CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000135639/1-1356 MAEARKRRELLPLIYHHLLQAGYVRAAREVKEQSGQKSFLTQPVTLLDIYTHWQQTSELG ENSRNOP00000045755/1-1395 MAEARKRRELLPLIYHHLLQAGYVRAAREVKEQSGQKNFLTHPVTLLDIYTHWQQTSELG ENSP00000400939/1-1525 MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG ENSCPOP00000002489/1-1349 MAEARKRRELLPLIYQHLLHAGYVRAAREVKEQSGQKSFLAQPFTLLDIYTHWQQTSELG XP_004854564.1/1-1468 MAEARKRRELLPLIYQHLLHAGYVRAAREVKEQSGQKSFLAQPFTLLDIYTHWQQTSEIG ***************:***:***************** **::*.**************:* ENSMUSP00000135639/1-1356 QKQKAEDDETLQAKKSRVSDPVSSSESS--DQEKEEEAATERAKATPRPTPVNSAT--AA ENSRNOP00000045755/1-1395 LKQKAENDETLQAKKSRVSDPISSSESS---EEEEEEAETGTAKATPRPTPVNSTA--AA ENSP00000400939/1-1525 RKRKAEEDAALQAKKTRVSDPISTSESS----EEEEEAEAETAKATPRLASTNSSVLGAD ENSCPOP00000002489/1-1349 QKRKAEDDAALQAKKTRVSDPLSSSESS-DEEEEDEEAEARTAKAAPRPASTNSLARGVD XP_004854564.1/1-1468 QKRKAEDDAALQAKKTRVSDPISSSESSEEEEEEEEEAEAKAAKTTPRPASTNSSAMGMV *:***:* :*****:*****:*:**** *::*** : **::** :..** . ENSMUSP00000135639/1-1356 LPSKVKEKGK--TKTANKTVNSVSHPGSGKTVVHLLSGKSPKKSAEPLANTVLASETEEE ENSRNOP00000045755/1-1395 LPSNMKQKAK--TKTANKTVNSVLPPASGKTAVQLLSGKSPKKSAEPLASIVLASETEEE ENSP00000400939/1-1525 LPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEE ENSCPOP00000002489/1-1349 LPSSMKEKAKAQARSTSKTMNSMPHLAPGKAAGHFLSGKSPKKSAQSSGSIILVSETEEE XP_004854564.1/1-1468 LPSSMKEKAK--TRNTSKTVNSVPHLASGKAVVHLLSGKSPKKSAELSGSTVLVSETEEE ***.:*:*.* :..:.** **: ..**:. ::******:***: .. *.****** ENSMUSP00000135639/1-1356 GNAQALGPTAKSGTVSAGQGSSSSEDSSISSDETDVEVKSPAKPAQAKASAAPAKDPPA- ENSRNOP00000045755/1-1395 GSAQVLGPTAKPGMVSAGQASSSSEDTSSSSDETDVEVKPSTKP-QAKAPVTPAKDPPA- ENSP00000400939/1-1525 GSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR ENSCPOP00000002489/1-1349 GSIRALGATAIPGTVSADQVDNSSKDSSSSSDETDVEVKSSGKAAQVRPSPAPAKESSAN XP_004854564.1/1-1468 GSIQALEAAAKPGTVSAGQADNSNKDTSSSSDETDVEVKSSVETSQVRPSLTLAKESSAS *. .: .:* .* ***.* ..*.:*:* ******** *.. :. *.:.. . :*:..* ENSMUSP00000135639/1-1356 RTAPGPTKLGNVAPTPAKPARAAAAAAAAAVAAAAAAAAEESESSEEDSDSEDEAPAGLP ENSRNOP00000045755/1-1395 RTASGPTKLGDVTP---------------ASARAAATKAAESESSEEDSESEDEAPAGLP ENSP00000400939/1-1525 KAAPAPGKVGDVTPQ--------VKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR ENSCPOP00000002489/1-1349 KVAPSPRKVGGLVPQ--------AGGGALTPAGSAKVLKEDPGNSKE-SESEEEPP---- XP_004854564.1/1-1468 KAAPSPGKVGGVARQ--------ARGGALTPAGSAVKP-------------EEEPPTGAP :.*..* *:*.:. . * * *:*.