CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000113783/1-1048 ------------------------------------------------------------ ENSRNOP00000000337/1-1047 ------------------------------------------------------------ ENSP00000357948/1-1086 --------------------------------------------------------MSCL ENSCPOP00000002811/1-1058 ------------------------------------------------------------ XP_004874024.1/1-1152 MGKSAQEARATLDPPASSNFFLGPRALWTAAPRPLAKLAPQGAGDPPPARGRREPGLRRQ ENSMUSP00000113783/1-1048 -------------------MASPASTNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVES ENSRNOP00000000337/1-1047 -------------------MASPTSTNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVES ENSP00000357948/1-1086 SHSSLPSCCPPQEAS----MASPTSTNPAHAHFESFLQAQLCQDVLSSFQELCGALGLEP ENSCPOP00000002811/1-1058 -------------------MASSSSPNPAHAHFESFLQAQLCQDVLSSFRELCGALGVEP XP_004874024.1/1-1152 RPGALPSCSPPPRSPRGTSMASPTSINPAHAHFESFLQAQLCQDVLSSFQKLCEALRVES ***.:* **** ***:*:************: ** ** :*. ENSMUSP00000113783/1-1048 GGGLSQYHKIKAQLNYWSAKSLWAKLDKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAV ENSRNOP00000000337/1-1047 GGGLPQYHKIKAQLNYWSAKSLWAKLDKRASQPAYQQGQACTNTKCLVVGAGPCGLRAAV ENSP00000357948/1-1086 GGGLPQYHKIKDQLNYWSAKSLWTKLDKRAGQPVYQQGRACTSTKCLVVGAGPCGLRVAV ENSCPOP00000002811/1-1058 GCGLPQYHKIKAQLNYWSAKSLWAKLDKRASQPVYQQGQACTSTKCLVVGAGPCGLRAAV XP_004874024.1/1-1152 GGGLPQYHKIKAQLNYWSAKSLWAKLDKRASQPVYHQGQACTSTKCLVVGAGPCGLRAAV * **.****** ***********:******.**.*:**:***.**************.** ENSMUSP00000113783/1-1048 ELALLGARVVLVEKRIKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQ ENSRNOP00000000337/1-1047 ELALLGARVVLVEKRTKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQ ENSP00000357948/1-1086 ELALLGARVVLVEKRTKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQ ENSCPOP00000002811/1-1058 ELALLGARVVLVEKRTKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQ XP_004874024.1/1-1152 ELALLGAQVVLVEKRTKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQ *******:******* ******************************************** ENSMUSP00000113783/1-1048 LLLLKVALLLGVEIHWGVKFTGLQPPPRKGDGWRAQLQPNPPAQLASYEFDVLISAAGGK ENSRNOP00000000337/1-1047 LLLLKVALLLGVEIHWGFTFTGLQPPPKKGSGWRARIQPSPPAQLASYEFDVLISAGGGK ENSP00000357948/1-1086 LLLLKVALLLGVEIHWGVTFTGLQPPPRKGSGWRAQLQPNPPAQLANYEFDVLISAAGGK ENSCPOP00000002811/1-1058 LLLLKVALLLGVEIHWGVTFTGLQPPLRKGSGWRAQLQPKPPDQLANYEFDVLISAAGSK XP_004874024.1/1-1152 LLLLKVALLLGVEIHWSVTFTGLQPPSGKGSSWRAQLQPNPPDQLANYEFDVLISAAGGK ****************...