CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000112063/1-1212 MAACRAQPPTSEQAWLEAAQTFIQETLCPAGKEVDKELTRSVIACVKETWLSQGENQDLT ENSRNOP00000007447/1-1211 MAACRAQPPTSEEAWLEAAQAFIQETLCPVDEEPNEQVTRSVIDCVKETWLSQGENQDLT ENSP00000313759/1-1217 MAAGRAQVPSSEQAWLEDAQVFIQKTLCPAVKEPNVQLTPLVIDCVKTVWLSQGRNQGST ENSCPOP00000002973/1-1208 KGYCRF--PRKEQAWLEATRAFIQETICPTDQEPDVHLTQLVIDCVKRIWCSQERNQGFA XP_004857547.1/1-1212 ----MWKIHQKEQAWLEAAQTFIQEAVCPADKEPTAHLTQSVIDCVKRIWCSQGRNQGFG .*:**** ::.***:::**. :* .:* ** *** * ** .**. ENSMUSP00000112063/1-1212 LPFSYSFVSVQSLKTHQRLPCCSHLSWSQSAYQAWTRGGRPGDGVLPREQLILLGTLVDL ENSRNOP00000007447/1-1211 LPLSYSFVSVQNLKTNQHLPCCSHLSWSDNAYQAWTRGAGPGGSVLPREQLLLLGTLVDL ENSP00000313759/1-1217 LPLSYSFVSVQDLKTHQRLPCCSHLSWSSSAYQAWAQEAGPNGNPLPREQLLLLGTLTDL ENSCPOP00000002973/1-1208 LPLNYSFASVQKLRSHHQ-PCCSHLSWSSSAYEAWAQEAESSGNPLPQEQLLLLGTLTDL XP_004857547.1/1-1212 LPLSYSFVSVQKLRSRHH-PCCSHLSRSCSAYETWAQEAGPNGNPLPQEQLLLLGTLTDL **:.***.***.*::.:: ******* * .**::*:: . .... **:***:*****.** ENSMUSP00000112063/1-1212 LGDSEQECRSGSLYVRDNTGTLDCELIDLDLSWLGHLFLFPSWSYLPSAKRNSLGEGHLE ENSRNOP00000007447/1-1211 LGDLEQESRSGGLYVRDNTGTLDCELIDLDLSWLGHLFLFPSWSYLPPAKRNSLGAGHLE ENSP00000313759/1-1217 SADLEQECRNGSLYVRDNTGVLSCELIDLDLSWLGHLFLFPRWSYLPPARWNSSGEGHLE ENSCPOP00000002973/1-1208 SQDSEQESRDGSLFVRDNTGILGCELLGLDLSWLGHLFLFPSWSYLPPAKWDSSGEGHLE XP_004857547.1/1-1212 SQDLEQECRDGSLFVRDNTGILGCELIDLDLSWLGHLFLFPSWSYLPPAKWNSSREGHLE * ***.*.*.*:****** *.***:.************* *****.*: :* **** ENSMUSP00000112063/1-1212 LWGTPVPVFPLTVSPGPLIPIPVLYPEKASHLLRYRKKSSIKEINLAGKLVHLSALIITQ ENSRNOP00000007447/1-1211 LWGTPVPVFPLTVSPGPLTPIPVLYPEKASYLLRYRKKCKIKELNLAGKLVHLSALMVTQ ENSP00000313759/1-1217 LWDAPVPVFPLTISPGPVTPIPVLYPESASCLLRLRNKLRGVQRNLAGSLVRLSALVKSK ENSCPOP00000002973/1-1208 LWDAPVPVFPLSVSPEPLTPLPVLYPRMASQVLGHRSKLRNAQSNLAGKLVRLSPLVRSQ XP_004857547.1/1-1212 LWGAPVPVFPLAISPDPLTPIPVLYPEIASRVLRHRSKLREVQSNLAGKLVRLSPLVRSQ **.:*******::** *: *:*****. ** :* *.* : ****.**:**.