CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000131842/1-1503 MKPEPRTLPPSPNWYCSRCSDAAPGGIFGFAARTSVFLVRVGPGAGASPGAPPFRVVGEL ENSRNOP00000050493/1-1497 MKPEPRTLPPSPNWYCARCSDAAPGGIFGFAARTSVFLVRVGPGAGASPGAPPFRVVGEL ENSP00000285873/1-1508 MGQEPRTLPPSPNWYCARCSDAVPGGLFGFAARTSVFLVRVGPGAGESPGTPPFRVIGEL ENSCPOP00000003133/1-1519 MGPEPQTLPPSPNWYCTRCSDAVPGGLFGFAARTSVFLVRVGPGAGATAGTPPFRVIGEL XP_004836563.1/1-1509 MGPEPQTLPPSPNWYCTRSSDAVPGGLFGFAARTSVFLVCVGPGAGAIPGMPPFRVVGEL * **:**********:*.***.***:************ ****** .* *****:*** ENSMUSP00000131842/1-1503 VGHTERVSGFTFSHHPGQYNLCATSSDDGTVKVWDVETKTVVTEHTLHQHTISALHWSPT ENSRNOP00000050493/1-1497 VGHTERVSGFTFSHHPGQYNLCATSSDDGTVKIWDVETKAVVTEHALHQHTISALHWSPT ENSP00000285873/1-1508 VGHTERVSGFTFSHHPGQYNLCATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWSPR ENSCPOP00000003133/1-1519 VGHTERVSGFTFSHHPGQYNLCATSSDDGTVKIWDVETKTVVTEHALHQHTIAALHWSPR XP_004836563.1/1-1509 VGHTERVSGFTFSHHPGQYNLCATSSDDGTVKIWDVETKTVVTEHALHQHTISALHWSPQ ********************************:******:*****:******::***** ENSMUSP00000131842/1-1503 VKDLIVSGDEKGVVFCYWLNRNDSQHLFTEPRTIFCLTCSPHHENLVAIGYKDGIVVIID ENSRNOP00000050493/1-1497 VKDLIVSGDEKGVVFCYWLNRSDSQHLFTEPRAIFCLTCSPHHENLVAIGYKDGIVIIID ENSP00000285873/1-1508 VKDLIVSGDEKGVVFCYWFNRNDSQHLFIEPRTIFCLTCSPHHEDLVAIGYKDGIVVIID ENSCPOP00000003133/1-1519 VKDLIVSGDEKGVVFCYWINRNDSQRLFVEPRTIFCLTCSPHHEDLVAIGYKDGIVVIID XP_004836563.1/1-1509 VKDLIVSGDEKGVVFCYWINRNDSQRLFIEPRTIFCLTCSPHHEDLVAIGYKDGMVVIID ******************:**.***:** ***:***********:*********:*:*** ENSMUSP00000131842/1-1503 ISKKGEVIHRLRGHDDEIHSIAWCPLSGEDCLSISQEENSEEPDIPNGKLIAETPITKGC ENSRNOP00000050493/1-1497 ISKKGEVVHRLRGHDDEIHSIAWCPLSGEDCLSINQEENSEEPDIPNGKLIAETPITKGC ENSP00000285873/1-1508 ISKKGEVIHRLRGHDDEIHSIAWCPLPGEDCLSINQEETSEEAEITNGNAVAQAPVTKGC ENSCPOP00000003133/1-1519 ISKKGEVIHRLRGHDDEIHSIVWCPLPGEDCLSVNQEENSEEPEIPNEKVTPPTTEAKGC XP_004836563.1/1-1509 ISKKGEVIHRLRGHDDEIHSIAWCPLPGEDCLSINQEENSEEPEITNGKVTTQTPEAKGC *******:*************.****.******:.***.***.:*.