CLUSTAL W(1.81) multiple sequence alignment ENSP00000005286/1-1024 MCARMAGRTTAAPRGPYGPWLCLLVALALDVVRVDCGQAPLDPVYLPAALELLDAPEHFR ENSMUSP00000025645/1-1018 ----MTERKAAAPRGPYGAWFCLLVALALEVVRVSSNHDTLDPIYLPVALELLDAPEHFR ENSRNOP00000037012/1-1021 ----MTERAAAAPRGPYGAWLCLLVALALEVVRVGSNQDTLDPIYLPVALELLDAPEHFR ENSCPOP00000003275/1-991 -----ARGPMAAPRRA---PLCLLVALVLDTTRAHSGWD----VYLPATLELLDAPEYFR XP_004874330.1/1-1002 ---------MAGPRGT---ALCLLVALALDAFRVHGDLDT--AVYLPAALELLDAPEHFL *.** . :******.*:. *. . :***.:********:* ENSP00000005286/1-1024 VQQVGHYPPANSSLSSRSETFLLLQPWPRAQPLLRASYPPFATQQVVPPRVTEPHQRPVP ENSMUSP00000025645/1-1018 VQQVGHYPPANSSLASRSETFLLMQPWPRAQPLLRASYPPFATQQVVPPRVTEPHRRPVP ENSRNOP00000037012/1-1021 VQQVGHYPPANSSLGSRSETFLLMQPWPRAQPLLRASYPPFATQQVVPPRVTEPHRRPVP ENSCPOP00000003275/1-991 AQQLGHYPPVNSSLGSRSETFLLLHPWPRAQPLFRASYPPFTTQQVVPPRATEPLHRPVP XP_004874330.1/1-1002 VQRASHYAPANSSLGSRSETFLLLHPWPRAQPLLRASYPPFATQQVVPPRATEPPQRPVP .*: .**.*.****.********::********:*******:********.*** :**** ENSP00000005286/1-1024 WDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGSGSLPCARLHATHPAGTAHQACRFQPS ENSMUSP00000025645/1-1018 WDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGPGSLPCARLHATHPAGTAHRACRFQPS ENSRNOP00000037012/1-1021 WDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGPGSLPCARLHATHPAGTAHQACRFQPS ENSCPOP00000003275/1-991 WDVRAVSVEATVTPAKPHARVLFHLKGQDWPPGPGSLPCARLYAMHPEGTAHRACRVQPA XP_004874330.1/1-1002 WDVRAVSVEAAVTPAEPHARVVFHLRGQDWPPGPSSLPCARLYATHPAGTTQRACRFQPA **********:****:*:***:***:*******..*******:* ** **:::***.**: ENSP00000005286/1-1024 LGACVVELELPSHWFSQASTTRAELAYTLEPAAEGPGGCGSGEENDPGEQALPVGGVELR ENSMUSP00000025645/1-1018 LGACVVELQFPSHWFSQSATTRAELAYTLEPAGEGPGGCGLGTEEEPREQALPVGGVELH ENSRNOP00000037012/1-1021 LGACVVELEFPSQWFSQSATTRAELAYTLEPAGEGPGGCGPGTEEEPKEQALPVGSVELH ENSCPOP00000003275/1-991 LGACVVELELPAPWFSWGTSSRAALAYTLEPTAEGPGGCAPGGDEDPGQQAFPVDSVELR XP_004874330.1/1-1002 LGACAVELALPAPWFSGGAPSRAELAYALEPATEGPGGCAPGRDEDLGQRALPVGSVELR ****.*** :*: *** .:.:** ***:***: ******. * ::: ::*:**..