CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000128736/1-1531 MSCKESPHVGASTTTVSSVAVHAGDSKIVIAVVKCGKWVRLQLAESQPNLLEIGSSQDET ENSRNOP00000036469/1-1530 MSCKESPHVGVSTTTVSSVAVQAGDSKIVIAVVKCGKWVRLQLAEAQPNLLEIGSSQDET ENSP00000395995/1-1530 MSSQGSPSVALSTTTVSSVAVQAGDSKIVIAVIKCGKWVQLQLAESQPNLLEIGSSQDET ENSCPOP00000003572/1-1376 ------------------------------------------------------------ XP_004868204.1/1-1531 MYCPRSSGAEFSTTTVCSVAVQAGDSKIVIAVVKCGKWVQFQLAESQPNLLEIGSSQDET ENSMUSP00000128736/1-1531 KKLLHDHELLLAKLKALEDRVWELLREADRTAEANKAQSQVYDAMAQTLGEAWATLVSML ENSRNOP00000036469/1-1530 RKLLHDHELLLAKLKALEDRVWGLLQEADRTAEANKEQSEVYDAMAQTLGEAWATLVSML ENSP00000395995/1-1530 KKLLHDHELLLAKLKALEDRVWELLQEADKTAEENKDQSQVYDAMAETLGEAWAALVSML ENSCPOP00000003572/1-1376 --------------QALEDRVWELLQEADKTAEENKDQSQVYDAMAQTLGDAWAALVSML XP_004868204.1/1-1531 KKLLHDHELLLTKLKALEDGVWELLQEADKTAEENKDQSQVYDAMAQTLGEAWTALVSML :**** ** **:***:*** ** **:******:***:**::***** ENSMUSP00000128736/1-1531 ERRRELLGLTSEFFQSALEFAIKIDQAEAFLQNPHEFESTEALQSLLLLHDRHAKELLER ENSRNOP00000036469/1-1530 ERRRELLGLTSEFFQSALEFAIKIDQAEDFLQNPHEFESAEALQSLLLLHDRHAKELLER ENSP00000395995/1-1530 ERRTELLRLTSEFFENALEFAIKIDQAEDFLQNTHEFESAESLKSLLQLHEHHTKELLER ENSCPOP00000003572/1-1376 ERRRELLRLTSEFFDYALEFAIKIDQAEDFLQNPPEFESAEALKLLLHLHEHHTKELLER XP_004868204.1/1-1531 ERRSELLTLTSEFFESALEFAIKIDQAEDFLQNPHEFESAEALKSLLQLHEHHTKELLER *** *** ******: ************ ****. ****:*:*: ** **::*:****** ENSMUSP00000128736/1-1531 SLDLLNKSQQLTDFIEKFKCEGSTMNSELIQGAQSSCLKIDSLLELLQDRRRQLDKYLQQ ENSRNOP00000036469/1-1530 SLVLLNKSQQLTDFIEKFKCDGSPVNSELIQGAQSSCLKIDSLLELLQDRRRQLDKHLQQ ENSP00000395995/1-1530 SLALLNKSQQLTDFIEKFKCEGPNVNPELTQGAHSSCLKVDRLLELLQDRRRQLDKYLKQ ENSCPOP00000003572/1-1376 SLALLNKSQQLTDFIEQFKCDGPYVNSELVQGARSSCLKIDSLLELLQDRRRQLDKHLQQ XP_004868204.1/1-1531 SLALLNKSQQLTDFIEKFKCDGHYVNSDLIQGAQSSCLKIDSLLELLQDRRRQLDKHLQQ ** *************:***:* :*.:* ***:*****:* **************:*:* ENSMUSP00000128736/1-1531 QRQELSQVLQLCLWDQQENQVSSWFQKAIRDLQEQSLGASLSDNRELICKHEDLIVKAKE ENSRNOP00000036469/1-1530 QRQELSQVLQLCLWDQQESQVSCWFQKTIRDLQEQSLGSSLSDNKELIRKHEDLTIKAKE ENSP00000395995/1-1530 QWQELSQVLQICQWDQQENQVTCWFQKTIRNLQEQSLGSSLSDNEDRIHKQEELIIKAKE ENSCPOP00000003572/1-1376 QRQELAHVLHMCLWNQQEDQVTCWFQKTMRDLQEQSLGVSLSDNEELISKHEKLIMKAKE XP_004868204.1/1-1531 QRQELCQALQMCLWDQQEDQVTCWFQKTIKELQEQSLGSSLSDNEELICKHENLIIKAKE * ***.:.