******* **..***::**.** ***.*********.*.* ENSMUSP00000113783/1-1048 FVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQKFFQSLLKATGIDL ENSRNOP00000000337/1-1047 FVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQKFFQSLLKATGIDL ENSP00000357948/1-1086 FVPEGFKVREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQSFFQSLLKATGIDL ENSCPOP00000002811/1-1058 FVPEGFTVREMRGKLAIGITANFVNRRTAEETQVPEISGVARIYNQKFFQSLLKATGIDL XP_004874024.1/1-1152 FVPEGFTVREMRGKLAIGITANFVNRRTVEETQVPEISGVARIYNQKFFQSLLKATGIDL ******.:***************** **.*****************.************* ENSMUSP00000113783/1-1048 ENIVYYKDETHYFVMTAKKQCLLRLGVLRQDLSETDQLLGKANVVPEALQRFARAAADFA ENSRNOP00000000337/1-1047 ENIVYYKDDTHYFVMTAKKQCLLRLGVLRQDLPETDQLLGKANVVPEALQQFARAAADFA ENSP00000357948/1-1086 ENIVYYKDDTHYFVMTAKKQCLLRLGVLRQDWPDTNRLLGSANVVPEALQRFTRAAADFA ENSCPOP00000002811/1-1058 ENIVYYKDDTHYFVMTAKKQCLLRLGVLRQDRLETEQLLSSANVVPEALQRFVRAAADFA XP_004874024.1/1-1152 ENIVYYKDDTHYFVMTAKKQCLLRLGVLRQDWPETDRLLGSANVVSEALQRFARAAADFA ********:********************** :*::**..****.****:*.******* ENSMUSP00000113783/1-1048 THGKLGKLEFAQDARGRPDVAAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWP ENSRNOP00000000337/1-1047 TQGKLGKLEFAQDARGRPDVAAFDFTSMMRSESSARIQEKHGARLLLGLVGDCLVEPFWP ENSP00000357948/1-1086 THGKLGKLEFAQDAHGQPDVSAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWP ENSCPOP00000002811/1-1058 TNGKLGKLEFAQDARGRPDISAFDFTSMLRAECSARVQEKHGARLLLGLVGDCLVEPFWP XP_004874024.1/1-1152 TNGKLGKLEFAQDAHGQPDVSAFDFTTMMRAECSARVQEKHGARLLLGLVGDCLVEPFWP *:************:*:**::*****:*:*:*.***:*********************** ENSMUSP00000113783/1-1048 LGTGVARGFLAAFDAAWMVKRWAEGAGPLEVLAERESLYQLLSQTSPENMHRNVAQYGLD ENSRNOP00000000337/1-1047 LGTGVARGFLAAFDAAWMVKRWAEGTGPLELLAERESLYQLLSQTSPENMHRNVAQYGLD ENSP00000357948/1-1086 LGTGVARGFLAAFDAAWMVKRWAEGAESLEVLAERESLYQLLSQTSPENMHRNVAQYGLD ENSCPOP00000002811/1-1058 LGTGVARGFLAAFDAAWMVKRWAEGTEPLEVLAERESLYQLLSQTSPENMHRNVAQYGLD XP_004874024.1/1-1152 LGTGVARGFLAAFDAAWMVKRWAEGTEPLEVLAERESLYQLLSQTSPENMHRNVAQYGLD *************************: .**:***************************** ENSMUSP00000113783/1-1048 PATRYPNLNLRAVTPNQVQDLYDMMDKEHAQRKSDEPDSRKTTTGSAGT-EELLHWCQEQ ENSRNOP00000000337/1-1047 PATRYPNLNLRAVTPNQVQDLYDIMDKEHARKKSDETDARKTTTGSAGT-EELLHWCQEQ ENSP00000357948/1-1086 PATRYPNLNLRAVTPNQVRDLYDVLAKEPVQRNNDKTDTGMPATGSAGTQEELLRWCQEQ ENSCPOP00000002811/1-1058 PASRYPNLNLKAVTPNQVRDLYDVVAKGPVPKKNDKPNRGNPTTGSAGTQEELLHWCQEK XP_004874024.1/1-1152 PASRYPNLNLQAVTPNQVRDLYDVVAKQPVPKKSDKPDTGNLTTGPAGTQEELLCWCQEK **:*******:*******:****:: * . ::.