CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000022469/1-1593 MAAATLSFGPEREAEPAKEARVVGSELVDTYTVYVIQVTDGNHEWTIKHRYSDFHDLHEK ENSRNOP00000032758/1-1502 MAAATLSFGPEREAEPAKEARVVGSELVDTYTVYVIQVTDGNHEWTIKHRYSDFHDLHEK ENSP00000418232/1-1504 -MATARTFGPEREAEPAKEARVVGSELVDTYTVYIIQVTDGSHEWTVKHRYSDFHDLHEK ENSCPOP00000002956/1-1450 -AATARGFGPEREAEPAKEARVVGSELVDTYTVYIIRVTDGNHEWTVKHRYSDFHDLHEK XP_004864451.1/1-1505 MAAAAAA--AEREAEPAKEARVVGSELVDTYTVYIIQVTDGSHEWTVKHRYSDFHDLHEK *:: .************************:*:****.****:************* ENSMUSP00000022469/1-1593 LVAERKIDKSLLPPKKIIGKNSRSLVEKRERDLEVYLQTLLTTFPDVAPRVLAHFLHFHL ENSRNOP00000032758/1-1502 LVAERKIDKTLLPPKKIIGKNSRSLVEKREKDLEVYLQTLLKTFPDVAPRVLAHFLHFHL ENSP00000418232/1-1504 LVAERKIDKNLLPPKKIIGKNSRSLVEKREKDLEVYLQKLLAAFPGVTPRVLAHFLHFHF ENSCPOP00000002956/1-1450 LVAEKKIDKNLLPPKKIIGKNSRSLVEKREKDLEVYLQTLLTSFPGVAPRVLAHFLHFHF XP_004864451.1/1-1505 LIAEKKIDKNLLPPKKIIGKNSRSLVEKREKDLEVYLQTLLAVFPGVAPRVLAHFLHFHF *:**:****.********************:*******.** **.*:***********: ENSMUSP00000022469/1-1593 YEVNGVTAALAEELFEKGEQLLGAGEVFAIRPLQLYAITEQLQQGKPTCASGDAKTDLGH ENSRNOP00000032758/1-1502 YEINGVTAALAEELFEKGEQLLGAGEVFAIRPLQLYAITEQLQQGKPTCASGDAKTDLGH ENSP00000418232/1-1504 YEINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGH ENSCPOP00000002956/1-1450 YEVNGITAALAEELYEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGH XP_004864451.1/1-1505 YEINGITAALAEELYEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGH **:**:********:*************** ******:********************** ENSMUSP00000022469/1-1593 ILDFTCRLKYLKVSGTEGPFGTSNIKEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVTSK ENSRNOP00000032758/1-1502 ILDFTCRLKYLKVSGTEGPFGTSNIREQLLPFDLSIFKSLHQVEMSHCDAKHVRGLVTSK ENSP00000418232/1-1504 ILDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVASK ENSCPOP00000002956/1-1450 ILDFTCRLKYLKVSGTEGAFGTSNIQEQLLPFDLSIFKSLHQVEISHCDAKNIRGLVASK XP_004864451.1/1-1505 ILDFTCRLKYLKVSCTEGPFGSSNIQEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVASK ************** ***.**:***:******************:******::****:** ENSMUSP00000022469/1-1593 PTLATMSVRFSATSMKEVLAPEASEFDEWEPEGTATLGGPVTAIIPTWQALTTLDLSHNS ENSRNOP00000032758/1-1502 PTLATMSVRFSAASMKEVLVPEASEFDEWEPEGT-TLGGPVTAVIPTWQALTTLDLSHNS ENSP00000418232/1-1504 PTLATLSVRFSATSMKEVLVPEASEFDEWEPEGT-TLEGPVTAVIPTWQALTTLDLSHNS ENSCPOP00000002956/1-1450 PTLATLSIRFSATSMKEVLVPEASEFDGWEPEGT-ALEGSVTAIIPTWQALTTLDLSHNS XP_004864451.1/1-1505 PTLATLSIRFSATSMKEVLVPEASEFDEWEPEGT-ALEGPVTAIIPTWQALTTLDLSHNK *****:*:****:******.******* ****** :* *.