CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000003527/1-1157 SAGGGPEMDEYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEV XP_004840468.1/1-1154 MPGGGSEMDEYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEV ENSP00000380150/1-1154 MPGGGPEMDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEV ENSMUSP00000082941/1-1154 MPGGGPAMDDYMETLKDEEEALWDNVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEV ENSRNOP00000049153/1-1157 LTGGGPAMDDYMETLKDEEEALWDNVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEV .***. **:*********:***:************************************ ENSCPOP00000003527/1-1157 LNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVV XP_004840468.1/1-1154 LSAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVV ENSP00000380150/1-1154 LNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVV ENSMUSP00000082941/1-1154 LNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVV ENSRNOP00000049153/1-1157 LNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVV *.********************************************************** ENSCPOP00000003527/1-1157 EEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLAKSRQLEDEKKQLMLTRVELLTFQDRY XP_004840468.1/1-1154 EEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLAKSRQLEDEKKQLTLTRVELLTFQDRY ENSP00000380150/1-1154 EEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERY ENSMUSP00000082941/1-1154 EEGHEGLTHFLMNEVIKLQQQVKAKDLQRCELLAKSRQLEDEKKQLSLIRVELLTFQERY ENSRNOP00000049153/1-1157 EEGHEGLTHFLMNEVIKLQQQVKAKDLQRCELLAKSRQLEDEKKQLNLIRVELLTFQERY *********************:************: *********: * ********:** ENSCPOP00000003527/1-1157 YKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKME XP_004840468.1/1-1154 YKMKDERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKME ENSP00000380150/1-1154 YKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKME ENSMUSP00000082941/1-1154 YKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKME ENSRNOP00000049153/1-1157 YKMKEERDSHNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKME ****:****:************************************************** ENSCPOP00000003527/1-1157 EECKLERNQSLKLKNDIESRPKKEQVLELERENEMLKTKIQELQSIIQAGKRSLPDSNKA XP_004840468.1/1-1154 EECKLERNQSLKLKNDIESRPKKEQVLELERENEMLKTKIQELQSIIQAGKRSLPDSDKA ENSP00000380150/1-1154 EECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKA ENSMUSP00000082941/1-1154 EECKLERNQSLKLKNDIENRPRKEQVLELERENEMLKTKIQELQSIIQAGKRSLPDSDKA ENSRNOP00000049153/1-1157 EECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKIQELQSIIQAGKRSLPDSDKA ******************.**:***************** *****************:** ENSCPOP00000003527/1-1157 ILDILEHDRKEALEDRQELVNKIYNLQEEVRQAEELRDKYLEEKEDLELKCSTLGKDCEM XP_004840468.1/1-1154 ILDILEHDRKEALEDRQELVNKIYNLQEEVRQAEELRDKYLEEKEDLELKCSTLGKDCEM ENSP00000380150/1-1154 ILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEM ENSMUSP00000082941/1-1154 ILDILEHDRKEALEDRQELVNKIYNLQEEVRQAEELRDKYLEEKEDLELKCSTLGKDCEM ENSRNOP00000049153/1-1157 ILDILEHDRKEALEDRQELVNKIYNLQEEVRQAEELRDKYLEEKEDLELKCSTLGKDCEM *********************:*******.