CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000112170/1-858 ------------------------------------------------------------ ENSRNOP00000040476/1-1683 MARIHSPSCHSVSVKWQQLSRDAPEPLQAPTCVPSLFHNDRLLVYGFIPHCTQASLCAFI ENSP00000414663/1-867 ------------------------------------------------------------ ENSCPOP00000002603/1-793 ------------------------------------------------------------ XP_004854951.1/1-791 ------------------------------------------------------------ ENSMUSP00000112170/1-858 ------------------------------------------------------------ ENSRNOP00000040476/1-1683 QEKEFCTMVSTTELQKTTGTVACFLLTPWVIWCCLHVHQYRFYSSTSGPAGNISEANGLF ENSP00000414663/1-867 ------------------------------------------------------------ ENSCPOP00000002603/1-793 ------------------------------------------------------------ XP_004854951.1/1-791 ------------------------------------------------------------ ENSMUSP00000112170/1-858 ------------------------------------------------------------ ENSRNOP00000040476/1-1683 LLPTASSCQQLLSRGWLHLAGLAYAMIHKLAARALIRDYEDGILHDNETNHEMKKNIMKS ENSP00000414663/1-867 ------------------------------------------------------------ ENSCPOP00000002603/1-793 ------------------------------------------------------------ XP_004854951.1/1-791 ------------------------------------------------------------ ENSMUSP00000112170/1-858 ------------------------------------------------------------ ENSRNOP00000040476/1-1683 LIIELSKENSLITQFTSFVAVEKRDVNEVPLANAPSISELVAKEDVDFLPYVSWQEKQPE ENSP00000414663/1-867 ------------------------------------------------------------ ENSCPOP00000002603/1-793 ------------------------------------------------------------ XP_004854951.1/1-791 ------------------------------------------------------------ ENSMUSP00000112170/1-858 ------------------------------------------------------------ ENSRNOP00000040476/1-1683 TFTSQPFSISSEGNEELSLLTAAKKCKVKTRKMRNLKVSEDFEGTPAMAQSPTTAQSDFH ENSP00000414663/1-867 ------------------------------------------------------------ ENSCPOP00000002603/1-793 ------------------------------------------------------------ XP_004854951.1/1-791 ------------------------------------------------------------ ENSMUSP00000112170/1-858 ------------------------------------------------------------ ENSRNOP00000040476/1-1683 LPLSVCPQPVKLKKGRKFQKLRMADEPRKAPVSMVSSAPAVTAGFSFLSARHSSSAFLSP ENSP00000414663/1-867 ------------------------------------------------------------ ENSCPOP00000002603/1-793 ------------------------------------------------------------ XP_004854951.1/1-791 ------------------------------------------------------------ ENSMUSP00000112170/1-858 ------------------------------------------------------------ ENSRNOP00000040476/1-1683 LCNISLPPPPLSPVGFIPTNSCRPMSNYSHKLAKATDICDSEPPLRGFRGASPKDTSSRG ENSP00000414663/1-867 ------------------------------------------------------------ ENSCPOP00000002603/1-793 ------------------------------------------------------------ XP_004854951.1/1-791 ------------------------------------------------------------ ENSMUSP00000112170/1-858 ------------------------------------------------------------ ENSRNOP00000040476/1-1683 TGFRGGTFSDSFAGSKDFDPGKFSQDLNNIVSSPKAPELAATQRSPLRSPPKPLSVPPLV ENSP00000414663/1-867 ------------------------------------------------------------ ENSCPOP00000002603/1-793 ------------------------------------------------------------ XP_004854951.1/1-791 ------------------------------------------------------------ ENSMUSP00000112170/1-858 ------------------------------------------------------------ ENSRNOP00000040476/1-1683 VCEFSSELPQSHSFHFQSGSVHRSPNYRMSDMASLRSALSLDYSAWDCVLEEADSLDGGS ENSP00000414663/1-867 ------------------------------------------------------------ ENSCPOP00000002603/1-793 ------------------------------------------------------------ XP_004854951.1/1-791 ------------------------------------------------------------ ENSMUSP00000112170/1-858 ------------------------------------------------------------ ENSRNOP00000040476/1-1683 FETETDEAAAYTACEFLTSMETPSHEEFVIGDDEGRQSPVSWTSLFALQTEDGFWKLTPE ENSP00000414663/1-867 ------------------------------------------------------------ ENSCPOP00000002603/1-793 ------------------------------------------------------------ XP_004854951.1/1-791 ------------------------------------------------------------ ENSMUSP00000112170/1-858 ------------------------------------------------------------ ENSRNOP00000040476/1-1683 LGLILKLNVNALLNSLEEKGIRSLGTKGRERLLDLIATLLVLQFLYTKLEQEGMAAKSLI ENSP00000414663/1-867 ------------------------------------------------------------ ENSCPOP00000002603/1-793 ------------------------------------------------------------ XP_004854951.1/1-791 ------------------------------------------------------------ ENSMUSP00000112170/1-858 ------------------------------------------------------------ ENSRNOP00000040476/1-1683 KMDDVLISRSCFNSVCLILRSPIKILHQNSPPDLELDHLPPLQKQVLLFHPQIVHEELQP ENSP00000414663/1-867 ------------------------------------------------------------ ENSCPOP00000002603/1-793 ------------------------------------------------------------ XP_004854951.1/1-791 ------------------------------------------------------------ ENSMUSP00000112170/1-858 ------------------------------------------------------------ ENSRNOP00000040476/1-1683 VSNWLYAIDSTTDTIYASQNRIKPFDPPIHFPRTPQGSWERPFAGLATLCVNPRLDAHNW ENSP00000414663/1-867 ------------------------------------------------------------ ENSCPOP00000002603/1-793 ------------------------------------------------------------ XP_004854951.1/1-791 ------------------------------------------------------------ ENSMUSP00000112170/1-858 ----------------------------MAAAAEEGMSAAALVMSVPDSIGRSPES-EGV ENSRNOP00000040476/1-1683 LASPTVESRRRSGLGRSGQRAELSRPFVMAAATEENMSVAALVMSVPDNIGRSPEVEGG- ENSP00000414663/1-867 -----------------------------MEQVAEGARVTAVPVSAADSTEELAEVEEGV ENSCPOP00000002603/1-793 -----------------------------MMAASEGAVVSIVTESDADSNAELREV-GGV XP_004854951.1/1-791 -----------------------------MAAAAEGAVVTAESESGADSNGESREVEGGV . *. .: * .*. . * * ENSMUSP00000112170/1-858 GAGDEEKDAATKGTVAVGDSEEDGEDVFEVERILDMKCEGGKNLYKVRWKGYTSEDDTWE ENSRNOP00000040476/1-1683 GAAGEEKDAATKGTVAVGDSEEDGEDVFEVERILDMKCEGGKNLYKVRWKGYTSDDDTWE ENSP00000414663/1-867 GVVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDMKTEGGKVLYKVRWKGYTSDDDTWE ENSCPOP00000002603/1-793 GAVGQEKDPATKTAETAGDSEEDGEDVFEVERILDMKTEAGRILYKVRWKGYTSDDDTWE XP_004854951.1/1-791 GASGEE-DPATKAAEAAGDSEEDGEDVFEVERILDMKTDAGRILYKVRWKGYTSDDDTWE *. .:: *.*:: : : **************:***** :.