*: :: ENSMUSP00000112063/1-1212 NKRYFIMTLGE----LAQAGSQVSIIVQIPAQMVWHRVLRPGRAYVLTKLQVTKTRIHLS ENSRNOP00000007447/1-1211 NKRYFIMTLGE----LAQAGSQVSVIVQIPAQMVWHRVLRPGRAYVLTKLRITKTRGHRS ENSP00000313759/1-1217 QKAYFILSLGR----SHPAVTHVSIIVQVPAQLVWHRALRPGTAYVLTELRVSKIRGQRQ ENSCPOP00000002973/1-1208 QKTYFILSLGEPTSAAGQAVGQVPIIVQVPAQLVWHRALRPGEDYVLTELRVSRIHGHRY XP_004857547.1/1-1212 QKTYFVLSLGESPLAVGHAVSQVPIIVQIPAQLVWHRALRPSEDYVLTGLRVSRIHGHRY :* **:::**. * :*.:***:***:****.***. **** *:::: : : ENSMUSP00000112063/1-1212 CIWTTIPSSTLKPLRPGYVQ--ELELDLEFSKADLKPPPQPTSSKDSRGQEGLVRASKVL ENSRNOP00000007447/1-1211 CIWTTIPSSTLMPLRPGYVQ--ELELDVAFADAGHKPLPEPTSSRDSRGQEGLVRGSKVL ENSP00000313759/1-1217 HVWMTSQSSRLLLLKPECVQELELELEGPLLEADPKPLPMPSNSEDKKDPESLVRYSRLL ENSCPOP00000002973/1-1208 RVWTTTPASNLVLLNPECVR---------ALEAEPKPFPAPSNSQAGKGQKGLSQDSLLL XP_004857547.1/1-1212 RVWTTTPSSNLMLLNPECVQ--ELELEGPFLEAEPKRFSVPSNSPDQKEQKTLSRNSTLL :* * :* * *.* *: .* * . *:.* : : * : * :* ENSMUSP00000112063/1-1212 HYLGTVTAVLHESAGLYILDGQLILCLAYQKIHGLRRVIRPGVCLELRDVHLLQAVGGAT ENSRNOP00000007447/1-1211 HYLGTVTDVLNESASLYILDGQLILCLAYQKIHGLRRVIRPGVCLELRDVHLLQGLGGGT ENSP00000313759/1-1217 SYSGAVTGVLNEPAGLYELDGQLGLCLAYQQFRGLRRVMRPGVCLQLQDVHLLQSVGGGT ENSCPOP00000002973/1-1208 HYKGTVTGVLNEPAGLYELDRQLELCLAYQQFQGLRRVMRPGVSLELRDVHLLQLLGGGT XP_004857547.1/1-1212 HYRGTVTGVLNEPAGLYELDRQLELCLAYQQFHGLRRVMRPGVCLELQDVHLLQSVGGGT * *:** **:*.*.** ** ** ******:::*****:****.*:*:****** :**.* ENSMUSP00000112063/1-1212 TKPVLALCLHGTVRLQGFSCLKPLTLPSSKVYGASLYEQLVWKCQLGLPLYLWAAKTLED ENSRNOP00000007447/1-1211 TKPVLALCLHGTVRLQGFSCLKPQNLPSYKVHGASLYEQLVWKCQLGLPLYLWATKALEE ENSP00000313759/1-1217 RRPVLAPCLRGAVLLQSFSRQKPGAHSSRQAYGASLYEQLVWERQLGLPLYLWATKALEE ENSCPOP00000002973/1-1208 ERPVLAPCLHGAVLLRAFSCQKPGAQSSHQVHGAPLYEQLIWKHQLGLPLYLWASRALVE XP_004857547.1/1-1212 TRPVLASCLRGAILLRSFSCQKPGTQSSHQVHEATLYEQLIWKRQLGLPLYLWAIRALVE :**** **:*:: *:.** ** .* :.: *.