CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000113717/1-1553 ------------------------------------------------------------ ENSRNOP00000013552/1-1551 ------------------------------------------------------------ ENSP00000298281/1-1555 ------------------------------------------------------------ ENSCPOP00000003702/1-1515 RCRRHFVSEKEASVAAGSGRRSPVRRRRFIPVVPPVSSPNPPPRSACGEAGAAGDQGRGS XP_004868330.1/1-1550 ------------------------------------------------------------ ENSMUSP00000113717/1-1553 --------------------------MSEQTPAEAGAAGAREDACRDYQSSLEDLTFNSK ENSRNOP00000013552/1-1551 --------------------------MSEQTPAEAGAAGAREDACRDYQSSLEDLTFNSK ENSP00000298281/1-1555 --------------------------MSEQTPAEAGAAGAREDACRDYQSSLEDLTFNSK ENSCPOP00000003702/1-1515 GVGREAGCRERLQLQLRRTSEGGRGAMSEQTPAEAGAAGAREDACRDYQSSLEDLTFNSK XP_004868330.1/1-1550 --------------------------MSEQTPAEAGPAGAREDACRDYQSSLEDLTFNSK **********.*********************** ENSMUSP00000113717/1-1553 PHINMLTILAEENLPFAKEIVSLIEAQTAKAPSSEKLPVMYLMDSIVKNVGREYLTAFTK ENSRNOP00000013552/1-1551 PHINMLTILAEENLPFAKEIVSLIEAQTAKAPSSEKLPVMYLMDSIVKNVGREYLTAFTK ENSP00000298281/1-1555 PHINMLTILAEENLPFAKEIVSLIEAQTAKAPSSEKLPVMYLMDSIVKNVGREYLTAFTK ENSCPOP00000003702/1-1515 PHINMLTILAEENLPFAKEIVSLIEAQTAKAPSSEKLPVMYLMDSIVKNVGREYLTAFTK XP_004868330.1/1-1550 PHINMLTILAEENLPFAKEIVSLIEAQTAKAPSSEKLPVMYLMDSIVKNVGREYLTAFTK ************************************************************ ENSMUSP00000113717/1-1553 NLVATFICVFEKVDENTRKSLFKLRSTWDEIFPLKKLYALDVRVNSLDPAWPIKPLPPNV ENSRNOP00000013552/1-1551 NLVATFICVFEKVDENTRKSLFKLRSTWDEIFPLKKLYALDVRVNSLDPAWPIKPLPPNV ENSP00000298281/1-1555 NLVATFICVFEKVDENTRKSLFKLRSTWDEIFPLKKLYALDVRVNSLDPAWPIKPLPPNV ENSCPOP00000003702/1-1515 NLVATFICVFEKVDENTRKSLFKLRSTWDEIFPLKKLYALDVRVNSLDPAWPIKPLPPNV XP_004868330.1/1-1550 NLVATFICVFEKVDENTRKSLFKLRSTWDEIFPLKKLYALDVRVNSLDPAWPIKPLPPNV ************************************************************ ENSMUSP00000113717/1-1553 NTSSIHVNPKFLNKSPDEPSTPGTVVSSPSISTPPIVPDIQKNLTQEQLIRQQLLAKQKQ ENSRNOP00000013552/1-1551 NTSSIHVNPKFLNKSPDEPSTPGTVVSSPNISTPPIVPDIQKNLTQEQLIRQQLLAKQKQ ENSP00000298281/1-1555 NTSSIHVNPKFLNKSPEEPSTPGTVVSSPSISTPPIVPDIQKNLTQEQLIRQQLLAKQKQ ENSCPOP00000003702/1-1515 NTSSIHVNPKFLNKSPDEPSTPGTVVSSPSISTPPIVPDIQKNLTQEQLIRQQLLAKQKQ XP_004868330.1/1-1550 NTSSIHVNPKFLNKSPEEPSTPGSVVSSPSISTPPIVPDIQKNLTQEQLIRQQLLAKQKQ ****************:******:*****.