* : . :. :*** ENSMUSP00000131842/1-1503 YLATGSKDQTIRIWSCSRGRGVMVLKLPFLKRRSGGVDPTVKERLWLTLHWPKNQPTQLV ENSRNOP00000050493/1-1497 YLATGSKDQTIRIWSCSRGRGVMVLKLPFLKRRSGGVDPTVKERLWLTLHWPKNQPTQLV ENSP00000285873/1-1508 YLATGSKDQTIRIWSCSRGRGVMILKLPFLKRRGGGIDPTVKERLWLTLHWPSNQPTQLV ENSCPOP00000003133/1-1519 YLATGSKDQTVRIWSCARGRGVMTLKIPFLKRRGGGVDPTVKERLWLTLYWPKNQPTQLV XP_004836563.1/1-1509 YLATGSKDQTIRIWSCARGRGVVLLKIPFLKRRGGGVDPTVKERLWLTLYWPKNQPTQLV **********:*****:*****: **:******.**:************:**.******* ENSMUSP00000131842/1-1503 SSCFGGELLLWDLTQSWRRKYTLFSTSAEGHNHSRIVFNLCSLKTEDGKQLLLSTSMDRD ENSRNOP00000050493/1-1497 SSCFGGELLLWDLTQSWRRKYTLFSTSAEGHNHSRIVFNLCPLKTEDGKQLLLSTSMDRD ENSP00000285873/1-1508 SSCFGGELLQWDLTQSWRRKYTLFSASSEGQNHSRIVFNLCPLQTEDDKQLLLSTSMDRD ENSCPOP00000003133/1-1519 SSCFGGELLLWDLTQSWRRKYTLFSAS-EGQNHSRIVFNLCPLQTEDEKQLLLSTSMDRD XP_004836563.1/1-1509 SSCFGGELLLWDLTQSWRRKYTLFSAS-EGQNHSRIVFNLCPLQTEDDKHLLLSTSMDRD ********* ***************:* **:**********.*:*** *:********** ENSMUSP00000131842/1-1503 VKCWDMATLECCWTLPSLGGFAYSLAFSPVDVGSLAIGVGDGMIRVWNTLSIKNNYDVKN ENSRNOP00000050493/1-1497 VKCWDMATLECCWTLPSLGGFAYSLAFSPVDVGSLAIGVGDGMIRVWNTLSIKNNYDVKN ENSP00000285873/1-1508 VKCWDIATLECSWTLPSLGGFAYSLAFSSVDIGSLAIGVGDGMIRVWNTLSIKNNYDVKN ENSCPOP00000003133/1-1519 VKCWDMTTLECCWTLPSLGGFAYSLAFSPEDTGYLAVGVGDGMIRVWNTASQKNNYDVKN XP_004836563.1/1-1509 VKCWDMTTLECCWTLPSLGGFAYSLAFSPEDTGYLAIGVGDGMIRVWNTSSKKNNYDVKN *****::****.****************. * * **:************ * ******** ENSMUSP00000131842/1-1503 FWQGVKSKVTALCWHPNKEGCLAFGTDDGKVGLYDTCSNKPPQISSTYHKKTVYRLAWGP ENSRNOP00000050493/1-1497 FWQGVKSKVTALCWHPNKEGCLAFGTDDGKVGLYDTCSNKPPQISSTYHKKTVYRLAWGP ENSP00000285873/1-1508 FWQGVKSKVTALCWHPTKEGCLAFGTDDGKVGLYDTYSNKPPQISSTYHKKTVYTLAWGP ENSCPOP00000003133/1-1519 FWQGVKSKVTALCWHPKKEHCLAFGTDDGKVGLYDTYSNKPPQISSTYHKKTVYTLAWGP XP_004836563.1/1-1509 FWQGVKSKVTALCWHPKKEHCLAFGTDDGKVGLYDTYSNKPPQISSTYHKKTVYTLAWGP ****************.