CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000003740/1-1498 ------MTRILIACKVVKTLKSSLCLTNV-VPQRWKYFSRSN-SQFPVQAQTAHIVLEDG XP_004851167.1/1-1501 ------MTRILTACKVVKTLKSGLRFTNATVLQRSRYFSRRSINHAPIQAQTAHIVLEDG ENSP00000402608/1-1506 MPQIIKMTRILTAFKVVRTLKTGFGFTNVTAHQKWK-FSRPGIRLLSVKAQTAHIVLEDG ENSMUSP00000027144/1-1500 ------MTRILTACKVVKTLKSGFGFANVTTKRQWD-FSRPGIRLLSVKAKTAHIVLEDG ENSRNOP00000019021/1-1500 ------MTRILTACKVVKTLKSGFGLANVTSKRQWD-FSRPGIRLLSVKAQTAHIVLEDG ***** * ***:***:.: ::*. :: *** . .::*:********* ENSCPOP00000003740/1-1498 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEALTDPAYKGQILTMANPIIGNGGVPDTSALD XP_004851167.1/1-1501 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEALTDPAYRGQILTMANPIIGNGGVPDTSALD ENSP00000402608/1-1506 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALD ENSMUSP00000027144/1-1500 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEALTDPAYKGQILTMANPIIGNGGAPDTTARD ENSRNOP00000019021/1-1500 TKMKGYSFGHPSSVAGEVVFNTGLGGYSEALTDPAYKGQILTMANPIIGNGGAPDTTARD ***************************.**:*****:***************.***:* * ENSCPOP00000003740/1-1498 ELGLSKYLESDGIKVAGLLVLNYSNDYNHWLATKSLGQWLKEEKVPAIYGVDTRMLTKII XP_004851167.1/1-1501 ELGLSKYLESDGIKVAGLLVLNYSNDYNHWLATKSLGQWLNEEKVPAIYGVDTRMLAKII ENSP00000402608/1-1506 ELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII ENSMUSP00000027144/1-1500 ELGLNKYMESDGIKVAGLLVLNYSNDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII ENSRNOP00000019021/1-1500 ELGLNKYMESDGIKVAGLLVLNYSHDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII ****.**:**:****:*****:**:***************:***************:*** ENSCPOP00000003740/1-1498 RDKGTMLGKIEFEGQPVYFMDPNKQNLIAEVSTKEVKVYGKGNPTKVVAVDCGIKNNVIR XP_004851167.1/1-1501 RDRGTMLGKIEFEGQSVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIR ENSP00000402608/1-1506 RDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIR ENSMUSP00000027144/1-1500 RDKGTMLGKIEFEGQSVDFVDPNKQNLIAEVSTKDVKVFGKGNPTKVVAVDCGIKNNVIR ENSRNOP00000019021/1-1500 RDKGTMLGKIEFEGQSVDFVDPNKQNLIAEVSTKDVKVFGKGNPTKVVAVDCGIKNNVIR **:************.* *:**************:***:********************* ENSCPOP00000003740/1-1498 LLVKRGAEVHLVPWNYDFTQMEYDGLLIAGGPGDPTLAQPLIQNVKKVLESDRKEPLFGI XP_004851167.1/1-1501 LLVKRGAEVHLVPWNYDFTQMEYDGLLIAGGPGNPTLAQPLIQNVKKVLESDRKEPLFGI ENSP00000402608/1-1506 LLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGI ENSMUSP00000027144/1-1500 LLVKRGAEVHLVPWNHDFTQMEYDGLLIAGGPGNPALAQPLIQNVKKILESDRKEPLFGI ENSRNOP00000019021/1-1500 LLVKRGAEVHLVPWNHDFTQMDYDGLLIAGGPGNPALAQPLIQNVKKILESDRKEPLFGI ***************:***:*:***:*******:*:**:******:*:************ ENSCPOP00000003740/1-1498 STGNLITGLAAGAKTYKMRMPNRGQNQPVLNITNRQAFITAQNHGYALDNALPAGWKPLF XP_004851167.1/1-1501 STGNLITGLAAGAKSYKMPMPNRGQNQPVLNITNRQAFITAQNHGYALDNALPAGWKPLF ENSP00000402608/1-1506 STGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNTLPAGWKPLF ENSMUSP00000027144/1-1500 STGNIITGLAAGAKSYKMSMANRGQNQPVLNITNRQAFITAQNHGYALDNTLPAGWKPLF ENSRNOP00000019021/1-1500 STGNIITGLAAGAKSYKMSMANRGQNQPVLNITNRQAFITAQNHGYALDNTLPAGWKPLF ****:*********:*** *.*************:***************:********* ENSCPOP00000003740/1-1498 VNVNDQTNEGIMHESKPFFAVQFHPEVSPGPTDTEYLFDSFFSLIKKGKATTIASVLPKP XP_004851167.1/1-1501 VNVNDQTNEGIMHESKPFFAVQFHPEVSPGPTDTEYLFDSFFSLIKKAKGTTVTSVLPKP ENSP00000402608/1-1506 VNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKP ENSMUSP00000027144/1-1500 VNVNDQTNEGIMHESKPFFAVQFHPEVSPGPTDTEYLFDSFFSLIKKGKGTTITSVLPKP ENSRNOP00000019021/1-1500 VNVNDQTNEGIMHESKPFFAVQFHPEVSPGPTDTEYLFDSFFSLIKKGKGTTITSVLPKP ***************************:*** ***************.*.**::****** ENSCPOP00000003740/1-1498 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE XP_004851167.1/1-1501 ALIASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE ENSP00000402608/1-1506 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE ENSMUSP00000027144/1-1500 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE ENSRNOP00000019021/1-1500 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE **:********************************************************* ENSCPOP00000003740/1-1498 VGLKQADTVYFLPITPQFVTEVIKAERPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV XP_004851167.1/1-1501 VGLKQADTVYFLPITPQFVTEVIKAERPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV ENSP00000402608/1-1506 VGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV ENSMUSP00000027144/1-1500 VGLKQADAVYFLPITPQFVTEVIKAERPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV ENSRNOP00000019021/1-1500 VGLKQADAVYFLPITPQFVTEVIKAERPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV *******:******************:********************************* ENSCPOP00000003740/1-1498 LGTSVESIMATEDRQLFADKLNEINEKIAPSFAVESVEAALKAADSIGYPVMIRSAYALG XP_004851167.1/1-1501 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALG ENSP00000402608/1-1506 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALG ENSMUSP00000027144/1-1500 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESMEDALKAADTIGYPVMIRSAYALG ENSRNOP00000019021/1-1500 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESMEDALKAADTIGYPVMIRSAYALG *****************:******************:* ******:************** ENSCPOP00000003740/1-1498 GLGSGICPNKETLMDLSTKAFALTNQILVERSVTGWKEIEYEVVRDADDNCVTVCNMENV XP_004851167.1/1-1501 GLGSGICPNRETLLDLSTKAFAMTNQILVERSVTGWKEIEYEVVRDADDNCVTVCNMENV ENSP00000402608/1-1506 GLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENV ENSMUSP00000027144/1-1500 GLGSGICPNKETLIDLGTKAFAMTNQILVERSVTGWKEIEYEVVRDADDNCVTVCNMENV ENSRNOP00000019021/1-1500 GLGSGICPNKETLMDLGTKAFAMTNQILVERSVTGWKEIEYEVVRDADDNCVTVCNMENV *********:***:**.*****:*******:***************************** ENSCPOP00000003740/1-1498 DAMGVHTGDSVVVAPAQTLSNAEFQMLRQSSINVVRHLGIVGECNIQFALHPTSMEYCII XP_004851167.1/1-1501 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII ENSP00000402608/1-1506 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII ENSMUSP00000027144/1-1500 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSVNVVRHLGIVGECNIQFALHPTSMEYCII ENSRNOP00000019021/1-1500 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII ****************************::*:**************************** ENSCPOP00000003740/1-1498 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI XP_004851167.1/1-1501 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI ENSP00000402608/1-1506 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI ENSMUSP00000027144/1-1500 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI ENSRNOP00000019021/1-1500 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI ************************************************************ ENSCPOP00000003740/1-1498 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIDGFTSRLPMNKEW XP_004851167.1/1-1501 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSVDGFTPRLPMNKEW ENSP00000402608/1-1506 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEW ENSMUSP00000027144/1-1500 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSVDGFTPRLPMNKEW ENSRNOP00000019021/1-1500 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSVDGFTPRLPMNKEW **********************************************::***.******** ENSCPOP00000003740/1-1498 PSNLDLKKELSEPTSTRMYAIAKAIENNMSLDEIEKLTFIDKWFLYKMRDILNMEKTLKQ XP_004851167.1/1-1501 PSNLDLQKELSDPSSIRIYAIAKAMEENVSLDEIEKLTSIDKWFLYKMRDILNMEKTLKG ENSP00000402608/1-1506 PSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKG ENSMUSP00000027144/1-1500 PANLDLKKELSEPSSTRIYAIAKALENNMSLDEIVRLTSIDKWFLYKMRDILNMDKTLKG ENSRNOP00000019021/1-1500 PANLDLRKELSEPSSTRIYAIAKALENNMSLDEIVKLTSIDKWFLYKMRDILNMDKTLKG *:****:****:*:* *:******:::*:***** :** ***************:**** ENSCPOP00000003740/1-1498 LNSESLSQETLKKAKEIGFSDKQIAKCLGLTEAQMRELRLKKGIRPWVKQIDTLAAEYPS XP_004851167.1/1-1501 LNSESISEETLRRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS ENSP00000402608/1-1506 LNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS ENSMUSP00000027144/1-1500 LNSDSVTEETLRKAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS ENSRNOP00000019021/1-1500 LNSESVTEETLRQAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS ***:*:::***::***********:********* *******.