CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000067075/1-1111 MAEAGPPPARFPPARLPPAGSSRAGLPPTGSPPASTPALASQWLAVKRLPRAAAKAPNLQ ENSRNOP00000050503/1-1037 ------------------------------------------------------------ ENSCPOP00000003257/1-1001 ------------------------------------------------------------ ENSP00000359610/1-1070 --------------------------------------MPQAAASAPWTSVSCGRIPGLP XP_004862368.1/1-999 ------------------------------------------------------------ ENSMUSP00000067075/1-1111 LNQDHCSFVPFTQAVPVQVDMAMALHRVRIAEKYGKNYLCLLQAVFLAETGLLLQLKDIN ENSRNOP00000050503/1-1037 --------------------MAMALHRVRIAEKYGKNYLCLLQAVFLAETGLLLQLKDIN ENSCPOP00000003257/1-1001 ---------------------------------------CFLSFLFFTERELLFCVKDIS ENSP00000359610/1-1070 QNPDGCTFMPIAQAIPLQVDMAMALQRVRIAEKYGKNYLCLLQAVFVAETDLLLRIKDIS XP_004862368.1/1-999 ------------------------------------------------------------ ENSMUSP00000067075/1-1111 HFLMQDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLNYLTSIARQSGSDSRFTI ENSRNOP00000050503/1-1037 HFLMQDIAFLSGGRGRDNAWIITFPENCNFRCIPEEVIAKVLNYLTSIARQSGSDSRFTI ENSCPOP00000003257/1-1001 HFLMQNIAFLSGGRGKDNAWIITFPENCNFKCIPEEVIAKVLTYLTSIVRQNASDCQFTL ENSP00000359610/1-1070 HFLMQDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTI XP_004862368.1/1-999 ---MQDIAFLSGGRGKDNAWIITFPENCNFRCIPEEILAKVLTYLTSIVRQNGPDSQFTL **:*********:**************:*****::****.*****.**...*.:**: ENSMUSP00000067075/1-1111 ILDRRLDTWASLKISLQKISASFPGSLHLVLVLRPTSFLQRTFTDIGFRFSQEDFMLKLP ENSRNOP00000050503/1-1037 ILDRRMDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFRFSQEDFMLKLP ENSCPOP00000003257/1-1001 ILDRRLDTWSSLKISLQKISASFPGNLHLILVLRPTSFLQRTFTDIGFRFSQEDFMVKLP ENSP00000359610/1-1070 ILDRRLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLP XP_004862368.1/1-999 ILDRRLDTWSSLKISLQKISASFPGNLHLILVLRPTSFLQRTFTDIGFRFSQEDFLLKLP *****:***:***************.***:****************** ******::*** ENSMUSP00000067075/1-1111 VVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIEKFAVTVKEMAQMLQSFGT ENSRNOP00000050503/1-1037 VVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIEKFAVTVKEMAQMLQSFGT ENSCPOP00000003257/1-1001 VVMLSSVSDLLAYIDGKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGT ENSP00000359610/1-1070 VVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGT XP_004862368.1/1-999 VVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGT ***********:***.**************************:**:************** ENSMUSP00000067075/1-1111 ELAETELPQDILSIEEILAGRAERYHLLKNDLTAVTKEGKVLLMNLQVPATEETVSSSLE ENSRNOP00000050503/1-1037 ELAETELPDDIPSIEEILAGRAERYHLLKNDLTTVTKEGKVLLMNLQVPDTEENLSSSHE ENSCPOP00000003257/1-1001 ELAESELPNDIPSIEETLALRAERYHVLKNDITAVTKEGKVLLTNLEVPDAEEAASSSLE ENSP00000359610/1-1070 ELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLE XP_004862368.1/1-999 ELAETELPDDIPSIEKTLALHAERYHLLKNDITAVTKEGKILLTNLEVPNTEEAVSSRLE ****:***:** ***: ** :*****:****:*:******:** **:** :* ** * ENSMUSP00000067075/1-1111 CTQHINGDWQTIKKLLAQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQEAVTQVEFL ENSRNOP00000050503/1-1037 CPQHINGDWQTIKKLLAQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQEFQEVVTQVEFL ENSCPOP00000003257/1-1001 QHRNISGEWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWRFEQDFQELVTEVELL ENSP00000359610/1-1070 CHRQISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFL XP_004862368.1/1-999 RHRHISGNWQTVNKLLAQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQELVTEVELL ::*.