CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000003238/1-1512 MATLCLTVNAGAPP------------------LEALLTAEHVKGDVSISVEEGKENILRV XP_004867452.1/1-1511 MATLCLTVNAGAPP------------------LEALLAAEHVKEDVSISVEGGKENVLRV ENSP00000355890/1-1512 MATLSLTVNSGDPP------------------LGALLAVEHVKDDVSISVEEGKENILHV ENSMUSP00000045841/1-1512 MAALCLTVNAGNPP------------------LEALLAVEHVKGDVSISVEEGKENLLRV ENSRNOP00000033323/1-1486 MAALCLTVNAGNPPLGCRVKVNKRNKSFMLSFLEALLAVEHVKGDVSISVEEGKENLLRV **:*.****:* ** * ***:.**** ******* ****:*:* ENSCPOP00000003238/1-1512 SENVAFADINSILRYLARVATTAGLYGANLMEHAEIDHWLEFSATKLSSCDLFTSAIDEL XP_004867452.1/1-1511 SENVAFTDVYSILRYLARVAATAGLYGANVMEHAEIDHWLEFSATKLASCASFASAVNEL ENSP00000355890/1-1512 SENVIFTDVNSILRYLARVATTAGLYGSNLMEHTEIDHWLEFSATKLSSCDSFTSTINEL ENSMUSP00000045841/1-1512 SETVAFTDVNSILRYLARIATTSGLYGTNLMEHTEIDHWLEFSATKLSSCDRLTSAINEL ENSRNOP00000033323/1-1486 SESVVFTDTNSILRYLARVAATSGLYGSNLMEHTEIDHWLEFSATKLSSCDVLTSAIKEL **.* *:* ********:*:*:****:*:***:*************:** ::*::.** ENSCPOP00000003238/1-1512 NHCLSLRTFLVGNSLTLADFCVWATLKGSAAWQEESKQSKGPVHVRRWFSFLEAQQAFQS XP_004867452.1/1-1511 NHCLSLRTFLVGNSLTLADFCVWAALKGNAAWQEEATQSKGPVHVKRWFSFLEAQRVFQS ENSP00000355890/1-1512 NHCLSLRTYLVGNSLSLADLCVWATLKGNAAWQEQLKQKKAPVHVKRWFGFLEAQQAFQS ENSMUSP00000045841/1-1512 NHCLSLRTYLVGNSLTLADLCVWATLKGSAAWQEHLKQNKTLVHVKRWFGFLEAQQAFRS ENSRNOP00000033323/1-1486 NHCLSLRTYLVGNSLTLADLCVWATLKGNAACQEHLRQSKTLVHVNRWYGFLEAQQAFRS ********:******:***:****:***.** **. *.* ***.**:.*****:.*:* ENSCPOP00000003238/1-1512 VSAKWGIAANKARVAPEKKQDIGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQ XP_004867452.1/1-1511 VSAKWGVPASKTQAASEKKQDVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQ ENSP00000355890/1-1512 VGTKWDVSTTKARVAPEKKQDVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQ ENSMUSP00000045841/1-1512 VGTKWDVSGNRATVAPDKKQDVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQ ENSRNOP00000033323/1-1486 VGTKWDASANKATGAPDRKQDIGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQ *.:**. . .:: *.::***:************************************** ENSCPOP00000003238/1-1512 HYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQFTYTSDHFETIMKYAEK XP_004867452.1/1-1511 HYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQFTYTSDHFETIMKYAEK ENSP00000355890/1-1512 HYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQFTYTSDHFETIMKYAEK ENSMUSP00000045841/1-1512 HYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQFTYTSDHFETIMKYAEK ENSRNOP00000033323/1-1486 HYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQFTYTSDHFETIMKYAEK ************************************************************ ENSCPOP00000003238/1-1512 LIKEGKAYVDDTPAEQMKAEREQRVESRHRNNSVEKNLQMWEEMKKGSQFGQSCCLRAKI XP_004867452.1/1-1511 LIKEGKAYVDDTPAEQMKAEREQRVESRHRSNSVEKNLQMWEEMKKGSQFGQSCCLRAKI ENSP00000355890/1-1512 LIQEGKAYVDDTPAEQMKAEREQRIDSKHRKNPIEKNLQMWEEMKKGSQFGQSCCLRAKI ENSMUSP00000045841/1-1512 LIQEGKAYVDDTPAEQMKAEREQRTESKHRKNSVEKNLQMWEEMKKGSQFGQSCCLRAKI ENSRNOP00000033323/1-1486 LIEEGKAYVDDTPADEMKAE------------PVEKNLQMWEEMKRGSQFGQSCCLRAKI **:***********::**** .:***********:************** ENSCPOP00000003238/1-1512 DMSSNNGCMRDPTLYRCKIQPHPRTGSRYNIYPTYDFACPIVDSIEGVTHALRTTEYHDR XP_004867452.1/1-1511 DMSSNNGCMRDPTLYRCKIQPHPRTGSRYNVYPTYDFACPIVDSIEGVTHALRTTEYHDR ENSP00000355890/1-1512 DMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTYDFACPIVDSIEGVTHALRTTEYHDR ENSMUSP00000045841/1-1512 DMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTYDFACPIVDSIEGVTHALRTTEYHDR ENSRNOP00000033323/1-1486 DMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTYDFACPIVDSIEGVTHALRTTEYHDR **************************.:**:***************************** ENSCPOP00000003238/1-1512 DEQFYWIIEALGIRKPYIWEYSRLNLNNTVLSKRKLTWFVNEGLVDGWDDPRFPTVRGVL XP_004867452.1/1-1511 DEQFYWVIEALGIRKPYIWEYSRLNLNNTVLSKRKLTWFVHEGLVDGWDDPRFPTVRGVL ENSP00000355890/1-1512 DEQFYWIIEALGIRKPYIWEYSRLNLNNTVLSKRKLTWFVNEGLVDGWDDPRFPTVRGVL ENSMUSP00000045841/1-1512 DEQFYWIIEALGIRKPYIWEYSRLNLNNTVLSKRKLTWFVNEGLVDGWDDPRFPTVRGVL ENSRNOP00000033323/1-1486 DEQFYWIIEALGIRKPYIWEYSRLNLNNTVLSKRKLTWFVNEGL---------------- ******:*********************************:*** ENSCPOP00000003238/1-1512 RRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEAVPVNIPE XP_004867452.1/1-1511 RRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVVPVLVPE ENSP00000355890/1-1512 RRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVIPVNVPE ENSMUSP00000045841/1-1512 RRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVVPVNVLD ENSRNOP00000033323/1-1486 ----------------GSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVIPVNILD ************************************.:** : : ENSCPOP00000003238/1-1512 AQEEMKEVARHPKNPEVGLKPVWYSSRVLIEGADAQTLAEGETVTFINWGNISITSIHKN XP_004867452.1/1-1511 VQEEMKEAARHPKNPEVGLKPVWYSPRVLIEGADAETLTEGETVTFINWGNISITKIHRN ENSP00000355890/1-1512 AQEEMKEVAKHPKNPEVGLKPVWYSPKVFIEGADAETFSEGEMVTFINWGNLNITKIHKN ENSMUSP00000045841/1-1512 AQEEMKEVARHPKNPDVGLKPVWYSPKVFIEGADAETFSEGEMVTFINWGNINITKIHKN ENSRNOP00000033323/1-1486 AQEEMKEVARHPKNPDVGLKPVWYSPKVFIEGADAETFSEGEMVTFINWGNINITKIHKN .******.*:*****:*********.:*:******:*::*** ********:.**.