CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000033991/1-1401 -----METTSLQRKFPEWMSMQSQRCATEEK-ACVQKSVLEDNLPFLEFPGSIVYSYEAS ENSRNOP00000055596/1-1400 -----METTSLRRKFPEWMSTQNKSCATQEK-ASIQKSVLEDDLPFLEFTGSVVYSYEAS ENSP00000298139/1-1432 MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDAS ENSCPOP00000002674/1-1433 MNEKKLETTSQQRKFPKWMSVPNKGCTPKGKEPCIQKSIFEDDLSFLEFTGSIVYSYEAS XP_004855469.1/1-1406 MNEKKLETISQQRKFPEWMSMQNKGCAIEGKKAHIQKSVFEDDLPFLEFTGSIVYSYEAS :** : :** *:**. .: *: : : . ::**::**:*.****.**:****:** ENSMUSP00000033991/1-1401 DCSFLSEDISMRLSDGDVVGFDMEWPPIYKPGKRSRVAVIQLCVSESKCYLFHISSMSVF ENSRNOP00000055596/1-1400 DCSFLSEDISMHLSDGDVVGFDMEWPPIYKQGKRSRVAVIQLCVSESKCYLFHISSMSVF ENSP00000298139/1-1432 DCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVF ENSCPOP00000002674/1-1433 DCSFLSQDISMRLSPGDVIGFDMEWPPTYSKGKLSRVALIQLCVSESKCYLFHISSMSVF XP_004855469.1/1-1406 DCSFLSEDISMSLSAGDVIGFDMEWPPIYNKGKLSRVALVQLCVSESKCYLFHISSMSVF ******:**** ** ***:******** *. ** .:**::*************:****** ENSMUSP00000033991/1-1401 PQGLKMLLENKSIKKAGVGIEGDQWKLLRDFDVKLESFVELTDVANEKLKCAETWSLNGL ENSRNOP00000055596/1-1400 PQGLKMLLENKSIRKAGVGIEGDQWKLLRDFDVKLESFVELTDVANRKLKCAETWSLNGL ENSP00000298139/1-1432 PQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL ENSCPOP00000002674/1-1433 PQGLKMLLENEAIKKAGVGIEGDQWKLLRDFDIKLKSFVELTDVANQKLKSTEIWSLNGL XP_004855469.1/1-1406 PQGLKMLLENETIKKAGVGIEGDQWKLLRDFDIKLKSFVELTDVANQKLKCMEIWSLNGL **********::::******************:**:.*********.***. * ****.* ENSMUSP00000033991/1-1401 VKHVLGKQLLKDKSIRCSNWSNFPLTEDQKLYAATDAYAGLIIYQKLGNLGDTAQVFALN ENSRNOP00000055596/1-1400 VKHVLGKQLLKDKSIRCSNWSDFPLSEDQKLYAATDAYAGLIIYQKLENLGDAVQVFALN ENSP00000298139/1-1432 VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAIN ENSCPOP00000002674/1-1433 VKHLFGKQLLKDKSVRCSNWSNFPLSEDQKLYAATDAYAGLIIYQKLESLSDAVQRFDTN XP_004855469.1/1-1406 VKHLFGKQLLKDKSIRCSNWSIFPLSEDQKLYAATDAYAGLIIYQKLESLGDAIQMFDTN ***::*********:****** ***:**************:***::* *.*: * * * ENSMUSP00000033991/1-1401 KAEENLPLEMKKQLNSISEEMRDLANRFPVTCRNLETLQRVPVILKSISENLCSLRKVIC ENSRNOP00000055596/1-1400 KAEESLPMEMKKQLNSISEEMRDLANHFPVTCRNLETLQRVPMILENISENLCSLRKVIC ENSP00000298139/1-1432 KEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMII ENSCPOP00000002674/1-1433 KGEEILPSEIMKQLTAISREVMDLVEHFPDTYRKLENPQRVPIILKNISENLYSLRKMIF XP_004855469.1/1-1406 KVEEILPSEMKKQLTAISEEVMDLANHFPDTCRKLENPQRVSIILKNISENLYSLRKMMF * ** * :: ***.:**.