*::* *:***.**:.****::::******* *****.: * *:*.* :**** ENSMUSP00000128736/1-1531 WDSAVEKLKSQALGILLSKDLAGKEHLQLSNQKLNRLQEEFGRLMVERKAWLSMANDFFT ENSRNOP00000036469/1-1530 WDLAMEKLKSQALGILLSKDLTEKEHLQLSNQKLNRLQEEFGRLMVDRKAWLTMAHDFFT ENSP00000395995/1-1530 WNSAVEKLKSEALRILLSKDYVEKEHLQLSHQKLSQLQEEFGQLMVERNTWLKKANEFFN ENSCPOP00000003572/1-1376 WNSTVEELKGKALALLLSKDCVEREQLQLSNQKLNRLQDELGQLIMDRKIQLQKANDFFS XP_004868204.1/1-1531 WNSTVEKLKGEAVGILLSKDYVEREHLQLSNQKLNRFQDELGQLMMERKIWLKKANDFFS *: ::*:**.:*: :***** . :*:****:***.::*:*:*:*:::*: * *::**. ENSMUSP00000128736/1-1531 SANKSFDVLGKVEAYLKLLKSEGLSLPVLAAKHEELHREIKDSTATALQKGRTLISQVDS ENSRNOP00000036469/1-1530 SANEAFDVLGKVEDYLKLLKSEGLSLPALAAKHEELHREIKDSTAAALQKGRTLISQVDS ENSP00000395995/1-1530 SANKAFDVLGRVEAYLKLLKSEGLSLAVLAVRHEELHRKIKDCTTDALQKGQTLISQVDS ENSCPOP00000003572/1-1376 SANKAFDVLGRIEAYLKLLKSEGLSLPDLAARHEELHREIKECAADALQKGQTLISQVDS XP_004868204.1/1-1531 NANKAFDVLGRVEAYLKLLKSEGLSLPVLAARHEALHREIKECTVDTLQKGQTLISQVDS .**::*****::* ************. **.:** ***:**:.:. :****:******** ENSMUSP00000128736/1-1531 CRSRVTGIHEMMGYIQNRVDCLTEQCTAHEEFARKRQQLATSVDDYLRKVEMSIQEIRPI ENSRNOP00000036469/1-1530 CRAQVTGIHETMGRIQKRVDRLSQQCTAHQEFALKKQQLATSVDDYLRKVEMSVQEMRLV ENSP00000395995/1-1530 CSSQVSGIHEMMGCIKRRVDHLTEQCSAHKEYALKKQQLTASVEGYLRKVEMSIQKISPV ENSCPOP00000003572/1-1376 CSPLVSGVQEMMGCVQRRVDHLAKQCSAREELAFRKQQLTASVEGYLNKVEMSIQKISSV XP_004868204.1/1-1531 CSSRVSGIHEMMGCMQRRMDLLTEQCSAHKQLALKKQQLTASVEGYLRKVEMSVQKISPV * . *:*::* ** ::.*:* *::**:*::: * ::***::**:.**.*****:*:: : ENSMUSP00000128736/1-1531 LATTLDVASSPSESEKILNKYLELDIQVKETAHALEAAAKIMTEKNELELNEVALLPLKV ENSRNOP00000036469/1-1530 LATTLDVGSSPSESEKILNKYLELDIQAKETAHALEAAAKITTEKNELELNEVALLPFKV ENSP00000395995/1-1530 LSNAMDVGSTRSESEKILNKYLELDIQAKETSHELEAAAKTMMEKNEFVSDEMVSLSSKA ENSCPOP00000003572/1-1376 LSSAMDVGSSLFETEKLLNKYLDLDSQAKETSQALQAATKIMTENNEFEPEEVASLSFKA XP_004868204.1/1-1531 LSSAMNIGSSLSESEKILNKYLELDIQAKATSHALEAATKIMTEKNEFEPDDVASLSFKA *:.::::.