CLUSTAL W(1.81) multiple sequence alignment ENSP00000446280/1-1860 --MGWGSR-CCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKY ENSMUSP00000025618/1-1877 MDWDWGNR-CSRPGRRDLLCVLALLAGCLLPVCRTRVYTNHWAVKIAGGFAEADRIASKY ENSRNOP00000016164/1-915 MDWGWGSR-CCRPGRRDLLCVLALLAGCLLPVCRTRVYTNHWAVKIAGGFAEADRIASKY ENSCPOP00000002433/1-1147 ----WGSRCCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKISGGFSEADRIASKY XP_004862588.1/1-913 --MGWGSR-CCCPGRLDLLCVLALLWGCLLPVCRTRVYTNHWAVKIAGGFPEADRIASKY **.* *. *** ********* ********************:***.**:****** ENSP00000446280/1-1860 GFINIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYD ENSMUSP00000025618/1-1877 GFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYD ENSRNOP00000016164/1-915 GFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYD ENSCPOP00000002433/1-1147 GFINIGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYD XP_004862588.1/1-913 GFINIGQIGALKDYYHFHHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYD ****:************:*********:******************************** ENSP00000446280/1-1860 FSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERT ENSMUSP00000025618/1-1877 LSHAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERT ENSRNOP00000016164/1-915 LSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERT ENSCPOP00000002433/1-1147 LNRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERT XP_004862588.1/1-913 LSRTQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERT :.::******************************************************** ENSP00000446280/1-1860 HPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNA ENSMUSP00000025618/1-1877 HPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNA ENSRNOP00000016164/1-915 HPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNA ENSCPOP00000002433/1-1147 HPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNA XP_004862588.1/1-913 HPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNA *********************************************:************** ENSP00000446280/1-1860 KIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVR ENSMUSP00000025618/1-1877 KIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVR ENSRNOP00000016164/1-915 KIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVR ENSCPOP00000002433/1-1147 KIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVR XP_004862588.1/1-913 KIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVR **********************:************************************* ENSP00000446280/1-1860 MGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLAT ENSMUSP00000025618/1-1877 MGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLAT ENSRNOP00000016164/1-915 MGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLAT ENSCPOP00000002433/1-1147 MGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLAT XP_004862588.1/1-913 MGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLAT ************************************************************ ENSP00000446280/1-1860 TYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVR ENSMUSP00000025618/1-1877 TYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVR ENSRNOP00000016164/1-915 TYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVR ENSCPOP00000002433/1-1147 TYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVR XP_004862588.1/1-913 TYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVR ************************************************************ ENSP00000446280/1-1860 TSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIK ENSMUSP00000025618/1-1877 TSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIK ENSRNOP00000016164/1-915 TSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIK ENSCPOP00000002433/1-1147 TSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIK XP_004862588.1/1-913 TSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHACVESTDRQIK **********************************************:**.