CLUSTAL W(1.81) multiple sequence alignment ENSP00000406012/1-1462 MALYYDHQIEAPDAAGSPSFISWHPVHPFLAVAYISTTSTGSVDIYLEQGECVPDTHVER ENSMUSP00000024983/1-1464 MALYFDHRIKAPDTPSSPSHITWHPTHPFLAVASISPSSGGNVDIYLEQGEPVPDTHIER ENSRNOP00000022063/1-1463 MALYFDHRIKAPDASSSPSHITWHPTHPFLAVASVSPSSGGNVDIYLEQGEPVPDTHIER ENSCPOP00000002994/1-1461 MALYFDHRIKAPNSVGPPFHISWHTVHPFLAVASMSAASGGNVDIYLEQGEHVPETHIER XP_004873802.1/1-1458 MALYFDHQIKAPNSVGSPFHISWHAVHPFLAVASMSAASRGSVDIYLEQGEHVPETHIER ****:**:*:**:: ..* .*:**..******* :*.:* *.********* **:**:** ENSP00000406012/1-1462 PFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMPLTHTADITVLRWSPSGNCLLS ENSMUSP00000024983/1-1464 SFQATSLCWHPTRLILAIGWETGEVIMFNKQDKEQHTVPLPHTTDIAILSWSTSGSCLVS ENSRNOP00000022063/1-1463 SFQATSLCWHPTRLILAIGWETGEVIMFNKQDKEQHTVPLPHTTDIAILSWSTSGSCLVS ENSCPOP00000002994/1-1461 SFRVTCLCWHPTRLLLAVGWETGEVIVFNKQDKEQHTMPPTHISDITILTWSTSGNCLVS XP_004873802.1/1-1458 SFRVTSLCWHPTRLLLAVGWETGEVIVFNKQDKEQHTMPPTHITDITILTWSTNGSCLVS .*:.:.********:**:******* :**********:* .* :**::* **..*.**:* ENSP00000406012/1-1462 GDRLGVLLLWRLDQRGRVQGTPLLKHEYGKHLTHCIFRLPPPGEDLVQLAKAAVSGDE-K ENSMUSP00000024983/1-1464 GDKLGVLLLWRLDQRGRVQGTPLLKHEYGKALTHCIFRLPPPGEDLVQLAKAAVSGDE-K ENSRNOP00000022063/1-1463 GDKLGVLLLWRLDQRGRVQGTPLLKHEYGKPLTHCIFRLPPPGEDLVQLAKAAVSGDE-K ENSCPOP00000002994/1-1461 GDKLGVLLLWRLDQRGRVQGTPLLKHEYEKHLTHCIFRLPPPGEDLVQLARAAVSGDERK XP_004873802.1/1-1458 GDRLGVLLLWRLDQRGRVQGTPLLKHEYEKHLTHCIFRLPPPGKDLVQLARAAVNGDE-K **:************************* * ************:******:***.*** * ENSP00000406012/1-1462 ALDMFNWKKSSSGSLLKMGSHEGLLFFVSLMDGTVHYVDEKGKTTQVVSADSTIQMLFYM ENSMUSP00000024983/1-1464 ALDMFNWRKSSFGSFLKTGSQEGLSFFVSLMDGTVHYVDEKGKTAQVASTDSSIQTLFYI ENSRNOP00000022063/1-1463 ALDMFNWRKSSFGSFLKTGSQEGLSFFVSLMDGTVHYVDEKGKTAQVASTDSSIQTLFYI ENSCPOP00000002994/1-1461 EIKLMNSLRLSNGNKIEIPACERLHTDLPLFSGSVHYVDEKGKTTCVASMDSSIQTLFYI XP_004873802.1/1-1458 ALDMFNWKKSSFGSFLKMGSQEGLSFFISLMDGSVHYVDEKGKTTCVASTHSSIQTLFYI :.::* : * *. :: : * * :.*:.*:**********: *.* .