** **************** ***************** ***** ENSMUSP00000131842/1-1503 PVPPMSLGGEGDRPSLTLYSCGGEGVVLQHNPWKLSGEAFDINKLVRDTNSIRYKLPVHT ENSRNOP00000050493/1-1497 PVPPMSLGGEGDRPSLTLYSCGGEGIVLQHNPWKLSGEAFDINKLMRDTNSIRYKLPVHT ENSP00000285873/1-1508 PVPPMSLGGEGDRPSLALYSCGGEGIVLQHNPWKLSGEAFDINKLIRDTNSIKYKLPVHT ENSCPOP00000003133/1-1519 PVPPMSLEGEGDRPSFTLYSCGGEGIVLQHHPWRFSGEAFDINKLIRDTNAVKYKLPVHT XP_004836563.1/1-1509 PVPPMSLGGEGDRPSFTLYSCGGEGIVFQHNPWKFGGEAFDINKLIRDTNAIKNKLPVHT ******* *******::********:*:**:**::.*********:****::: ****** ENSMUSP00000131842/1-1503 EISWKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVWHHEHGSRPELSCLL ENSRNOP00000050493/1-1497 EISWKGDGKVMALGNEDGSIEIFQVPNLKLLCTIQQHHKLVNAIVWHHEHGSRPELSCLL ENSP00000285873/1-1508 EISWKADGKIMALGNEDGSIEIFQIPNLKLICTIQQHHKLVNTISWHHEHGSQPELSYLM ENSCPOP00000003133/1-1519 DISWKADGKFMALGNEDGSIEIFQVPNLKLMCTIQQHHKLLNTMSWHHEHGSQPELSYLL XP_004836563.1/1-1509 EISWKADGKFMALGNEDGSIEIFQGPKLKLMCSIQQHHKLLNTMSWHHEHGSQPELSYLL :****.***.:************* *:*:*:*:*******:*:: *******:**** *: ENSMUSP00000131842/1-1503 ASGSNNAVIYVHNLKAVLESNPESPITITEPYRTLSGHTAKITSLAWSPHHDGRLVSACY ENSRNOP00000050493/1-1497 ASGSNNAVIYVHNLKAVLESNPESPITITEPYRTLSGHTAKVTSLAWSPHHDGRLVSACY ENSP00000285873/1-1508 ASGSNNAVIYVHNLKTVIESSPESPVTITEPYRTLSGHTAKITSVAWSPHHDGRLVSASY ENSCPOP00000003133/1-1519 ASGSNNAVIYVHNLKTVLESSSESPVTITEPFRTLSGHTAKITCLAWSPHHDGILVSASY XP_004836563.1/1-1509 ASGSNNAVIYVHNLKTVLEAKPESPVTITEPFLTLSGHTAKITCLAWSPHHDGILVSASY ***************:*:*:..***:*****: ********:*.:******** ****.* ENSMUSP00000131842/1-1503 DGTAQVWDALREEPLFNFRGHRGRLLCVAWSPVDPECIYSGADDFCVYRWLTSMQDHSRP ENSRNOP00000050493/1-1497 DGTAQVWDALREEPLFNFRGHRGRLLCVAWSPVDPECIYSGADDFCVYRWLTSMQDHSRP ENSP00000285873/1-1508 DGTAQVWDALREEPLCNFRGHRGRLLCVAWSPLDPDCIYSGADDFCVHKWLTSMQDHSRP ENSCPOP00000003133/1-1519 DGTAQVWDTLREQPLHNFRGHRGRLLCVVWSPLEPECIYSGADDFCVYRWLPSAQDHSRP XP_004836563.1/1-1509 DGTAQVWDTLREQPLHNFRGHRGRLLCVVWSPLDPECIYSGADDFCVYRWLPSTQAHSRP ********:***:** ************.***::*:***********::**.* * **** ENSMUSP00000131842/1-1503 PQGKKCIELEKKRLSQFKPKLKKKKKPTLRLPVKQDSSVGNEDESVKENSGPAENGLSDQ ENSRNOP00000050493/1-1497 PQGKKCIELEKKRLSQFKPKLKKKKKPTLRLPIKQDSSIGNEDESVRENLAPVENGLSDQ ENSP00000285873/1-1508 PQGKKSIELEKKRLSQPKAKPKKKKKPTLRTPVKLESIDGNEEESMKENSGPVENGVSDQ ENSCPOP00000003133/1-1519 PQGKKGIELEKKRLSQPKPKPKKKKKPTSQVPVKQESFEGNEEENTKENAVPVENGVSDP XP_004836563.1/1-1509 PQGKKSIELEKKRLSQPKPKPKKKKKPTSQMPVKQESFEGNEEESTKENTAPVENGLSDQ ***** ********** *.