***: ENSP00000005286/1-1024 PADPPQYQEVPLDEAVTLRVPDMPVRPGQLFSATLLLRHNFTASLLTLRIKVKKGLHVTA ENSMUSP00000025645/1-1018 PEDPPQYQEVPLDEAVTLRAPDVPMRPGQLFTATLLLRHNFTASLLTLRIKVKKGLQVIA ENSRNOP00000037012/1-1021 PEDPPQYQEVPLDEVVTLRAPDVPVRPGQLFTATLLLRHNFTASLLTLRIKVKKGLQVTA ENSCPOP00000003275/1-991 PEDPPQHQEVPLDEAVTLRVPDAPVRPGQPFTATVLLRHNFTASVLTLRIKVKKGLQVVA XP_004874330.1/1-1002 PEDPPQHREVPLDEAVTLRVPDAPVRPGQPFTSTLLLQRNFTASDLTLRVKVKKGLQVTA * ****::******.****.** *:**** *::*:**::***** ****:******:* * ENSP00000005286/1-1024 ARPAQPTLWTAKLDRFKGSRHHTTLITCHRAGLTEPDSSSPLELSEFLWVDFVVENSTGG ENSMUSP00000025645/1-1018 ARPAQPTLWTAKLDRFKGSKHHTSLITCHRAGPAGPD-SSPLELSEFLWVDFAVENSTGG ENSRNOP00000037012/1-1021 ARPAQPTFWTAKLDRFKGSKHHTSLITCHRTGPAGPD-SSPLELSEFLWVDFAVENSTGG ENSCPOP00000003275/1-991 ARPAQPMLWTATLDRVRGSKHHSTLITCQLLGPEGPDSSSSPELSEFLWVDFLVENGTGV XP_004874330.1/1-1002 ARPVQPALWTAKLDRVRGSKHHSTLITCHRAEFAGPD-PSVPEPSEFLWVDFLVENSTGG ***.** :***.***.:**:**::****: ** .* * ******** ***.** ENSP00000005286/1-1024 GVAVTRPVTWQLEYPGQAPEAEKDKMVWEILVSERDIRALIPLAKAEELVNTAPLTGVPQ ENSMUSP00000025645/1-1018 GVAVTRPVTWQLEYPGQAPEAEKDKMVWEILVSERDIRALIPLAKAEELVNTAPLTGVPQ ENSRNOP00000037012/1-1021 GVAVTRPVTWQLEYPGQAPEAEKDKMVWEILVSERDIRALIPLAKAEELVNTAPLTGVPQ ENSCPOP00000003275/1-991 GVAVTRPITWQLEYPGQAPDAEKDKMVWEILVSERDTRALVPLAKVEELVNTAPLTGHPG XP_004874330.1/1-1002 GVVVTRAVTWQLEYPGQAPAAEKDKMVWEILVSERDIRALVPLAKAEELVNTALLTGQPG **.***.:*********** **************** ***:****.******* *** * ENSP00000005286/1-1024 HVPVRLVTVDGGGALVEVTEHVGCESANTQVLQVSEACDAVFVAGKESRGARGVRVDFWW ENSMUSP00000025645/1-1018 RIPVRLVTVDSGGALEEVTEHIGCESANTQVLQVSEACDAVFVAGQESRGAKGVRVDFWW ENSRNOP00000037012/1-1021 RIPVRLVTVDSGGALEEVTEHIGCESANTQVLQVSEACDAVFVAGQESRGAKGVRVDFWW ENSCPOP00000003275/1-991 RIPVRLVTVDTGGVLAEVTEHIGCESANTQVLQVSEACDTVFVAGTESRGAKGVRVDFWW XP_004874330.1/1-1002 HVPVRLVTMDAGGVLAEVTEHIGCKSADTQVLQVSEACDALFVAGTESRGAKGVRVDFWW ::******:* **.* *****:**:**:***********::**** *****:******** ENSP00000005286/1-1024 RRLRASLRLTVWAPLLPLRIELTDTTLEQVRGWRVPGPAEGPAEPAAEASDEAERRARGC ENSMUSP00000025645/1-1018 RRLRASLKLTVWAPLLPLRIELTDTTLEQIRGWRVPGSAEGQLEPET-AAEEVERRSRGC ENSRNOP00000037012/1-1021 RRLRASLKLTVWAPLLPLRIELTDTTLEQIRGWRVPGPAEGQLEPEA-AAEEVERRSRGC ENSCPOP00000003275/1-991 RRLRASLLLTVWAPLLPLRIELSDATLEQVRGWRVPGPTDGALEPNP-AVEEAEPRSRSC XP_004874330.1/1-1002 RRLRASLRLTVWAPLLPLRIDLTDATLEQVRGWRVPGPADGTQEPEP--AEEAERRPRGC ******* ************:*:*:****:*******.::* ** . :*.