***:***************. ENSMUSP00000022469/1-1593 ICEIDESVKLIPKIEYLDLSHNGLRVVDNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNVK ENSRNOP00000032758/1-1502 ISEIDESVKLIPKIEYLDLSHNGVLVVDNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNVK ENSP00000418232/1-1504 VSEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIK ENSCPOP00000002956/1-1450 ISEIDESVKLIPKIEFLDLSHNGVLLMDNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNIK XP_004864451.1/1-1505 ISEIDESVKLIPKIEFLDLSHNGVLVVDNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNIK :.*************:*******: ::************************:******:* ENSMUSP00000022469/1-1593 TLNLAGNFLESLSGLHKLYSLVNVDLRDNRIEQLDEVKSIGSLPCLERLTLLNNPLSIIP ENSRNOP00000032758/1-1502 TLNLAGNFLERLSGLHKLYSLVNLDLRDNRIEQLDEVKSIGNLPCLEHVALLNNPLSIIP ENSP00000418232/1-1504 TLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIP ENSCPOP00000002956/1-1450 TLNLAGNLLENLSGLHKLYSLVNLDLSNNRIEQMEEVRSIGGLPCLEHVSLLNNPLSIIP XP_004864451.1/1-1505 TLNLAGNLLESLNGLHKLYSLVNLDLSNNRIEQMEEVRSIGSLPCVEHVSLLNNPLSIIP *******:** *.**********:** :*****::**:***.***:*:::********** ENSMUSP00000022469/1-1593 DYRTKVLSQFGERASEICLDDVATTEKELDTVEVLKAIQKAKDVKSKLSNTEKKAGEDFR ENSRNOP00000032758/1-1502 DYRTKVLSQFGERASEICLDDVATTEKELDTVEVLKAIQKAKDVKSKLSSTEKKVGEDFR ENSP00000418232/1-1504 DYRTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSR ENSCPOP00000002956/1-1450 DYRTKVLAQFGERASEVCLDNTVTTEKELDTVEVLKAIQKAKDVKSKLSHPEKKVGDDSR XP_004864451.1/1-1505 DYRTKVLAQFGERASEVCLDSTVTTEKELDTVEVLKAIQKAKDVKSKLNNSEKKVGEDSR *******:********:***...*******************:*****. .*** *:* * ENSMUSP00000022469/1-1593 LPPAPCIRPGGSPP-AAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLPPEDHRPIA ENSRNOP00000032758/1-1502 LPTAPCIRPSSSPPTAVPTSASLPQPILSNQGIMFVQEEALASSLSSTDSLPPDD-RPIA ENSP00000418232/1-1504 LSAAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEH-QPIA ENSCPOP00000002956/1-1450 LSAVPCTRPSGSPPLSAPTSASLPQPIFSNQGVMFVQEEALASSLSSTDSLVPED-RPIA XP_004864451.1/1-1505 LSAAPFVRPSGSPPSTAPTSASLPQPILSNQGVMFVQEEALASSLSSTDSLTPDD-RPIA *...* **..*** .*:********:****:****************** *:. :*** ENSMUSP00000022469/1-1593 RACSDSLESIPAGQVASDDLRDVPGAVGGVSPDHAEPEVQVVPGSGQIIFLPFTCIGYTA ENSRNOP00000032758/1-1502 QACSNSMGSLPTGQVAAEDLRDLPGAVGGVSPDHAEPEVQVVPGSGQIIFLPFTCIGYTA ENSP00000418232/1-1504 QGCSDSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTA ENSCPOP00000002956/1-1450 QGYSDSLESIPAGQAASSDLRDVPGAIGGASPEHMEPEVQVVPGSGQIIFLPFTCIGYTA XP_004864451.1/1-1505 RACSDSLESIPAGQASPDDLRDVPGAVGGASPEHTEPEVQVVPGSGQIIFLPFTCIGYTA :. *:*: *:*:**.:..****:***:**.**:* ************************* ENSMUSP00000022469/1-1593 TNQDFIQRLSTLIRQAIERQLPAWIEAANQREEAHGEQGEEEE-EEEEEEDVAENRYFEM ENSRNOP00000032758/1-1502 TNQDFIQRLSTLIRQAIERQLPAWIEAANQREEAHGEQGEEEE--EEEEEDVAESRYFEM ENSP00000418232/1-1504 TNQDFIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEEEDEEEEEEEDVAENRYFEM ENSCPOP00000002956/1-1450 TNQDFIQRLSTLIRQAIERQLPAWIEAAN----------------------VAENRYFEM XP_004864451.1/1-1505 TNQDFIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEEDD--DEDEEDVVENRYFEM ***************************** *.