*: *:**:*****:** *.* *:: *:**:* *:**: :::. *. *. ENSMUSP00000128736/1-1531 KWLEEELSTLGRSISCRSRILQTYVAFRKSSEEAEEQLQSLKEFYLTEIPWKDEDDAVVK ENSRNOP00000036469/1-1530 KRLEEELSTLSRSVSYRSQVLQTYIAFRKSSEEVEEQLQSLKEFYLTESPWEDEDDAVVT ENSP00000395995/1-1530 RWLAEELNLFGQSIDYRSQVLQTYVAFLKSSEEVEMQFQSLKEFYETEIPQKEQDDAKAK ENSCPOP00000003572/1-1376 KWLEEELNILSESISSRSQVLQTYVAFLKSSEEVEEQFQSLKKFYQTKIPRKEEDDAKAQ XP_004868204.1/1-1531 KWLEEELNILGQSISSRSQVLQTYVAFLKSAEEVEEQFQSLKKFYQTEIPRKEEVDAKAM : * ***. :..*:. **::****:** **:**.* *:****:** *: * ::: ** . ENSMUSP00000128736/1-1531 CQSNSAERKWQLFLKKSFLTQDLSLEFLNLINMAKENEILNVKNEMHIMENIMEKQTNGR ENSRNOP00000036469/1-1530 CQSNSAERKWQLFLKKSFLTQDLSLEFLNLISMAKENEILNVKKEMHIVENVMEKQTNGR ENSP00000395995/1-1530 HCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVYLMKNTMENQKAER ENSCPOP00000003572/1-1376 FWSGSAEKQWQLFLKKSFLSQDLGIKFLNLIQMVKKSEITNGENEAHIMESTLENQKAER XP_004868204.1/1-1531 YWTGSAEKQWQIFLKKTFLAQELGLEFLNLIKMVKENEIANGNNEAHIMENTMEKQKAGQ :.***::**:****:*::*:*.::*****.*.*:.** : ::* ::::. :*:*. : ENSMUSP00000128736/1-1531 EELSHLRVAWYLKAIEGKPAREQWEMFKEKLTKTTHSVKLLHEVLMPVSALDLGGSLQST ENSRNOP00000036469/1-1530 EELSRLRMAWHLKAMEGKPVKERWETFKEKLKKTTHNVKLLHEVLMPVSALDLGGNLQSM ENSP00000395995/1-1530 EELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFI ENSCPOP00000003572/1-1376 AELSHLRVAWQLEATSREPMKQRWGAFKEQLKKTSHNLKLLQEVLMPVSALDLGGSLQTI XP_004868204.1/1-1531 AELSRLRIARQLEATARKPMKQQWGAFKEQLKKTTHSLKLLQEVLMPVSALDLGGSRQTI *** **:* *:* :* :::* ***:*.**:*.:***:*.***********. * ENSMUSP00000128736/1-1531 SDLRRRWIAMKPQLQQLHEDVQQITKEWEVLSSQGAPLKEKAEQLKDLVHLHRRQRERIQ ENSRNOP00000036469/1-1530 SDLRRRWIAMQPQLQQLHEDVQQIMKEWEVLSGQGVPLKEKAEQLKDLIHLHQRQRERIQ ENSP00000395995/1-1530 LDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQ ENSCPOP00000003572/1-1376 ADLQKKWTEMRPQFQQLHDEVQYIVKESQGLSDKGAPVKEKSQQLKDIIHLHQKQTERIQ XP_004868204.1/1-1531 SDLQGKWNEMKPQIQQLHYEVQYIMEESEELSRKGAPVKEKAQQLKDLIHLHQKQTERVQ **: :* *:**:***: :** * :* : *: :*.