* ******* : *:* :* ***:*. :** *.***:** ENSMUSP00000131842/1-1503 DGEEEAQEPELP--PSPVVCVEPVSCTDICSGFEKSKVTV-SSKATSLKKEPAKEKPEAL ENSRNOP00000050493/1-1497 DGEEEAQEPELP--PSPVVCGEPVSCTAVSLGLEKSKVTV-TSKVASLKKEPPKEKPEAL ENSP00000285873/1-1508 EGEEQAREPELPCGLAPAVSREPVICTPVSSGFEKSKVTI-NNKVILLKKEPPKEKPETL ENSCPOP00000003133/1-1519 ECEEEAQELEMP--FSLLIPKEPVVYTQISSSCEKSKAIINNNKITVLKKEPPKEKPEAL XP_004836563.1/1-1509 EGEEE--EEEAPRALTPTVPREPVLCTPISSSCEKSKATI-NNKIAVLKKEPPKEKPEAL : **: * * * : : *** * :. . ****. : ..* *****.*****:* ENSMUSP00000131842/1-1503 LKKRKARSMLPLSTSLDHRSKEELHRDCLVLATATHAK-------AELNEDVSADLEERF ENSRNOP00000050493/1-1497 LKKRKARSMLPLSTSLDHRSKEELHRDCLVLATATHAR-------AELHEDVSADLEERF ENSP00000285873/1-1508 IKKRKARSLLPLSTSLDHRSKEELHQDCLVLATAKHSR--------ELNEDVSADVEERF ENSCPOP00000003133/1-1519 MKKRKARSMLPLSTSLDHRSKEELHHDCLVLATAKHATVLCHCKLTELNKDLSADLEDRF XP_004836563.1/1-1509 MKRRKARSMLPLSTSLDHRSKEELHHDCLVLATAKHSK-------AELSEDVSADLEERF :*:*****:****************:********.*: ** :*:***:*:** ENSMUSP00000131842/1-1503 HLGLFTDRATLYRMMETEGKGHLESGHPELFHQLMLWKGDLKGVLQAAAERGELTDSLVA ENSRNOP00000050493/1-1497 HLGLFTDRAALYRMMETEGKGHLESGHPELFHQLMLWKGDLKGVLQAAAERGELTDSLVA ENSP00000285873/1-1508 HLGLFTDRATLYRMIDIEGKGHLENGHPELFHQLMLWKGDLKGVLQTAAERGELTDNLVA ENSCPOP00000003133/1-1519 HLGLFTDRDTLYRMIETEGKGHLENGHPELFHQLMLWKGDLQGVLQTAAERGELTDNLVA XP_004836563.1/1-1509 HLGLFSDRDTLYRMIETEGKGHLENGHPELFHQLMLWKGDLQGVLQTAAERGELTDNLVA *****:** :****:: *******.****************:****:*********.*** ENSMUSP00000131842/1-1503 VAPVAGYSVWLWAVEAFAKQLCFQDQYVKAASYLLSIHKVYEAVELLKSNHLYREAIAVA ENSRNOP00000050493/1-1497 VAPVAGYSVWLWAVEAFAKQLCFQDQYVKAASYLLSIHRVYEAVELLRSNHLYREAIAVA ENSP00000285873/1-1508 MAPAAGYHVWLWAVEAFAKQLCFQDQYVKAASHLLSIHKVYEAVELLKSNHFYREAIAIA ENSCPOP00000003133/1-1519 MAPVAGYHVWLWAVEAFAKQLCFQDQYVKAASHLLSIHKVYEAVELLKSHHFYREAIAVA XP_004836563.1/1-1509 MAPVAGYHVWLWAVEAFAKQLCFQDQYVKAASHLLSIHKVYEAVELLKSNHFYREAIAVA :**.