*:.: :**.*** **** ****: ENSMUSP00000113783/1-1048 TAGFPGVHVTDFSSSWADGLALCALVHHLQPGLLEPSELQGMGALEATTWALRVAEHELG ENSRNOP00000000337/1-1047 TAGFPGVSVTDFSSSWADGRALCALVHRLQPGLLEPSELQGMSALEATAWALRVAEYELG ENSP00000357948/1-1086 TAGYPGVHVSDLSSSWADGLALCALVYRLQPGLLEPSELQGLGALEATAWALKVAENELG ENSCPOP00000002811/1-1058 TAGYPGVHVTDLSSSWADGRALCALVHRLQPSLLGPSEVQDMGALEATTWALRAAEHELG XP_004874024.1/1-1152 TAGYPGVHVTNLSSSWADGLALCALVHRLQPSLLEPSELQGLGALEATAWALKVAEHELG ***:*** *:::******* ******::***.** ***:*.:.*****:***:.** *** ENSMUSP00000113783/1-1048 ITPVLSAQAVMAGSDPLGLIAYLSHFHSAFKNTSHSS----GLVSQPS-GTPSAILFLGK ENSRNOP00000000337/1-1047 IIPVLSAQAVVAGSDPLGLIAYLSHFHSAFKNTPHSS----GLVSQPH-GTPSAILFLGK ENSP00000357948/1-1086 ITPVVSAQAVVAGSDPLGLIAYLSHFHSAFKSMAHSP----GPVSQASPGTSSAVLFLSK ENSCPOP00000002811/1-1058 ITPVVSAQAVVAGSDPLGLIAYLSHFHSAFKNTPNSP----GPVNQGSPGTSSAVLFLGK XP_004874024.1/1-1152 ITPVVSAQAVVTGSDPLGLIAYLSHFHSAFKNTPSSPGDLKGPVSQASPGTSSAVLFLGK * **:*****::*******************. . *. * *.* **.**:***.* ENSMUSP00000113783/1-1048 LQRSLQRTRAK--------------VDEETPSTEEPPVSEPSMSPNTPELSEHQ----EA ENSRNOP00000000337/1-1047 LQRSLQRTRTK--------------VEEETPCTEEPPVSEPSVPPALP--SEHE----EA ENSP00000357948/1-1086 LQRTLQRSRAKENAEDAGGKKLRLEMEAETPSTEVPPDPEPGVPLTPP--SQHQ----EA ENSCPOP00000002811/1-1058 LQRTLQRTRAKENSGDAGGKKPRLEVEADTPRTEEPPAPESRGPLVPP--PQQQ----EA XP_004874024.1/1-1152 LQRTLQRTRAKENREDAGGKKPRLEVEADPPSTEEPPALGPSVPLKPP--SQQQKELVQA ***:***:*:* :: :.* ** ** . . * .::: :* ENSMUSP00000113783/1-1048 GAEELCELCGKHLYILERFCVDGHFFHRSCFCCHTCEATLWPGGYGQHPGDGHFYCLQHL ENSRNOP00000000337/1-1047 GAEDVCELCGKRLYILERFCVDGHFFHRGCFCCRTCEATLRPGGYGQYPGDGYFYCLQHL ENSP00000357948/1-1086 GAGDLCALCGEHLYVLERLCVNGHFFHRSCFRCHTCEATLWPGGYEQHPGDGHFYCLQHL ENSCPOP00000002811/1-1058 DARGLCALCGEHLYILERFCVDGHFFHRSCFRCHACEATLWPGGYGQHP-DGHFYCLQHL XP_004874024.1/1-1152 GARDLCALCGERLYILERFCVDGHFFHRSCFHCHACEATLWPGGYGQHPGDGHFYCLQHL .* :* ***::**:***:**:******.** *::***** **** *:* **:******* ENSMUSP00000113783/1-1048 PQEDQKEADNNGSLESQELPTPGDSNMQPDPSSP--PVTRVSPVPSPSQPARRLIRLSSL ENSRNOP00000000337/1-1047 PQEDQKEADNNGSPENQELPTPGDSTTQSGPSSPVPPVTEASPVPSPSQPARRLIRLSSV ENSP00000357948/1-1086 PQTDHKAEGSDRGPESPELPTPSENSMPPGLSTPTASQEGAGPVPDPSQPTRRQIRLSSP ENSCPOP00000002811/1-1058 PGTDHKKDIMDGGSTSPELPTPDANSVPPGPLTPTAPQEEASPIPCPRQPARRLIRLSSP XP_004874024.1/1-1152 PKTGHKEDIMDGGPDSPELPLPDENSVPPDPLTPTAP-KEASPIPCPSQPARRLIRLSSL * .:* : . . *** *. .. .. :* . ..