CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000073855/1-1561 MLSWRLQTGSEKAELQELNARLYDYVCRVRELERENLLLEEELRSRLSREDRWAEDQALY ENSRNOP00000046923/1-1557 MLSWRLQTSSEKAELQELNARLYEYVCRVRELERENLLLEEELRSRLSREDRWAEDQALY ENSP00000336775/1-1564 MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARC ENSCPOP00000003367/1-1215 MLSWRLQTGSEKAELQELNARLYDYVSRVRELERENQLLEAQLRGRRGEERLWAEGQARF XP_004852760.1/1-1247 MLSWRLQTGPEKAELRDLNARLHDYVCRVRELERENQLLEEQLRGRRGEEQLWAEGQARF ********..*****::*****::**.********* *** :**.* ..* ***.** ENSMUSP00000073855/1-1561 AEEARSLRQQLDELNWSTALAEGERDALRRELLELQREGVEAGTARSRLDAELGAQRREL ENSRNOP00000046923/1-1557 AEEARSLRQQLDELSWSTALAEGERDALRRELLDLQREGLEASTARGRLDAELEAQRREL ENSP00000336775/1-1564 AEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQREL ENSCPOP00000003367/1-1215 AEEARGLRAQLDALSWETALAEGERDA-------LQRLGAEERAARGRLDAELHAQHHEL XP_004852760.1/1-1247 AEEARGLRAQLDALSWETALAEGERDALRRELRELRRLGAEESAARGRLDAELVAQRREL *****.** *** *.* ********** *:* . * :**.****** **::** ENSMUSP00000073855/1-1561 EEALGARAALEALLGRLETERRDLDAAHERQVRDLRARAASLTMHFRARATSPAAPPPRL ENSRNOP00000046923/1-1557 EEALGARAALEALLGRLEAERRDLDAAHERQVRELRARASSLTMHFRARATGPAAPPPRL ENSP00000336775/1-1564 QEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRL ENSCPOP00000003367/1-1215 QEALGAQAALEALLGQLQAERRDLEAVHQRDVRELRERAASLTMHYQL----------RL XP_004852760.1/1-1247 QEALGARAALEAVLGRLQAERHGLDAARERAVRELRARASALTVHFRARAR-PAAPPPRL :*****:*****:**:*::**:.*:*.::* **:** **::**:*:: ** ENSMUSP00000073855/1-1561 RDVHDSYALLVAESWRESVQLYEDEVRELEQALRRGQESRLQAEDEARLCAQEADALRNQ ENSRNOP00000046923/1-1557 RDVHDSYALLVAESWRESMQLYEDEVRELEQALRRGQESRLQAEDEARLCAQEADALRNQ ENSP00000336775/1-1564 REVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEA-ALRRE ENSCPOP00000003367/1-1215 REVHDSYALLVAESWQETVQLYEDEVRELEEALRRGQESRREAEEEVRLCAQEAEALQRQ XP_004852760.1/1-1247 RELHGSCALLAAESWRESVQLYEDEVRELELALRRGQESRREAEEEARRGAQEAESLQRQ *::*.* ***.****:*::*********** ********* :**:*.* **** :*:.: ENSMUSP00000073855/1-1561 ALELEQLRARLEDELLRMREEYGMQAEERQRVIDSLEDEKEALTLAMADRLRDYQELLQV ENSRNOP00000046923/1-1557 ALELEQLRARLEDELLRMREEYGMQAEERQRVIDSLEDEKDALTLAMADRLREYQELLQV ENSP00000336775/1-1564 ALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV ENSCPOP00000003367/1-1215 ALELAQLRARLEDELRRMHEEYDLQADERQRLISCLEDEKEALTLAMAERLRDYQELVQV XP_004852760.1/1-1247 ALELEQLRVRLEEELRRLREEHGLRAEERQRVIDCLEDEKEALTLAMAERLRDYQELVRV ** * ***.***: * *::**:.::*:****:*..