*****:*: ********** ::* : ENSMUSP00000112063/1-1212 LIYKLCPHVLRCHQFLKQPSPGKPSLGLQLLAPSWDVLIPPGSPMRHAYSEILEEPHNCP ENSRNOP00000007447/1-1211 LVYKLCPHVLRCQQFLKHSSPGKPSLGLQLLAPSWDVLIPPGSPIRHAHSEILEEPHNCP ENSP00000313759/1-1217 LACKLCPHVLRHHQFLQHSSPGSPSLGLQLLAPTLDLLAPPGSPVRNAHNEILEEPHHCP ENSCPOP00000002973/1-1208 LACKLCPHMLRHGQFLQHSSPAHPSLGLQLLAPALNDLAPPGSARRNVHSEILEEPHRCP XP_004857547.1/1-1212 LVCKLCPHVLRHHQFLQHSS-GNPSLGLQLLAPALDDLAPPSSTIRNAHNEILEEPHHCP * *****:** ***::.* . **********: : * **.*. *:.:.*******.** ENSMUSP00000112063/1-1212 LQKYTPLQTPYSFPTMLALAEEGQHRAWATFDPKAMLPLPEASHLTSCQLNRHLAWSWVC ENSRNOP00000007447/1-1211 LQKYTPLQTPYTFPTILALAEEGQHRAWATFDPRALLPFPEAFHLTSCQLNRRLAWSWLC ENSP00000313759/1-1217 LQKYTRLQTPSSFPTLATLKEEGQRKAWASFDPKALLPLPEASYLPSCQLNRRLAWSWLC ENSCPOP00000002973/1-1208 LQKYVRLQTPCSFPTLDALAAEGQQKAWASFDPKALLPLPEAAYLTSCQLNQRLAWSWFC XP_004857547.1/1-1212 LQKYTRLQTPYSFPTLAMLAEEGQHKAWASFDPKALLPLPEAAYLTSCQLNRRLAWSWFC ****. **** :***: * ***::***:***:*:**:*** :*.*****::*****.* ENSMUSP00000112063/1-1212 LPSCVFQPAQVLLGVLVASSRKGCLELRDLRGSLPCIPLTESSQPLIDPNLVGCLVRVEK ENSRNOP00000007447/1-1211 LPSSMFQPAPVLLGVLVASSHKGCLQLRDVRGSLPCIPLPESSQPLIDPKLIGCLVRVEK ENSP00000313759/1-1217 LLPSAFCPAQVLLGVLVASSHKGCLQLRDQSGSLPCLLLAKHSQPLSDPRLIGCLVRAER ENSCPOP00000002973/1-1208 IRPSAFCPAQVLVGVLVASSRKGYLCLRDQSGALPCLLLAQDSQPVTDSRLIGCLVRAER XP_004857547.1/1-1212 LRSSAFHPTQVLLGILVASCCKGCLRLRDQSGSLSCLLLAEDSQPVTDSRLIGCLVRAER : .. * *: **:*:****. ** * *** *:*.*: *.: ***: *..*:*****.*: ENSMUSP00000112063/1-1212 FQLVVEREVRSSFPSWEEMGMARFIQKKQARVYVQFYLADALILPVPRPTF----GSEPS ENSRNOP00000007447/1-1211 FQLVVEREVRSSFPSWEELGMASLIQKKQARVYVQFYLADALILPVPRPTV----GLEPS ENSP00000313759/1-1217 FQLIVERDVRSSFPSWKELSMPGFIQKQQARVYVQFFLADALILPVPRPCLHSATPSTP- ENSCPOP00000002973/1-1208 FQLVVERNVKSNFPSWKELGVADFIQKQKARVYIQIFLADCLILPVPRSAPHSVTSPASA XP_004857547.1/1-1212 FQLIIERNVKSNFPSWKELGMGDFIQKRKARVYVQFFLADSLILPVPRSALHAPTPSAPP ***::**:*:*.****:*:.: :***::****:*::***.