* ENSMUSP00000135639/1-1356 SQVKASGKGPHVRADSVSAKGISGKGPILATPGKTGPAATQAKAERP--EKDSETSSEDD ENSRNOP00000045755/1-1395 SQVTTPGKGLHVRAASVSAKGMSRKGPISATPEKTGPITPQAKTGRP--QKDMETSSEDD ENSP00000400939/1-1525 SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKP--EEDSESSSEES ENSCPOP00000002489/1-1349 SQVKVSEKILPVRAASASTKGTPGKGATCALPGKVGPVTGQAKVGRPEQEQDSGSSSEEE XP_004854564.1/1-1468 SQVKASEKILQVRLAPASAKGTPGKQATCALPGKGGPLATQAKARRP--EQDSESSSEGE ***... * ** ...:** . * . * * * *. : *:*. :* ::* :*** . ENSMUSP00000135639/1-1356 SDSEDEMPVTVNTPQARTSGKSPRARGTSAPAKESSQKGAPAVTPGKARPVA--AQAGKP ENSRNOP00000045755/1-1395 SDSEDEMPVTVTTPQARPSGKSPQVRGTSAPAKESSQKGAPAVTPGKTRPVAAQAQAGKP ENSP00000400939/1-1525 SDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKR ENSCPOP00000002489/1-1349 SHSEVEMPAATTAPQAKSAGKTSQVRAATAPAKESPRKGAPPACPGKAGPAATQTQVGRQ XP_004854564.1/1-1468 SDSEVETPPVMTALQAKLSGKTLQVRAASAPAKESPRKGHPPATPGKTGPAATQAQVGKQ *.** * * . **: :**: :. .::******.:** ... ***: *.. :*.*: ENSMUSP00000135639/1-1356 EAK-----SSEESESDSGETPAAATLTTSPAKVKPLGKSSQVRPVSTVTPGSSGKGANLP ENSRNOP00000045755/1-1395 ETR-----SSEESESDSGETPAAGTLTTSPAKVKPLGKSPQVRPASTANLGSSRKGANPP ENSP00000400939/1-1525 EED--SQSSSEESDSE-EEAPAQA---------KPSGKAPQVRAASAPAKESPRKGAAPA ENSCPOP00000002489/1-1349 AEDSVSSSSSEESDSD-TETPAPQAPVAKPVQLKPLGKTPQVRAAPAPAKESPRKGVPPA XP_004854564.1/1-1468 EED--SDSSSEESDSD-GETPAAQTLA------KPSGKILQVRPASGPTKGLLGKGAAPK *****:*: *:** ** ** ***... **. ENSMUSP00000135639/1-1356 CPGKVGSAALRVQMVKKEDVSESSSAELDSD----------------------------- ENSRNOP00000045755/1-1395 CLGKVGSAVLKVQTGKEEEDSESSSEESDSD----------------------------- ENSP00000400939/1-1525 PPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGM ENSCPOP00000002489/1-1349 PPAKTGPAATQAQMGKRKRDSDSSSSSEESDSD--------------------------- XP_004854564.1/1-1468 PPQKSG------------------------------------------------------ * * ENSMUSP00000135639/1-1356 -------GPGSPAKA--------------------------------------------- ENSRNOP00000045755/1-1395 -------GAVNAAKAKP------------------------------------------- ENSP00000400939/1-1525 GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGN ENSCPOP00000002489/1-1349 -------GETPAPRIPA------------------------------------------- XP_004854564.1/1-1468 ------------------------------------------------------------ ENSMUSP00000135639/1-1356 --------KASLALPQKVRPVATQVKTDRGKGHSGS--SEESSDS--EEEAAPAASAAQA ENSRNOP00000045755/1-1395 -----PGRKATPALPRKTGPVATQVKTDKGKDHAES--SEESTDS--EEEAAPAASAAQA ENSP00000400939/1-1525 ILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES--SEESSDSADSEEAPAAMTAAQA ENSCPOP00000002489/1-1349 --------TSPAQPPQKSAPVAIQVKTEMSKEDSDSSDSDESSDS--EEEAPAAAPAAQE XP_004854564.1/1-1468 -------------------PVAIQVKAEKSKDDSES--SEESSDS--EEEAPAAVTPAQA *** ***:: .: * *:**:** .***..* ..