*.***** ENSMUSP00000022469/1-1593 GPPDAEEEEGSGQGEEDEED-EDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIH ENSRNOP00000032758/1-1502 GPPDAEEEEGSGQGEEDEED-EDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIH ENSP00000418232/1-1504 GPPDVEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIH ENSCPOP00000002956/1-1450 GPPDS-------------------------LALEWALGTDEDFLLEHIRILKVLWCFLIH XP_004864451.1/1-1505 GPPDTEEEEG-GPGEEEEEE-EEEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIH **** ********:********************* ENSMUSP00000022469/1-1593 VQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPE ENSRNOP00000032758/1-1502 VQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPE ENSP00000418232/1-1504 VQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPE ENSCPOP00000002956/1-1450 VQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPE XP_004864451.1/1-1505 VQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPE ************************************************************ ENSMUSP00000022469/1-1593 LCLVLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTTLQEFLRQ ENSRNOP00000032758/1-1502 LCLVLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQ ENSP00000418232/1-1504 LCLVLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQ ENSCPOP00000002956/1-1450 LCLVLKVRHSENTLFIISDATNLHEFHSDLRSCFAPQHMAMLCSPILYGSHTSLQEFLCQ XP_004864451.1/1-1505 LCLVLKVRHSENTLFIISDAANLQEFHADLRSCFAPQHMAMLCSPILYSSHTSLQEFLRQ ********************:**:***:********************.***:***** * ENSMUSP00000022469/1-1593 LLTFYKVAGGSQERSQGCFPVYLVYSDKRMVQTPAGDYSGNIEWASCTLCSAVRRSCCAP ENSRNOP00000032758/1-1502 LLTFYKVAGGSQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAP ENSP00000418232/1-1504 LLTFYKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAP ENSCPOP00000002956/1-1450 LLTFYKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAP XP_004864451.1/1-1505 LLTFYKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAP **********.**********************.************************** ENSMUSP00000022469/1-1593 SEAVKSAAIPYWLLLTSQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTR ENSRNOP00000032758/1-1502 SEAVKSAAIPYWLLLTSQHLNVIKADFNPMPSRGTHNCRNRNSFKLSRVPLSTVLLDPTR ENSP00000418232/1-1504 SEAVKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTR ENSCPOP00000002956/1-1450 SEAVKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTR XP_004864451.1/1-1505 SEAVKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHHCRNRNSFKLSRVPLSTVLLDPTR ****************.**************.