*******. . ENSMUSP00000112063/1-1212 QTASSCPEGPHLGQSRLFLLSHKEALMKRNFCLLPGDSSQPAKPTLSFHVSGTWLCGTQR ENSRNOP00000007447/1-1211 ETASSCPEGPQVGQSRLFLLFYKEALMKRNFCLLPGDSSRPAEPTLSFRVSGTWLCGTQK ENSP00000313759/1-1217 QTDPTGPEGPHLGQSRLFLLCHKEALMKRNFCVPPGASPEVPKPALSFYVLGSWLGGTQR ENSCPOP00000002973/1-1208 QMEPSCLEQPPEGQSRLFVLSHKETLMKLNFCASSRASTEVLKPTFSFQVSGVWLGGTQR XP_004857547.1/1-1212 QTEPTCPEGPHVGQSRLFLLSHKETLIKLNFCASSRASAEVLKPTFSFQVSGIWLGGTQR : .: * * ******:* :**:*:* *** . *.. :*::** * * ** ***: ENSMUSP00000112063/1-1212 KEGSGWSPPESLAVESKDQKVFLIFLGSSVRWFPFLYPNQVYRLVASGP-SQTP-VFETE ENSRNOP00000007447/1-1211 REGSGWSPPESLAAENKDQKVFFIFLGSSVQWFPFLYPNQVYRLVA--P-DSTPALFETN ENSP00000313759/1-1217 KEGTGWGLPEPQGNDDNDQKVHLIFFGSSVRWFEFLHPGQVYRLIA--PGPATPMLFEKD ENSCPOP00000002973/1-1208 KMGTGWGPPEPLKEENRDQKVLLLFRGSSVRWFAFLHPGQVYRLVA--P-PSTPMLFEAE XP_004857547.1/1-1212 KEGTGWGPPEPLKDENKDQKVLLLFLGSSVRWFAFLHPGQVYRLVT--P-HSTPMLFEAE : *:**. **. :..**** ::* ****:** **:*.*****:: * ** :** : ENSMUSP00000112063/1-1212 GSAGTSRRPLELADCGSCLTVQEEWTLELGSSQDIPNVLEVPRTLPESSLAQLLGDNSPD ENSRNOP00000007447/1-1211 HSSGTPHRPLELTDYVSCLTIQEDWTLELGSSQDIPNVLEVPRTLSESSLAHLLSDNSPN ENSP00000313759/1-1217 GSSCISRRPLELAGCASCLTVQDNWTLELESSQDIQDVLDANKSLPESSLTDLLSDNFTD ENSCPOP00000002973/1-1208 GASCVSRRPLELAAGGSCLTVQDEWTLEPESSQDVPEALSLQRALPESSLPSLLSGNFTD XP_004857547.1/1-1212 GSSCTSQRPLELAGCVSCLTVQDEWTLELESSQDVPEELGVHRALPESSLPNLLSGNFTD :: .:*****: ****:*::**** ****: : * ::*.****. **..* .: ENSMUSP00000112063/1-1212 SLVSFSAEILSRILCEPPLALRRMKPGNAGAIKTGVKLTVALEMDDCEYPPHLDIYIEDP ENSRNOP00000007447/1-1211 FLVSFSAEVLSRILCEPPLALRRIKPGNAGAIKAGVKLTVALEMEDCDYPPHLDIYIEDP ENSP00000313759/1-1217 SLVSFSAEILSRTLCEPLVASLWMKLGNTGAMRRCVKLTVALETAECEFPPHLDVYIEDP ENSCPOP00000002973/1-1208 SLVSFSAEILSRTVCGPLLGRCWTKPGSARAPRRCVKLTVALGTAHCEFPPHLDVYMEEP XP_004857547.1/1-1212 SLVSFSAEILSRTVCEPLLAPCWTKPGNTRALRRCVKLTVALEPANCEFPPHLDIYMEEP *******:*** :* * :. * *.: * : ******* .