**:* ENSCPOP00000003238/1-1512 ADGKIVSLDGKLNLENKDYKKTTKITWLAETTRALPTPTICVTYEHLITKPVLGKDEDFK XP_004867452.1/1-1511 ADGKIVSLDGKLNLENKDYKKTTKITWLAETAQALPVPTICVTYEHLITKPVLGKDEDFK ENSP00000355890/1-1512 ADGKIISLDAKLNLENKDYKKTTKVTWLAETTHALPIPVICVTYEHLITKPVLGKDEDFK ENSMUSP00000045841/1-1512 ADGKITSLDAKLNLENKDYKKTTKITWLAESTHALSIPAVCVTYEHLITKPVLGKDEDFK ENSRNOP00000033323/1-1486 PDGKITSLDAKLNLENKDYKKTTKITWLAETTQALPVPAVCVTYEHLITKPVLGKDEDFK .**** ***.**************:*****:::**. *.:******************** ENSCPOP00000003238/1-1512 QYVNKNSKREELMLGDPCLKDLKKGDIIQLQRRGFFICDEPYEPTSPYSCKEAPCVLIYI XP_004867452.1/1-1511 QYINKNSKREELMLGDPCLKDLKKGDIIQLQRRGFFICDQPYEPVSPYSCKEAPCILIYI ENSP00000355890/1-1512 QYVNKNSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICDQPYEPVSPYSCKEAPCVLIYI ENSMUSP00000045841/1-1512 QYINKDSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICDQPYEPVSPYSCREAPCILIYI ENSRNOP00000033323/1-1486 QYVNKDSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICDQPYEPVSPYSCKEAPCILIYI **:**:**:******************************:****.*****:****:**** ENSCPOP00000003238/1-1512 PDGHTKEMPTSGSKEKTKGEATKTEQDKLFRNMSLPPVNKSGASSEDPLVLHKRVAAQGD XP_004867452.1/1-1511 PDGHTKEMPTSGSKEKTKGEATKTEMSPSLKERPAPPVYKSWAPSEDFLVLYNRVATQGD ENSP00000355890/1-1512 PDGHTKEMPTSGSKEKTKVEATKNETSAPFKERPTPSLNNNCTTSEDSLVLYNRVAVQGD ENSMUSP00000045841/1-1512 PDGHTKEMPTSGSKEKTKVEISKKETSSAPKERPAPAVSSTCATAEDSSVLYSRVAVQGD ENSRNOP00000033323/1-1486 PDGHTKEMPTSGSKEKTKVEISKKETGSAPKERPAAAVSAPCAAAEDAAILYSRVAVQGD ****************** * :*.* . :: . ..: :.:** :*:.***.*** ENSCPOP00000003238/1-1512 MVRELKAKKAAKEDIDAAVKQLLALKAEYKEKTGQEYKPGHPPAAGAQDVSCRSLATVQE XP_004867452.1/1-1511 TVRELKARKAAKEDIDAAVKQLLALKAEYKEMTGQEYKPGSPPAAGAQEAASQSPAAALE ENSP00000355890/1-1512 VVRELKAKKAPKEDVDAAVKQLLSLKAEYKEKTGQEYKPGNPPAEIGQNISSNSSASILE ENSMUSP00000045841/1-1512 VVRELKAKKAPKEDIDAAVKQLLTLKAEYKEKTGQEYKPGNPSAAAVQTVSTKSSSNTVE ENSRNOP00000033323/1-1486 AVRDLKAKKAPKEDIDAAVKQLLTLKAEYKEKTGQEYRPGNPPTAAVQTVSTKSPSNTGE **:***:**.***:********:******* *****:** *.: * : .* : * ENSCPOP00000003238/1-1512 SRSLYDKVAVQGELVRKLKAEKALKAKINEAVECLLSLKAEYKAKTGKEYVPGQPPSAVS XP_004867452.1/1-1511 SRSLYDRVAAQGELVRKLKAEKALKAKINQAVECLLSLKAEYKEKTGKEYVPGQPPAP-S ENSP00000355890/1-1512 SKSLYDEVAAQGEVVRKLKAEKSPKAKINEAVECLLSLKAQYKEKTGKEYIPGQPPLSQS ENSMUSP00000045841/1-1512 STSLYNKVAAQGEVVRKLKAEKAPKAKVTEAVECLLSLKAEYKEKTGKDYVPGQPPASQN ENSRNOP00000033323/1-1486 YTSLYNKVAAQGELVRKLKAEKAPKAKINDAVECLLSLKAEYKEKTGKEYVPGQLPASQN ***:.**.