* *.*.* ENSP00000005286/1-1024 HLQYQRAGVRFLAPFAAHPLDGGRRLTHLLGPDWLLDVSHLVAPHARVLDSRVASLEGGR ENSMUSP00000025645/1-1018 RLQYQRAGVRFLVPFAAHPLDGGRRLTHLLGPDWLLDVSHLVAAHAHVQDPRIASLEGGR ENSRNOP00000037012/1-1021 RLQYQRAGVRFLVPFAAHPLDGGRRLTHLLGPDWLLDVSHLVAAHAHVQDPRIATLEGGR ENSCPOP00000003275/1-991 RLLYQRASVRVLAPFAAHTQD-GRHLEHLLGPDWLLDVTDLVLPHAHVQDPRVASLEGGP XP_004874330.1/1-1002 RLLYQRAGVRVLAPFAAHAQDGGR-LTHLLGPDWLLDVTHLVAPHARVQDPRVASLEGGR :* ****.**.*.*****. * ** * ***********:.** .**:* *.*:*:**** ENSP00000005286/1-1024 VVVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELRVQPVMGISLTLSRGTAHPG ENSMUSP00000025645/1-1018 ILVGREPGVTSIEVRSPLSDAILGEQALAVTDDKVSVLDLRVQPVMGISLSLSRGMSHPG ENSRNOP00000037012/1-1021 ILVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLDLRVQPVMGISLSLSRGVSHPG ENSCPOP00000003275/1-991 VLVGREPGVTAIEVRSPLSGAILGEQALAVTDDKVSVLQLRVQPVMGISLALSRGTAHPG XP_004874330.1/1-1002 VLVGREPGVTAIEVRSPLSDAILGEQALAVTDDKVSVLDLRVQPVMGIALALSRGTAHPG ::********:********.:*****************:*********:*:**** :*** ENSP00000005286/1-1024 EVTATCWAQSALPAPKQEVALSLWLSFSDHTVAPAELYDRRDLGLSVSAEEPGAILPAEE ENSMUSP00000025645/1-1018 EVTATCWAQSALPAPKQEVALSLWLSFSDHTLAPAELYDRNDLGLSVSAEEPSAVLPAEE ENSRNOP00000037012/1-1021 EVTATCWAQSALPAPKQEVALSLWLSFSDHTLAPAELYDRNDLGLSVSAEEPSAVVPAEE ENSCPOP00000003275/1-991 EVTATCWAQSAVPGQKQEVALSLWLSFSDHTEAPAELYDRRDLGLSVSAEEPSAVLPTTE XP_004874330.1/1-1002 EVTATCWAQSAPPAPKQEVALSLWLSFSDRTMAPAELYDRRDLGLSISAEEPGAVLPATE *********** *. **************:* ********.*****:*****.*::*: * ENSP00000005286/1-1024 QGAQLGVVVSGAGAEGLPLHVALHPPEPCRRGRHRVPLASGTAWLGLPPASTPAPALPSS ENSMUSP00000025645/1-1018 QGAQLGVVVSGVGAEGLPLHVALHPPEPCRRGRHRVPLASGTAWLGLPPLPTPVPALPSS ENSRNOP00000037012/1-1021 QRAQLGVVVSGVGAEGLPLHVALHPPEPCRRGRHRVPLASGTAWLGLPPLPTPAPALPSS ENSCPOP00000003275/1-991 QGAWLGVLVSGVGAEALPLHVALHPPEPCRRGRHRVPLASGTAWLGLPPTPTPARALPSS XP_004874330.1/1-1002 RGTQLGVVVSGSGTEALPLHVALYPPEPCRRGRHQVPLASSTAWLGLPPTPMPAPALPPS : : ***:*** *:*.*******:**********:*****.******** . *. ***.