*: ***********:***** ENSMUSP00000112170/1-858 PEVHLEDCKEVLLEFRKKLAENKAKAVRKDIQRLSLNNDIFEADSDSDQQSDTKEDISPR ENSRNOP00000040476/1-1683 PEVHLEDCKEVLLEFRKKVAENKAKAVRKDIQKLSLNNDIFEADSDIDQQGDTKEDTSPR ENSP00000414663/1-867 PEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPK ENSCPOP00000002603/1-793 PEIHLEDCKEVLLEFRKKVAENKAKAAKKDIQKLSLNNDIFEADSDSDQRSETKEDISPR XP_004854951.1/1-791 PEIHLEDCKEVLLEFRKKVAENKAKAVKKDIQKLSLNNDIFEANSDSDQQSEAKEGTSPR **:***************:*******.:****:**********:** **:.::**. **: ENSMUSP00000112170/1-858 KKKKKIKCKEETSPEDLRKKRTKMGKLKDKFKTELESTSEIIGFDVKTKKRIWEVKEELK ENSRNOP00000040476/1-1683 KKKKKIKYKEDKSPDDLRKKRAKMGKLKDKFKTELESTSEILGFDVKTKKRILEVKEELK ENSP00000414663/1-867 KKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELK ENSCPOP00000002603/1-793 ----------------------------DKSKSELDSSSESLVCDLRTKKRILEAKGETK XP_004854951.1/1-791 KKKKKLRQKEEKSPDDLKKKKAKTGKLKDKSKSELDSSSESLVFDLRTKKRILEAKEELK ** *.:*:*: * : *::***** *.* * * ENSMUSP00000112170/1-858 DSKKPKKDEIKETKELKKANKRAEVRDLKIKIREDVKENRKTKKERYIESPLESESP--N ENSRNOP00000040476/1-1683 DSKKPKKDEIKETKK----TKRADIRDLKIKIREDVKDNRKTKKERYIDSPLESESP--N ENSP00000414663/1-867 ESKKPKKDEVKETKELKK-VKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLN ENSCPOP00000002603/1-793 D-------------------------------------------EKYAESQLEFDSSVLN XP_004854951.1/1-791 DAKKPKKDEIKETKELKK-VKKAEIRDLKGKIREDTKENRKTRKEKYVESQLEFESSVLN : *:: :* :* :*. * ENSMUSP00000112170/1-858 DSLILEDDSEDFISDNREENQNVRSVRDKTAQETVQEGIFEKHLDDLISIEEDAGTRVRR ENSRNOP00000040476/1-1683 DSFTLEDESEDFLSDNK-EKQNVRTAKDKTGQDTVQESIFEKHLDDLISIEE-AGTRVRR ENSP00000414663/1-867 DSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRR ENSCPOP00000002603/1-793 DFPLQEDDSEDFYSDSREEKQKINSPEDKIVEDAVQEKLFDKQLDAPGSADEDADGKTKR XP_004854951.1/1-791 DSPLQEDNSEDLKSDNREEKQKIKSPKDKIGEDAVQEKLSDRQLDDTGSADEGAGSKAKR * **:**.: **.: *:*: .: .:: :: * :: ** * :* :. : :* ENSMUSP00000112170/1-858 KKTKPRKFEEPKEIKKLESTNAFLERRAIPKKQRNQDKGISNLELNKLPSPVFAQTLKSS ENSRNOP00000040476/1-1683 KKKQPRKFEEPKEIKKLENTNNFLERKMIPKKQRNQDKGRSNPELSKLPSPVFAQTMKSL ENSP00000414663/1-867 KKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLM-PVSAQTPKGR ENSCPOP00000002603/1-793 RKKKLRRNEEPKEGTRPEN-SAFSEKKTLPKKQRNQDRSRTNTELDKLLPLASVQAQRSP XP_004854951.1/1-791 RKKKLRKSEEPKEGTKLESENAFSERKTLPKKQRNRDRGRNNTESDKPFPPTSVPSQKSS :*. *: *:.:* : *. . * *:: :******:*:. . * .* . . : :. ENSMUSP00000112170/1-858 RLSGEEKSLKSPDLAEEEKE-KKNEPKGKYQKRYDLDKEEK-ARKEPKVLKSFKEIRNAF ENSRNOP00000040476/1-1683 RLSGEEKGLKSSDLAEEEKE-RKNEPKEKYQKRYDFDKEEK-ARKEPKGLKSFKEIRNAF ENSP00000414663/1-867 RLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEK-GRKEPKGLKTLKEIRNAF ENSCPOP00000002603/1-793 RAAGEEQGLWAADSAEEKCYSQRLIFTEKVMEKRETDHTERHGRKDPKGLKTFKEIRNAF XP_004854951.1/1-791 RSAGEERGLRSSDSAEEEKEIKKNEPKEKYQKRCDSEKEEK-GRKEPKGLKTFKEIRNAF * :***:.* :.* ***. :: . * :: : :: *: .**:** **::******* ENSMUSP00000112170/1-858 DLFKKTTEEKNDVLENNSKREEISLDSKIMNDNKTKD-KCSLKEKRNTRDETDTWAYIAA ENSRNOP00000040476/1-1683 DLFKKTAEEKND-LENNSKREEISLDYKITHDNKTKD-KCSLREERNTRDETDTWAYIAA ENSP00000414663/1-867 DLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERRNTRDETDTWAYIAA ENSCPOP00000002603/1-793 DLVKKTTEEKSDAPETSWKREET-LDCKTTEDQKTKENKYSTKERRSTRDETDTWAHIAA XP_004854951.1/1-791 DLFKKTTEEKNDAPENNWKKEEI-LDCKTAEDQKTKENKYSCKERRTTRDETDTWVHIAA **.