*:** ***: ENSP00000406012/1-1462 EKREALVVVTENLRLSLYTVPPEGKAEEVMKVKLSGKTGRRADIALIEGSLLVMAVGEAA ENSMUSP00000024983/1-1464 ERREALVVVTENLLLSLYVVTPEGEAEEVMKVKLSGKTGCRADITLIEGSLLVTAIGEPV ENSRNOP00000022063/1-1463 EKREALVVVTQNLLLSLYVVNPEGEAEEVMKVKLSGKTGRRADITLIEGSLLVTAIGEPV ENSCPOP00000002994/1-1461 EKREALVVVTENLQLSLYTVMPEGKAEEVMKVKLSGKTGVRADITLIEGSLLVMAIGESV XP_004873802.1/1-1458 EKREALVVVTENLLLSLYMVMPEGKAEEVMKVKLSGKTGLRADITLIEGSLLVMAIGEAI *:********:** **** * ***:************** ****:******** *:**. ENSP00000406012/1-1462 LRFWDIERGENYILSPDEKFGFEKGENMNCVCYCKVKGLLAAGTDRGRVAMWRKVPDFLG ENSMUSP00000024983/1-1464 LRFWDLERGENYILSLQEKFGFEKGESINCVCFCKAKGLLAAGTNKGRVAMWKKVPSFPN ENSRNOP00000022063/1-1463 LRFWDLERGENYILSLQEKFGFEKGENINSVCYCKAKGLLAAGTHKGRVAMWKKVPVSPS ENSCPOP00000002994/1-1461 LRFWNLERGENYILSLSEKFGFEKGENINCVCYCKAKGLLAAGTDKGRIAMWKRVAGSVS XP_004873802.1/1-1458 LRFWDLERGDNYILNLEEKFGFEKEENINCICYCKAKGLLAAGTDKGRIAMWKRVAGSPS ****::***:****. .******* *.:*.:*:**.********.:**:***::*. . ENSP00000406012/1-1462 SPGAEGKDRWALQTPTELQGNITQIQWGSRKNLLAVNSVISVAILSERAMSSHFHQQVAA ENSMUSP00000024983/1-1464 GRGAEGKDMWALQTPTELEGNITQIKWGSRKNLLAVSSTESVSILSEQAMSSHFHQQVAA ENSRNOP00000022063/1-1463 GRGAEGKDMWALQTPTELEGNITQIKWGSRKNLLAVSTSDSVSILSEQAMSSHFHQQVAA ENSCPOP00000002994/1-1461 TREVEGKDTWTPQTLTELEGNITQIKWGSRKNLLAVNNISSVVILREQAMSSHFHQQVAS XP_004873802.1/1-1458 SREVEGKDKWAPQTPTELEGNITQIKWGSRKNLLAVNNISSIVILREQAVSLHFHQQVAS .**** *: ** ***:******:**********.. *: ** *:*:* *******: ENSP00000406012/1-1462 MQVSPSLLNVCFLSTGVAHSLRTDMHISGVFATKDAVAVWNGRQVAIFELSGAAIRSAGT ENSMUSP00000024983/1-1464 VQISPSLVNVSFLSTGGTHSLHTDMHISGVFATKDAVAVWNGKQVAIFEPSGSTLRNAGT ENSRNOP00000022063/1-1463 VQISPSLVNVSFLSTGSTHSLRTDMHISGVFATKDAVAVWNGKQVAIFEPSGSTLRNAGT ENSCPOP00000002994/1-1461 VQVSPNLLNVSFLSTGGVYSLRTDMHIGGVFATKDAVAVWNGKHVAIFEPFGATLRNAGT XP_004873802.1/1-1458 VQVSPSLLNVSFLSKGGVYSLHTDMHISGVFATKDAVAVWNGTHVAIFEPSGATLRNAGT :*:**.*:**.***.* .:**:*****.************** :***** *:::*.