*:***::****::*:*::* **:* ENSMUSP00000128736/1-1531 EYEEILYKTVQFHQVKEELVHLIKPRELELLAQPMELASSEEVQMQLGRSQERRAHVDHL ENSRNOP00000036469/1-1530 EYEEILYKTVQFHQVKEELTHLIKPRELELLAQPMELEGSKEVLMQLGRSQGRRAHVDHL ENSP00000395995/1-1530 DYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHL ENSCPOP00000003572/1-1376 DYENVLYKLVQFHQVKEELGRLTKSKELEFQDQLKELSDAHEAQIHLGRSQEKQAHVERL XP_004868204.1/1-1531 DYENVLYKLVQFHLVKEELGRLTKSRELEF--QLKELGDAHEGQSHLVRCQEKQAHVEHL :**::*** **** ***** :* *.:***: * ** .:.: :* .* ::*:*::* ENSMUSP00000128736/1-1531 HQLALTLGVDIISSVQQPNCSNISAKNLQQQLEALELESRSWSAQAKEHERVLSCSLEYC ENSRNOP00000036469/1-1530 HRLALSLGVDIISSVQRPNCSNISAKSLQQQLEALELDSRDWSAKAKEYEQVLACSLEYC ENSP00000395995/1-1530 HRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYC ENSCPOP00000003572/1-1376 QELAFSLGVDIISSAQQPNCSNISAKNLQQQLEALEVDHMNWRARAKEHEQAWSLSLEFC XP_004868204.1/1-1531 RELALSLGVDIISSAQRPNCSNVSAKNLEQQMEALDSDHRNWRVRAKEQEQAWSCSLELC :.**::********.*:*:***:***.*:**:* *: : .* .:*:* :. : *:* * ENSMUSP00000128736/1-1531 TARDEISELKESFKDIKKKFNNLKFNYSKKNEKSRNLKTLQYQIQQVDTYAEKIQALRKK ENSRNOP00000036469/1-1530 TTREEINELKESFKDIKKKFNNLKFNYSKKNEKSRNLKTLQYQIQQVETYADKIQALRKK ENSP00000395995/1-1530 AMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRK ENSCPOP00000003572/1-1376 ATGAEINELKESFKDIKKKFNNLKFNYTKKNEKARNLKALKYHIQQVDMYAEKMQALRRK XP_004868204.1/1-1531 ATGEEINELNVSFKDIKKKFNNLKFNYTKKNEKARNLKALKYHIQQVDMYAEKMQALRRR : **.**: ****************:*****:****:*:*:****: **:*:***::: ENSMUSP00000128736/1-1531 MEKVNNKTSDSFLSYPSNKANMLSEAMEDLKKNVDDFDKVVTDYKMNLDLTEHLQEVIEE ENSRNOP00000036469/1-1530 MEKVNKKISDSVLSYPSNKANTLVEAMEDLKKHVDDFDKVVTDYKMNLDLTEHLQEVIEE ENSP00000395995/1-1530 MEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEE ENSCPOP00000003572/1-1376 MEKLSSKTSDSFLNYPSNKVNVILEAMKDLQKHVNDFDKVVTDYKTNLDLTEHLQELIEE XP_004868204.1/1-1531 MEKLNSKTSDYFLNYPSNKVNVLLEAMKDLQKHVDDFNKIVTDYKTNLGLTEHLQEVTEE ***:..* ** .*.***:*.* : *.*:**:*:*:**:*:***** **.