CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000049460/1-1356 ------------MAEVKVEV-ASIDWQKRCLSLETQLFRFRLQASKIRELLADKMQELEQ ENSRNOP00000014257/1-1360 CWILELLGVFGIMAEVKVEV-VGIDWQKRCLSLETQLFRFRLQASKIRELLADKMQELEQ ENSP00000330278/1-1364 ------------MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQ ENSCPOP00000003000/1-1361 ------------MAELQVGTQASVDWQKRCLTLETQLVRFRLQASKIRELLADKMQELEQ XP_004837409.1/1-1366 ------------MAEFKVDTQASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQ ***.:* . ..:*******:*****.********************** ENSMUSP00000049460/1-1356 RLLEAEQRAENAETQVGVMEEKIKLSNLKSVDSTGTLHQKYQELLRAVQGKDELISQLQA ENSRNOP00000014257/1-1360 RLLEAEQRAENAETQVGVMEEKIKLSNLKSVDSTGSLHQKYQELLKAMQGKDELIGQLQA ENSP00000330278/1-1364 RLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEA ENSCPOP00000003000/1-1361 RLLEAEERAEKAETQVGVMEEKVKLSNLRNVDSAGSLHRKYQELLKAMQGKVELISQLEA XP_004837409.1/1-1366 RLLEAEERAEKAETQVGVMEEKVKLSNLRNVDSTGSLHRKYQELLKAMQSQVELISQLEA ******:***:***********:*****:.*** *:**:******:*::.: ***.**:* ENSMUSP00000049460/1-1356 QLEKQKQTRAEEAKIVQEKAAKIKEWVTVKLAELEMENQQLKTCNQQLVEQVAALQDALE ENSRNOP00000014257/1-1360 QLEKQKQTRAEEAKIVQEKAAKIKEWVTVKLAELEMENQHLKTCNQQLVEQVAALQDALE ENSP00000330278/1-1364 QLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALE ENSCPOP00000003000/1-1361 QLEKQKQMRAEEAKVVQKKAAKIKEWVALKLTELEMENQHLKSCNQHLMEQVGTLQAALE XP_004837409.1/1-1366 QLEKQKQMRAEEAKIVQKKAAKIKEWVALKLTELEMENQHLKSCNQHLVEQVGALQTALE ******* ****** **:*********::**::******:**: **:*:***.:** *** ENSMUSP00000049460/1-1356 DLRMTPSEELLVVPEGTPERDPVPSGPSDQPVEQDSNPHTQILKVAVPTPSLGTLQ-SRD ENSRNOP00000014257/1-1360 DLRMTPSEELLGVPEGTPEGDPVPSGPSAQPVEQDSNPNTQISKVAVPTP-LGTLQ-SKD ENSP00000330278/1-1364 AIQIAPSRKLLVPPYGAAEQDSVPSEPGIQPMGQDSGSQAQGLKAAVLAPSPGALQ-SKD ENSCPOP00000003000/1-1361 ALQMGPPGKLPVIPKGAQEQESVPAEVGAQPVGQDGGSQAPDFKAAVPIPSLDASE-SKG XP_004837409.1/1-1366 ALQMAPSGKLLVIPKGTPELESVPAESGAQPVGQDSGSQALDLKVAIPAPSLDAPKSSKG ::: *. :* * *: * :.**: . **: **...:: *.*: * .: : *:. ENSMUSP00000049460/1-1356 SLSEARSL-EDLRFSMVHPGETAEAKTLQSHLQKEGSPSQLCMKPGNPKHGSASYRESLV ENSRNOP00000014257/1-1360 FLSEARSP-EDLSFSMAHPGDIAEAKTLQSHLQREGSPSQPFMKPGSPRCGSASYREGLI ENSP00000330278/1-1364 SVSEAASPLEDSSSSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLV ENSCPOP00000003000/1-1361 FLSEARSPVEDTSSSALHPGEVAKAKVLQPHLESEHFPSQLCMKPGAPRRGSASCGDSLV XP_004837409.1/1-1366 FLSQARNSTEDSCSSTFHPEEVAETTVLQPHLESEHFPSQLCVKPGASGCGSASCGEGVV :*:* . ** * *. : .::. **.** * * * :* .*** :.:: ENSMUSP00000049460/1-1356 TAQGGTFPGTKTSAREGGPGSSLTLPKVRAPSIPRDSFQVAKRHHSQPQVGPGHCDHVVS ENSRNOP00000014257/1-1360 TAQGGTFPGTKISAREGGPGSSLTLPKVRAPSIPRDSFQVAKRHHSQPQVGPGHVDHVVS ENSP00000330278/1-1364 TAQRGMLPGTKTSAREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVN ENSCPOP00000003000/1-1361 PAQERVLLGIKTSAREGGPGSSLTLPKVRVPSSPQDSIQMTKRHHSQPSVGPRHSEHVVN XP_004837409.1/1-1366 TAQERVLPGIKTSAREGGPGSSLTLPKVRAPSTPQDSIQVTKRHHSQPHVGPRRFEHVMN .** : * * *****************.