*** ************************:*****:********:*:*:******:* ENSMUSP00000131842/1-1503 KARLRPEDPVLKELYLSWGSILERDGHYAIAAKCYLGATSAYDAAKVLARKGDAASLRTA ENSRNOP00000050493/1-1497 KARLRPEDPVLKDLYLSWGSILERDGHYAIAAKCYLGATSAYDAAKVLARKGDAASLRTA ENSP00000285873/1-1508 KARLRPEDPVLKDLYLSWGTVLERDGHYAVAAKCYLGATCAYDAAKVLAKKGDAASLRTA ENSCPOP00000003133/1-1519 KARLRPEDPVLKDLYLSWGAILERDGHYAVAAKCYLGATSPFDAAKVLAKKGDAASLRTA XP_004836563.1/1-1509 KARLRPEDPVLKELYLGWGTTLERDGHYAVAAKCYLGATSPYDAAKVLAKKGDAASLRTA ************:***.**: ********:*********..:*******:********** ENSMUSP00000131842/1-1503 AELAAIAGEHELAASLALRCAQELLLMKNWVGAQEALGLHESLQGQRLVFCLLELLCRHL ENSRNOP00000050493/1-1497 AELAAIAGESELAASLALRCAQELLLLKNWVGAQEALGLHESLQGQRLVFCLLELLCRHL ENSP00000285873/1-1508 AELAAIVGEDELSASLALRCAQELLLANNWVGAQEALQLHESLQGQRLVFCLLELLSRHL ENSCPOP00000003133/1-1519 AELAAITGENELSVLLALRCAQELLLTKNWVGAQEALQLHGSLQGQRLVFCLLELLCRHL XP_004836563.1/1-1509 AELAAIAGENELAASLALRCAQELLLVKNWVGAQEALQLHGSLQGQRLVFCLLELLCWHL ******.** **:. *********** :********* ** ***************. ** ENSMUSP00000131842/1-1503 EEKQPLEVRGPSSIYHQWATGSEGTLVQRVTGVWRSAFSVDTPEQCQAALQKLQDVKYPS ENSRNOP00000050493/1-1497 EEKQPPEVRGPSSIYHQWATGSEGTLVQRVTGVWRSAFSVDTPEQCRAALQKLQDVKYPS ENSP00000285873/1-1508 EEKQLSEGK-SSSSYHTWNTGTEGPFVERVTAVWKSIFSLDTPEQYQEAFQKLQNIKYPS ENSCPOP00000003133/1-1519 EEKQLPEAR-YTPSHHTWAMDSEGPFVQRVTSVWKRVFGLDSPLQCRAALQKLQDIKYPS XP_004836563.1/1-1509 EEKQLPEARSSSSSYHTWATDTKEPFLQRVTSAWKSVFSLDSPAQCRAALQRLQDIKYPS **** * : :. :* * .:: .:::***..*: *.:*:* * : *:*:**::**** ENSMUSP00000131842/1-1503 ATSNTPFRQLLLHVCHDLTLAMLSQQAAAWEEAVPALLQAVVRSYTSGNFTLMQEIYSAF ENSRNOP00000050493/1-1497 ATSNTPFRQLLLHVCHDLTLAMLSQQAASWEEAVPALLQAVVRSYTSGNFTLMQEIYSAF ENSP00000285873/1-1508 ATNNTPAKQLLLHICHDLTLAVLSQQMASWDEAVQALLRAVVRSYDSGSFTIMQEVYSAF ENSCPOP00000003133/1-1519 ATNNTPSHQLLLHICHDLTLAVLSQQVASWDEAVQALLRAVVRSYDSGSFTVMQGVCSAF XP_004836563.1/1-1509 STSNTPYRQLLLHICHDLTLAVLSQQTATWEEAVQALLRAVLRSYDSGNFTIMQEVCSAF :*.*** :*****:*******:**** *:*:*** ***:**:*** **.