***:********: ***:.:**********:** ****:*:*** * . . ENSCPOP00000003238/1-1512 SEARPAGSCEPAGPESLEARALYDRVAAQGEAVRKLKAEEAPADQVDAAVQVLLQLKAQY XP_004867452.1/1-1511 SKSSPAGDRESSGPEAPEAQVLFARVAAQGEVVRKLKAEKASKDQVDPAVQVLLQLKAQY ENSP00000355890/1-1512 SDSSPTRNSEPAGLETPEAKVLFDKVASQGEVVRKLKTEKAPKDQVDIAVQELLQLKAQY ENSMUSP00000045841/1-1512 SHSNPVSNAQPAGAEKPEAKVLFDRVACQGEVVRKLKAEKASKDQVDSAVQELLQLKAQY ENSRNOP00000033323/1-1486 SHSSPVSNAKPVGSETPEAKLLFDRVACQGEVVRKLKAEKASKDQVDSAVQELLQLKAQY *.: *. . :. * * **: *: :**.***.*****:*:*. **** *** ******** ENSCPOP00000003238/1-1512 KALAGVEYKPVSATGAEDRGKKKKEKENKSEKQNKPQTPNGSHGKDSSKSQGSGLAPSGA XP_004867452.1/1-1511 KALAGVEYKPVSATGADDRDKKKKDKENKSEKQNKPQKAHDGHGKEPFNSQGSGPTPGGA ENSP00000355890/1-1512 KSLIGVEYKPVSATGAEDKDKKKKEKENKSEKQNKPQKQNDGQRKDPSKNQGGGLSSSGA ENSMUSP00000045841/1-1512 KSLTGIEYKPVSATGAEDKDKKKKEKENKSEKQNKPQKQNDGQGKDSSKSQGSGLSSGGA ENSRNOP00000033323/1-1486 KSLTGIEYKPVSATGAEDKDKKKKEKENKSEKQNKPQKQNDGQGKDSSKSQGSGLSSGGA *:* *:**********:*:.****:************. :..: *:. :.**.* :..** ENSCPOP00000003238/1-1512 GEGQGPKKQTRLGLEAKKEENLADWYSQVITKSEMIEYYDVSGCYILRPWAYSIWESIKA XP_004867452.1/1-1511 GEGQGPRKQTRLGLEAKKEENLADWYSQVITKSEMIEYYDVSGCYILRPWAYSIWESIKA ENSP00000355890/1-1512 GEGQGPKKQTRLGLEAKKEENLADWYSQVITKSEMIEYHDISGCYILRPWAYAIWEAIKD ENSMUSP00000045841/1-1512 GEGQGPKKQTRLGLEAKKEENLAEWYSQVITKSEMIEYYDVSGCYILRPWSYSIWESIKD ENSRNOP00000033323/1-1486 GEGQGPKKQTRLGLEAKKEENLAEWYSQVITKSEMIEYYDVSGCYILRPWSYSIWESIKD ******:****************:**************:*:*********:*:***:** ENSCPOP00000003238/1-1512 FFDAEIKKLGVENCYFPIFVSQSALEKEKTHIADFAPEVAWVTRSGKTELAEPIAIRPTS XP_004867452.1/1-1511 FFDAEIKKLGVENCYFPIFVSQSALEKEKTHVADFAPEVAWVTRSGKTELAEPIAIRPTS ENSP00000355890/1-1512 FFDAEIKKLGVENCYFPMFVSQSALEKEKTHVADFAPEVAWVTRSGKTELAEPIAIRPTS ENSMUSP00000045841/1-1512 FFDAEIKKLGVENCYFPIFVSQAALEKEKNHIEDFAPEVAWVTRSGKTELAEPIAIRPTS ENSRNOP00000033323/1-1486 FFDAEIKKLGVENCYFPIFVSQGALEKEKNHIADFAPEVAWVTRSGKTELAEPIAIRPTS *****************:****.******.*: *************************** ENSCPOP00000003238/1-1512 ETVMYPTYAKWVQSHRDLPIRLNQWCNVVRWEFKHPQPFLRTREFLWQEGHSAFATFEEA XP_004867452.1/1-1511 ETVMYPAYAKWVQSHRDLPIRLNQWCNVVRWEFKHPQPFLRTREFLWQEGHSAFATFEEA ENSP00000355890/1-1512 ETVMYPAYAKWVQSHRDLPIKLNQWCNVVRWEFKHPQPFLRTREFLWQEGHSAFATMEEA ENSMUSP00000045841/1-1512 ETVMYPAYAKWVQSHRDLPVRLNQWCNVVRWEFKHPQPFLRTREFLWQEGHSAFATFEEA ENSRNOP00000033323/1-1486 ETVMYPAYAKWVQSHRDLPIRLNQWCNVVRWEFKHPQPFLRTREFLWQEGHSAFATFEEA ******:************::***********************************:*** ENSCPOP00000003238/1-1512 AEEVMQILELYARVYEELLAIPVVRGRKTEKEKFAGGDYTTTVEAFISASGRAIQGGTSH XP_004867452.1/1-1511 AEEVLQILELYTRVYEELLAIPVVKGRKTEKEKFAGGDYTTTVEAFISASGRAIQGATSH ENSP00000355890/1-1512 AEEVLQILDLYAQVYEELLAIPVVKGRKTEKEKFAGGDYTTTIEAFISASGRAIQGGTSH ENSMUSP00000045841/1-1512 ADEVLQILELYARVYEELLAIPVVRGRKTEKEKFAGGDYTTTIEAFISASGRAIQGATSH ENSRNOP00000033323/1-1486 ADEVLQILELYARVYEELLAIPVVRGRKTEKEKFAGGDYTTTLEAFISASGRAIQGATSH *:**:***:**::***********:*****************:*************.