*: **.:::* : :**. :**.::*:.***** ***::: ENSMUSP00000033991/1-1401 GPTNTETRLKPGSSFNLLSSEDSAAAGEKEKQIGKHSTFAKIKEEPWDPELDSLVKQEEV ENSRNOP00000055596/1-1400 ASTDTGTKLEPGGGSHLLSSEGSAAVGEKEKQMGEHRTFPKIKEEAWDPELDSLVKHEAV ENSP00000298139/1-1432 GSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE ENSCPOP00000002674/1-1433 ASADAEPELRSHKNVHLLSLEDSTGDGQQQEQTRKQNSFTKVKAETRDTTFDSLIKHSGE XP_004855469.1/1-1406 ASTNTEPELRPRSNFKLSSLEDSTAGGQQQKQTREHKIFTRVKDETWETTLDKFIKHDGE ..:: ..*.. . :* * *.*: * :::* :: : ::: *. :. :* : *:. ENSMUSP00000033991/1-1401 DVFRNQVKQEKGESENEIEDNLLREDMERTCVIP-SISENELQDLEQQAKEEKYNDVSHQ ENSRNOP00000055596/1-1400 DVFRKQVKQEKGGFEDEMEDSLLREVMERTCLMP-SISEYDLQDLEQQAKEEKHNAISHQ ENSP00000298139/1-1432 DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYK ENSCPOP00000002674/1-1433 DVLGNAVKQEDDGFEDGINDRELKEDMERACLMSLDITEYDLQMLEQQAQETHSRNVSFQ XP_004855469.1/1-1406 GVLGNKMKQEGDGSEDGIKDNKLKENMERTCLMSLDNTEYELQILEQQAQEKNLSDVSFQ .*: : :::: . *: ::* *:* ***:*::. . :* :** ****::* ::.: ENSMUSP00000033991/1-1401 LSE---------------------------HLSPNDDENDSSYIIESDEDLEMEMLKSLE ENSRNOP00000055596/1-1400 FSE---------------------------HLSPDDDEKDSSYIIESDEDLEMEMLKSLE ENSP00000298139/1-1432 STEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLE ENSCPOP00000002674/1-1433 SAEVLNKNYDHDFITYLIDQSRNFISSLLRHLSLNDNEQESSYIIESDEDLEMEMLKSLE XP_004855469.1/1-1406 TAE---------------------------RLSPSDNEKDSSYIIESDEDLEMEMLKSLE :* :** .*:*:::**:**************** ENSMUSP00000033991/1-1401 NLNSDVVEPTHSTWLEMGTNGRLPP-EEEDGHGNEAIKEEQE-EEDHLLPEPNAKQINCL ENSRNOP00000055596/1-1400 NLNSDVGEPTHSKWLETGGSVNLPP-EEEDGDGKEAFEEEQE-EEDHLLPEPNAKQINCL ENSP00000298139/1-1432 NLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL ENSCPOP00000002674/1-1433 NLNSDAAETDHSKCSETERNACFPV--EADEDKNESIDEEEEGEEDHFLPEPNAKQVTCL XP_004855469.1/1-1406 NLNSDAIETIHSECSEIRGNLSLPT--EEDEDKNEAFEE----EEDHFLPEPNAKQVICL ****.. *. ** : . :* * : . :*: . ::*.: * ** :*: ** ENSMUSP00000033991/1-1401 KTYFGHSSFKPVQWKVIHSVLEERRDNVVVMATGYGKSLCFQYPPVYTGKIGIVISPLIS ENSRNOP00000055596/1-1400 KTYFGHCSFKPVQWKVIHSVLEERRDNVVVMATGYGKSLCFQYPPVYTGKIGIVISPLIS ENSP00000298139/1-1432 KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLIS ENSCPOP00000002674/1-1433 KTYFGHHNFKPVQWKVIYSVLEERRDNVVVMATGYGKSLCFQYPPVYLGKIGIVVSPLIS XP_004855469.1/1-1406 KTYFGHHSFKPVQWKVIHSVLEERRDNVVVMATGYGKSLCFQYPPVYVGKIGLVISPLIS * **** .