**:** : *** ENSMUSP00000131842/1-1503 LPGGCDHLRDKLGDL-SPAMAAYKSLEAFCIYGQLYEVWWSLCGPGPESSVWVLSAE-ST ENSRNOP00000050493/1-1497 LPGGCDHLRDKLGDL-SPTMAAFKSLEAFFIYGQLYEVWWSLCGPGSESSIWVWSAE-ST ENSP00000285873/1-1508 LPDGCDHLRDKLGDHQSPATPAFKSLEAFFLYGRLYEFWWSLSRPCPNSSVWVRAGH-RT ENSCPOP00000003133/1-1519 LPDGCDHLRDKLGDHESLAAPAFRSLEAFFMYGRLYEIWWSVSGPCSKPSVWVRAAHGNT XP_004836563.1/1-1509 LPDGCDHLSDKLGDRQSSATPALRSLEAFFTYGHLYEIWWSLSRPCPEASVWVRADHGKT **.***** ***** * : .* :***** **:***.***:. * .:.*:** : . * ENSMUSP00000131842/1-1503 VSDKQSKPEDSASAEDME----------QPPGPGPRLSAESERLLSACKELFSERHASLQ ENSRNOP00000050493/1-1497 VSDKQSKPGDSASAEDME----------QPLGPGLRLSAESERLLSACKELFSERHASLQ ENSP00000285873/1-1508 LSVEPSQQLDTASTEETDPETS-QPEPNRPSELDLRLTEEGERMLSTFKELFSEKHASLQ ENSCPOP00000003133/1-1519 VPTARSQQENGASTEETGSEAACLPEPGSPPGLSIGLSRESEHVLSACQKLLSETHASLQ XP_004836563.1/1-1509 LSTEQSQQVDRASAEDTGSQAACQPEPGNPPELSLRLSGESARVLSACRELFSEQHASLQ :. *: : **:*: * . *: *. ::**: ::*:** ***** ENSMUSP00000131842/1-1503 TSQRTVAEVQETLAEMIRQHQKSQLCKATTNGPSRDEPSRDEPSQEAERAPSQPPSPT-- ENSRNOP00000050493/1-1497 TSQRTVAEVQETLAEMIRQHQKSQLCKATANG-----PNRDEPSQQAERAPSQPPSPT-- ENSP00000285873/1-1508 NSQRTVAEVQETLAEMIRQHQKSQLCKSTANG-----PDKNEPEVEAEQPLCSSQSQC-- ENSCPOP00000003133/1-1519 NAQRTVAQVQESLAEMIQQHRKSLLSKPMASA-----LRNNEPDQETEAPPSEAQSQCNS XP_004836563.1/1-1509 NARRTVAQVQETLAEMIHQHRKSLLCKSIASG-----PDKNEPEQETELSLAGPQSQC-- .::****:***:*****:**:** *.*. :.. .:**. ::* . . . * ENSMUSP00000131842/1-1503 -REERNAPVSLPELTRRLTEANERIAEFPESVKAWPFPDVLECCLVLLHIGSQCPDAVDP ENSRNOP00000050493/1-1497 --EERNAPVSLPELTRRLTEANERIAEFPESVKAWPFPDVLECCLVLLHIGSQCPGAVNP ENSP00000285873/1-1508 -KEEKNEPLSLPELTKRLTEANQRMAKFPESIKAWPFPDVLECCLVLLLIRSHFPGCLAQ ENSCPOP00000003133/1-1519 KEEEENEPVSLPELTRRLTEANQRMAKFPESIKTWPFPDVLECCLVLLHIGAQCPGCITE XP_004836563.1/1-1509 -KEEENEPVSLPELTRRLTEANQRIATFPESIKTWPFPDVLECCLVLLHISSQCPGCVPQ **.* *:******:******:*:* ****:*:************** * :: *..: ENSMUSP00000131842/1-1503 EMQQQAQELLHKYGHTRAYRRHCQSRHT ENSRNOP00000050493/1-1497 EMQQQAQKLLQKYGHTRAYRRHCQIRHT ENSP00000285873/1-1508 EMQQQAQELLQKYGNTKTYRRHCQTFCM ENSCPOP00000003133/1-1519 ELQQQARELLRKYGNTKAHKRQRRTFCT XP_004836563.1/1-1509 ELQQQAQELLRKYACTTAYKRHSRTFCT *:****::**:**. * :::*: :