*. *:**:*::******* ** : :*:. ENSMUSP00000049460/1-1356 IEIGALSALHSPGSSKSEARAKVREEAEKMEMEALPPSGKQEERESLKSRRGELEDVELE ENSRNOP00000014257/1-1360 IEIGALSALHSSGLPKSEARAKVREEAEKMEMEELPPMGKKGERESLKPRRGELEGVEPE ENSP00000330278/1-1364 IETEAFSALHPSGLPELESRARSREEPEKMEMEEPPPAGKNEERESPKALGAELEEVELG ENSCPOP00000003000/1-1361 VEVGALSTVHTSGLSKLETCADFREEPEKMETGELPPAGKEEERGSLKAASTKLEDVRLG XP_004837409.1/1-1366 AESGALSALHPFGLSKLETYADFWEEPEKMEMGELPPAGKEEERKSLKAPTTELEEVKLG * *:*::*. * .: *: * **.**** ** **: ** * *. :** *. ENSMUSP00000049460/1-1356 NKPPTPPLHRFPSWESRIYAMATSGMQLSEVSSRRSNAACYASGPSALAFPGAFSGLVYK ENSRNOP00000014257/1-1360 NKPPTPPLHRFPSWERRIYAMATSGMQLSDVSS-RNTASCFASGPPALAFPGAFSGLIYK ENSP00000330278/1-1364 NKPPTPPLHQFSSWESRIYAVATSGMRLSDMSP-RSNTACCASSPPALVSPGSFSGLVYK ENSCPOP00000003000/1-1361 SKPPTPPLHRFPSWESRIYAVATSGMQVSDVSP-RSSAACCASSPPALVCSGPFCGFVYK XP_004837409.1/1-1366 NKPPTPPLHRFPSWESRIYAVATSGMQVSDVSP-QSNAAGCASSPPALVCPGPFSGLTYK .********:*.*** ****:*****::*::*. :..:: **.*.**. .*.*.*: ** ENSMUSP00000049460/1-1356 NVTVPVYTALKGKATQISNVPFVDESSGSDDDCGSQASFRMSVPCSEYRKTSGLGSPRAI ENSRNOP00000014257/1-1360 NVTVPVYTALKGKATQISNVPFVDESSGSDDDCGSQASFRMSVPCSEYRKTSGLGSPRAI ENSP00000330278/1-1364 NVTVPVYTALKGRATQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAI ENSCPOP00000003000/1-1361 NVTVPVYTALKGKATQISSVPFMDESSGSDDDCSSQASFRMSVPCSECRKTSGLGSPRAI XP_004837409.1/1-1366 NVPVPVYTALKGKATQISSVPFLDESSGSDDDCSSQASFRMSVPCSECRKTSGLGSPRAI **.*********:*****.:**:**********.******:***.** ************ ENSMUSP00000049460/1-1356 KRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSSYSTD------GEALEKSGYL ENSRNOP00000014257/1-1360 KRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSAYSTD------GETLEKSGYL ENSP00000330278/1-1364 KRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGLG-GESLEKSGYL ENSCPOP00000003000/1-1361 KRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKMQRTSCYSAEWLGLG-MESLEKSGYL XP_004837409.1/1-1366 KRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKMQRTSCYSTEGQGLGTGTSLEKSSYL **********************************:****.**:: :****.** ENSMUSP00000049460/1-1356 LKMGSRVKTWKRRWFVLRQGQILYYKSPSDVIRKPQGQVDLNSHCQIVREEEAQTFQLIS ENSRNOP00000014257/1-1360 LKMGSRVKTWKRRWFVLRQGQILYYKSPNDVIRKPQGQVDLNSHCQIVRGEEAQTFQLIS ENSP00000330278/1-1364 LKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLIS ENSCPOP00000003000/1-1361 LKMGSRVKTWKRRWFVLRQGQIMYYKSPNDVILKPQGQVDLNSHCQIVRGEGAQTFQLIS XP_004837409.1/1-1366 LKMGSRVKTWKRRWFVLRQGQIMYYKSPNDVILKPQGQVDLNSHCQIVRGEGAQTFQLIS *****:****************:*****.*** **********:***** * :******* ENSMUSP00000049460/1-1356 GNKTYYLTAESPSLLEEWIRVLQSLLKVQVTGPPALHQ-GGTKPTVKGWLTKVKHGHSKL ENSRNOP00000014257/1-1360 GNKIYYLTAESPSLLEEWIRVLQSLLKVQVTGPPALHQ-GGTKPTVKGWLTKVKHGHSKL ENSP00000330278/1-1364 EKKTYYLTADSPSLLEEWIRVLQSLLKVQATGPPALLR-GGTKPTVKGWLTKVKHGHSKV ENSCPOP00000003000/1-1361 EKKTYYLMADSPSVLEEWIRALQSLLKVQANQGRSLAGWGGV-----GLLSQVKHGHSKL XP_004837409.1/1-1366 EKKTYYLMADSPSLLEEWIRALQSLLKVQATGPPALSQ-GGTKPAVKGWLTKVKHGHSKL :* *** *:***:******.