CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000027056/1-1598 --------MSDESAREVDKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAAAK ENSRNOP00000063421/1-1216 ------------------------------------------------------------ ENSCPOP00000002552/1-1595 -----------EGAKDAEKQLRLRVCVLSELQKTERDYVGTLEFLVSVRAAPLRVPRGSV ENSP00000288368/1-1606 MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASK XP_004842140.1/1-1602 MSEESRGDGRAESAKDAEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAAAK ENSMUSP00000027056/1-1598 VDKNVTEETVKMLFSNIEEILIVHKEFLKVVEECLYPEPSAQQEVGACFLHFKDKFRIYD ENSRNOP00000063421/1-1216 ------------------------------------------------------------ ENSCPOP00000002552/1-1595 LHLHICLSFSQMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYD ENSP00000288368/1-1606 VDKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYD XP_004842140.1/1-1602 VDKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYD ENSMUSP00000027056/1-1598 EYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLL ENSRNOP00000063421/1-1216 ------------------------------------------------------------ ENSCPOP00000002552/1-1595 EYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLL ENSP00000288368/1-1606 EYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLIL XP_004842140.1/1-1602 EYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLL ENSMUSP00000027056/1-1598 KELLKRTPRRHSDYTAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQAHIEGWEGSNIT ENSRNOP00000063421/1-1216 ------------------------------------------------------------ ENSCPOP00000002552/1-1595 KELLKRTPRKHSDYAAVTEALQAMKGVCSNINEAKRQMEKLEALEEWQSHIEGWEGSNIT ENSP00000288368/1-1606 KELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNIT XP_004842140.1/1-1602 KELLKRTPRKHSDYAAVTEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNIT ENSMUSP00000027056/1-1598 DTCTEMLMCGVLMKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGYRYVFRGRI ENSRNOP00000063421/1-1216 -------MCGVLMKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYVFRGRI ENSCPOP00000002552/1-1595 DTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKGSADGHRYLFRGRI ENSP00000288368/1-1606 DTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI XP_004842140.1/1-1602 DTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKGSTDGHRYLFRGRI *****:*********************************.*:**:**:***** ENSMUSP00000027056/1-1598 NTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKSPEEKHEWFEAILKER ENSRNOP00000063421/1-1216 NTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKSPEEKHEWFEAILKER ENSCPOP00000002552/1-1595 NTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKER ENSP00000288368/1-1606 NTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKER XP_004842140.1/1-1602 NTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKER ********************************************:*************** ENSMUSP00000027056/1-1598 ERRKGLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLL ENSRNOP00000063421/1-1216 ERRKGLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLL ENSCPOP00000002552/1-1595 ERRKGLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLL ENSP00000288368/1-1606 ERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLL XP_004842140.1/1-1602 ERRK----GMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLL **** **********************:***************************** ENSMUSP00000027056/1-1598 EIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRSEMQDVIS ENSRNOP00000063421/1-1216 EIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRSEMQDVIS ENSCPOP00000002552/1-1595 EIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVIS ENSP00000288368/1-1606 EIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVIS XP_004842140.1/1-1602 ETGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVIS * **************************************************.******* ENSMUSP00000027056/1-1598 KGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFAVGLC ENSRNOP00000063421/1-1216 KGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFAVGLC ENSCPOP00000002552/1-1595 KGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGMGLC ENSP00000288368/1-1606 KGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLC XP_004842140.1/1-1602 KGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGTALC ****************:**************************************. .