*** ENSP00000406012/1-1462 FLCETPVLAMHEENVYTVESNRVQVRTWQGTVKQLLLFSETEGNPCFLDICGNFLVVGTD ENSMUSP00000024983/1-1464 FLCETSVLAMHEESIYTVEPNRLQVRTWQGTVKQLLLFSETEGSPCFLDVCGTFLVAGTD ENSRNOP00000022063/1-1463 FLCETSVLAMHEESIYTVEPNRLQVRTWQGTVKQLLLFSETEGSPCFLDVCGTFLVAGTD ENSCPOP00000002994/1-1461 FLCESPVLAMHEENVYTVEPNRVQVRTWQGTVKQLLLFSETEGNPCILDICGNFLVVGTD XP_004873802.1/1-1458 FLCESPVLAMHEENVYTVEPNRVQVRTWQGTVKQLLMFSKTEGNPCFLDICGNFLVVGTD ****:.*******.:****.**:*************:**:***.**:**:**.***.*** ENSP00000406012/1-1462 LAHFKSFDLSRREAKAHCSCRSLAELVPGVGGIASLRCSSSGSTISILPSKADNSPDSKI ENSMUSP00000024983/1-1464 LAHFKSFDLSRREAKVHCSCKNLAQLVPDVGSITSLRCNANGNKISILLSKVNNSPDSKI ENSRNOP00000022063/1-1463 LAHFKSFDLSRREAKVHCSCKNLAQMIPDVGSITSLRCNANGNKISILLSKVDNSPDSKI ENSCPOP00000002994/1-1461 LAHFKSFDLSRREAKVHCSCRNLAELIPDVGSIVSLKCNASGNKISILLSKADNTPDSRI XP_004873802.1/1-1458 LAHFKSFDLSRREAKVHCNCRNLAELIPDVGSIISLRCNASGSKISILLSKVDNTPDSRI ***************.**.*:.**:::*.**.* **:*.:.*..**** **.:*:***:* ENSP00000406012/1-1462 CFYDVEMDTVTVFDFKTGQIDRRETLSFNEQETNKSHLFVDEGLKNYVPVNHFWDQSEPR ENSMUSP00000024983/1-1464 YIYDVEMDTVNVFNFTTGQIGQIQTLPFNEPPTNETRSFMDKSLAGYTPVNHFWDQSEPR ENSRNOP00000022063/1-1463 YVYDVEMDTVNVFNFKTGHIGQIQTLPFNEPPTNEAHFFMNESLASYVPVNHFWDQSEPR ENSCPOP00000002994/1-1461 CFYNVEMDTVTVFDLKTGQIDQRDILLFNGQETNKNHIFTDERLKNYIPARHYWDQSEPR XP_004873802.1/1-1458 CLYDVEMDSVAILDLKTGEIDQRETLPFNGQETNKSHIFTDERLTNYIPMNHYWDQNEPR .*:****:* ::::.**.*.: : * ** **: : * :: * .* * .*:***.*** ENSP00000406012/1-1462 LFVCEAVQETPRSQPQSANGQPQD--GRAGPAADVLILSFFISEEHGFLLHESFPRPATS ENSMUSP00000024983/1-1464 LFVCEALQEAPGAQPQAVDKQPRVE-EGTCHKEEVLILSFFASEEHGFLLHDSFPRPSTY ENSRNOP00000022063/1-1463 LFVCEALQEAPGAQPQAIDKQPHME-EGTCHKEEVLILSFFASEEHGFLLHDSFPRPSTY ENSCPOP00000002994/1-1461 LFVCEAMQEALGTQAMGARGIPFTKNELPSPTQDVLILSFFVSEDHGFLLHDSFPCPPAY XP_004873802.1/1-1458 LFVCEVMQEALGAQATG-GKQPYPE-ESTSPTEDVLILSFFVSEDHGFLLHDSFPRPPAY *****.:**: :*. . * . :******* **:******:*** *.: ENSP00000406012/1-1462 HSLLGMEVPYYYFTRKPEEADREDEVEPGCHHIPQMVSRRPLRDFVGLEDCDKATRDAML ENSMUSP00000024983/1-1464 