** ENSMUSP00000135639/1-1356 KPAL-EKQMKASSRKG---TPASATGAS----TSSHCKAGAVTSSASLSSPALAKGTQRS ENSRNOP00000045755/1-1395 KPAP-IKQMKASPRKG---TAASTTGAS----ASSPRKAGTKTSSASLSSLALPKGTQKP ENSP00000400939/1-1525 KPALKIPQTKACPKKTN--TTASAKVAPVRVGTQAPRKAGTATSPAG-SSPAVAGGTQRP ENSCPOP00000002489/1-1349 KPALKTPQAKASPRKSALLTPTSAKGPPVRVGTPAPWKAGTMTSA---PAPALPPGTQRP XP_004854564.1/1-1468 KPELKMPQTKASPSKSILLTPTSAKGAPVRVGTPAPWKAGTVASA---SSSALPRGAQRP ** * **.. * *.:*:. .. : : ***: :*. .: *:. *:*:. ENSMUSP00000135639/1-1356 DVDSSS----ESESEGAAPSTPRVQGKSGGKGLQGKAA-------LGQGVAPVHTQKTGP ENSRNOP00000045755/1-1395 DVDSSS----EWESEGAAPGTTGVQGKSGGKGLQGRAA-------SGQGVAPLHAQKTGP ENSP00000400939/1-1525 AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGP ENSCPOP00000002489/1-1349 ENDSLSSE--ESEAEGATPAAAVAQTKQ-------QAASAPTKGPAGQGVTPAPPGKTRP XP_004854564.1/1-1468 KDNSSSSEE-ESEGKEATPAAAVAQAKSLGKGLRGQAASAPTMGPSGQGATPVPPGKTRP :* * : * : : ... * *. :** ***.:* . ** * ENSMUSP00000135639/1-1356 SV---KAMAQEDSESLEEDSSSEEEDE--TPAQATPLGRLPQAKANPPPTKTP----PAS ENSRNOP00000045755/1-1395 SGAQVKATAQEDSESSEEESSSEEEDE--TPAQVMALGRLPPAKANPPPTKTP----LAS ENSP00000400939/1-1525 TVTQVKAEKQEDSESSEEESDSEEAAA--SPAQVKTSVKKTQAKANPAAARAPSAKGTIS ENSCPOP00000002489/1-1349 TIA--APAGKESSESSEEDSDDSEAAAVMTPPQVKASGKTPQAKASPASTTASAVKGAAS XP_004854564.1/1-1468 TVAQVRAEAHESSESSEEESDDSEVGAVVTPAQAKAPGKTPQAKANPASTKASTDKEAAW : . :*.*** **:*...* :*.*. . : . ***.*..: :. ENSMUSP00000135639/1-1356 ASGKAVA--------APTKGKPPV---PNSTVSARGQRSVPAAGKAGAPATQAQKGPVAG ENSRNOP00000045755/1-1395 ASGKAAAVV------PPPKGKAPASTVQNSTISARGQRAVPATGKAGAPATQAQKGPMAG ENSP00000400939/1-1525 APGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP--- ENSCPOP00000002489/1-1349 APGKLVTPVAQGKRGPMAK---------NGAIPARGQASVSAVEKAVTAAAQA------- XP_004854564.1/1-1468 TPAKLVTAVVQAKPGSMAKGKSPVRAPKNSTISARGQASVPASGKAVTAAAQSQKGPTQE :..* .: . .* *.:: *** :*.: ** :.*:*: ENSMUSP00000135639/1-1356 TGEDSESSSKEESDSEE--ETPAQIKPVGKTSQVRAASAPAKESPKKGAHPGTPGKTGSS ENSRNOP00000045755/1-1395 TGEDSESSSEEESDSEE--ETPAQVKPVGKTSQVRAASAPVKESPNKGAYSGTSRKTGPP ENSP00000400939/1-1525 --EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPS ENSCPOP00000002489/1-1349 --EKDSESSEESSESEE--KVPAQVGPAAALCYASAGPPPSRAQLHHPPSP-PTRHLSDS XP_004854564.1/1-1468 SEEKDLESSEESSESEE--ELPTQAKPSGKTLQVRAATAPAKESSRKGPSPTTPGKTGPA *.. **:*.*:*** : :* * . *. .* : . .: . . .. : . . ENSMUSP00000135639/1-1356 ATQAQPG-KTEDSDSSS-EESDSDTEMPSAQ----------------------------- ENSRNOP00000045755/1-1395 ATQAQTG-KTEDSESSS-EESDSDREIPPAI----------------------------- ENSP00000400939/1-1525 AAQAG---KQDDSGSSS-EESDSDGEAPAAV----------------------------- ENSCPOP00000002489/1-1349 SSLSRGGVKQEDSDSSSGEESDSDRETLAPQ----------------------------- XP_004854564.1/1-1468 GTQAQVGKQEEDSDSSS-EESDSDGETPAAQLKPLGKTPQVKAASATANGSPRKGAPPAP .: : : :** *** ****** * .. ENSMUSP00000135639/1-1356 ------------------------------------------------------------ ENSRNOP00000045755/1-1395 -----------------------------------TPA---------------------- ENSP00000400939/1-1525 -----------------------------------TSA---------------------- ENSCPOP00000002489/1-1349 -----------------------------------TPA---------------------- XP_004854564.1/1-1468 PGKTGPAAIQAQVQSQLWKVLSRAEVPISGAVGHASPAAVRVHVCVQKPASRLPSANTLH ENSMUSP00000135639/1-1356 ----------DAISQPARGKASGPASPEKSIEGSSESSDEDLPSGQAIKSPPVSVNRNSS ENSRNOP00000045755/1-1395 ---------QDGISQSTRSKLSGLAPPEKSTEESSESSDEDLPSGQAIKSPPISVNPNRG ENSP00000400939/1-1525 --------QKDSNSKPARSKTLAPAPPERNTEGSSESSEEELPLTQVIKPPLIFVDPNRS ENSCPOP00000002489/1-1349 --------QKNITSKTARSSTVTPAPPEKNPEGSSESSDEELPPSQVIKPPLIFVDPNRS XP_004854564.1/1-1468 MLLQVLSLQKNINSKTVGSNTLTPAPREKSPEGSSESSEEELPSSQVIKTPLIFVDPNRS : *:.. .. *. *:. * *****:*:** *.**.* : *: * . ENSMUSP00000135639/1-1356 PAVPAPTPEGVQAVNTTKKASGTTAQSSSSESEDGDEDLIPATQPSTYALRTS-VTTPAA ENSRNOP00000045755/1-1395 PAAPVPTPEQHQAVNT-RKAQASGSTAQSSSSESEDEDMIPATQPPTLAIRTN-VTTPTA ENSP00000400939/1-1525 PAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTA ENSCPOP00000002489/1-1349 PAGPAVTPAQAQAASAPRKARAPSSTAGSSSSESEDEDVIPATQSSAPAVRTD-ATMPTT XP_004854564.1/1-1468 PAGPAATPTQAQAASPPRKARASSSTAGSS-SEGEDEDVIPATQSSTLAVRKEVVTVPTA ** *. ** **... :** .. : : ** **. ***:***** : .:*.. .* *:: ENSMUSP00000135639/1-1356 LSRAASQ-----PSKSEQSSRMPKGKKAKAAASA-------------------------- ENSRNOP00000045755/1-1395 LSQTAAQ-----PSKSEQSSRMPKGKKPKTASTQ-------------------------- ENSP00000400939/1-1525 HPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEA ENSCPOP00000002489/1-1349 STRTAPR-----ASASEESSRASEDKKQEVAASQ-------------------------- XP_004854564.1/1-1468 SPRMAPR-----ASSSLESSRVSPGQKQEAAAPQVTKRNLASLPLTQAALKVLAQKASEG .: *.: .* * :*** . .:* : .:. ENSMUSP00000135639/1-1356 -----------QTSSAVETLPMMPPQSAPIQPKATNKLGKSKLPEKQQLA--------PG ENSRNOP00000045755/1-1395 ------------ISSAMEALPVTLPQSTPAQSKTTNKLGDPKLAEKQQLT--------PG ENSP00000400939/1-1525 QPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQAT---------K ENSCPOP00000002489/1-1349 -----------QAGSAAGTLPVTQPQSTAVQARVANKLRQTKLSEGQQNTAIPSGCPKAE XP_004854564.1/1-1468 -------QPSSEAGSDAGTLPVTCPQSNPVQARVTNKLRKPKPSEGQQTTVTTSGHLKAT .* :** *** . *.: :*** ..* .* ** : ENSMUSP00000135639/1-1356 YPKAPRSSEDSSDTSSEDEEDAKRPQMPKSAHRLDPDPSQKETVVEETPTESSEDEMVAP ENSRNOP00000045755/1-1395 YPKAPRSSEDSSDTSSESEEDAKRPQMSKSSQRLDPDASQKETVVEETPTESSDDEMVAP ENSP00000400939/1-1525 APESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAP ENSCPOP00000002489/1-1349 APGSSDDSEDSSDDSSENEEDAEGPQKAKSDPRLGPPLSKRETLVEETTAESSEDEVVAP XP_004854564.1/1-1468 APGSSDNSDDSSDNSSGSEEDAEEPLMTKSAPGLGPSPSKRETLVEETTAESSEDEVVVP * :. .*:**** ** .