****:**: ** ENSMUSP00000128736/1-1531 CNFWYEDASATVVRVGKYSMECQTREAVDILHRQFNKFITPSVPQQEERIQEVIDLAQRL ENSRNOP00000036469/1-1530 CNFWYEDASATVVRVGKYSMECQTREAVDILHRQFQKFVTPSVPQQEERIQEVVSLAQRL ENSP00000395995/1-1530 CHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHL ENSCPOP00000003572/1-1376 CYFWYEDASATIVRVGKYSMECKTTEAVEILHQQFNKFIAPSVPQQEERIQEVTDLARRL XP_004868204.1/1-1531 CYFWYEDASATIVRVGKYSMACKTKEAVEILHQQFNKFIAPSVPQQEERIQEVTDLAQRL * *********:******* *:* ***.***:**:**::************. .**::* ENSMUSP00000128736/1-1531 YGLEEGQKYAEKIVTRHKEILESITELCGSLVELKEKLMQGEVPKMNSDLEDFHDNCIDL ENSRNOP00000036469/1-1530 YGLEEGQKYAEKIVTRHKEILESITELCGSLVELKEKLMQGDVPKVNSNLEDFHGNSIDL ENSP00000395995/1-1530 YGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDL ENSCPOP00000003572/1-1376 YGMEEGKKYTEKIVAKHKEILESITELCGSLTELEEKLKQGDALKMNPSLEDFHSNCIDL XP_004868204.1/1-1531 YGLEEGEKYTEKIVAKHKEVLESITELCESLAELEEKLKQGDILKMNPKLEDFHDNCIDL **:***:** ****::***:***:**** **.**:*** **: *:*..***** : *** ENSMUSP00000128736/1-1531 LKGPGKDDQKTFSEERNEGQVQGADVLAVNGTREDGLPMDLRRTSSDKEDSAQGLILPED ENSRNOP00000036469/1-1530 LKEPGRDEQTTFSEERSEGQAQGADVSAINGTREDGLPVGL-RQSFDKEDSAQGLTLPED ENSP00000395995/1-1530 LKEPAKNKQTIFNEERNKGQVQVADLLGINGTGEERLPQDL-KVSTDKEGGVQDLLLPED ENSCPOP00000003572/1-1376 ITEPLRNKQKVFNEEINKGQMQGADILAISETGEDGLPRKPSRLSSAKEGSVQGLLLPED XP_004868204.1/1-1531 LKEPVRNKQIILNEEINKGQAPGADIWAINGTGDCGLAPNLRQLSSAKEGRVQGLLLPED :. * ::.* :.** .:** **: .:. * : *. : * **. .*.* **** ENSMUSP00000128736/1-1531 TLSGEESECISSDDISLPPLPVSPESPLA-PSDMEVEELTSSSALALHISGYRMHPGTGG ENSRNOP00000036469/1-1530 TLSGEDSECISSDDISLPPLPVTPESPLA-PSDMEVEEPASSSALALHISGYRMRTGTGG ENSP00000395995/1-1530 MLSGEEYECVSPDDISLPPLPGSPESPLA-PSDMEVEEPVSSS-LSLHISSYGVQAGTSS ENSCPOP00000003572/1-1376 VLSGEESECVSPDDISLPPLPESPESPLTLSSDMEVEEAPSPSASSLPMSSSNMQSKTCG XP_004868204.1/1-1531 MPSGEESECVSSDNISLPPLPGSPESPLALSSDMEVEEPPSPSALSLPMSSSSLQSRTCG ***: **:*.*:******* :*****: .******* *.