****************************** ENSCPOP00000003527/1-1157 YKHRMTTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIE XP_004840468.1/1-1154 YKHRMTTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIE ENSP00000380150/1-1154 YKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIE ENSMUSP00000082941/1-1154 YKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIE ENSRNOP00000049153/1-1157 YKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIE *****.****************************************************** ENSCPOP00000003527/1-1157 MVRREACIVNLESKLRRLSKDSGTLDQSLPRNLPATIISQSFGDASPRTNGQEADDSSTS XP_004840468.1/1-1154 MVRREACIVNLESKLRRLSKDSGTLDQSLPRNLPATIIPQSFGDASPRTNGQEADDSSTS ENSP00000380150/1-1154 MVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTS ENSMUSP00000082941/1-1154 MVRREACIVNLESKLRRLSKDNGSLDQSLPRHLPATIISQNLGDTSPRTNGQEADDSSTS ENSRNOP00000049153/1-1157 MVRREACIVNLESKLRRLSKDSGSLDQSLPRHLPATIISQSLGDTSPRTNGQEADDSSTS *********************...*******:**.***.*.:**:*************** ENSCPOP00000003527/1-1157 EESPEDSKYFPPYHPPRRRMNLKGIQLQRAKSPISLKRASDFQ-----VKGHGDDSTDAS XP_004840468.1/1-1154 EESPEDSKYFPPYHPPRRRMNLKGIQLQRAKSPISLKRASDFQ-----VKGFGDDTTDAS ENSP00000380150/1-1154 EESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQ-----AKGHEEEGTDAS ENSMUSP00000082941/1-1154 EESPEDSKYFLPYHPPRRRMNLKGIQLQRAKSPISMKQASEFQ-----VKGHEEDFTDGS ENSRNOP00000049153/1-1157 EESPEDSKYFLPYHPPRRRMNLKGIQLQRAKSPISMKQASEFQALMRTVKGHEEDFTDGS ********** *****:******************:*::*:** .**. :: **.* ENSCPOP00000003527/1-1157 PSSAHSLPITSSFSKMQPHRSRSSIMSITAEPPGNDSIVRRCKEDAPPRSAVEEDNDSCG XP_004840468.1/1-1154 PSSARSLPITSSFSKMQPHRSRSSIMSITAEPPGNDSIVRRCKEDAPPRSAVEEDNDSCG ENSP00000380150/1-1154 PSSCGSLPITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGG ENSMUSP00000082941/1-1154 PSSSRSLPVTSSFSKMQPHRSRSSIMSITAEPPGNDSIVRRCKEDAPHRSTVEEDNDSCG ENSRNOP00000049153/1-1157 PSSSRSLPVTSSFSKMQPHRSRSSIMSITAEPPGNDSIVRRCKEDAPHRSTVEEDNDSCG ***. ***:*.**:**** ********************** ***** **:******* * ENSCPOP00000003527/1-1157 FDALDLDAQSLAQNSAGPDGPHSSADDSHHQSESLDAYDLEQVNLMFRKFSLERPFRPSV XP_004840468.1/1-1154 FDALELDDDSHDRYSFGPPSIHSSS--SSHQSESLDAYDLEQVNLMFRKFSLERPFRPSV ENSP00000380150/1-1154 FDALDLDDDSHERYSFGPSSIHSSS--SSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSV ENSMUSP00000082941/1-1154 FDALDLDDENHERYSFGPPSIHSSS--SSHQSEGLDAYDLEQVNLMLRKFSLERPFRPSV ENSRNOP00000049153/1-1157 FDVLDLDDENHERYSFGPPSIHSSS--SSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSV **.*:** :. : * ** . ***: * ****.************:************* ENSCPOP00000003527/1-1157 TSVGQVRGSGPSVQHVTLSGDGLVNQLTLLGGNARGSFVHAVKQGSLAEKAGLHQGHQLL XP_004840468.1/1-1154 TSVGQVRGPGPSVQHATVNGDGLFTQLTLLGGNARGSFVHVVKQGSLAEKAGLREGHQLL ENSP00000380150/1-1154 TSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQLL ENSMUSP00000082941/1-1154 TSGGHVRGTGPLVQHTTLNGDGLITQLTLLGGNARGSFIHSVKPGSLAERAGLREGHQLL ENSRNOP00000049153/1-1157 TSGGHVRGTSPLVQHTTLNGDGLITQLTLLGGNAHGSFIHSVKPGSLAEKAGLREGHQLL ** *:***..* ***.*:.**.* .*********:***:* ** *****:***::***** ENSCPOP00000003527/1-1157 LLEGCIRGERQSVPLDTCTKEEARWTIQRCSGPVTLHYKVNHEGYQRLLKDMEEGLITSG XP_004840468.1/1-1154 LLEGCIRGERQSVPLDTCTKEEARWTIQRCSGPVTLHYKANHEGYQKLLRDMAEGLITSG ENSP00000380150/1-1154 LLEGCIRGERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSG ENSMUSP00000082941/1-1154 LLEGCIRGERQSVPLDACTKEEARWTIQRCSGLITLHYKVNHEGYRKLLKEMEDGLITSG ENSRNOP00000049153/1-1157 LLEGCIRGERQSVPLDACTKEEARWTIQRCSGPVTLHYKVNHEGYRRLLKEMEDGLITSG ****************:******:******** :*****.