QSLLGMEVPHYYFTKKPGEADKEDRVDSGYYHIPQMVAKRPLRDFVGLEDCDKSTRDAML ENSRNOP00000022063/1-1463 QSLLGLEVPHYYFTKKPGEADKEDKMDSGHYHIPQMVAKKPLRDFVGLEDCDKPTRDAML ENSCPOP00000002994/1-1461 QTLLGMEVPHYYFTKKPGEADGEDREHSEHHDIPEMVARRPLRDFVGLEDCDKPTQEAML XP_004873802.1/1-1458 QTLLGMEVPHYYFTKKPGEADGEDRVHSEHYCIPQMVARRPLRDFVGLEDCDKPTQDAML ::***:***:****:** *** **. .. : **:**:::*************.*::*** ENSP00000406012/1-1462 HFSFFVTIGDMDEAFKSIKLIKSEAVWENMARMCVKTQRLDVAKVCLGNMGHARGARALR ENSMUSP00000024983/1-1464 NFSFFVTIGDMDEAFKSIKLIKSEAVWENMARMCVKTQRLDVAKVCLGNMGHARGARALR ENSRNOP00000022063/1-1463 NFSFFVTIGDMDEAFKSIKLIKSETVWENMARMCVKTQRLDVAKVCLGNMGHARGARALR ENSCPOP00000002994/1-1461 NFSFFITVGDMDEAFKSIKLIKSEHVWENMARMCVKTQRLDVAKVCLGNMGHARGARALR XP_004873802.1/1-1458 NFSFFITVGDMDEAFKSIKLIKSEAVWENMARMCVKTQRLDVAKVCLGNMGHARGAQALR :****:*:**************** *******************************:*** ENSP00000406012/1-1462 EAEQEPELEARVAVLATQLGMLEDAEQLYRKCKRHDLLNKFYQAAGRWQEALQVAEHHDR ENSMUSP00000024983/1-1464 EAEQEPELEARVAMLAIQLGMLEEAEQLYKKCKRYDLLNKFYQASDQWQKAVEVAELHDR ENSRNOP00000022063/1-1463 EAEREPELEARVAMLAIQLGMLEEAEQLYKKCKRYDLLNKFYQASDQWQKAVEVAELHDR ENSCPOP00000002994/1-1461 EAEQEPQPEARVAMLATQLGMLEDAEQLYKKCKRYDLLNKFFQASGQWQKAVEVAEQYDR XP_004873802.1/1-1458 EAEQEPELEARVAMLAIQLGMLEDAEQLYKKCKRYDLLNKFFQASGQLQKAVEVAEQYDR ***:**: *****:** ******:*****:****:******:**:.: *:*::*** :** ENSP00000406012/1-1462 VHLRSTYHRYAGHLEASADCSRALSYYEKSDTHRFEVPRMLSEDLPSLELYVNKMKDKTL ENSMUSP00000024983/1-1464 VHLRTTYYNYAKHLEASADCGQALSYYEKSDTHRFEVPRMLSEDLQSLELYINRMKDKTL ENSRNOP00000022063/1-1463 VHLRTTYYNYAKHLEASADCGLALSYYEKSDTHRFEVPRMLSEDLQSLELYINRMKDKTL ENSCPOP00000002994/1-1461 VHLRTTYYNYARHLEANGDCNLALSYYEKSDTHHFEVPRMLAEDLQSLEFYINKMKDKTL XP_004873802.1/1-1458 MHLRTTYYNYAKHLEANSDCSLALSYYEKSDTHRFEVPRMLAEDLKSLELYINKMKDKTL :***:**:.** ****..