****************************** ENSMUSP00000113717/1-1553 LLELQQKKLELELEQAKAQLAVSLSVQQETANLGPGSVPSKLHVPQIPTMAVKTPHQVPV ENSRNOP00000013552/1-1551 LLELQQKKLELELEQAKAQLAVSLSVQQETANLGPGSAPSKLHVPQIPTMAVKTPHQVPV ENSP00000298281/1-1555 LLELQQKKLELELEQAKAQLAVSLSVQQETSNLGPGSAPSKLHVSQIPPMAVKAPHQVPV ENSCPOP00000003702/1-1515 LLELQQKKLELELEQAKAQLAVSLGVQPETSNLGPGSAPSKLHVSQIPAMTVKAPHQVPV XP_004868330.1/1-1550 LLELQQKKLELELEQAKAQLAVSLGVQPETSNLGPGSAPSKLHVSQIPAMAVKAPHQVPV ************************.** **:******.******.***.*:**:****** ENSMUSP00000113717/1-1553 QPDKSRAGPSLQMQDLKGTNRDPRLNRMSQHSSHGKEQSHRKEFVMNTINQSDIKTSKNV ENSRNOP00000013552/1-1551 QPDKSRVGPSLQMQDLKGTNRDPRLNRMSQHSSHGKEQSHRKEFVMNTINQSDIKTSKTV ENSP00000298281/1-1555 QSEKSRPGPSLQIQDLKGTNRDPRLNRISQH-SHGKDQSHRKEFLMNTLNQSDTKTSKTI ENSCPOP00000003702/1-1515 QPEKNRPGPSLQIQDLKGTNRDPRLNRMSQHSSHGKDQSHRKEFLMNTLNQSDNKTSKAV XP_004868330.1/1-1550 QPEKNRPGPSLQIQDLKGTNRDPRLNRMSQHSSHGKDQSHRKEFLMNTLNQSDIKTGKAV *.:*.* *****:**************:*** ****:*******:***:**** **.* : ENSMUSP00000113717/1-1553 PSEKLNSSKQEKSKSGERITKKELDQLDSKSKSKSKSPSPLKNKLSHTKDLKNQDSESMR ENSRNOP00000013552/1-1551 PSEKLNSSKQEKSKSGERITKKELDQLDSKSKSKSKSPSPLKNKLSHTKDLKNQESESMR ENSP00000298281/1-1555 PSEKLNSSKQEKSKSGEKITKKELDQLDSKSKSKSKSPSPLKNKLSHTKDLKNQESESMR ENSCPOP00000003702/1-1515 PSEKLNSSKQEKSKSGEKVIKKELDQLA---------PSPLKNKLSHTKDLKSQESESVR XP_004868330.1/1-1550 PSEKLNSSKQEKSKSGEKVIKKELDQLDSKSKSKSKSPSPLKNKLSHTKDLKSQESESVR *****************:: ******* ***************.*:***:* ENSMUSP00000113717/1-1553 LSDMSKRDPRLKKHLQDKAEGKDEDVKEKRKTAEKKEKDEHMKSSEHRVIGSRSKIINGI ENSRNOP00000013552/1-1551 LSDMNKRDPRLKKHLQDKAEGKDEDVKEKRKTAEKKDKDEHMKSSEHRLIGSRSKIINGV ENSP00000298281/1-1555 LSDMNKRDPRLKKHLQDKTDGKDDDVKEKRKTAEKKDKDEHMKSSEHRLAGSRNKIINGI ENSCPOP00000003702/1-1515 LSDMNKRDPRLKKHLQDKTDCKDDD-----------NKDEHMKSSEHRLIGSRNKIINGV XP_004868330.1/1-1550 LSDMNKRDPRLKKHLQDKTDGKDDDVKEKRKTAEKKDKDEHIKSSEHRLIGSRNKIINGV ****.*************:: **:* :****:******: ***.