*:*************** ENSCPOP00000003740/1-1498 VTNYLYVTYNGQEHDINFDEHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV XP_004851167.1/1-1501 VTNYLYVTYNGQEHDINFDEHGLMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV ENSP00000402608/1-1506 VTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV ENSMUSP00000027144/1-1500 VTNYLYVTYNGQEHDIKFDEHGIMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV ENSRNOP00000019021/1-1500 VTNYLYVTYNGQEHDIKFDEHGIMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV ***************::**:**:************************************* ENSCPOP00000003740/1-1498 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACSGCIISVGGQIPNNLAVPLYRNGV XP_004851167.1/1-1501 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACSGCIISVGGQIPNNLAVPLHKNGV ENSP00000402608/1-1506 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGV ENSMUSP00000027144/1-1500 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACNGCIISVGGQIPNNLAVPLYKNGV ENSRNOP00000019021/1-1500 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACNGCIISVGGQIPNNLAVPLYKNGV ************************************.******************::*** ENSCPOP00000003740/1-1498 RIMGTSPMQIDRAEDRSMFSAVLDELKVAQAPWKAVNTLNEALEFAESVGYPCLLRPSYV XP_004851167.1/1-1501 KIMGTSPLQIDRAEDRSIFSAVLDELKVDQAPWKAVNTLNEALEFAKSVGYPCLLRPSYV ENSP00000402608/1-1506 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYV ENSMUSP00000027144/1-1500 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFANSVGYPCLLRPSYV ENSRNOP00000019021/1-1500 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFANSVGYPCLLRPSYV :******:*********:********** *****************:**.********** ENSCPOP00000003740/1-1498 LSGSAMNVVFSEDEMKRFLEEATRVSQEHPVVLTKFIEGAREVEMDAVGKDGRVIAHAIS XP_004851167.1/1-1501 LSGSAMNVVFSEEEMKRFLEEATRVSQEHPVVLTKFIEGAREVEMDAVGKDGRVISHAIS ENSP00000402608/1-1506 LSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAIS ENSMUSP00000027144/1-1500 LSGSAMNVVFSEDEMKRFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKEGRVISHAIS ENSRNOP00000019021/1-1500 LSGSAMNVVFSEDEMKRFLEEATRVSQEHPVVLTKFIEGAREVEMDAVGKEGRVISHAIS ************:***:*******************:*************:****:**** ENSCPOP00000003740/1-1498 EHVEDAGVHSGDATLMLPTQTISQGGIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV XP_004851167.1/1-1501 EHVEDAGVHSGDATLMLPTQTISQGAVEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV ENSP00000402608/1-1506 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV ENSMUSP00000027144/1-1500 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV ENSRNOP00000019021/1-1500 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV *************************.:********************************* ENSCPOP00000003740/1-1498 IECNLRASRSFPFVSKTLGVDFIDVATKVMTGEQIDEQHLPILERPIIPADYVAIKAPMF XP_004851167.1/1-1501 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGEKIDEQHLPTLDRPIIPADYVAIKAPMF ENSP00000402608/1-1506 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMF ENSMUSP00000027144/1-1500 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGESIDEKRLPTLEQPIIPSDYVAIKAPMF ENSRNOP00000019021/1-1500 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGESVDEKHLPTLEQPIIPSDYVAIKAPMF ****************************** **.:**::** *::****:********** ENSCPOP00000003740/1-1498 SWPRLRDADPILRCEMASTGEVACFGEDIHTAFLKAMLSTGFKLPQKGILIGIQQSFRPR XP_004851167.1/1-1501 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKLPQKGILIGIQQSFRPR ENSP00000402608/1-1506 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR ENSMUSP00000027144/1-1500 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR ENSRNOP00000019021/1-1500 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR ***************************.***************:**************** ENSCPOP00000003740/1-1498 FLGVAEQLHKEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNRSLSSIRKLMKDGSID XP_004851167.1/1-1501 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGKID ENSP00000402608/1-1506 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID ENSMUSP00000027144/1-1500 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID ENSRNOP00000019021/1-1500 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID *********:********************************** ********::**.** ENSCPOP00000003740/1-1498 LVINLPNNNTKFVHDNYVIRRTAVDSGVALLTNFQVTKLFAEAMQKSRNVDSKSLFHYRQ XP_004851167.1/1-1501 LVINLPNNNTKFVHDNYVIRRTAVDSGIALLTNFQVTKLFAEAMQKSRNVDSKSLFHYRQ ENSP00000402608/1-1506 LVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQ ENSMUSP00000027144/1-1500 LVINLPNNNTKFVHDNYVIRRTAVDSGIALLTNFQVTKLFAEAVQKSRTVDSKSLFHYRQ ENSRNOP00000019021/1-1500 LVINLPNNNTKFVHDNYVIRRTAVDSGIALLTNFQVTKLFAEAVQKARTVDSKSLFHYRQ ***************************:.**************:**:*.*********** ENSCPOP00000003740/1-1498 RSTGKA- XP_004851167.1/1-1501 YSAKKAA ENSP00000402608/1-1506 YSAGKAA ENSMUSP00000027144/1-1500 YSAGKAA ENSRNOP00000019021/1-1500 YSAGKAA *: **