********** ENSP00000446280/1-1860 TIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLL ENSMUSP00000025618/1-1877 TIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLL ENSRNOP00000016164/1-915 TIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLL ENSCPOP00000002433/1-1147 TIRPNSAVRSIFKASGCSDNPNHYVNYLEHVVVRVTITHPRRGDLAIYLTSPSGTRSQLL XP_004862588.1/1-913 TIRPNSAIRSIYKALGCSDNANHYVKYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLL *******:***:** *****.*::*:********:************************* ENSP00000446280/1-1860 ANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYG ENSMUSP00000025618/1-1877 ANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYG ENSRNOP00000016164/1-915 ANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYG ENSCPOP00000002433/1-1147 ANRLFDHSMEGFKNWEFMTIHCWGEQAAGDWILEVYDTPSQLRNFKTPGKLKEWSLVLYG XP_004862588.1/1-913 ANRLFDHSMEGFKNWEFMTIHCWGEQAAGDWILEVYDTPSQLRNFKTPGKLKEWSLVLYG *************************:*****:**************************** ENSP00000446280/1-1860 TSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCL ENSMUSP00000025618/1-1877 TSVQPYSPTNEFPKVERFRYSRVEDPTDDYGAEDYAGPCDPECSEVGCDGPGPDHCSDCL ENSRNOP00000016164/1-915 TSVQPYSPTNEFPKVERFRYSRVEDPTDDYGAEDYAGPCDPECSEVGCDGPGPDHCTDCL ENSCPOP00000002433/1-1147 TSEQPYSPTNEFPKVERFRYSRVEDPTEDYGAEDYAGPCDPECSEVGCDGPGPDHCSDCL XP_004862588.1/1-913 TSVQPYSPTNEFPKVERFRYSRVEDPTEDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCL ** ************************:***:************************.*** ENSP00000446280/1-1860 HYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEET ENSMUSP00000025618/1-1877 HYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGNQCLSCKYGYFLNEET ENSRNOP00000016164/1-915 HYHYKLKNNTRICVSSCPPGHFHADKKRCRKCAPNCESCFGSHADQCLSCKYGYFLNEET ENSCPOP00000002433/1-1147 HYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPSCESCFGSHSDQCLSCKYGYFLNEET XP_004862588.1/1-913 HYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCLSCKYGYFLIEET **:******************:************.********.:**:******** *** ENSP00000446280/1-1860 NSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYF ENSMUSP00000025618/1-1877 SSCVTQCPDGSYEDIKKNVCGKCSENCKACIGFHNCTECKGGLSLQGSRCSVTCEDGQFF ENSRNOP00000016164/1-915 SSCVAQCPEGSYQDIKKNICGKCSENCKTCTGFHNCTECKGGLSLQGSRCSVTCEDGQFF ENSCPOP00000002433/1-1147 NSCVVHCPDGSYQDTKKNLCRKCSENCKTCTEPHNCTECRDGLSLQGARCSVTCEDGWYF XP_004862588.1/1-913 NSCIIHCPDGSYQDTKKNLCRKCGENCKTCTESHNCTECRDGLSLQGAQCSVTCEDGWYF .**: :**:***:* ***:* **.****:* ******:.******::***:**** :* ENSP00000446280/1-1860 NGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKK ENSMUSP00000025618/1-1877 NGHDCQPCHRFCATCSGAGADGCINCTEGYVMEEGRCVQSCSVSYYLDHSSEGGYKSCKR ENSRNOP00000016164/1-915 SGHDCQPCHRFCATCAGAGADGCINCTEGYVMEEGRCVQSCSVSYYLDHSLEGGYKSCKR ENSCPOP00000002433/1-1147 NGQDCQPCHRFCATCVGAGADGCINCTEGYFMEEGRCVQSCGISYYLDQSAEHGYKFCKR XP_004862588.1/1-913 SGQDCQPCHRFCATCAGAGADGCINCTEGYFMEEGRCVQSCSISYYLDHSAEHGYKSCKR .*:************ **************.