*:***::***:***************************:***:**: **:**:* ENSMUSP00000067075/1-1111 LSQQRELGDITGNLAQVKQRLKKLEILDDKSQELLTKARIVILRGHKLASNHHYALDLIC ENSRNOP00000050503/1-1037 LSQQRELGDVTGNLAQVKQRLKKIEILDDKSQELLAKGRIVILHGHKLASNHHYALDLIC ENSCPOP00000003257/1-1001 LNQQAELGDVTGNI---------VESLDENSQKLLGKAQFLMLHGHQLASNHHYALDLIC ENSP00000359610/1-1070 LNQQAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLIC XP_004862368.1/1-999 LNQQAELGDVTGNIAQIKQKLKQLESLDENSQDLLAKAQFLILHGHRLAVNHHYALDLIC *.** **.*:**.: :* **::**.** *.::::*:**:** ********** ENSMUSP00000067075/1-1111 QRCNELRYLSDILVNEIRTKRVQLSRTFKVHRLLQQARQCCDQGECLLASQGMDKFQTKE ENSRNOP00000050503/1-1037 QRCNELRYLSDILVNEIRSKRIQLSRTFKMHRLLQQARQCCDQGECLLANRGMDKFQTKE ENSCPOP00000003257/1-1001 QRCNELRYLSDILASEMKSKQIQLSRTFNMHKLLQQARQCCDEGECLLANQEMDKFQSKE ENSP00000359610/1-1070 QRCNELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKE XP_004862368.1/1-999 QRCNELRYLSDILASEIKTKQIQLSRTFKMHKLLQQAHQCCDEGKCLLANQEIDKFQSKE *************..*:::*::******::*:*****:****:*:****.: :****:** ENSMUSP00000067075/1-1111 DAQKALQDVDNFLQMAMPFINYDIESLQYEFDVLLSPELKAQMQNIQLKLENIRSAFQNQ ENSRNOP00000050503/1-1037 DAQKALQDVDNFLQMAMPFINYDIENLQFEFDVLLSPELKAQMKNIQRKLENIRSVFENQ ENSCPOP00000003257/1-1001 EAQKALQDIENFLTMALPFINYDLESLQYEFDVFLSPELKVQMQAVQLKLENIRSIFENQ ENSP00000359610/1-1070 DAQKALQDIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQ XP_004862368.1/1-999 DAQKALQDIENFLEMALPFISYDLESLQYEFDIILSPELKIQIQTVQLKLENIRSIFETR :*******::*** **:***.*: *.**:***::****** *:: :* ******* *:.: ENSMUSP00000067075/1-1111 QAGCKSLKEVPEGAFQNLVPASENVMRSRMIFFSPKH----------------VK--KSW ENSRNOP00000050503/1-1037 QNAYKISKDRPEGAVQRMIPAPESVMRARTIFFSPKH----------------VK--KSW ENSCPOP00000003257/1-1001 QAGFRNTADKHGRPIQFVMPTPENAIIPRAPFFSPKP----------------GKKWKTW ENSP00000359610/1-1070 QAGFRNLADKHVRPIQFVVPTPENLVTSGTPFFSSKQ----------------GK--KTW XP_004862368.1/1-999 QAGFSNVTDKHVRPIQFVVPMPENVITSRVPFFSPKPVGVGYSFFQACKLFSKGK--KTW * . : ..* ::* .*. : . ***.* * *:* ENSMUSP00000067075/1-1111 RQIHAQSNVKVEAVEDSQEKNSDQSPKL---DNSLDILKNHVLNELIQTERAYVRELFTV ENSRNOP00000050503/1-1037 RQIQAQSNVKVQATQDSQEKNFDQPPKL---DSSLDILKNHVLNELIQTERAYVRELFTV ENSCPOP00000003257/1-1001 RQ--SQSNLKIEVVHDCQEKRSPGQPSSLDNDNNLDIIKRHVFNELIQTERVYVQELFAV ENSP00000359610/1-1070 RQ--NQSNLKIEVVPDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTV XP_004862368.1/1-999 RQ--NQSNLKIEVVHDCREKRSPRPSSSLDNDSSVAIIKKHVLNELIQTERVYVQELFTV ** ***:*::.. *.:**. .. ...: ::*.**:********.**:**::* ENSMUSP00000067075/1-1111 LLGYRSEMDNPQMFDLMPPLLRNKKDVLFGNMAEIYEFHNNIFMSRLEDCSDAPERVGPC ENSRNOP00000050503/1-1037 LLGYRSEMDNPQMFDLMPPLLRNKKDVLFGNMAEIYEFHNNIFMSRLEDCSDAPERVGPC ENSCPOP00000003257/1-1001 LLGYRAEMDNPEMFDLIPPVLRNKKDVLFGNMTEIYEFHSNIFIGSLENCSQVPERVASC ENSP00000359610/1-1070 LLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPC XP_004862368.1/1-999 LLGYRAEMDNPEMFDLMPPLLRNKKDVLFGNMAEIYEFHNNIFMSSLENCSDAPERVGPC *****:*****:****:**:******:*****:******.:**:. **:*:..