** ENSMUSP00000027056/1-1598 DNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNE ENSRNOP00000063421/1-1216 DNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNE ENSCPOP00000002552/1-1595 DSGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNE ENSP00000288368/1-1606 DNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNE XP_004842140.1/1-1602 DNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNE *.**********************:*********************************** ENSMUSP00000027056/1-1598 GSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFLRPFPEVDCFLKSCL ENSRNOP00000063421/1-1216 GSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFLRPFPEVDCFLKSCL ENSCPOP00000002552/1-1595 GSYGFGLEDKNKVPIIKLVERGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCL ENSP00000288368/1-1606 GSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCL XP_004842140.1/1-1602 GSYGFGLEDKNKVPIIKMVERGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCL *****************:**:************************:*** ********** ENSMUSP00000027056/1-1598 NSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCII ENSRNOP00000063421/1-1216 NSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCII ENSCPOP00000002552/1-1595 NSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCII ENSP00000288368/1-1606 NSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCII XP_004842140.1/1-1602 NSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLQPGQCII *****************************************************:****** ENSMUSP00000027056/1-1598 KVNGINVSKETHASVIAHVTACRKYKRPMKQDSIQWVYDSLESAQEDIQKSHSKPPGDGA ENSRNOP00000063421/1-1216 KVNGINVSKETHASVIAHVTACRKYKRPMKQDSIQWVYDSLESAQEDIQKSHSKPPGDEA ENSCPOP00000002552/1-1595 KVNGINVSKESHDSVIAHLTACRKYRRPMKQDSIQWVYNSIESAQEDLQKSNSKAPGEES ENSP00000288368/1-1606 KVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEA XP_004842140.1/1-1602 KVNGINVSKESHASVIAHVTACRKYKRPMKQDSIQWVYDSIESAQEDLQKSNSKAPGEEA **********:* *****:******:** *********:*:******:***:**.**: : ENSMUSP00000027056/1-1598 GDAFECKVEDVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGTKCNVVEKMV ENSRNOP00000063421/1-1216 GDVFDCKVEDVMDKFNTLAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGTKCNVVEKMV ENSCPOP00000002552/1-1595 GDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMI ENSP00000288368/1-1606 GDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMI XP_004842140.1/1-1602 GDAFDCKVEEAIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMI **.*:****:.:*****:******************************** ********: ENSMUSP00000027056/1-1598 EPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIATDLQSKFTSMCSERIEHVCHRI ENSRNOP00000063421/1-1216 EPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIATDLQSKFTSMCSERVEHVCHRI ENSCPOP00000002552/1-1595 EPKGFFSLTAKILEALAKSDDHFIQNCSSLNSLNEVIPADLQSKFHAICSERIERICQRI ENSP00000288368/1-1606 EPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQRI XP_004842140.1/1-1602 EPKGFFSLTAKILEALAKSDDHFVQNCTNLNSLNEVIPADLQSKFNAICSKRIEHIRHRI ********************:**:***:.********.:****** ::**:*:*:: :** ENSMUSP00000027056/1-1598 SSYGRFSRVLKNRAWPTFKQAKPKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGV ENSRNOP00000063421/1-1216 SSYGRFSRVLKNRAWPTFKQAKAKMSPLHSSDFCPTNCHVNVMEVSYPKASASLGSAFGV ENSCPOP00000002552/1-1595 LSYKKFSRFLRNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGV ENSP00000288368/1-1606 SSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGV XP_004842140.1/1-1602 SSYKKFSRVLKNRSWPTFKQAKSKISPLHSSDFCPTNCHINVMEVSYPKTSTSLGSAFGV ** :***.*:**:********.*:**************:*********:*:******** ENSMUSP00000027056/1-1598 QLDSRKHNSHDKENKSVEPGKLSPMVYIQHTITTMAAPSGLSLGHKDGHGLQYLLKEEDL ENSRNOP00000063421/1-1216 QLDSRKHNSHDKENRSADPGKLSPMVYIQHTITTMAAPSGLSLGHKDGHGLRYLLKEEDL ENSCPOP00000002552/1-1595 QLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPSGLSLGQKDGHGLRYLLKEEDL ENSP00000288368/1-1606 QLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPSGLSLGQQDGHGLRYLLKEEDL XP_004842140.1/1-1602 QLDNRKHNSHDKENKSSDQGKLSPMVYIQHTITTMAAPSGLSLGQQGGHGLRYLLKEEDL ***.**********:* : *************************::.****:******** ENSMUSP00000027056/1-1598 ETQDIYHKLLGKLQTALKEVEMSVCQIDDLLSSITYSPKLERKTTECVTPMDSDNEKGER ENSRNOP00000063421/1-1216 ETQDIYHKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTTEYVIPTDSDNEKGER ENSCPOP00000002552/1-1595 ETQDIYQKLLGKLQTALKEVEICVCQIDDLLSSITNSPKLEHKTSECVASLDSDSEKGER ENSP00000288368/1-1606 ETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTSEGIIPTDSDNEKGER XP_004842140.1/1-1602 ETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSITNSPKLEHKRSECITPTDSDNEKGER ******:**************:.************ *****:* :* : . ***.