*****: ENSMUSP00000113717/1-1553 VQKQDMVTEELEKQGTKPGRSSTRKRSRSRSPKSRSPIIHSPKRRDRRSPKRRQRSMSPN ENSRNOP00000013552/1-1551 VQKQDMVTEELEKQGTKPGRSSTRKRSRSRSPKSRSPIVHSPKRRDRRSPKRRQRSMSPT ENSP00000298281/1-1555 VQKQDTITEESEKQGTKPGRSSTRKRSRSRSPKSRSPIIHSPKRRDRRSPKRRQRSMSPT ENSCPOP00000003702/1-1515 VQKQDTITEESEKQGTKPGRSSTRKRSRSRSPKSRSPIIHSPKRRDRRSPKRRQRSMSPT XP_004868330.1/1-1550 VQKQDTIIEESEKQGTKPGRSSTRKRSRSRSPKSRSPIIHSPKRRDRRSPKRRQRSMSPT ***** : ** ***************************:********************. ENSMUSP00000113717/1-1553 LAPKAGKMRQSGLKQSHMEEFPPPSREERNIKRSAKQDVRDPRRLKKMDEDRPQETAGQH ENSRNOP00000013552/1-1551 LAPKAGKMRQSGLKQSHMDEFPPPSREERNIKRSAKQDVRDPRRLKKMDEDRPQETAGQH ENSP00000298281/1-1555 STPKAGKIRQSGAKQSHMEEFTPPSREDRNAKRSTKQDIRDPRRMKKTEEERPQETTNQH ENSCPOP00000003702/1-1515 LIPKAGKIRQSGVKQSHMEEFTPPSREERSAKRSTKQDVRDPRRMKKTEEERPQEIASQH XP_004868330.1/1-1550 LIPKAGKIRQSGVKQSHMEEFTPPSREERNAKRSTKQDVRDPRRMKKTEEERPQEIANQH *****:**** *****:**.*****:*. ***:***:*****:** :*:**** :.** ENSMUSP00000113717/1-1553 SMKSGGDPKENIENWQSSKSAKRWKSGWEENKSLQQGDEHSKPPHLRHRESWSSTKGILS ENSRNOP00000013552/1-1551 SMKSGGDPKENIENWQSSKSAKRWKSGWEENKSLQQGDEHSKPPHLRHRESWSSTKGILS ENSP00000298281/1-1555 STKSGTEPKENVENWQSSKSAKRWKSGWEENKSLQQVDEHSKPPHLRHRESWSSTKGILS ENSCPOP00000003702/1-1515 STKLGSEPKENIENWQSSKSTKRWKSGWEENKSLQQGDEHGKSPHLRHRESWSSTKGILS XP_004868330.1/1-1550 STKSGTEPKENIENWQSSKSTKRWKSGWEENKSLQQGDEHSKSPHLRHRESWSSTKGILS * * * :****:********:*************** ***.*.***************** ENSMUSP00000113717/1-1553 PRAPK-QQHRLSVDANLQIPKELTLASKRELLQKTSERLASGEITQDEFLVVVHQIRQLF ENSRNOP00000013552/1-1551 PRAPK-QQHRLSVDANLQIPKELTLASKRELLQKTSERLASGEITQDEFLVVVHQIRQLF ENSP00000298281/1-1555 PRAPKQQQHRLSVDANLQIPKELTLASKRELLQKTSERLASGEITQDDFLVVVHQIRQLF ENSCPOP00000003702/1-1515 PRAPK-QQHRLSVDANLQIPKELTLASKRELLQKASERLASGEITQDEFLVVVHQIRQLF XP_004868330.1/1-1550 PRAPK-QQHRLSVDANLQIPKELTLASKRELLQKTSERLASGEITQDEFLVVVHQIRQLF ***** ****************************:************:************ ENSMUSP00000113717/1-1553 QYQ-EGVREEQRSPFNDRFPLKRPRYEDSDKPFVDGPASRFAGLDTNQRLTALAEDRPLF ENSRNOP00000013552/1-1551 QYQ-EGVREEQRSPFNDRFPLKRPRYEDSDKPFVDGPASRFAGLDTNQRLTALAEDRPLF ENSP00000298281/1-1555 QYQ-EGVREEQRSPFNDRFPLKRPRYEDSDKPFVDSPASRFAGLDTNQRLTALAEDRPLF ENSCPOP00000003702/1-1515 QYQEEGVREEQRSPFNDRFPLKRPRYEDSDKPFVDSPASRFAGLDTNQRLTALAEDRPLF XP_004868330.1/1-1550 QYQ-EGVREEQRSPFNDRFPLKRPRYEDSDKPFVDSPASRFAGLDTNQRLTALAEDRPLF *** *******************************.