*::*****:*:*:* ENSMUSP00000112063/1-1212 QLPPQIGLLPGARVHFSQLEKRISRSNIVYCCFRSSTSVQVLSFPPETKASAPLPHIYLA ENSRNOP00000007447/1-1211 HLPPPIGLLPGARVHFSQLEKKISRSNVVYCCFRSTTSVQVLSFPPETKASAPLPHICLA ENSP00000313759/1-1217 HLPPSLGLLPGARVHFSQLEKRVSRSHNVYCCFRSSTYVQVLSFPPETTISIPLPHIYLA ENSCPOP00000002973/1-1208 HLPVPLGLLPGARVHFSRLEKRVSRSHNVYCCFQSSTHVQVLSFPPETTVSVPLPHIYLA XP_004857547.1/1-1212 HFPVPLGLLPGAQVHFSQLEKRVSRSHNVYCCFQSSTYVQVLSFPPETTVSVPLPHIYLA ::* :******:****:***::***: *****:*:* **********. * ***** ** ENSMUSP00000112063/1-1212 ELLQGDRPPFQATTSCHIVYVLSLQILWVCAHCTSICPQGKCSRRDPSCPSQRAVSQANI ENSRNOP00000007447/1-1211 ELLQGDRPPFQATTSCHIVYVLSLQILWVCAHCTSICPQGKCSRQDPSCPSQRAISQASI ENSP00000313759/1-1217 ELLQGGQSPFQATASCHIVSVFSLQLFWVCAYCTSICRQGKCTRLGSTCPTQTAISQAII ENSCPOP00000002973/1-1208 E-LHGGRAPLRATASCHVVSVFSLELQWVCAHCSSVCLQGRCTRQDPSCPTQTSVSQASI XP_004857547.1/1-1212 ELLRGGRAPFRATASCHVVSVFSLQLLWVCTHCSSVCPQGRCTRQGSTCPTQTSVSQASI * *:*.:.*::**:***:* *:**:: ***::*:*:* **:*:* ..:**:* ::*** * ENSMUSP00000112063/1-1212 RLLVEDGTAEATVICRNHLVARALGLSPSEWSSILEHARGPGRVALQFTGLGGQTESASK ENSRNOP00000007447/1-1211 RLLVEDGTAEATVTCRNHHVATTLGLSPSEWSNVLDRARGPGRVALQFKGPGAQTESASK ENSP00000313759/1-1217 RLLVEDGTAEAVVTCRNHHVAAALGLCPREWASLLDFVQVPGRVVLQFAGPGAQLESSAR ENSCPOP00000002973/1-1208 RLLVEDGTAEAMVTCKNHHVTEALGLCPSEWTSLLESARGPGRVALQFTRPGAHLESSAE XP_004857547.1/1-1212 RLLVEDGTAEAMVTCKNHHVAEALGLHPSEWTLVLECARGPGRVALQFTQPGAQMESSAK *********** * *:** *: :*** * **: :*: .: ****.*** *.: **::. ENSMUSP00000112063/1-1212 THEPLTLLLRTLCTSPFVLRPVKLSFALERRPTDISPREPSRLQQFQCGELPLLTRVNPR ENSRNOP00000007447/1-1211 TGEPLTLLLQTLCTSPFVLRPIKLSFALERRPCDITPIEPPRLQQFQCGELPLLTRVNPR ENSP00000313759/1-1217 VDEPMTMFLWTLCTSPSVLRPIVLSFELERKPSKIVPLEPPRLQRFQCGELPFLTHVNPR ENSCPOP00000002973/1-1208 KIGPLTLFLRALCTSPAVLRPVELSFELERRPCNIGPLEPPRLQRFQCGELPVLTRLNPR XP_004857547.1/1-1212 MGEPLTLFLRTLCTSPSVLRPIVLSFELEKRPCNITPLEPPRLQRFQCGELPLLTKMNPR *:*::* :***** ****: *** **::* .* * **.***:*******.**::*** ENSMUSP00000112063/1-1212 LRLVCLSLQEPELPNPPQASAASS ENSRNOP00000007447/1-1211 LRLVCLSLQEPELPSPPQASAAAS ENSP00000313759/1-1217 LRLSCLSIRESEYSSSLGILASSC ENSCPOP00000002973/1-1208 LRLTCLSIREPQLPGPLGARASPC XP_004857547.1/1-1212 LRLACLSIQEPEHPGSLGAFAS-C *** ***::*.: ... *: .