****..* ENSMUSP00000067075/1-1111 FLERKDDFQMYAKYCQNKPRSELIWRKYSECAFFQECQRKLKHRLGLDSYLLKPVQRITK ENSRNOP00000050503/1-1037 FLERKEDFQMYAKYCQNKPRSELIWRKYSECAFFQECQRKLKHRLGLDSYLLKPVQRITK ENSCPOP00000003257/1-1001 FLERKNDFHIYAKYCQNKPSGESRVIKWILCMFFKERQRKLNHRLGLDSYLLKPVQRITK ENSP00000359610/1-1070 FLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITK XP_004862368.1/1-999 FLERKDDFQIYAKYCQNKPRSEAIWKKYSECAFFKERQRKLNHRLGLDSYLLKPVQRITK *****:**::********* .* *: * **:* ****:*** ************** ENSMUSP00000067075/1-1111 YQLLLKELLKYSKEGEGTTKLKEALDSMLELLKSVNDSMHQTAINGYVGNINELGKMVLQ ENSRNOP00000050503/1-1037 YQLLLKELLKYSKEGEGTTKLKEALDSMLELLKSVNDSMHQTAINGYVGNMNDLGKMILQ ENSCPOP00000003257/1-1001 YQLLLKELLKYSRDSEGSSQLQEALDTMLDLLKYVNDSMYQISINGYVGNLNDLGKMVLQ ENSP00000359610/1-1070 YQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQ XP_004862368.1/1-999 YQLLLKELLKYSKDSEGSTQLQEALDTMLALLKSVNDSMHQIAINGYIGNLSELGKMIMQ ************:: **:: *::***:** *** *****:* :****:**:.:****::* ENSMUSP00000067075/1-1111 GSFNVWLGHRKGATKMKDFARFKPMQRHLFLYEKAVMFCKRRFESGEGADRYPSYSFKHC ENSRNOP00000050503/1-1037 GAFSVWVGHRKGATKMKDFARFKPMQRHLFLYEKAVMFCKRRFESGEGADRYPSYSFKHC ENSCPOP00000003257/1-1001 GGFSVWIGHRKGATKMKDFARFKPMQRHLFLYEKAVIFCKRRNESGEGMEKYPSYSFKHC ENSP00000359610/1-1070 GGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHC XP_004862368.1/1-999 GGFSVWIGHRKGATKMKDFARFKPMQRHLFLYEKAIVFCKRRTETGEGSDRYPSYSFKHC *.*.**:**:********:****************::***** *:*** ::********* ENSMUSP00000067075/1-1111 LKMEDVGITEHVKGDNRKFEIRYSEKEEIYIVQAPNVDVKMLWLKEIRKILVQQKELMT- ENSRNOP00000050503/1-1037 LKMEEAGITEHVKGDNRKFEIWYGEKEEIYIVQAPNIDVKMLWLKEIRNILLKQQELLT- ENSCPOP00000003257/1-1001 LKMDEVGITEYVKGDNRKFEIWYGGKEEVYIIQAPNVDVKMSWLKEIRNILLKQQELMTE ENSP00000359610/1-1070 WKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLT- XP_004862368.1/1-999 LKMDEVGITEYVKGDNRKFEIWYGGKEEVYIVQAPNVDVKMSWLKEIRNILLKQQELMT- **::.****:********** *. ***:**:**.*:**** ******:**::*:**:* ENSMUSP00000067075/1-1111 --AKTQQDQALDQD--QLFPQQQNAELCKSSPFCVC------EETLFNATEAGAEVEQAG ENSRNOP00000050503/1-1037 --AKTQQDQLSDQD--QLPPQQQNAELCKSSPIFVCHSFRKQEETLLNAVEAGAEVEQAS ENSCPOP00000003257/1-1001 IIKKMQQDQVTERD--QLSAGQNDEK----------------HQAAFVSVEE-AESEHTG ENSP00000359610/1-1070 VKKRKQQDQLTERDKFQISLQQNDEK----------------QQGAFISTEE-TELEHTS XP_004862368.1/1-999 VKKQMQQDQLTEQD--QLSPQQNDEK----------------PQAAFVSVEE-TETEHTG : **** ::* *: *:: : : : :.* :* *::. ENSMUSP00000067075/1-1111 ALIKVREAAVLAQAEASSAAWNGMLPSAEGAAAIAEHSYNYFSSNNDHGE--DRTQMRHM ENSRNOP00000050503/1-1037 AMMEVREAALLVQAEANCTTWNGMLPCTEGTAATAEHPCNSLSPNSDNGE--DRSQMRSM ENSCPOP00000003257/1-1001 AVVQGSETSVPVQAEAS-AVWPEKSQSAENPEEPEEWANNYFYSAYAGNEEGDTPLLRSV ENSP00000359610/1-1070 TVVEVCEAIASVQAEAN-TVWTEASQSAEISEEPAEWSSNYFYPTYDENEEENRPLMRPV XP_004862368.1/1-999 AMVEGSETIVSVQAEAN-AVWPEKSQSAENPEEPEEWPSNYFYSTFDGNEEGNRTLMRPV :::: *: .****. :.* .:* . * . * : . .* : . :* : ENSMUSP00000067075/1-1111 SEVTF-- ENSRNOP00000050503/1-1037 SEVQF-- ENSCPOP00000003257/1-1001 SDVALLY ENSP00000359610/1-1070 SEMALLY XP_004862368.1/1-999 SDMAVLY *:: .