************************ ENSMUSP00000113717/1-1553 DGPGRPSVTRDGPAKMIFEGPNKLSPRIDGPPTPGSLRFDGSPGQMGGGGPMRFEGPQGQ ENSRNOP00000013552/1-1551 DGPGRPSVTRDGPTKMIFEGPNKLSPRIDGPPTPGSLRFDGSPGQIGGGGPMRFEGPQGQ ENSP00000298281/1-1555 DGPSRPSVARDGPTKMIFEGPNKLSPRIDGPPTPASLRFDGSPGQMGGGGPLRFEGPQGQ ENSCPOP00000003702/1-1515 DGPSRPSVSRDGPTKMIFEGPNKLSPRIDGPPAPGSL----------------------- XP_004868330.1/1-1550 DGPTRPSVSRDGPTKMIFEGPNKLSPRIDGPPTPGSLRFDGSPGQMGGGGPLRFEGPQGQ *** ****:****:******************:*.** ENSMUSP00000113717/1-1553 LGGGCPLRFEGPPGPVGTPLRFEGPIGQGGGGGFRFEGSPSLRFEGSTGGLRFEGPGGQP ENSRNOP00000013552/1-1551 LGGGCPLRFEGPPGPVGTPLRFEGPIGQGGGGGFRFEGSPSLRFEGSAGGLRFEGPGGQP ENSP00000298281/1-1555 LGGGCPLRFEGPPGPVGTPLRFEGPIGQAGGGGFRFEGSPGLRFEGSPGGLRFEGPGGQP ENSCPOP00000003702/1-1515 ---------QGPPGPVGAPLRFEGPIGQAGGGGFRFEGSPGMRFEGSAGGLRFEGPGGQP XP_004868330.1/1-1550 LGGGCPLRFEGPPGPVGTPLRFEGPIGQAGGGGFRFEGSPGMRFEGSAGGLRFEGPGVQP :*******:**********.***********.:*****.********* ** ENSMUSP00000113717/1-1553 VGGLRFEGHRGQPVGGLRFEGPHGQPVGSLRFDNPRGQPVGGLRFEGGHGPSGAAIRFDG ENSRNOP00000013552/1-1551 VGGLRFEGHRGQPVGGLRFEGPHGQPVGSLRFDNPRGQPVGGLRFEGGHGPSGAAIRFDG ENSP00000298281/1-1555 VGGLRFEGHRGQPVGGLRFEGPHGQPVGGLRFDNPRGQPVGGLRFEGGHGPSGAAIRFDG ENSCPOP00000003702/1-1515 ------------------------------------------------------------ XP_004868330.1/1-1550 VGGLRFEGHRGQPVGSLRFEGPHGQPVGGLRFDNPRGQPVGGLRFEGGHGPSGGAIRFDG ENSMUSP00000113717/1-1553 PHGQPGGGGGIRFEGPLLQQGVGMRFEGPHGQSVAGLRFEG-HNQLGGNLRFEGPHGQPG ENSRNOP00000013552/1-1551 PHGQP--GGGIRFEGPLLQQGVGMRFEGPHGQSVAGLRFEG-HNQLGGNLRFEGPHGQPG ENSP00000298281/1-1555 PHGQP--GGGIRFEGPLLQQGVGMRFEGPHGQSVAGLRFEGQHNQLGGNLRFEGPHGQPG ENSCPOP00000003702/1-1515 ---------------PLLQQGVGMRFEGPHGQSVGGLRFEGQHNQLGGNLRFDGPHGQPG XP_004868330.1/1-1550 PHGQP--GSGIRFEGPLLQQGVGMRFEGPHGQSVGGLRFEGQHNQ----LRFDGPHGQPG *******************.