****:*********************** ENSMUSP00000022469/1-1593 SCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVISKNP ENSRNOP00000032758/1-1502 SCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLKDLKTVVIAKNP ENSP00000418232/1-1504 SCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVIAKTP ENSCPOP00000002956/1-1450 SCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRIYNQLRASLQDLKTVVIAKSS XP_004864451.1/1-1505 SCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRIYNQLRASLQDLKTVVIAKTP ***************************************:********:*******:*.. ENSMUSP00000022469/1-1593 SAKPRNQ-------PAKSRASAEQRLQETPADAPAPAAVPPTASAPAPAEALAPDLAPVQ ENSRNOP00000032758/1-1502 SARPRTQGPLAGGQPAKSRVSAEQRLQETPAEAP-------------------------- ENSP00000418232/1-1504 GTGGSPQGSFADGQPAERRASNDQRPQEVPAEAL-------------------------- ENSCPOP00000002956/1-1450 TNGARPQSPPVDGQPAEGKASTSEEPREGCSFTR-------------------------- XP_004864451.1/1-1505 TPGTRSQSPLVDGQPAEDRARHDQRPQEGPAEAT-------------------------- * **: :. .:. :* : : ENSMUSP00000022469/1-1593 APGEDRGLTSAEAPAAAEAPAAAEAPAAAEAPAAAEAPAAAEAPAAAEAPAPAEAPAAAE ENSRNOP00000032758/1-1502 ------------------------------------------------APAPAAAESAAE ENSP00000418232/1-1504 ------------------------------------------------APAPAEVPAPAP ENSCPOP00000002956/1-1450 ------------------------------------------------TGRPRLLP-PTQ XP_004864451.1/1-1505 ------------------------------------------------AGAPAPAPASAP : * .: ENSMUSP00000022469/1-1593 APAAAEAPAAAEAPAAAEAPASAEAPAPNQAPAPARGPAPARGPAPAGGPAPAEALAQAE ENSRNOP00000032758/1-1502 APAAAEASAPAGAPAPAGAPAPAGAPAGAQAPA----------------P------AQAE ENSP00000418232/1-1504 AAASASGPAKTPAPAEASTSALVPEETPVEAPA----------------P------PPAE ENSCPOP00000002956/1-1450 YWAACDFGGSSPKKPEASAPALVPEEAPVETPP--------------------------- XP_004864451.1/1-1505 APTSAEAQAPPPAPAEASAPALVPEEAPIETPT----------------PAAAEALTQAE ::.. . . . * :.* . : ::*. ENSMUSP00000022469/1-1593 VPAQYPSERLIQSTSEENQIPSHLPVCPSLQHIARLRGRAIIDLFHNSIAEVENEELRHL ENSRNOP00000032758/1-1502 VPAQYPSERLIQSTSEENQIPSHLPVCPSLQHIARLRGRAIIDLFHSSIAEVENEELRHL ENSP00000418232/1-1504 APAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRGSAIIELFHSSIAEVENEELRHL ENSCPOP00000002956/1-1450 -PAQYPSEQLIQSTSEENQIPLHLPVCPSLQHIASLQGKAVIELFHSSIAEVENEELRHL XP_004864451.1/1-1505 APAQYPSEQLIQSTSEENQIPFHLPVCPSLQHIAGLSGKAVIELFHSSIAEVENEELRHL *******:***:******** ***.****:*:* * * *:*:***.