*** ENSCPOP00000003238/1-1512 HLGQNFSKMCEIIFEDPKSPGEKQFAYQCSWGLTTRTIGVMVMVHGDNTGLVLPPRVAAI XP_004867452.1/1-1511 HLGQNFSKMCEIVFEDPKTPGEKQFAYQCSWGLTTRTIGVMVMVHGDNTGLVLPPRVASV ENSP00000355890/1-1512 HLGQNFSKMFEIVFEDPKIPGEKQFAYQNSWGLTTRTIGVMTMVHGDNMGLVLPPRVACV ENSMUSP00000045841/1-1512 HLGQNFSKMCEIVFEDPKTPGEKQFAYQCSWGLTTRTIGVMVMVHGDNMGLVLPPRVASV ENSRNOP00000033323/1-1486 HLGQNFSKMCEIVFEDPKTPGEKQFAYQCSWGLTTRTIGVMIMVHGDNMGLVLPPRVASV ********* **:***** ********* ************ ****** *********.: ENSCPOP00000003238/1-1512 QVVIIPCGITNALSEEDKEALLAKCEDYRRRLLGADVRARVDLRENYSPGWKFNHWELKG XP_004867452.1/1-1511 QVVVIPCGITNALSEGDREALMVKCSDYCRRLLGADIRTRVDLRDNYSPGWKFNHWELKG ENSP00000355890/1-1512 QVVIIPCGITNALSEEDKEALIAKCNDYRRRLLSVNIRVRADLRDNYSPGWKFNHWELKG ENSMUSP00000045841/1-1512 QVVVIPCGITNALSEEDREALMAKCNEYRRRLLGANIRVRVDLRDNYSPGWKFNHWELKG ENSRNOP00000033323/1-1486 QVVVIPCGITNTLSEEDREALMAKCNEYRRRLLGADIRARVDLRDNYSPGWKFNHWELKG ***:*******:*** *:***:.**.:* ****..::*.*.***:*************** ENSCPOP00000003238/1-1512 VPIRLEVGPRDMKSCQFVAVRRDTGEKLTVAESEAEPRLQAMLEEIQAHLFQRALEDLKT XP_004867452.1/1-1511 VPIRLEVGPRDMKSCQFVAVRRDTGEKLTIAESEAEAKLEALLEDIHASLFRRASEDLKT ENSP00000355890/1-1512 VPIRLEVGPRDMKSCQFVAVRRDTGEKLTVAENEAETKLQAILEDIQVTLFTRASEDLKT ENSMUSP00000045841/1-1512 VPVRLEVGPRDMKSCQFVAVRRDTGEKLTIAEKEAEAKLEKVLEDIQLNLFTRASEDLKT ENSRNOP00000033323/1-1486 VPVRLEVGPRDMKSCQFVAVRRDTGEKLTIAEKEAESKLKGVLEDIQLNLFTRASEDLKS **:**************************:**.***.:*: :**:*: ** ** ****: ENSCPOP00000003238/1-1512 HMVVVNTMEDFQKTLDAGKIAQIPFCGEIECEDWIKKTTARDQDLEPGAPSMGAKSLCIP XP_004867452.1/1-1511 HMVVADTMEDFQKTLDAGKVAQIPFCGEIDCEDWIKKTTTRDQDLEPGAPSMGAKSLCIP ENSP00000355890/1-1512 HMVVANTMEDFQKILDSGKIVQIPFCGEIDCEDWIKKTTARDQDLEPGAPSMGAKSLCIP ENSMUSP00000045841/1-1512 HMVVSNTLEDFQKVLDAGKVAQIPFCGEIDCEDWIKKMTARDQDVEPGAPSMGAKSLCIP ENSRNOP00000033323/1-1486 HMVVSDTLEDFQKVLDSGKVAQIPFCGEIDCEDWIKKTTARDQDVEPGAPSMGAKSLCIP **** :*:***** **:**:.********:******* *:****:*************** ENSCPOP00000003238/1-1512 FQPLQELPPGARCVCSRNPAKFYTLFGRSY XP_004867452.1/1-1511 FRPLQELQPGARCVCGKNPAKFYTLFGRSY ENSP00000355890/1-1512 FKPLCELQPGAKCVCGKNPAKYYTLFGRSY ENSMUSP00000045841/1-1512 FNPLCELQPGAMCVCGKNPAKFYTLFGRSY ENSRNOP00000033323/1-1486 FNPLCELQPGAMCVCGKNPAKFYTLFGRSY *.** ** *** ***.:****:********