***** ENSMUSP00000027056/1-1598 NSKRVCFNVAGDEQEDSGHDTVSNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDS ENSRNOP00000063421/1-1216 NSKRVCFNVAGDEQEDSGHDTVSNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDS ENSCPOP00000002552/1-1595 NSKRVCFNVAGDEQEDSGHDTISNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDS ENSP00000288368/1-1606 NSKRVCFNVAGDEQEDSGHDTISNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDS XP_004842140.1/1-1602 NSKRVCFNVAGDEQEDSGHDTISNRDSYSDCNSNRNSTASFTSICSSQCSSYFHSDEMDS *********************:*************** ********************** ENSMUSP00000027056/1-1598 GDELPISVRISHDKQDKIHTCLEQLFSQIDSIINLLKGQAVIRAFEQTKYLTPGRGLQEF ENSRNOP00000063421/1-1216 GDELPTSIRISHDKQDKIHTCLEQLFIQLDSITNLLKGRAVVRAFEQTKYLTPGRGLQ-- ENSCPOP00000002552/1-1595 GDELPLSVRISHEKQDKIHSCLEHLFSQVDSITNLLKGQAVVRAFEQTKHLTPGRGLQEF ENSP00000288368/1-1606 GDELPLSVRISHDKQDKIHSCLEHLFSQVDSITNLLKGQAVVRAFDQTKYLTPGRGLQEF XP_004842140.1/1-1602 GDELPLSVRISHEKQDRIHSCLEHLFSQVDSITNLLKGQAVVRAFEQTKHLTPGRGLQEF ***** *:****:***:**:***:** *:*** *****:**:***:***:******** ENSMUSP00000027056/1-1598 QQEMEAKLSCPRRLRLHLKQDPWNLPSSIQALAQSIRKHAEEVKCRILLALLEYSDSETQ ENSRNOP00000063421/1-1216 -------------------------------------------------------DSETQ ENSCPOP00000002552/1-1595 QQEMEPKLSGPKRLRLHIKQDPWNLPSSTRALAQNIRKFVEEVKCRILLALLEYSDSETQ ENSP00000288368/1-1606 QQEMEPKLSCPKRLRLHIKQDPWNLPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDSETQ XP_004842140.1/1-1602 QQEMEPKLSCPKRLRLHIKQDPWNLPSSVQALAQNIRKFVEEVKCRILLALLEYSDSETQ ***** ENSMUSP00000027056/1-1598 LRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETCEASRRWLDQIANAGVLFHF ENSRNOP00000063421/1-1216 LRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHF ENSCPOP00000002552/1-1595 LRRDMVFCQSLVATVCAFSEQLMAALNQMFDDSKENEMETWEASRRWLDQIANAGVLFHF ENSP00000288368/1-1606 LRRDMVFCQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHF XP_004842140.1/1-1602 LRRDMVFCQSLVATVSAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHF *********:*****.***************:******** ******************* ENSMUSP00000027056/1-1598 QSLLSPNLKDEQAMLEDTLVALFDLEKVSFFFKPSEEDPLVANVPLTYQVEGSRQALKVY ENSRNOP00000063421/1-1216 QSLLSPNLKDEQAMLEDTLVALFDLEKVSFFFKPSEEEPLVANVPLTYQVEGSRQALKVV ENSCPOP00000002552/1-1595 QSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEKEPLVANVPLTYQAEGTRQALKIY ENSP00000288368/1-1606 QSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVY XP_004842140.1/1-1602 QSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLIANVPLTYQAEGTRQALKIY ********.*********************:*****::**:********.**:*****: ENSMUSP00000027056/1-1598 FYMDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYCYRDNISVEEFQAQINTASLEK ENSRNOP00000063421/1-1216 FYMDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYCYRDNISVEEFQAQINTASLEK ENSCPOP00000002552/1-1595 FYIDSYHFDQLPQRLKNGGGFKIHPVLFAQALESMEGYYYRDNVSVEEFQAQINAASLEK ENSP00000288368/1-1606 FYIDSYHFEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYRDNVSVEEFQAQINAASLEK XP_004842140.1/1-1602 FYIDSYHFEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYRDNVSVEEFQAQINAASLEK **:*****:*******************:********* ****:**********:***** ENSMUSP00000027056/1-1598 VKQYNQKLRAFYLDKSNSPPNTTSKAAYIDKLMKPLNALDELYRLITSFIRSKRIAACVN ENSRNOP00000063421/1-1216 VKQYNQKL---------------------------------------------------- ENSCPOP00000002552/1-1595 VRQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACAN ENSP00000288368/1-1606 VKQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACAN XP_004842140.1/1-1602 IKQYNQKLRAFYVDKSNSPPNSTSKAAYVDKLMRSLNALDELYRLVTSFIRSKRIAACAN ::****** ENSMUSP00000027056/1-1598 TPCSASGVGLLSVSSELCDRLGACHIIMCSSGVHRCTLSVTLEQTITLARSHGLPPRYIM ENSRNOP00000063421/1-1216 ----------------------------------RCTLSVTLEQAITLARSHGLPPRYIM ENSCPOP00000002552/1-1595 TACSASGVGLLSVSSELCDRLGACHIIMCSNGVHRCTLSVTLEQAIILARSHGLPPRYIM ENSP00000288368/1-1606 TACSASGVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAIILARSHGLPPRYIM XP_004842140.1/1-1602 TACSASGVGLLSVSSELCDRLGACHIIMCNSGVHRCTLSVTLEQTIILARSHGLPPRYIM **********:* ************* ENSMUSP00000027056/1-1598 QAMDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPVGEE ENSRNOP00000063421/1-1216 QATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPVGDE ENSCPOP00000002552/1-1595 QATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPAGEE ENSP00000288368/1-1606 QATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPAGEE XP_004842140.1/1-1602 QATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPVGEE ** ***************************************.*:*