* *.***.* *.. *:** ** * .*:***: * * :*.*.********.:*** ENSMUSP00000112170/1-858 EGDQEVSDSVCQTDETSDGRQPVLSLGMDLQLEWMKLEDFQKHLDGEDEPFITTNRIPNN ENSRNOP00000040476/1-1683 EGDQEVSDSVCQTDESSDGKQPILSLGMDLQLEWMKLEDFQKHLDGEDEPFITANRIPSN ENSP00000414663/1-867 EGDQEVLDSVCQADENSDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATDAIPSN ENSCPOP00000002603/1-793 EDEQEGLDSVCSADENLDGRQHILSLGMDLQLEWMKLEDFQRHLDGEDETSDTANAIPNH XP_004854951.1/1-791 EDEQEGLDSVCPTDESLDGRQQILSLGMDLQLEWMKLEDFQRHLDGEDETFATADAIPSH *.:** **** :**. **:* :******************:****:** ::: **.: ENSMUSP00000112170/1-858 LLRDAVKNGDYIAVKVALNSNEEYNLDQE----DSTGMTLVMLAAAGGQDDLLRLLITKG ENSRNOP00000040476/1-1683 LLRDAVKNGDYIAVKVALNSNEEYNLDQE----DSTGMTLVMLAAAGGQDDLLRLLITKG ENSP00000414663/1-867 VLRDAVKNGDYITVKVALNSNEEYNLDQE----DSSGMTLVMLAAAGGQDDLLRLLITKG ENSCPOP00000002603/1-793 LLRDAVKNGDYISVKVALNSNEDYNLDQEKPIKDSSGMTLVMLAAAGGQDDLLRLLITKG XP_004854951.1/1-791 LLRDAVKNGDYISVKVALNSNEEYNLDQE----DSSGMTLVMLAAAGGQDDLLRLLITKG :***********:*********:****** **:************************ ENSMUSP00000112170/1-858 AKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVR ENSRNOP00000040476/1-1683 AKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVR ENSP00000414663/1-867 AKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVR ENSCPOP00000002603/1-793 AKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNLQQSNGETALMKACKRGNSDIVR XP_004854951.1/1-791 AKVNGQQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVR *****:*******************************:********************** ENSMUSP00000112170/1-858 LVIECGADCNILSKHQNSALYFAKQCNNVLVYELLKSHLETLSRVAEETIRDYFESRLAL ENSRNOP00000040476/1-1683 LVIECGADCNILSKHQNSALYFAKQCNNVLVYELLKSHLETLSRVAEETIRDYFESRLAL ENSP00000414663/1-867 LVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLAL ENSCPOP00000002603/1-793 LVIECGADCNILSKHQNSALHFAKQCNNVLVYDLLKSHLETLSRVAEETIRDYFEARLAL XP_004854951.1/1-791 LVIEYGADCNILSKHQNSALHFAKQCNNVLVYDLLKSHLETLSRVAEETIRDYFEARLVL **** ***************:****.******:***.*************:****:**.* ENSMUSP00000112170/1-858 LEPVFPIACHRLCEGPDFSTDFNYMPPQNMPEGSGVLLFIFHANFLGKDVIARLCGPCSV ENSRNOP00000040476/1-1683 LEPVFPIACHRLCEGPDFSTDFNYMPPQNMPEGSGVLLFIFHANFLGKDVIARLCGPCSV ENSP00000414663/1-867 LEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSV ENSCPOP00000002603/1-793 LEPVFPIACHRLCEGPDFSTDFNYKPPQNMPEGCGILLFIFHANFLGKEVIARLCGPCSV XP_004854951.1/1-791 LEPVFPIACHRLCEGPDFSTDFSYKLPQNMPEGKPVF---------------------TL **********************.* ***:*** :: :: ENSMUSP00000112170/1-858 QAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPFAKV----KLLIGAYRVQLQ ENSRNOP00000040476/1-1683 QAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPFAKLIGHQLLWTGDVSMQYT ENSP00000414663/1-867 QAVVLNDKFQLPVFLTGSRSVVQAGVQWRGLQLTGVLTSQAQAILPPQPPNYLGLKMHAT ENSCPOP00000002603/1-793 QAVVLNDKFQLPVFLDSHFVYSFCPVPGPNKLFIRLTEAPAAKV----KLLIGAYRVQLQ XP_004854951.1/1-791 KLLSLKDTL--------------------------------------------------- : : *:*.: ENSMUSP00000112170/1-858 -------------------- ENSRNOP00000040476/1-1683 TDVLHSRNVSCGMQTSTLAP ENSP00000414663/1-867 TSG----------------- ENSCPOP00000002603/1-793 -------------------- XP_004854951.1/1-791 --------------------