****** *** ***:******* ENSMUSP00000113717/1-1553 VGIRFEGPIVQQGGGMRFEGP-VPGGGLRIEGPLGQGGPRFEGCHSLRFDGQPGQPSLLP ENSRNOP00000013552/1-1551 VGIRFEGPLVQQGGGMRFEGP-VPGGGLRIEGPLGQGGPRFEGCHSLRFDGQPGQPSLLP ENSP00000298281/1-1555 VGIRFEGPLVQQGGGMRFEGPSVPGGGLRIEGPLGQGGPRFEGCHALRFDGQPGQPSLLP ENSCPOP00000003702/1-1515 VGIRFEGPLVQQGGGMRFEGP-VPGGGLRIEGPLGQGGPRFEGCHALRFDGQPGQPSLLP XP_004868330.1/1-1550 VGIRFDGPLVQQGGGMRFEGP-VPGGGLRIEGPLGQGGPRFEGCHALRFDGQPGQPSLLP *****:**:************ ***********************:************** ENSMUSP00000113717/1-1553 RFDGLHGQPGPRFERT-GQPGPQRFDGPPGQQVQPRFDGVPQRFDGPQHQQASRFDIPLG ENSRNOP00000013552/1-1551 RFDGLHGQPGPRFERT-GQPGPQRFDGPPGQQVQPRFDGVPQRFDGPQHQQASRFDIPLG ENSP00000298281/1-1555 RFDGLHGQPGPRFERTPGQPGPQRFDGPPGQQVQPRFDGVPQRFDGPQHQQASRFDIPLG ENSCPOP00000003702/1-1515 RFDGLHGQPGPRFERT-GQPGPQRFDGPPGQQVQPRFDGIPQRFDGPQHQQASRFDIPLG XP_004868330.1/1-1550 RFDGLHGQPGPRFERT-GQPGPQRFDGPPGQQVQPRFDGIPQRFDGPQHQQASRFDIPLG **************** **********************:******************** ENSMUSP00000113717/1-1553 LQGTRFDNHPSQRIE--SFNHSGPYNDPPGNTFNVPSQGLQFQRHEQIFDTPQGPNFNGP ENSRNOP00000013552/1-1551 LQGTRFDNHPSQRIE--SFNQTGPYSDPPGNAFNVPSQGLQFQRHEQIFDTPQGPNFNGP ENSP00000298281/1-1555 LQGTRFDNHPSQRLESVSFNQTGPYNDPPGNAFNAPSQGLQFQRHEQIFDSPQGPNFNGP ENSCPOP00000003702/1-1515 LQGTRFDNHPSQRLESVSFNQTGPYNDSPGNAFNTPSQGLQFQRHEQIFDSPQGPNFNGP XP_004868330.1/1-1550 LQGTRFDNHPSQRLESVSFNQTGPYNDPPGSAFNTPSQGLQFQRHEQIFDSPQGPNFNGP *************:* ***::***.*.**.:**.***************:********* ENSMUSP00000113717/1-1553 HGPGNQNFPNPINRASGHYFDEKNLQSSQFGNFGNLPTPISVGNIQASQQVLTGVAQPVA ENSRNOP00000013552/1-1551 HGPGNQNFPNPINRPSGHYFDEKNLQSSQFGNFGNLPTPMSVGNIQTSQQVLTGVAQPVA ENSP00000298281/1-1555 HGPGNQSFSNPLNRASGHYFDEKNLQSSQFGNFGNIPAPMTVGNIQASQQVLSGVAQPVA ENSCPOP00000003702/1-1515 HGPGNQNFSNPLNRASGHYFDEKNLQNSQFGNFGNLPAPMQVGNIQASQQVLTGVAQPVA XP_004868330.1/1-1550 HGPGNQNFSNPLNRASGHYFDEKNLHGSQFGNFGSLPAPMSVGNIQASQQVLTGVAQPVA ******.*.**:**.**********:.*******.:*:*: *****:*****:******* ENSMUSP00000113717/1-1553 FGQGQQFLPVHPQNPGAFIQNPSGGLPKAYPDNHLSQVDVNELFSKLLKTGILKLSQPDS ENSRNOP00000013552/1-1551 FGQGQQFLPVHPQNPGAFIQNPSGGLPKAYPDNHLSQVDVNELFSKLLKTGILKLSQPDS ENSP00000298281/1-1555 FGQGQQFLPVHPQNPG-FVQNPSGALPKAYPDNHLSQVDVNELFSKLLKTGILKLSQTDS ENSCPOP00000003702/1-1515 FGQGQQFLPVHPQNPGAFVQNPSGALPKAYPDNHLSQVDVNELFSKLLKTGILKLSQPDS XP_004868330.1/1-1550 FGQGQQFLPVHPQNPGAFVQNPSGALPKAYPDNHLSQVDVNELFSKLLKTGILKLSQPDS **************** *:*****.********************************.