**. ***********:*******:*** ***:*:*:****** ENSP00000406012/1-1462 WRWWAQYLESQGEMDAALHYYELARDHFSLVRIHCFQGNVQKAAQIANETGNLAASYHLA ENSMUSP00000024983/1-1464 WRWWAQYLESQAEMDTALRYYELAQDYFSLVRIHCFQGNIQKAAEIANETGDWAASYHLA ENSRNOP00000022063/1-1463 WRWWAQYLESQAEMDTALRYYELAQDYFSLVRIHCFQGNIQKAAEIANETGDWAASYHLA ENSCPOP00000002994/1-1461 WRWWAQYLESQAEMDAALHYYELAQDYFSLVRIHCFQGNISKASEIANETGNWAASYHLA XP_004873802.1/1-1458 WRWWAQYLESQAEMDAALHYYELAQDYFSLVRIHCFQGNIPKAAEIANETGNWAASYHLA ***********.***:**:*****:*:************: **::******: ******* ENSP00000406012/1-1462 RQYESQEEVGQAVHFYTRAQAFKNAIRLCKENGLDDQLMNLALLSSPEDMIEAARYYEEK ENSMUSP00000024983/1-1464 RQYESQDEVKQAVHFYTRAQAFNNAIRLCKENGLDDQLMNLALLSSPEDMIEAARYYEEK ENSRNOP00000022063/1-1463 RQYESQDEVKQAVHFYTRAQAFNNAIRLCKENGLDDQLMNLALLSSPEDMIEAARYYEEK ENSCPOP00000002994/1-1461 RQYESQEDVKQAVLFYTRAQAFNNAIRLCKENGLDDQLMNLALLSSPEDMIEAARYYEEK XP_004873802.1/1-1458 RQYESQEDVRQAVCFYTRAQAFNNAIRLCKENGLDDQLMNLALLSSPEDMIEAARYYEEK ******::* *** ********:************************************* ENSP00000406012/1-1462 GVQMDRAVMLYHKAGHFSKALELAFATQQFVALQLIAEDLDETSDPALLARCSDFFIEHS ENSMUSP00000024983/1-1464 GEQMDRAVMLYHKAGHFSKALELAFTTQQFAALQLIAEDLDEKSDPALLARCSDFCIEHR ENSRNOP00000022063/1-1463 GEQMDRAVMLYHKAGHFSKALELAFTTQQFAALQLIAEDLDEKSDPALLARCSDFCIEHR ENSCPOP00000002994/1-1461 GDQMDRAVMLYHKAGHFSKALELAFATQQFAALQLIAEDLDEKSDPALLSRCSDFCIEHK XP_004873802.1/1-1458 GDQMDRAVMLYHKAGHFSKALELAFATQQFAALQLIAEDLDEKSDPALLSRCSDFCIEHK * ***********************:****.***********.******:***** *** ENSP00000406012/1-1462 QYERAVELLLAARKYQEALQLCLGQNMSITEEMAEKMTVAKDSSDLPEESRRELLEQIAD ENSMUSP00000024983/1-1464 QFEKAVELLLAAKKYHEALQLCLEQNMTITEDMAEKMTVSKDSKDMSEESRRELLEQIAN ENSRNOP00000022063/1-1463 QFEKAVELLLAAKKYHEALQLCLEQNMTITEEMAEKMTVSKDSKDLSEESRRELLEQIAN ENSCPOP00000002994/1-1461 QFEKAMELLLAAKKYHEALQLCLEQNMTITEEMAEKMTVPKDSKVLSEESRRELLEQIAN XP_004873802.1/1-1458 QFEKAVELLLAAKKYHEALQLCLEQNMTITEEMAEKMTVPKDSKVLSEESRRELLEQIAN *:*:*:******:**:******* ***:***:*******.***. :.************: ENSP00000406012/1-1462 CCMRQGSYHLATKKYTQAGNKLKAMRALLKSGDTEKITFFASVSRQKEIYIMAANYLQSL ENSMUSP00000024983/1-1464 CCMRQGNYHLATKKYTQAGNKLKAMRALLKSGDTEKIVFFAGVSRQKEIYIMAANYLQSL ENSRNOP00000022063/1-1463 CCMRQGNYHLATKKYTQAGNKLKAMRALLKSGDTEKIVFFAGVSRQKEIYIMAANYLQSL ENSCPOP00000002994/1-1461 CCMHQGNYHLATKKYTQAGNKLKAMRALLKSGDTEKIVFFAGVSRQKEIYIMAANYLQSL XP_004873802.1/1-1458 CCMRQGNYHLATKKYTQAGNKLKAMRALLKSGDTEKIVFFAGVSRQKEIYIMAANYLQSL ***:**.