***** :******: **:**:*::* ENSMUSP00000073855/1-1561 KTGLSLEVATYRALLEGESNPEILIWTENIENVPQEPRNTSYRYTNSVLQRKNEKNLFPR ENSRNOP00000046923/1-1557 KTGLSLEVATYRALLEGESNPEILIWTENIENVPRESRNTSYRYTDSVLQRKNEKNLFPR ENSP00000336775/1-1564 KTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSR ENSCPOP00000003367/1-1215 KTGLSLEVATYRALLEGESNPEILIWTEEIENRPQDFRTTSYQYTDSILQRKNEKNLFPK XP_004852760.1/1-1247 KTGLSLEVATYRALLEGESNPEILIWTEHIEDVPQDFRNTSYRYTDSVSQ-KNERNLFPK ***********************:**:*.:*: * : *..**:**:*: * :**:***.: ENSMUSP00000073855/1-1561 RKTPWAAVNHSSASYSNWPGHLDSQTTTAVGSAARRGLLTSRHSSSATTSGQQKPLEKTI ENSRNOP00000046923/1-1557 RKTPWAAVNHSSTLYSNGPGHLDSQTTTAVGNAARRGFLTSCYSSSATTS-QQKPLEKTV ENSP00000336775/1-1564 QKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQ-QENSYGKAV ENSCPOP00000003367/1-1215 QKAPWLGFRHSSTVYSN--GPVGAQTGTSVGSPARRGFLSVGCSTSATTR-HEAIHEKTV XP_004852760.1/1-1247 QKAPFVALNHSSTAYSN--GYLGSQTTMPIGNTARRGFLASRYSASATTR-HKDVYEKTV :*:* ...***: *** * .:** .:*. ****:* *:**** :: *:: ENSMUSP00000073855/1-1561 SSRANLRPVTPTHGFLRNTDAQMKTLPHRSKVEGTGDTHARRATESVITRESYRGHQGHV ENSRNOP00000046923/1-1557 SSQASLRPVIPTHGFLRNTDAQVKTFSHGPKAEGMGDTLTRRATESVITRESYRGHQGNV ENSP00000336775/1-1564 SSQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKV ENSCPOP00000003367/1-1215 NSHTDFRTFSPARGLVRNTDAQAKTFPDRPKIEGTRDAPTPLPKGSTVTQESYRDRWDNV XP_004852760.1/1-1247 NSQTNFQTFSPTRGLVRNTDAQVRTFPDRAKTVVTSDAPMYLTKGSTVIQESCRDRWDSV .*::..:.. *: *::***:** :*:.. .* :. *.: :** *.: . * ENSMUSP00000073855/1-1561 AAGAVSSTPSNERTVILGKKLEAQATKEQERDRSGVIRIKPEEKMFDSKEKASEERNLRW ENSRNOP00000046923/1-1557 AAGAVNSTQSNERTVILGKKLETQATKEQERDRSGVVKLKPEEKMFDSKEKASEERNLRW ENSP00000336775/1-1564 AAGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRW ENSCPOP00000003367/1-1215 RAGASESTQSTEGTVTWGKKREAQATEEQERDRLRTIKMKPEEKMFDSKEKASEERNLRW XP_004852760.1/1-1247 TADASESTRSNERTIILQKKIEAKATREQESDRSGPIKMKPEEKMFDSKEKASEERNLRW *.* .** *.* *: ** *.:**.*** :* :: ********************* ENSMUSP00000073855/1-1561 EELTKLDRDARKRESRHLRDEAREKEALKERSVKEREVPISLEVSRGSRAEVSTIHLQSP ENSRNOP00000046923/1-1557 EELTKLD--ARERESQHLRNEAKGKETLTGRSRKEREVPISLEVSRGSKSEVSTIHLQSS ENSP00000336775/1-1564 EELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTP ENSCPOP00000003367/1-1215 EELTKLD-----------RERDKGQEPLQEKSVKERAVPIDVEAPQSNRSERFPRDIQMT XP_004852760.1/1-1247 EELTKLDKEARKRESQQMRGQAKGQESLKEKTVKDKEIPISLEVSQGSRSEVSPKDIQTP ******* : . : ::. :: ::: :**.:*..:. ::* . :* . ENSMUSP00000073855/1-1561 GRKDVSHSGGREAETKETRFRLDTQDTASSLQSDSTTETIAESIVTTILKQFTQSPGAEE ENSRNOP00000046923/1-1557 GRKDSANSREREVKTKETKFHLDGKDTAGSLQSDSTTETIAENIVTTILKQFTQSPGAEE ENSP00000336775/1-1564 -VKDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEA ENSCPOP00000003367/1-1215 GKKDSGVSTGSKAVTKETRFRLDTTDTAGVLQGDSTTETIAENIVTSILQHFTQSPEGGT XP_004852760.1/1-1247 RKKAAGDSKGSKAAARETRFRLDTSDTASALQGDSMTETIAENIVTSILKQFSQSPEEEA * . . :. ::* :*:*. *::. **.