPEVFLKLILAMLKKAPSASGLLILASVIRGCPRNALQPHVTVIATEL ENSRNOP00000035454/1-851 CVRAAELIGTFVSPEVFLKLILAMLKKAPSASGLLILASVIRGCPRNALQPHLKVIATEL ENSCPOP00000003805/1-848 CTRSAELIGTFVSPEVFLKLILSMLKKTPSSSSLLILASVIRGCPRDALQPHLKVITTEL XP_004840384.1/1-849 CERSAELIGTFVSPEVSLKLILSMLKKAPSSCSLLVLASIIRGCPRDALQPHLKVITTEL * *:***:******** *****: ***:**:..**:*** :*****:*****: .*:*** ENSP00000297440/1-855 AQAHICQASENDLYLERLLLCVQALVSVCHEDCGVASLQLLDVLLTIVALAGATGLRDKA ENSMUSP00000026975/1-853 AQEHICQGSENNLYLEHLLLCVQALLSVCQEDCRAASLQFLEVLVTIMAVSDAVGLEKKA ENSRNOP00000035454/1-851 AQEHICQGSENNSYLEHLLLCVQTLLSVCQEDCCAASLQLSEVLVTIMAVSDAVSLEKKA ENSCPOP00000003805/1-848 AQAHVSQASENDVYLEHLLLCVQSLVSVCQEDCSMASLQLMEVLVTVKALSGATALGDKA XP_004840384.1/1-849 AQAYICQASENDLYLERLLLCVQTLVSVCQEDCSVASLQLMEVLVTVMALSGATTLGNKA ** ::.*.***: ***:******:*:***:*** ****: :**:*: *::.*. * .** ENSP00000297440/1-855 QETMDSLAMVEGVSSCQDLYRKHIGPLLERVTASHLDWTAHSPELLQFSVIVAQSGPALG ENSMUSP00000026975/1-853 QKTMDTLAEVEDIPSSQDLYRKHVGALLERLTASHGEWAVHSVQLLKFTVLLTQAGPAVG ENSRNOP00000035454/1-851 QKTMDTLAEVEDIPSSQDLYRKHLGALLERLTASHGEWTVHSVQLLKFTVLLTQAGPAVG ENSCPOP00000003805/1-848 RETMESLAMVDNVPGSQDLYRKYMGPLLERLTASHSDWTAHSVELLQFCEVITQSGPAVG XP_004840384.1/1-849 QETMESLAMVENVPSSQDLYRKHMGPLLERLTASHNDWTAHSVELLQFCEVVTRSGPAMG ::**::** *:.:...******::*.****:**** :*:.** :**:* :::::***:* ENSP00000297440/1-855 EALPHVVPTLRACLQPSQDPQMRLKLFSILSTVLLRATDTINSQGQFPSYLETVTKDILA ENSMUSP00000026975/1-853 EALQHVIPTLRACLQPSTDPHMRLKLFSILSMMLLRPKDTVDSQGQFRGYLDMVINDILA ENSRNOP00000035454/1-851 EALQHVIPTLRACLQPTTDPHMRLKLFSILSSLLLRPKDTVDSQGQFHGYLDMVINDILA ENSCPOP00000003805/1-848 ETLQHVVPTLRTCLQTTRDPHMCLKLFSILSSLLMRSKDTINSQGQFCVYLDTVVKDILM XP_004840384.1/1-849 EALQHVVPTLKTCLQTTRDPHMCLKLFSILSSLLLRPKDTINSQGQFCGYLDTLVKDILM *:* **:***::***.: **:* ******** :*:*..**::***** **: : :*** ENSP00000297440/1-855 PNLQWHAGRTAAAIRTAAVSCLWALTSSEVLSAEQIRDVQETLMPQVLTTLEEDSKMTRL ENSMUSP00000026975/1-853 PNLQWHAGRTAAAIRTAAISCLWALISSDILSAKQVQEAQETLMPQVLATLEDDSQTTRL ENSRNOP00000035454/1-851 PNLQWHAGRTAAAIRTATISCLWALISSDILSAKQVQEAQETLMPQVLATLEDDSQTTRL ENSCPOP00000003805/1-848 PNLQWRAGKTAAAIRTAAVSCLWALTSSDILSTKQVQDVQDALLPRVLATLEEDLQTARL XP_004840384.1/1-849 PNLQWRAGKTAAAIRTAAMSCLWALTSSDILSAKQVQDVQDALLPRVLATLEEDMQTTRL *****:**:********::****** **::**::*:::.*::*:*:**:***:* : :** ENSP00000297440/1-855 ISCRIINTFLKTSGGMTDPEKLIRIYPELLKRLDDVSNDVRMAAASTLVTWLQCVKGANA ENSMUSP00000026975/1-853 MSCRIINMFLKNSGDTMEPEKFLKVYPELLKRLDDVSNDVRMAAASALLTWLKCIESLDG ENSRNOP00000035454/1-851 ISCRIISRFLKNSGDTMEPEKFLKVYPELLKRLDDVSNDVRMAAASALLTWLKCIESVDG ENSCPOP00000003805/1-848 ISCRIINIFLKTSGDVIDPDKFIKIYPELLKRLDDVSNDVRMAAASALLTWLRCIQSADG XP_004840384.1/1-849 ISCRIINIFLKTSGDVMDPDKFIKVYPELLKRLDDVSNDVRIAAASTLLTWLRCIQSSDG :*****. ***.**. :*:*::::****************:****:*:***:*::. :. ENSP00000297440/1-855 KSYYQSSVQYLYRELLVHLDDPERAIQDAILEVLKEGSGLFPDLLVRETEAVIHKHRSAT ENSMUSP00000026975/1-853 KSAYQSSVQFLYRELLVHLDDPESAIQDTVLEVLKEGSVLFPDVLVRETEAVVHKHRSAT ENSRNOP00000035454/1-851 KSAYQSSVQFLYRELLVHLDDPESAIQDTVLEVLKEGSVLFPDVLVRETEAVVHKHRSAT ENSCPOP00000003805/1-848 KSYYQSSIQYLYRELLVHLDDPESAIQDAVLEVLKEGSMLFPDLLVRETEAVVHKHRSAT XP_004840384.1/1-849 KSYYQSSIQYLYRELLIHLDDPESAIQDAVLEVLKEGSMLFPDLLVRETEAVVHKHRSAT ** ****:*:******:****** ****::******** ****:********:******* ENSP00000297440/1-855 YCEQLLQHVQAVPATQ ENSMUSP00000026975/1-853 YCEQLLQHMQTMAAAR ENSRNOP00000035454/1-851 YCEQLLQHMQTMAAAR ENSCPOP00000003805/1-848 YCEQLLQHVQATAAAQ XP_004840384.1/1-849 YCEQLLQYVQATAAAQ *******::*: .*::