*:* * **:** ***** ENSMUSP00000113783/1-1048 ERLRLSSLNIIPDSGAEPPPKPPRSCSDLARESLKSSFVGWGVPVQAPQVPEAIEKGDDE ENSRNOP00000000337/1-1047 ERLRLSSLNIIPDSGVEPPPKPPRSCLDLAQESLKSSFMGWGV-LRAPQVPEAIEKGEEE ENSP00000357948/1-1086 ERQRLSSLNLTPDPEMEPPPKPPRSCSALARHALESSFVGWGLPVQSPQALVAMEKEEKE ENSCPOP00000002811/1-1058 ERQRLSSLDINPSPEMEPPPKPPRSCSALAREALEGSFVGWGMPARSLPVFEAME-EEES XP_004874024.1/1-1152 ERQRLSSLNINPSPEMEPPPKPPRSCSALARQALEGSFVGWGVPVQSPPVFEAME-EEKS ** *****:: *.. ********** **:.:*:.**:***: :: . *:* :.. ENSMUSP00000113783/1-1048 EEEEEEEEEEEEPL-PPLEPELEQTLLTLAKNPGAMTKYPTWRRTLMRRAKEEEMKRFCK ENSRNOP00000000337/1-1047 EEEEEEEEEEEEELPPPLALEVEQSLLTLAKNSGDMTKYPTWRRTLMRRAKEEEMKRFCK ENSP00000357948/1-1086 SPFSSEEEEEDVPL----DSDVEQALQTFAKTSGTMNNYPTWRRTLLRRAKEEEMKRFCK ENSCPOP00000002811/1-1058 SSDNEEEEDDDEPL----DPDLEQALQTMAKNAGTMDKYPTWRRTLLRHAKEEEMKRFCK XP_004874024.1/1-1152 PSSSEEEEEEDEPL----DSDLEQALLTLAKNARTMNKYPTWRRTLLRHAKEEEMKRFCK ..***::: * ::**:* *:**.. * :********:*:*********** ENSMUSP00000113783/1-1048 AQAIQRRLNEIEATMRELEAEGTKLELALRKESSSPEQQKKLWLDQLLRLIQKKNSLVTE ENSRNOP00000000337/1-1047 AQAIQRRLNEIEAAMRELETEGMKLEVALRKESSSPEKQKKLWLEQLLQLIQKKNSLVTE ENSP00000357948/1-1086 AQTIQRRLNEIEAALRELEAEGVKLELALRRQSSSPEQQKKLWVGQLLQLVDKKNSLVAE ENSCPOP00000002811/1-1058 AQTIQRRLNEIEAALRELEAEGVKLELALRSQSTSPEQQKKLWLEQLLQLVQKKNSLVAE XP_004874024.1/1-1152 AQAIQRRLNEIEVALRELEAEGMKLELALRSQNSSPEQQKKLWLEQLLQLVQKKNSLVAE **:*********.::****:** ***:*** :.:***:*****: ***:*::******:* ENSMUSP00000113783/1-1048 EAELMITVQELDLEEKQRQLDHELRGYMNREETMKTEADLQSENQVLRKLLEVVNQRDAL ENSRNOP00000000337/1-1047 EAELMITVQELDLEEKQRQLDHEFRG-INREETLKTQADRLSEDRVLRKLLDVVNQRDAL ENSP00000357948/1-1086 EAELMITVQELNLEEKQWQLDQELRGYMNREENLKTAADRQAEDQVLRKLVDLVNQRDAL ENSCPOP00000002811/1-1058 EAELMITVQELDLEEKQWQLDHELRGYMNREETLKTAEDRQAEDEILRKLVEVVNQRDAL XP_004874024.1/1-1152 EAELMITVQELDLEEKQWQLDHELRGYMNREETLKTAADRQAEDQVLRKLVDIVNQRDAL ***********:***** ***:*:** :****.:** * :*:.:****:::******* ENSMUSP00000113783/1-1048 IQFQEERRLREMPA------ ENSRNOP00000000337/1-1047 IQFQEERRLREMPV------ ENSP00000357948/1-1086 IRFQEERRLSELALGTGAQG ENSCPOP00000002811/1-1058 IRFREECRLSELA------- XP_004874024.1/1-1152 IRFREECRLNELASGTGALG *:*:** ** *:.