* :* :*. ::. * . ENSMUSP00000128736/1-1531 LGKAQESALPSPIAFADGGHSKKDTFTSHFERPYPQLKAESSLASRGSAEMSTKLH-INV ENSRNOP00000036469/1-1530 LGKAPESVLPPPTAFTDGYHNKKDTFTSHFERPYPQFKAEPLLTSRGSGEMSTKLH-VNV ENSP00000395995/1-1530 PGDAQESVLPPPVAFADACNDKRETFSSHFERPYLQFKAEPPLTSRGFVEKSTALHRISA ENSCPOP00000003572/1-1376 PGEAQESVLLTPVTFANAY-NKRETFSSHFERPQAQFKAEPPLTSGGFLESSTAFLKISA XP_004868204.1/1-1531 PGEAQESVLPPPVTYADAYNNKKEIFSSHFERPYPQFKAEPPLTSGEFLESSTAFHKNSA *.* **.* .* ::::. .*:: *:****** *:***. *:* * ** : .. ENSMUSP00000128736/1-1531 KCPASMPHEVHDKALQQCSQARESTLEMQEKVHADSNVTKTQDRLHAALDVSPGLGSQPD ENSRNOP00000036469/1-1530 KCPARMPREVHDKALPPSSQAQEISLGTQEKVHADSNVTKTQDRLHAALDVSPGLSSQSD ENSP00000395995/1-1530 EHPESMMSEVHERALQQHPQAQGGLLETREKMHADNNFTKTQDRLHASSDAFSGLRFQSG ENSCPOP00000003572/1-1376 KQPESMPSDVHDRALQKH--AQESLLETQEKMHGLGSSTKTQDRLHASSDVFQGLGFQPG XP_004868204.1/1-1531 KQPESMLSDMHDRALQKHPQAQGSLLETQEKMHGHDNSTKTQDRLHASPAVLWSLGFPPG : * * ::*::** *: * :**:*. .. *********: . .* .. ENSMUSP00000128736/1-1531 TSESHQRRVGPQGNKKNSSAENSVVSLAGQAPHFSRLLSNVTVMEGSPVTLEVEVTGFPE ENSRNOP00000036469/1-1530 TSRSHQRQVGPQGDRKNSSAEKSVVSLAGQAPHFSRLLSNVTVTEGSPVTLEVEVTGFPE ENSP00000395995/1-1530 TSRGYQRQMVPREEIKSTSAKSSVVSLADQAPNFSRLLSNVTVMEGSPVTLEVEVTGFPE ENSCPOP00000003572/1-1376 TSPGLQRQMVPGEEAKSTSAKSNMVSLAGQAPHFSRLLSNVTVTEGSPVTLEVEVTGFPE XP_004868204.1/1-1531 TSLGSQRQMVPGEEAKTPSAKNSVVSLAGQAPHFSRLPSNVTVTEGSPVTLEVEVTGFPE ** . **:: * : *..**:..:****.***:**** ***** **************** ENSMUSP00000128736/1-1531 PTLTWFKKGQKLCADGHLQVLHKDTKHSVFIPKVCEADAGLYVAQAQNSSGTLSSKAILH ENSRNOP00000036469/1-1530 PTLTWFKKGQKLCADGHLQVLHKDTKHSVFIPKVCEADAGLYVAQAQNSSGTLSSKAILH ENSP00000395995/1-1530 PTLTWYKKGQKLSADGHLQVLHKETRHSVFIPKVCKADAGLYVARAQNSSGALSSNVILH ENSCPOP00000003572/1-1376 PTLTW------------------------------------------------------- XP_004868204.1/1-1531 PTLTWYKKGQHLSADGHLQVLHKETKHSVFIPEVCKADAGLYVAQAQNASGIVSSNVILH ***** ENSMUSP00000128736/1-1531 VTGNHGPPITRLNWIMLCIIYVSVSVIYWLLTR ENSRNOP00000036469/1-1530 VTGNHGPPITRINWIVLCIIYVSVSVIYWLLTQ ENSP00000395995/1-1530 VTGNCRLPITRVNWITLCVVYVSVSLMYWLLTQ ENSCPOP00000003572/1-1376 -------------WVA----YNDMS-------- XP_004868204.1/1-1531 VTGNLRPPIARISWVMLCVTYVSVSLMYWLLTW *: * .:*