*********:**********.****************** ****:*:***** ENSMUSP00000033991/1-1401 LMEDQVLQLELSNVPACLLGSAQSKNILGDVKLGKYRVIYITPEFCSGNLDLLQQLDSSI ENSRNOP00000055596/1-1400 LMEDQVLQLEMSNIPACLLGSAQPKNILGDIKLGRYRIIYITPEFCSGNLDLLQQLDSNI ENSP00000298139/1-1432 LMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADI ENSCPOP00000002674/1-1433 LMEDQVLQLEMSNIPACFLGSAQSNNVLEDAKLKKFSSYWPCDNYNNGSSTLLQVVHKDI XP_004855469.1/1-1406 LMEDQVLQLEMSNIPACFLGSAQSKNVLEDVKLGKYRIIYITPEFCSGNLDLLQHLEANI *********::**:***:*****.:*:* * ** :: : :: .*. *** :. .* ENSMUSP00000033991/1-1401 GITLIAVDEAHCISEWGHDFRSSFRMLGSLKTALPLVPVIALSATASSSIREDIISCLNL ENSRNOP00000055596/1-1400 GITLIAVDEAHCISEWGHDFRSSFRTLGSLKTALPLVPVIALSATASSSIREDIIRCLNL ENSP00000298139/1-1432 GITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL ENSCPOP00000002674/1-1433 GIALIAVDEAHCISEWGHDFRSSFRTLGSLKTALPLVPIVALTATASSSIQEDIIRCLKL XP_004855469.1/1-1406 GITLIAVDEAHCISEWGHDFRSSFRTLGSLKTALPLVPIVALTATASSSIQEDIIHCLKL **:******************.*** *********:**::**:*******:***: **:* ENSMUSP00000033991/1-1401 KDPQITCTGFDRPNLYLEVGRKTGNILQDLKPFLVRKASSAWEFEGPTIIYCPSRKMTEQ ENSRNOP00000055596/1-1400 KDPHITCTGFDRPNLYLEVERKTGNILQDLKPFLVRKTSSAWEFEGPTIIYCPSRKVTEQ ENSP00000298139/1-1432 RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLV-KTSSHWEFEGPTIIYCPSRKMTQQ ENSCPOP00000002674/1-1433 NNPQITCTSFDRPNLYLEVGRKTGNILQDLQPFLVKRTNSEWEFEGPTIIYCPSRKMTEQ XP_004855469.1/1-1406 SNPQITCTSFDRPNLYLEVGRKTGNILQDLQPFLVKKTSSEWEFEGPTIIYCSSRKMTEK :*:****.********** **********:**** ::.* ***********.***:*:: ENSMUSP00000033991/1-1401 VTAELGKLNLACRTYHAGMKISERKDVHHRFLRDEIQCVVATVAFGMGINKADIRKVIHY ENSRNOP00000055596/1-1400 VTVELGKLNVACQAYHAGMKISERKDIHHRFLRDEIQCVVATIAFGMGINKADIRKVIHY ENSP00000298139/1-1432 VTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHY ENSCPOP00000002674/1-1433 VTAELRKLNLACETYHAGMSSGTRKDVHHRFMRDEIQCIIATIAFGMGINKPDIRKIIHY XP_004855469.1/1-1406 VTAELRKLNLACGTYHAGMSFNTRKDVHHRFMRDEIQCVIATIAFGMGINKSDIRKVIHY ** ** ***::* :*****. . ***:****:******::**:********.***::*** ENSMUSP00000033991/1-1401 GAPKEMESYYQEIGRAGRDGLQSSCHLLWAPADFNTSRNLLIEIHDEKFRLYKLKMMVKM ENSRNOP00000055596/1-1400 GAPKEMESYYQEIGRAGRDGLQSSCHLLWAPADFNTSRNRLIEIHNEKFRLHKLKMMVKM ENSP00000298139/1-1432 GAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKM ENSCPOP00000002674/1-1433 GAPKEMESYYQEVGRAGRDGLPSSCHVLWAPADINLNRYRFFEIHNEKFRLYKLKMVAKM XP_004855469.1/1-1406 GAPKEMESYYQEIGRAGRDGLQSSCHVLWAPADFNLNRHHFIEIHNEKFRSYKLKMVAKM ****:*******:******** ****:******:* .