** ENSMUSP00000113717/1-1553 ATAQVTEAVAQPPPEEDEDQNEDQDVPDLTNFTIEELKQRYDSVINRLYTGIQCYSCGMR ENSRNOP00000013552/1-1551 ATAQVNEAVAQPPPEEEEDQNEDQDVPDLTNFTIEELKQRYDSVINRLYTGIQCYSCGMR ENSP00000298281/1-1555 ATTQVSEVTAQPPPEEEEDQNEDQDVPDLTNFTVEELKQRYDSVINRLYTGIQCYSCGMR ENSCPOP00000003702/1-1515 ATTQVNEVAAQPPPDEEEDQNEDQDVPDLTNFTIEELKQRYDSVINRLYTGIQCYSCGMR XP_004868330.1/1-1550 ATTQVNEVAAQPPPEEDEDQNEDQDVPDLTNFTVEELKQRYDSVINRLYTGIQCYSCGMR **:**.*..*****:*:****************:************************** ENSMUSP00000113717/1-1553 FTTSQTDVYADHLDWHYRQNRTEKDVSRKVTHRRWYYSLTDWIEFEEIADLEERAKSQFF ENSRNOP00000013552/1-1551 FTTSQTDVYADHLDWHYRQNRTEKDVSRKVTHRRWYYSLTDWIEFEEIADLEERAKSQFF ENSP00000298281/1-1555 FTTSQTDVYADHLDWHYRQNRTEKDVSRKVTHRRWYYSLTDWIEFEEIADLEERAKSQFF ENSCPOP00000003702/1-1515 FTTSQTDVYADHLDWHYRQNRTEKDVSRKVTHRRWYYSLTDWIEFEEIADLEERAKSQFF XP_004868330.1/1-1550 FTTSQTDVYADHLDWHYRQNRTEKDVSRKVTHRRWYYSLTDWIEFEEIADLEERAKSQFF ************************************************************ ENSMUSP00000113717/1-1553 EKVHEEVVLKTQEAAKEKEFQSVPAGPAGAVESCEICQEQFEQYWDEEEEEWHLKNAIRV ENSRNOP00000013552/1-1551 EKVHEEVVLKTQEAAKEKEFQSVPAGPAGAVESCEICQEQFEQYWDEEEEEWHLKNAIRV ENSP00000298281/1-1555 EKVHEEVVLKTQEAAKEKEFQSVPAGPAGAVESCEICQEQFEQYWDEEEEEWHLKNAIRV ENSCPOP00000003702/1-1515 EKAHEEVVLKTQEAAKEKEFQSVPAGPAGAVESCEICQEQFEQYWDEEEEEWHLKNAIRV XP_004868330.1/1-1550 EKVHEEVVLKTQEAAKEKEFQSVPAGPAGAVESCEICQEQFEQYWDEEEEEWHLKNAIRV **.********************************************************* ENSMUSP00000113717/1-1553 DGKIYHPSCYEDYQNTSSFDCTPSPSKTPVENPLNIMLNIVKNELQEPCESPKVKEEQID ENSRNOP00000013552/1-1551 DGKIYHPSCYEDYQNTSSFDCTPSPSKTPVENPLNIMLNIVKNELQEPCENPKVKEEQID ENSP00000298281/1-1555 DGKIYHPSCYEDYQNTSSFDCTPSPSKTPVENPLNIMLNIVKNELQEPCDSPKVKEERID ENSCPOP00000003702/1-1515 DGKIYHPSCYEDYQNTSSFDCTPSPSKTPVENPLNIMLNIVKNELQEPCESPKVKEEQID XP_004868330.1/1-1550 DGKIYHPSCYEDYQNTSSFDCTPSPSKTPVENPLNIMLNIVKNELQEPCESPKVKEEQID *************************************************:.******:** ENSMUSP00000113717/1-1553 APPACSEESVATPTEIKTESDTVESV ENSRNOP00000013552/1-1551 APPACSEESVATPTEIKTESDTVESV ENSP00000298281/1-1555 TPPACTEESIATPSEIKTENDTVESV ENSCPOP00000003702/1-1515 TPPACTEESI-TSTEIKTENDTVESV XP_004868330.1/1-1550 TPPACTEESITTSPEIKTENDTVESV :****:***: *..*****.******