********.. :* **. * *::*******: ENSMUSP00000049460/1-1356 VWCALVGKTFYYYRSHEDKRPLGCLPVQDAHIEEVDRSCDSDEDYEAGGTGRLLSSHCTL ENSRNOP00000014257/1-1360 VWCALVGKTFYYYRSHEDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTGRLLSSHCTL ENSP00000330278/1-1364 VWCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTRRLLSSHCTL ENSCPOP00000003000/1-1361 VWCALVGKTFYYYRSHEDKRPLGCLPVGDARIEEVDRSCDSDEDYEAGGTRRLLSSHCTL XP_004837409.1/1-1366 VWCALIGKTFYYYRSHEDKRPLGCLPVRDARIEEVDRSCDSDEDYEAAGTRRLLSSHCTL *****:** ****************** **:****************.** ********* ENSMUSP00000049460/1-1356 VIHPPEHSPTYLLIGTKHEKDTWLYHLTVAAGGSNAKVGTVYEQLIGKLMDGE-GNPDSP ENSRNOP00000014257/1-1360 VIHPPEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTVYEQLIGKLMDGE-GNPDSP ENSP00000330278/1-1364 VIHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGE-GDPDSP ENSCPOP00000003000/1-1361 VIHPPEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAQVGTAYEQLIGKLMDGEGGDPDSP XP_004837409.1/1-1366 VIHPPEHSPTYLLIGTKHEKDTWLYHLTVVAGGSSGKVGTAYEQLIGKLMDGE-GDPDSP ****.************************.****..:***.************ *:**** ENSMUSP00000049460/1-1356 LWRHPMLCYSQEGLCASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTA ENSRNOP00000014257/1-1360 LWRHPMLCYSQEGLCASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTA ENSP00000330278/1-1364 LWRHPMLCYSKDGLYASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTA ENSCPOP00000003000/1-1361 LWKHPILCYSKDGLYTSLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTV XP_004837409.1/1-1366 LWRHPTLCYSKDGLYTSLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTV **:** ****::** :*******************************************. ENSMUSP00000049460/1-1356 LQVCLVHPELQSEIYCQLMKQISCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQL ENSRNOP00000014257/1-1360 LQVCLVHPELQSEIYCQLMKQISRRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQL ENSP00000330278/1-1364 LQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQL ENSCPOP00000003000/1-1361 LQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVRQQL XP_004837409.1/1-1366 LQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQL ********************* * ********************************:*** ENSMUSP00000049460/1-1356 QRHADPRSETGQYAIYCQRAVERTLQTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHF ENSRNOP00000014257/1-1360 QRHADPRSETGQYAIYCQRAVERTLQTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHF ENSP00000330278/1-1364 QRHADPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHF ENSCPOP00000003000/1-1361 QRHADPRNETGQYATYCQRAVERTLQTGEREARPSHMEVVSILLRNPFHHSLPFSIPVHF XP_004837409.1/1-1366 QRHADPRNETGQYATYCQRAVERTLQTGEREARPSHMEVVSILLRNPFHHSLPFSIPVHF *******.