*****::*:::* :****** ENSCPOP00000003527/1-1157 DSFYIRLNLNISSQLDACSMSLKCDDIVHVRDTMYQDRHEWLCARVDPFTNHDLDMGTI- XP_004840468.1/1-1154 DSFYIRLNLNISSQLDACSMSLKCDDIVHVRDTMYQDRHEWLCARVDPFTDHDLDMGTI- ENSP00000380150/1-1154 DSFYIRLNLNISSQLDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDHDLDMGTI- ENSMUSP00000082941/1-1154 DSFYIRLNLNISSQLDACSMSLKCDDVVHVLDTMYQDRHEWLCARVDPFTDQDLDTGTI- ENSRNOP00000049153/1-1157 DSFYIRLNLNISSHSDTCSSGLLWSQTVGLSQSCGQRRRDWIPS---PKGESCVSWGTLR *************: *:*: .* .: * : :: * *::*: : * : :. **: ENSCPOP00000003527/1-1157 PSYSRAQQLLLVKLQRLMHRGSREETDSSSHHTLRVLRNTLQPEEPLSTSDPRVSPRLSR XP_004840468.1/1-1154 PSYSRAQQLLLVKLQRLMHRGNREEAD-TVHHTLRGLRNTLQPEEPLSTSDPRVSPRLSR ENSP00000380150/1-1154 PSYSRAQQLLLVKLQRLMHRGSREEVD-GTHHTLRALRNTLQPEEALSTSDPRVSPRLSR ENSMUSP00000082941/1-1154 PSYSRAQQLLLVKLQRLVHRGNREEAD-SAHHTLRSLRNTLQPEEMLSTSDPRVSPRLSR ENSRNOP00000049153/1-1157 PSFSRAQQLLLVKLQRLVHRGTREEAD-SAHHTLRSLRNTLQPEEPLSASDPRVSPRLSR **:**************:***.***.* ***** ********* **:*********** ENSCPOP00000003527/1-1157 ASFLFGQLLQFVSRSENKYKRMNSSERVRVISGSPLGSLARTSLDATKLSAEKQEELDPE XP_004840468.1/1-1154 ASFLFGQLLQFVSRSENKYKRMNSSERVRVISGSPLGSLARASLDATRLSAEKQEELDPE ENSP00000380150/1-1154 ASFLFGQLLQFVSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPE ENSMUSP00000082941/1-1154 ASFFFGQLLQFVSRSENKYKRMNSNERVRIISGSPLGSLSRSSLDATKLLTEKHEELDPE ENSRNOP00000049153/1-1157 ASFFFGQLLQFVSRSENKYKRMNSNERVRIISGSPLGSLSRSSLDATKLLTEKHEELDPE ***:********************.****:*********:*:*****:* :**:****** ENSCPOP00000003527/1-1157 SELSKNLSLI-PYSLVRAFHCERRRPVLFTPTMLAKTLVQKLLNSGGAMEFTLCKSDIVT XP_004840468.1/1-1154 SELSRNLSLT-PYSLVRAFHCERRRPVLFTPTVLTKTLVQKLLNSGGAMELTLCKSDTVT ENSP00000380150/1-1154 SELGKNLSLI-PYSLVRAFYCERRRPVLFTPTVLAKTLVQRLLNSGGAMEFTICKSDIVT ENSMUSP00000082941/1-1154 NELSRNLTLI-PYSLVRAFHCERRRPVLFTPTMLAKTLVQKLLNSGGAMEFTICKSDIVT ENSRNOP00000049153/1-1157 NELSRNLTLIPPTPLLLSVLTEGRRSGSIVPTM-EKDQMNIIWHPGGDRILTPLSADIVT .**.:**:* * .*: :. * **. :.**: * :: : :.** :* .:* ** ENSCPOP00000003527/1-1157 REEFLKKQKTETIIYSREKNPNTFECIVPANIEAVAAKNKHCLLEAGIGCVRDLIKCGIY XP_004840468.1/1-1154 REEFLKKQKTETIIYSREKNPNTFECIVPANIEAVAAKNKHCLLEAGMGCVRDLIKCGIY ENSP00000380150/1-1154 RDEFLRRQKTETIIYSREKNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIY ENSMUSP00000082941/1-1154 RDEFLRKQKTETIIYSREKNPNTFECIVPANIEAVAAKNKHCLLEAGIGCVRDLIKCKVY ENSRNOP00000049153/1-1157 RDEYLRKQKTETIIYSREKNPNTFECIVPANIEAVAAKNKHCLLEAGISCVRDLIKCKVY *:*:*::***************:****.*******************:.*.*****. :* ENSCPOP00000003527/1-1157 PIVLFVRVCEKNIKRFRKLLPRPETEEEFLRTCRLREKELEALPCLYATVEAEAWSSVEE XP_004840468.1/1-1154 PIVLFVRVCEKNIKRFRKLLPRPETEEEFLRACRLREKELEALPCLYSTVEAEAWSSVEE ENSP00000380150/1-1154 PIVLFIRVCEKNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEPDMWGSVEE ENSMUSP00000082941/1-1154 PIVLLIRVSEKNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEAEMWSSVEE ENSRNOP00000049153/1-1157 PIVLLIRVSEKNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEAEMWSSVEE ****::**.**********************.***:***********:***.: *.**** ENSCPOP00000003527/1-1157 LLRVLKDRICEEQRKTIWVDEDQL XP_004840468.1/1-1154 LLRVLKDRICEEQRKTIWVDEDQL ENSP00000380150/1-1154 LLRVVKDKIGEEQRKTIWVDEDQL ENSMUSP00000082941/1-1154 LLRVLKDKIVEEQRKTIWVDEDQL ENSRNOP00000049153/1-1157 LLRVLKDKIVEEQRKTIWVDEDQL ****:**:* **************