***.: * .** *.* *: **:****.:***:*::*.* ENSMUSP00000135639/1-1356 SQSLLSGYMTPGLTVANSQASKATPRPDSNSLASSAPATKDNPDGKQKSKSQH-AADTAL ENSRNOP00000045755/1-1395 SQSLLSGYVTPGLTVANSQPSKATPRPDANPLVSSAPATKDNPDGKQKSKSQDSTADTTL ENSP00000400939/1-1525 SQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQ-AAGMLS ENSCPOP00000002489/1-1349 SQSLLSGYVTPGLTMANNQASKATAGRESNPTISSASRTKD-PAGKPAAESQ--PAGIMS XP_004854564.1/1-1468 SQSLLSGFVTPGLTMANNRASKATARQNLHPSLSSPPPTKDDPAGKQAAESQH-IAGAVS *******::***** **.:.****. : . **. :** * ** ::.* *. ENSMUSP00000135639/1-1356 PKTGRKEASSGSTPQKPKKLKKSTSSSPAPTQTLPNSITQRLLEQAWPLSEAQVQASVVK ENSRNOP00000045755/1-1395 RKTGEKEASSGSTPQKPKKPKKSTLSSPAPAQTLPNSITQRLLEQPWPLSEAQVQASVMK ENSP00000400939/1-1525 PKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVK ENSCPOP00000002489/1-1349 PKPGRKEAASGPTTQKPRKPKKRPASTEASLQALQSSITQRLLGQPWPLSEAQVQASVVK XP_004854564.1/1-1468 PKPGRKEAASGPTPQKPRKPKKGPLSTSASLQTLQSNITQHLQGQPWPLNEAQVQASVVK *.* ***:**.*.**.:* ** . .. *. :* ..*** * *.***.********:* ENSMUSP00000135639/1-1356 VLTELLEQERLKATEAIKESGKKS---QKRKLSGD-LEAGAPKNKKKKEQPVP--RASAV ENSRNOP00000045755/1-1395 VLTELLEQERQKATEAIKESGKKG---QKRKLSGDQVEAGAPKNKKKKQQLAA--GTSAG ENSP00000400939/1-1525 VLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASV ENSCPOP00000002489/1-1349 VLTELLEQQRQKATDATKESSRKG---QKRKLSGNQAASKAPKSKKKKQLAAGELKEGAA XP_004854564.1/1-1468 VLTELLEQERKKAEDTARESSRKG---RKRKLSGDQVASRAPKGKKKKQLAAGEGREDAA ********:* *. :: :**.:*. :******: : :*:.****: . : ENSMUSP00000135639/1-1356 SPEKAPMTSKAKSKLDKGSAGGKG---KGSPGPQGAKEKPDGELLGIK----LESGEQSD ENSRNOP00000045755/1-1395 SPEKASRTSKAKSKLNKGSAGGKG---KGSPVPQGAKEKPEGKL-GIK----LESGEQSD ENSP00000400939/1-1525 SPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEEL--QKGMGTVEGGDQSN ENSCPOP00000002489/1-1349 SSEKASRTSKGKSKRGKASGDIKEKE-KGAPGSGGAMAKPEGEL--PK----VEGGDQND XP_004854564.1/1-1468 SSEKAPRTSKGKSKRDKASGDLKE-E-KGS-GSGGSKDKPDGEL--LK----VESGNQND *.**:. ***.*:* .*.*.. * **: . *: :*: :* * :*.*:*.: ENSMUSP00000135639/1-1356 PKSKSKKKKSLKKKKD-----------KEKKE-KKKGKKSLAKDSASPIQKKKKKKKKSA ENSRNOP00000045755/1-1395 PKSKKEKKKSSKKRKKEKRPQPRTLPHRSRRRKRRRRRQPSLLCEGQAAHRTESWQSVTI ENSP00000400939/1-1525 PKSKKEKKKSDKRKKD-----------KEKKEKKKKAKKASTKDSESPSQKKKKKKKKTA ENSCPOP00000002489/1-1349 PKTKKEKKKSSKSKCS-------------------------------------------- XP_004854564.1/1-1468 SKSKKEKKKSNKKKKD-----------KEKKE-KKKGKKPSAKDSDSPFQKKKKKKKKTA .*:*.:**** * : . ENSMUSP00000135639/1-1356 EPAV-------------------------- ENSRNOP00000045755/1-1395 PRPLTSGHCELGLDFLICPPSAEGDGWRCC ENSP00000400939/1-1525 EQTV-------------------------- ENSCPOP00000002489/1-1349 ------------------------------ XP_004854564.1/1-1468 EQTV--------------------------