****** **********:*********:************************ ENSMUSP00000049460/1-1356 ANGTYQVVGFDGSSTVDEFLQRLNQETGMRKPSQSGFALFTDDPSGRDLEHCLQGRVKIC ENSRNOP00000014257/1-1360 ANGTYQVVGFDGSSTVDEFLQRLNQETGMRKPS------FTDDPSGRDLEHCLQGRVKIC ENSP00000330278/1-1364 TNGTYHVVGFDGSSTVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKIC ENSCPOP00000003000/1-1361 ANGTYQVVGFDGSSTVDEFLQRLNQETGMRKSSHSGFALFTDDPCGRDLEHCLQGSVKIC XP_004837409.1/1-1366 ANGTYQVVGFDGSSTVDEFLQRLNQETGMRKSSQSGFALLTDDPSGRDLEHCLQGSVKIC :****:******************** ****.* :****.********** **** ENSMUSP00000049460/1-1356 DAISKWEQTLKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETERERLLLAFQASGEIVA ENSRNOP00000014257/1-1360 DAISKWEQTLKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETERERLLLAFQTSGEIVA ENSP00000330278/1-1364 DAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVA ENSCPOP00000003000/1-1361 DAISKWEQALKELHPGKSEGGTRIVKLMYKNRLHFRSQIKGETERERLLLTYQTNGEIVA XP_004837409.1/1-1366 DAISKWEQALKELHPGKSEGGTRIVKLMYKNRLHFRSHVKGETERERLLLAYQTNGEIVA ********::*************:*********:***::****:******: *:. **** ENSMUSP00000049460/1-1356 GRFPVTKELALEMAALMAQVEYGDLEKPTLPGPGGTPPTKAQHLLQQVLDRFYPRRYRNG ENSRNOP00000014257/1-1360 GRFPVTKELALEMAALMAQVEYGDLEKPTLPGPGGTPPAKAQHLLQQVLDRFYPRHYRNG ENSP00000330278/1-1364 GRFPINKELALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHG ENSCPOP00000003000/1-1361 GRFPVSKELALEMAGLMAQIEYGDMEKPILPGPGGTHPAKAQHLLQQVLDRFYPRHYRLG XP_004837409.1/1-1366 GRFPVSKELALEMASLMAQIEYGHMEKPILPGPGGTPPAKAQHLLQQVLDRFYPRHYRHG ****:.********.****:***.:*** ******* *:*************:**:** * ENSMUSP00000049460/1-1356 APPEQLRHLADMMATKWAALQGCSPPECIRIYLTVARKWPLFGAKLFAAQPAQ-LSPKEN ENSRNOP00000014257/1-1360 APPEQLRHLADMMATKWAALQGCSPPECIRIYLTVARKWPLFGAKLFAAQPAQPLSSKEN ENSP00000330278/1-1364 APAEQLRHLADMLTTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQ-LSSKEN ENSCPOP00000003000/1-1361 APPEQLRHLTSMLATRWASLQGRSLAEYTRTYLTVARKWPLFGAKLFAAQPAK-LLPKEN XP_004837409.1/1-1366 APPEQLRHLANMLATKWTSLQGCSLAEYTRTYLTVARKWPLFGAKLFAAQPAQ-LSSKEN **.******:.*::*:*::*** * .* * *********:***********: * .*** ENSMUSP00000049460/1-1356 TVVWIAVNEDGVSILDHRTMQVNITYPYSSVTTFGGCRDDFMLVIRSIPDQSSGKTRIDK ENSRNOP00000014257/1-1360 TPVWIAVNEDGVSILDQRTM-VNITYPYSSVTTFGGCRDDFMLVIRSIPDQNSGKTRIDK ENSP00000330278/1-1364 ALVWIAVNEDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLVIRSIPDKSSGKSHIEK ENSCPOP00000003000/1-1361 TLVWIAVNEDGVSILDHHTMQVQVTYPYSSVTTFGGCRDDFMLVIRSIPDQSSGKGHIDK XP_004837409.1/1-1366 TLVWIAVNEDGVSILDHHTMQVHVTYPYSSLTTFGGCRDDFMLVIRSTPDQSSGKGHIDK : **************:.** *::******:**************** **:.*** :*:* ENSMUSP00000049460/1-1356 LTFRMPAPKITETTLMMASYMNHCSATVNLSAKLPAARQPRDLDG-QFFASVSC-TKGSA ENSRNOP00000014257/1-1360 LTFRMPAPKITDTTLVMASYMNHCSATVNLSAKLPAARQPRDLDG-QFFASVSC-TKGSA ENSP00000330278/1-1364 LIFRMAAPKIAEATFIMASYMNHCTTTVNPPTNPPGACQLWELDGRQFFSSVSCATKGPT ENSCPOP00000003000/1-1361 LIFRMAAPKIAEATFIMASYMNHCSVPASSPTSLPAARPLRELDGRQFLAPVSCAAKGPT XP_004837409.1/1-1366 LIFRMAAPKIAEATFIMASYMNHCSATVNSPTYLPAAHLPRELDGQQFFASVSCATKGPI * ***.****:::*::********:.... .: *.* :*** **::.*** :**. ENSMUSP00000049460/1-1356 LL ENSRNOP00000014257/1-1360 LL ENSP00000330278/1-1364 LL ENSCPOP00000003000/1-1361 LL XP_004837409.1/1-1366 LL **