* ENSP00000005286/1-1024 PAWSPPATEATMGGKRQVAGSVGGNT--GVRGKFERAEEEARKEETEAREEEEEEEEEMV ENSMUSP00000025645/1-1018 PVRTSPFTEATVEGKRQIAGDMGGHV--GIRGKFERAEEEAGKEENEAK-EEEEDEEEMV ENSRNOP00000037012/1-1021 PARTPPFTEASVEGKRQVAGDMGSHVGPGIRGKFERAEEEAGKEENEAK-EEEEDEEEMV ENSCPOP00000003275/1-991 PAWSPPATEASIGGKRQAAGGV------GVRGKFEQAEEDTA----------------MV XP_004874330.1/1-1002 PTWSPLATEASVGGRRRAAGSV------DVRGKFEQAGEDSKARGEDKDEDEEEEEEEMV *. :. ***:: *:*: **.: .:*****:* *:: ** ENSP00000005286/1-1024 PAPQHVTELELGMYALLGVFCVAIFIFLVNGVVFVLRYQRKEPPDSATDPTSPQPHNWVW ENSMUSP00000025645/1-1018 PAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQRKEPPDSATDPASPQPHNWVW ENSRNOP00000037012/1-1021 PAPQRVTDLELGMYALLGIFCLAFLIFLVNGVVFVLRYQRKEPPDSATDPASPQPHNWVW ENSCPOP00000003275/1-991 PAPQRITDLELGMYALLGIFCLAILIFLVNGVVFVLRYQRKEPPDSAADPASPQPHNWVW XP_004874330.1/1-1002 PAPQRVTDLELGMYALLGVFCLAILIFLVNGVVFVLRYQRKEPPDGAADPASPQPHNWVW ****::*:**********:**:*::********************.*:**:********* ENSP00000005286/1-1024 LGTDQEELSRQLDR-QSPGPPKGEGSCPCESGGGGEAPT----LAPGPPGGTTSSSSTLA ENSMUSP00000025645/1-1018 LGTNQEELSRQLDRCSSSGPPKGEGGCPCESGAGGDAST----VAPSASESPAGSSSTLA ENSRNOP00000037012/1-1021 LGTNQEELSRQLDRCSSSSPPKGEGGCPCESGAGGDTST----VAPSASESPAGSSSTLA ENSCPOP00000003275/1-991 LGTDQEELSRQLDR-GAPELPSREGSCPCGSGVGGEAQTPVPVPVPGLPGNTPGPTSTLT XP_004874330.1/1-1002 LGTDQEELSRQLDR-GAPELPGAEGSCPCGSGVAGEPQA----PAPGLPGDTPGSSSTLA ***:********** :. * **.*** ** .*:. : .*. . .....:***: ENSP00000005286/1-1024 RKEAGGRRKRVEFVTFAPAPPAQ-SPEEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEE ENSMUSP00000025645/1-1018 RKEAGGRRKRVEFVTFAPAPPTQ-PPEEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEE ENSRNOP00000037012/1-1021 RKEAGGRRKRVEFVTFAPAPPAQEVPEEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEE ENSCPOP00000003275/1-991 RKEAGGRRKRVEFVTFSPVPPAQ-LPEEPV---AVQSILVAGEEDIRWVCEDMGLKDPEE XP_004874330.1/1-1002 RKEVGGRRRRVEFVTFAPVPPAP-LPEEPAGPPTVQSILVAGEEDIRWVCEDMGLKDPEE ***.****:*******:*.**: ****. :************************** ENSP00000005286/1-1024 LRNYMERIRGSS ENSMUSP00000025645/1-1018 LRNYMERIRGSS ENSRNOP00000037012/1-1021 LRNYMERIRGSS ENSCPOP00000003275/1-991 LRNYMERIRGSS XP_004874330.1/1-1002 LRNYMERIRGSS ************