* : **::**** :****:.** ENSMUSP00000033991/1-1401 EKYLHSSQCRRRIILSHFEDKCLQKASLDIMGTEKCCDNCRP-RLNHCLTANNSEDASQD ENSRNOP00000055596/1-1400 EKYLHSSRCRRQIILSHFEDKRLQKASLAVMGTEKCCDNCRP-RLNHCSSANNSEDTAQD ENSP00000298139/1-1432 EKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRS-RLDHCYSMDDSEDTSWD ENSCPOP00000002674/1-1433 EKYLHSNRCRRQIILSHFEDKKLQKVSLDIMGTEKCCDNCRSRRLNHCHSISDSDDTSQD XP_004855469.1/1-1406 EKYLHSSRCRRQIILCHFEDRQLQKASLDIMGTENCCDNCRS-RLNHCHSINDSSDTSQD ******.:***:***.****: :**.** :****:******. **:** : .:*.*:: * ENSMUSP00000033991/1-1401 FGPQAFQLLSAVDILQEKFGIGIPILFLRGSNSQRLPDKYRGHRLFGAGKEQAESWWKTL ENSRNOP00000055596/1-1400 FGPQAFQLLSAVDILQEKFGIKIPILFLRGSNSQRLPEKYHNHRLFGAGKEQAESWWKAL ENSP00000298139/1-1432 FGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAF ENSCPOP00000002674/1-1433 LGPQAFLLLSAVDILQEKFGIGIPILFLRGSSSQRLPDKYRRHSLFGAGKDQTESWWKAF XP_004855469.1/1-1406 FGPQAFLLLSAVDILQGKFGIGVPILFLRGSSSQRLPGPFRRHNLFGAGKDQTESWWKAF :***** ******** **** :********.****. :: * ***:**:*:*****:: ENSMUSP00000033991/1-1401 SHHLIAEGFLVEVPKENKYIKTCSLTKKGRKWLGEASSQSPPSLLLQANEEMFP-RKVLL ENSRNOP00000055596/1-1400 SHHLIAEGFLVEVPKQNKFIKTCSLTKKGRKWLGEAILQSPPSLVLQADEEAFS-RKALL ENSP00000298139/1-1432 SRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTES-QSLILQANEELCP-KKLLL ENSCPOP00000002674/1-1433 ARHLMTEGFLAEVPGSSRFIKTCTLTVKGRNWLVKASTESPQRLILEASEELCPKKKFLL XP_004855469.1/1-1406 SRHLVTEGFLVDVPGGNKFVKICTLTAKGRNWLFKANAESPQRLILQANEELWP-KKFLL :::*::****.:*. .:::* *:** ***:** :* :* *:*:*.** . :* ** ENSMUSP00000033991/1-1401 PSSNPVSPETTQHSSNQNPAGLTT-KQSNLERTHSYKVPEKVSSGTNIPKKSAVMPSPGT ENSRNOP00000055596/1-1400 SSSNPVSSETKPHSSNQKPTGSST-QQSNLEGAYSDKVPEKFSSGSNIPKKSVVMQSPGT ENSP00000298139/1-1432 PSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEK ENSCPOP00000002674/1-1433 PSSHTVSSGIEHHPSNQIPIRLTAEKQSNLEKMFSYKANDKISSGISIPKKSIMTQLPGN XP_004855469.1/1-1406 PSASTVSLGIEHHPSNQIPIELTAEKESNLEKMYSYKALDKISSGINIPKKSALGPNPTM .*: .** * ** * :: ::**** .* * :*.*** .*.*** : * ENSMUSP00000033991/1-1401 SSSPLEPAISAQELDARTGLYARLVEARQKHANKMDVPPAILATNKVLLDMAKMRPTTVE ENSRNOP00000055596/1-1400 SYSSWEPVISAQEVDTRTVLYARLVEARQKHANEVDVPPAVLATNKVLLDMAKMRPTTVE ENSP00000298139/1-1432 AYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVE ENSCPOP00000002674/1-1433 TYGSSGAVISAQEQKTQTVLYGKLVEARQKHANKRDVPPAILATNKLLVDMAKMRPTTVE XP_004855469.1/1-1406 SQSPSEPVISAQEQKTQSVLYGKLVEARQRHANKMDVPPAILATNKILLDLAKMRPTTVE : .. ..