** ***:**.***:**::*:*** ENSMUSP00000073855/1-1561 EATSFPDTKVTYVDRKEFPG-DGKTKTEIVVESKLTDVVDVSDEAGLDYLLSKDVKEVGL ENSRNOP00000046923/1-1557 NVSSLPDTKVTYLDRKEFPG-DRKTKTEIVMESKLTEDVDVSDEAGLDYLLSKDVKEVGL ENSP00000336775/1-1564 SADSFPDTKVTYVDRKELPG-ERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGL ENSCPOP00000003367/1-1215 SASSFPDTKVTYMDRKELPG-ESTTKTEIIVESKLTEDIDVSDEARLDYLLSKEVKEVDL XP_004852760.1/1-1247 SANSFPDTKVTYVDRKELPGEERTTKTEIVVESKLTEDIDVSDEASLEYLLSKDVKEVGL .. *:*******:****:** : .*****::*****: :****** *:*****::***.* ENSMUSP00000073855/1-1561 KGKSTETMIGEMINLGLKGREGRAKVVNVEIVEEPMSYIGGGKI-DFSTPFQVEEVDDVS ENSRNOP00000046923/1-1557 KGKSTETVIGEMINLGLKGREGRAKVVNVEIVEEPMSYVGGGKV-EFSTPFQVEEVDDVS ENSP00000336775/1-1564 KGKSAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVS ENSCPOP00000003367/1-1215 KGKSAEKMIGDIINLGLKGREGRAKVVNVEIVEEPMSYVGGRRMEEFSTPFRVEEVEDVS XP_004852760.1/1-1247 KGKSAEQMIGDIINLGLKGREGRAKVVNVEIVEEPMSYVGGRKTEELSSPFQVEEVDDVS ****:* :**::***********************:**:.* : ::* **:****:*** ENSMUSP00000073855/1-1561 PSPKGFVEEEDGEGETHMAFSMRPHQ-TKQPQGTIPHVEEVTEAGDSEGEQSYFVSTPDE ENSRNOP00000046923/1-1557 PSPKGFIEEEEGEGETHMAFSMHQRQRTNQPQVNVPHVEEVTEAGDSEGEQSYFVSTPDE ENSP00000336775/1-1564 PGPWGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDE ENSCPOP00000003367/1-1215 PGSRVLVEEEEGDGQAP---DANRHQRTKQPQENITRVEEVTEAGDSEGEQSYFVSTPDE XP_004852760.1/1-1247 PGSRGLVEEEERDGESHVTFSVNQHQRTKQPGENVTHAEEVSEAGDSEGDQSYFVSTPDE *.. :::**: *:: . . :: *:** . .:.***:*******:********** ENSMUSP00000073855/1-1561 YPGGHDREDDGSVYGQIHIEEESTIRYSWQDEIAQGTWRRKMRGDVGGEKPVKVLEVPAL ENSRNOP00000046923/1-1557 YPGGHDREDDGSVYGQIHIEEESTIRYSWQDEIAQGTWRRKARGDTGEEKHMKVLEVPSA ENSP00000336775/1-1564 HPGGHDR-DDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAP ENSCPOP00000003367/1-1215 YTAGPDREEEGSVYGQIHIEEESTIRYSWQDEIVQGTWRKRNRDSQAGEKDVKDVDVPAR XP_004852760.1/1-1247 LPAGHDREDEGSVYGQIHIEEESTIRYSWQDEIVQGTWRRRQRDSEAGERDVQDVDVPAH ..* ** ::***********************.*** *: :.. *: :: ::**: ENSMUSP00000073855/1-1561 SLGGAIGSAHLKEEA-SGELRAEPTVIEKEIKIPHEFHTSIKGVFSSEPRHQLVEVIGQL ENSRNOP00000046923/1-1557 SLGGAFGSAHVKEEA-SGELHAEPTIIEKEIKIPHEFHTSIKGVFSSEPRHQLVEVIGQL ENSP00000336775/1-1564 SLEGDLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQL ENSCPOP00000003367/1-1215 SVGADVGSAHWKEEA-SGEFHAEPTVIEKEIKIPHEFHTSMKDISSKEPREQLAEVIGKL XP_004852760.1/1-1247 SPGGDMGSAHWKEEA-SGEFHAEPTVIEKEIKIPHELHTSIRDTFSKEPREQLAEVIGKL * . .