************* ENSMUSP00000022469/1-1593 LWSSVVFYQTPGLEVTACVLLSSKAVYFILHDGLRRYFSEPLQDFWHQKNTDYNNSPFHV ENSRNOP00000032758/1-1502 LWSSVVFYQTPGLEVTACVLLSTKAVYFILHDGLRRYFSEPLQDFWHQKNTDYNNSPFHI ENSP00000418232/1-1504 MWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYFSEPLQDFWHQKNTDYNNSPFHI ENSCPOP00000002956/1-1450 LWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYFSEPLQDFWHQKNTDYNNSPFHI XP_004864451.1/1-1505 LWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYFSEPLQDFWHQKNTDYNNSPFHI :*********************:*****:******************************: ENSMUSP00000022469/1-1593 SQCFVLKLSDLQSVNVGLFDQYFRLTGSSPTQVVTCLTRDSYLTHCFLQHLMLVLSSLER ENSRNOP00000032758/1-1502 SQCFVLKLSDLQSVNVGLFDQYFRLTGSSPTQVVTCLTRDSYLTHCFLQHLMLVLSSLER ENSP00000418232/1-1504 SQCFVLKLSDLQSVNVGLFDQHFRLTGSTPMQVVTCLTRDSYLTHCFLQHLMVVLSSLER ENSCPOP00000002956/1-1450 SQCFVLKLSDLQSVNVGLFDQHFRLTGSSPAQVVTCLTRDSYLTHCFLQHLMLVLSSLER XP_004864451.1/1-1505 SQCFVLKLSDLQSVNVGLFDQHFRLTGSAPAQVVTCLTRDSYLTHCFLQHLMLVLSSLER *********************:******:* *********************:******* ENSMUSP00000022469/1-1593 TPSPEPVDKDFYSEFGDKNTGKMENYELIHSSRVKFTYPSEEEVGDLTYIVAQKMADPAK ENSRNOP00000032758/1-1502 TPSPEPIDKDFYSEFGDKNTGKMENYELIHSSRVKFTYPSEEEVGDLTYVVAQKMADPAK ENSP00000418232/1-1504 TPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYPSEEEIGDLTFTVAQKMAEPEK ENSCPOP00000002956/1-1450 TPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYPSEEEVGDLTYIVAQKTADPDK XP_004864451.1/1-1505 TPSPEPADKDFYSEFGDKTTGKMENYELIHSSRVKFTYPSEEEVGDLTYIVAQKTTDPEK ****** *********:*.************************:****: **** ::* * ENSMUSP00000022469/1-1593 NPALSILLYIQAFQVVTPHLGRGRGPLRPKTLLLTSAEIFLLDEDYIHYPLPEFAKEPPQ ENSRNOP00000032758/1-1502 NPALSILLYIQAFQVITPQLGRGRGPLRPKTLLLTSAEIFLLDEDYIHYPLPEFAKEPPQ ENSP00000418232/1-1504 APALSILLYVQAFQVGMPPPGCCRGPLRPKTLLLTSSEIFLLDEDCVHYPLPEFAKEPPQ ENSCPOP00000002956/1-1450 APTPSILLYVQAFLVGPLPPGRCRSPLRPKTLLLTSTELFLLDEDYIHYPLPEFAKEPPQ XP_004864451.1/1-1505 APAPSILLYVQAFQVDLPPPGSCRGPLRPKTLLLTSTEIFLLDEDYIHYPLPEFAKEPPQ *: *****:*** * * *.***********:*:****** :************* ENSMUSP00000022469/1-1593 RDRYRLDDGRRVRDLDRVLMGYYPYPQALTLVFDDTQGHDLMGSVTLDHFGEMPGGPGRV ENSRNOP00000032758/1-1502 RDRYRLDDGRRVRDLDRVLMGYNPYPQALTLVFDDTQGHDLMGSVTLDHFGEMPGGPGRA ENSP00000418232/1-1504 RDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGHDLMGSVTLDHFGEVPGGPARA ENSCPOP00000002956/1-1450 RDRYRLDDGRRVRDLDRILMGYQPYPQALTLVFDDMQGHDLMGCVTLDHFGEVPCGSARA XP_004864451.1/1-1505 RDRYRLGDGHRVRDLDRVLMGYQPYPQALTLVFDDMQGHDLMGSVTLDHFGEMQSGSARA ******.**:*******:**** .*********** *******.********: *..*. ENSMUSP00000022469/1-1593 GQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVELTG ENSRNOP00000032758/1-1502 GQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVELTG ENSP00000418232/1-1504 SQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVELTG ENSCPOP00000002956/1-1450 GQGHEIQWQVFVPSAESREKLISLLARQWEALCGRELPVELTG XP_004864451.1/1-1505 GQGREIQWQIFVPSAESREKLISLLARQWEALCGRELPVELTG .**:*:***:*********************************