******************************.***.****************** ENSP00000406012/1-1462 DWRKEPEIMKNIIGFYTKGRALDLLAGFYDACAQVEIDEYQNYDKAHGALTEAYKCLAKA ENSMUSP00000024983/1-1464 DWRKEPEIMKSIISFYTKGRALDLLAGFYDACAQVEIDEYQNYDKAHGALTEAYKCLSKA ENSRNOP00000022063/1-1463 DWRKEPEIMKNIISFYTKGRALDLLAGFYDACAQVEIDEYQNYDKAHGALTEAYKCLSKA ENSCPOP00000002994/1-1461 DWRKEPEIMKNIISFYTKGRALDLLAGFYDACAQVEIDEYQNYDKAHGALTEAYKCLSKA XP_004873802.1/1-1458 DWWKEPEIMKNIISFYTKGRALDLLAGFYDACAQVEIDEYQNYSKAHGALTEAYKCLAKA ** *******.**.*****************************.*************:** ENSP00000406012/1-1462 KAKSPLDQETRLAQLQSRMALVKRFIQARRTYTEDPKESIKQCELLLEEPDLDSTIRIGD ENSMUSP00000024983/1-1464 KTKNPLDQETKLAQLQSKMTLVKRFIQARRTYTEDPKESLRQCELLLEEPDLDSTIRVGD ENSRNOP00000022063/1-1463 KAKNPLDQETKLAQLQSKMTLVKRFIQARRTYTEDPKESVRQCELLLEEPDLDSTIRVGD ENSCPOP00000002994/1-1461 KAKSPLDQETKLAQLQNKMTLVKRFIQARRTYTEDPKESIRQCELLLEETDLDSTIRIGD XP_004873802.1/1-1458 KAKSPLDQETKLAQLQSKMTLVKRFIQARRSYTEDPKESIRQCELLLEETDLDSTIRTGD *:*.******:*****.:*:**********:********::********.******* ** ENSP00000406012/1-1462 VYGFLVEHYVRKEEYQTAYRFLEEMRRRLPLANMSYYVSPQAVDAVHRGLG-LPLPRTVP ENSMUSP00000024983/1-1464 VYGFLVEHHVQMEEYQMAYKYLEEMRKRLPSANMSYYVDQRTVDTVHQGLGLLPPSRIMP ENSRNOP00000022063/1-1463 IYGFLVEHHVQMEEYQMAYKYLEEMRKRLPSANMSYYVDQRTVDTVHQGLG-LPPSRIMP ENSCPOP00000002994/1-1461 VYGFLVERYVQMEEYQMAYRYLEEMRKKLPSANMSYYMDQRTMDTVYRALG-LPLTRMLP XP_004873802.1/1-1458 IFGFLVERYMQMEDYQMAYRYLEEMRKKLPSANMAYYVDQRTMDTVYRALG-LPLTHMLP ::*****:::: *:** **::*****::** ***:**:. :::*:*::.** ** .: :* ENSP00000406012/1-1462 EQVRHNSMEDARELDEEVVEEADDDP ENSMUSP00000024983/1-1464 ERVRHNSMEDHKEVYEEVIEEVDNDP ENSRNOP00000022063/1-1463 ERVRHNSMEDHKEVYEEVIEEVDNDP ENSCPOP00000002994/1-1461 EQTCHNSTEDQ----DEVVEEVDNDP XP_004873802.1/1-1458 ERTHHNSIEDQ----EEVVEEVDNDP *:. *** ** :**:**.*:**