**:* **:* ***::****:**********:***::. *.***.**.****:* ENSMUSP00000073855/1-1561 EETLPERMKEELSALTRQSQGESGSVSVDVKKVQSAAGGSVTLMAEVNLSQTVDADQLDL ENSRNOP00000046923/1-1557 EETLPERMKEELSALTRQSQGEPGSVSVDVKKVQSSAGGSVTLMAEVNLSQTVDADQLDL ENSP00000336775/1-1564 EETLPERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDL ENSCPOP00000003367/1-1215 EETLPERMKEELSALTREGQGEPGGISVDVKKLQSADSSSVTLVAEVNLSQTVDADQIDL XP_004852760.1/1-1247 EETLPERMKAELSTLTREGQGEPGSVSVDVKKLQTTGGSSVTLVAEVNLSQTVDADQLDL ********: ***:***:.** .*.:******:* : ..****:****:*******::** ENSMUSP00000073855/1-1561 EQLSRDEAGEIERAVESVVRESLAKRSSPVPRSPDREDGEEVPAGGILFKRWATRELYSP ENSRNOP00000046923/1-1557 EELSRDEAGEIEKAVESVVRESLTKRSSPVPRSPDREDGEEAPAGGFLFKRWATRELYSP ENSP00000336775/1-1564 EELSKDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIP ENSCPOP00000003367/1-1215 EELSRDEADEIERAVESVVRESLTRRHGRAPGSPDREDGVEVPAGGIQFKRWATRELYNP XP_004852760.1/1-1247 EGLSRDEADEIEKAVESVVRESLSKRQGQAPGSPDREDG------GVSFKRWATRELYGT * **:***.*:*:**********::: . .* ***.*.* *. *:******** . ENSMUSP00000073855/1-1561 SGERDDAGQVSPSSDQRVTQGPVSATVEVTSPTGFVQSHVLEDVSQSVRHVKLGPTEMWR ENSRNOP00000046923/1-1557 SGEKDDTDRVFHSSDQRVTQGPVSATVEVTSPTGFVQSHVLEDVSQSVRHVKLGPTEMWR ENSP00000336775/1-1564 SGESEVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWR ENSCPOP00000003367/1-1215 AGERDDAGQ-----EEPTVQGPVSATVEVSSPRGFMQSHVLEEQNQSVRHIKLGPTEIWR XP_004852760.1/1-1247 AGEGNDAGQASGSPEEPTAQGPVSATVEVSSPRGFMQSHVLEDLSQSVRHIRLGPTEVWR :** : :. : . **********:** ** **:***: .*:.**::***:*:** ENSMUSP00000073855/1-1561 TEQVTFGGPTAQVVEVS--GDFSEAVSSEGASRSVRHITLGPHQSQVSTEVIFRGSVPTW ENSRNOP00000046923/1-1557 TEQVSYGGPTSPVVEVS--EDFSEAVSSEGASRSVRHVTLGPRQNRVSTEVIFRGSVPTG ENSP00000336775/1-1564 TERMSYEGPTAEVVEVSAGGDLSQAASPTGASRSVRHVTLGPGQSPLSREVIFLGPAPAC ENSCPOP00000003367/1-1215 TEQVSFGGPTAQVVE--------------------------------------------- XP_004852760.1/1-1247 TEQVPHRGPTGEVVE--------------------------------------------- **::.. ***. *** ENSMUSP00000073855/1-1561 QETGDTEKPGPVVLSVGADISGSGRMPGSERSHTEKEIRFQGPVSGTAQVGGNFATEESV ENSRNOP00000046923/1-1557 QETGDTGEPDPAALSVEADISGSGRMPGSQQAHNEKETPFPGPISGAAQVGSNFSTEGSV ENSP00000336775/1-1564 PEAWGSPEPGPAESSADMDGSGRHSTFGCRQFHAEKEIIFQGPISAAGKVGDYFATEESV ENSCPOP00000003367/1-1215 ------------------------------------------------------------ XP_004852760.1/1-1247 ------------------------------------------------------------ ENSMUSP00000073855/1-1561 GSQTFVRSLQLGPKEGFREEIQFIAPIPDKVGWGE-EDSEHTKVSLERATSIQRIDIVPQ ENSRNOP00000046923/1-1557 GTQTFVRHLQLGSREGFREEIQFIAPIPDRAEWGE-EDSGYTRVSLGRSTSIQHIDIVPQ ENSP00000336775/1-1564 GTQTSVRQLQLGPKEGFSGQIQFTAPLSDKVELGVIGDSVHMEGLPGSSTSIRHISIGPQ ENSCPOP00000003367/1-1215 ------------------------------------------------------------ XP_004852760.1/1-1247 ------------------------------------------------------------ ENSMUSP00000073855/1-1561 RYLASKQM-----APQTLEFRDSEDMVMVEGSAGTIQATHNFTSDREILQNKENTFQRVI ENSRNOP00000046923/1-1557 RYQASKQV-----APQTLGFRDSEGVVLVERSAGMTQATHNFTSDREILKKEENTFQRVI ENSP00000336775/1-1564 RHQTTQQIVYHGLVPQLGESGDSESTVHGEGSADVHQATHSHTSGRQTVMTEKSTFQSVV ENSCPOP00000003367/1-1215 ------------------------------------------------------------ XP_004852760.1/1-1247 ------------------------------------------------------------ ENSMUSP00000073855/1-1561 SGSPPDSVGD--TGAEVTANVSRSFRHIQIGPTEEEPSEYFVTGRPVSKTFVLDGSVASP ENSRNOP00000046923/1-1557 SGSPPDSVGD--TGAEVTENISRSFRHIQIGPTEEDPSEYIVTSGPLSKTFVLDSSVASP ENSP00000336775/1-1564 SESPQEDSAEDTSGAEMTSGVSRSFRHIRLGPTETETSEHIAIRGPVSRTFVLAGSADSP ENSCPOP00000003367/1-1215 ------------------------------------------------------------ XP_004852760.1/1-1247 ------------------------------------------------------------ ENSMUSP00000073855/1-1561 GLVGGADGGSTPCRIALGPKETSFTFQMDLSDTRAIRSWTRDTGSEVEAHGVSHRGGWRI ENSRNOP00000046923/1-1557 GPGGGADGSSTPCHIALGPKETSFTFQMGVSDTRAIRSWTRDTGSEVEAHSVSHHGGWRV ENSP00000336775/1-1564 ELGKLADSSRTLRHIAPGPKETSFTFQMDVSNVEAIRSRTQEAG----ALGVSDRGSWRD ENSCPOP00000003367/1-1215 ---------------------------MDVSSRKATPTWTQEAGAEAEAHSA-----WGA XP_004852760.1/1-1247 ---------------------------MDVSSRKAAPTWTQEAGTEAEAHSVSDHGAWRD *.:*. .* : *:::* * .. * ENSMUSP00000073855/1-1561 AHSRDERVASTGSGASPGDAHQAPGEKGTEQAGFDKTVQLQRMVDQRSVASDEKKVALLY ENSRNOP00000046923/1-1557 AHSRDEQSASTSSQASAGDAHQARGEKGTEQAGFDKTVQLQRMVDQRSVASDEKKVALLY ENSP00000336775/1-1564 ADSRNDQAVGVSFKASAGEGDQAHREQGKEQAMFDKKVQLQRMVDQRSVISDEKKVALLY ENSCPOP00000003367/1-1215 ADSRKDLAAGVSSQASAVDRGQTHREEGTEQAEFDKTVQLQRMVDQRSVVSDEKKVALLY XP_004852760.1/1-1247 AGSRKDWAAGVSAQASASD--EAHQEEGTEQARFDKTVQLQRMVDQRSVISDEKKVALLY * **.: .... **. : :: *:*.*** ***.************ ********** ENSMUSP00000073855/1-1561 LDNEEEEEEEGEG-WF ENSRNOP00000046923/1-1557 LDN--EEEEEGEG-WF ENSP00000336775/1-1564 LDN---EEEENDGHWF ENSCPOP00000003367/1-1215 LDS---EEEESDGHWF XP_004852760.1/1-1247 LDS---EEEEGDGQWF **. ****.:* **