***** .:: **.:******:***: *****:*****:*:*:********* ENSMUSP00000033991/1-1401 NMKQIDGVSEGKAALLAPLLEVIKHFCQVTSVQTDLLSSAKPHKEQEKSQEMEKKDCSLP ENSRNOP00000055596/1-1400 NVKQIDGVSEGKAALLAPLTEVIKHFCQVNSVQTDLFASTKPQEDEEKSQEMENKACSLP ENSP00000298139/1-1432 NVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLS ENSCPOP00000002674/1-1433 NLKLIDGVSEGKATMLAPLLEVIKHFCQENSVQTDLFSSTKPQEEQKKSPEVNHEKCSFS XP_004855469.1/1-1406 NVKQIDGVSEGKATMLAPLLEVIKHFCQANSVQADLFSNTKSQ-EQKKSLEMKNENCSLP *:* *********::**** ******** .***:**::.:*.: :::.* ::: *::. ENSMUSP00000033991/1-1401 QSVAVTYTLFQEKKMPLHSIAENRLLPLTAAGMHLAQAVKAGYPLDMERAGLTPETWKII ENSRNOP00000055596/1-1400 QSAAVTYALFQEKKMSLHSIAENRLLPLTAVGMHLAQAVKAGHPLDMERAGLTPETRKII ENSP00000298139/1-1432 QSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKII ENSCPOP00000002674/1-1433 QSVAVTYSLFQEKKMSLDSVAKNRTLPLTVVGQHLAQVVKAGYSLDMERSGLTPEVQKII XP_004855469.1/1-1406 KCVAVTYSLFQEKKMSLDSIAKDRILPLTAVGMHLAQAVKAGYSLDMERAGLTPEIQKII :. *:**:*******.*.*:*:.* *** . * **:*.**** .**:**:***** *** ENSMUSP00000033991/1-1401 MDVIRNPPINSDMYKVKLIRMLVPENLDTYLIHMAIEILQSGSDSRT--QPPCDSSRKRR ENSRNOP00000055596/1-1400 MDVIRNPPINSDMYKVKLIRMLVPENIDTYLIHMMIEILESGSHGRT--QPSCDSNRKRC ENSP00000298139/1-1432 ADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGL--QPSCDVNKRRC ENSCPOP00000002674/1-1433 TAVIQNPPVNSDMSKIKLIRMLVPENIDTYLIHMVIAILESDRDHTLLCQPSFDSSKKRC XP_004855469.1/1-1406 ADVIRNPPINSDMSKIKLIRMLVPENIDTYLIHMVIEILETDHDNRLLCQPSSDSSIKRC **:***:**** *:.*********:******* * **: . . **. * . :* ENSMUSP00000033991/1-1401 FPSSAESCESCKESKEAV-TETKASSSESKRKLPEWFAKGNVPSADTGSSSSMAKTKKKG ENSRNOP00000055596/1-1400 LPSPAESCGSFKKSKEMV-TETKAPSEMSQRKLPEWFVKGNVPLAATG-SSSMAKTKKKG ENSP00000298139/1-1432 FPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGS----DTS-KKLMDKTKRGG ENSCPOP00000002674/1-1433 FPNSEESSSGSKRSKEEVGTNSKISSADSKRNLPEWFTKGNNTINDNS--------KKPG XP_004855469.1/1-1406 FPNSEESCSSSKRSKEDVGTNTKMSPATSKRNLPEWFTKGNETIVDTS-KKPVAKTKKTG :*.. * . . *.*** * ::: .. :*.** **.**. .. *: * ENSMUSP00000033991/1-1401 LFS ENSRNOP00000055596/1-1400 LFS ENSP00000298139/1-1432 LFS ENSCPOP00000002674/1-1433 LFS XP_004855469.1/1-1406 LFS ***