**:*******.:***:*:* * *** **: ENSP00000446280/1-1860 CDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDGEYVDEHGHCQTCEASCAKCQG ENSMUSP00000025618/1-1877 CDNSCLTCNGPGFKNCSSCPSGYLLDLGTCQMGAICKDGEYIDDQGHCQTCEASCAKCWG ENSRNOP00000016164/1-915 CDNSCLTCNGPGFKNCSSCPSGYLLDLGMCQMGAICKDA--TEE---------------- ENSCPOP00000002433/1-1147 CDTSCLTCHGPGFKDCTSCPSGYLLDLGTCQLGAICKDGEYTDEHGRCQACDASCAKCRG XP_004862588.1/1-913 CDTSCLTCNGPGFKNCTSCPSGYLLDLGVCQLGAICKDA--TEE---------------- ** *****:*****:*:*********** **:******. :: ENSP00000446280/1-1860 PTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTSCGADN ENSMUSP00000025618/1-1877 PTQEDCISCPVTRVLDDGRCVMNCPSWKFEFKKQCHPCHYTCQGCQGSGPSNCTSCRADK ENSRNOP00000016164/1-915 -------------------------SW--------------------------------- ENSCPOP00000002433/1-1147 PSQEECTSCFRTRVLDDGHCVLNCPSWKFEFQNRCHPCHHTCRGCRGSGPSSCTSCGADK XP_004862588.1/1-913 -------------------------SW--------------------------------- ** ENSP00000446280/1-1860 YGREHFLYQGECGDSCPEGHYATEGNTCLPCPDNCELCHSVHVCTRCMKGYFIAPTNHTC ENSMUSP00000025618/1-1877 HGQERFLYHGECLENCPVGHYPAKGHACLPCPDNCELCYNPHVCSRCMSGYVIIPPNHTC ENSRNOP00000016164/1-915 ----------------------AEGGFCM-------LVKKNNLCQRKV------------ ENSCPOP00000002433/1-1147 QGRERFLHQGECLESCPAGHAPAQGHTCLPCPDNCELCHHPHICTRCVSGYVLGPTNSTC XP_004862588.1/1-913 ----------------------AEGGFCM-------LVKKNNLCQRKV------------ ::* *: * ::* * : ENSP00000446280/1-1860 QKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYRFDHHCYKTCPEKTYS ENSMUSP00000025618/1-1877 QKLECRQGEFQDSEYEECMPCEEGCLGCTEDDPGACTSCATGYYMFERHCYKACPEKTFG ENSRNOP00000016164/1-915 ---------------------------------------------LQQLC---------- ENSCPOP00000002433/1-1147 EKLECGQGEVQDSDYEECLPCEEGCLGCTSGMFLPASFCASLPPRFEHRCYRACPEKTFA XP_004862588.1/1-913 ---------------------------------------------LQQLC---------- ::: * ENSP00000446280/1-1860 EEVECKACDSNCGSCDQNGCYWCEEGFFLLGGSCVRKCGPGFYGDQEMGECESCHRACET ENSMUSP00000025618/1-1877 VKWECRACGTNCGSCDQHECYWCEEGFFLSGGSCVQDCGPGFHGDQELGECKPCHRACEN ENSRNOP00000016164/1-915 ----CKTCTFQG------------------------------------------------ ENSCPOP00000002433/1-1147 EERECRACSAHCGSCSRHECFWCEQSFFLLG----------------------------- XP_004862588.1/1-913 ----CKTCTFQG------------------------------------------------ *::* : ENSP00000446280/1-1860 CTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDIL-------------------- ENSMUSP00000025618/1-1877 CTGSGYNQCSSCQEGLQLWHGTCLWSTWPQVEGKDWNEAVPTEKPSLVRSLLQDRRKWKV ENSRNOP00000016164/1-915 ------------------------------------------------------------ ENSCPOP00000002433/1-1147 ------------------------------------------------------------ XP_004862588.1/1-913 ------------------------------------------------------------ ENSP00000446280/1-1860 -------RKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCEN ENSMUSP00000025618/1-1877 QIKRDATSQNQPCHSSCKTCNGS--LCASCPTGMYLWLQACVPSCPQGTWPSVTSGSCEK ENSRNOP00000016164/1-915 ------------------------------------------------------------ ENSCPOP00000002433/1-1147 ------------------------------------------------------------ XP_004862588.1/1-913 ------------------------------------------------------------ ENSP00000446280/1-1860 CTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCRTCEGN ENSMUSP00000025618/1-1877 CSEDCVSCSGADLCQQCLSQPDNTLLLHEGRCYHSCPEGFYAKDGVCEHCSSPCKTCEGN ENSRNOP00000016164/1-915 ------------------------------------------------------------ ENSCPOP00000002433/1-1147 ------------------------------------------------------------ XP_004862588.1/1-913 ------------------------------------------------------------ ENSP00000446280/1-1860 ATNCHSCEGGHVLHHGVCQENCPERHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHD ENSMUSP00000025618/1-1877 ATSCNSCEGDFVLDHGVCWKTCPEKHVAVEGVCKHCPERCQDCIHEKTCKECMPDFFLYN ENSRNOP00000016164/1-915 ------------------------------------------------------------ ENSCPOP00000002433/1-1147 ------------------------------------------------------------ XP_004862588.1/1-913 ------------------------------------------------------------ ENSP00000446280/1-1860 DMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTY ENSMUSP00000025618/1-1877 DMCHRSCPKSFYPDMRQCVPCHKNCLECNGPKEDDCKVCADTSKALHNGLCLDECPEGTY ENSRNOP00000016164/1-915 ------------------------------------------------------------ ENSCPOP00000002433/1-1147 ------------------------------------------------------------ XP_004862588.1/1-913 ------------------------------------------------------------ ENSP00000446280/1-1860 YEKETKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKP ENSMUSP00000025618/1-1877 KEEENDECRDCPESCLICSSAWTCLACREGFTV-VHDVCTAPKECAAVEYWDEGSHRCQP ENSRNOP00000016164/1-915 ------------------------------------------------------------ ENSCPOP00000002433/1-1147 ---------------------------------------RCSRECAAIEYWDEDTHRCKP XP_004862588.1/1-913 ------------------------------------------------------------ ENSP00000446280/1-1860 CHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGR ENSMUSP00000025618/1-1877 CHKKCSRCSGPSEDQCYTCPRETFLLNTTCVKECPEGYHTDKDSQQCVLCHSSCRTCEGP ENSRNOP00000016164/1-915 ------------------------------------------------------------ ENSCPOP00000002433/1-1147 CHRRCFHCTGPAEDQCRSC----------------------------------------- XP_004862588.1/1-913 ------------------------------------------------------------ ENSP00000446280/1-1860 HSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRF ENSMUSP00000025618/1-1877 HSMQCLSCRPGWFQLGKECLLQCRDGYYGESTSGRCEKCDKSCKSCRGPRPTDCQSCDTF ENSRNOP00000016164/1-915 ------------------------------------------------------------ ENSCPOP00000002433/1-1147 ------------------------------------------------------------ XP_004862588.1/1-913 ------------------------------------------------------------ ENSP00000446280/1-1860 FFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICT ENSMUSP00000025618/1-1877 FFLLRSKGQCHRACPEHYYADQHAQTCERCHPTCDKCSGKEAWSCLSCVWSYHLLKGICI ENSRNOP00000016164/1-915 ------------------------------------------------------------ ENSCPOP00000002433/1-1147 ------------------------------------------------------------ XP_004862588.1/1-913 ------------------------------------------------------------ ENSP00000446280/1-1860 SDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSD ENSMUSP00000025618/1-1877 PECIVGEYREGKGENFNCKKCHESCMECKGPGSKNCTGCSAGLLLDMDDNRCLHCCNASH ENSRNOP00000016164/1-915 ------------------------------------------------------------ ENSCPOP00000002433/1-1147 ------------------------------------------------------------ XP_004862588.1/1-913 ------------------------------------------------------------ ENSP00000446280/1-1860 PPSAQECCDCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGR ENSMUSP00000025618/1-1877 SRRSQDCCDCQSSTDECILPAREAE-FYEHTKTALLVTSGAMLLLLLGAAAVVWRKSRSR ENSRNOP00000016164/1-915 ------------------------------------------------------------ ENSCPOP00000002433/1-1147 ------------------------------------------------------------ XP_004862588.1/1-913 ------------------------------------------------------------ ENSP00000446280/1-1860 VQPAAKAGYEKLADPNKSYSSYKSSYRESTSFEEDQVIEYRDRDYDEDDDDDIVYMGQDG ENSMUSP00000025618/1-1877 --PVAKGRYEKLAEPTVSYSSYRSSY-----LDEDQVIEYRDRDYDEDDEDDIVYMGQDG ENSRNOP00000016164/1-915 ------------------------------------------------------------ ENSCPOP00000002433/1-1147 ------------------------------------------------------------ XP_004862588.1/1-913 ------------------------------------------------------------ ENSP00000446280/1-1860 TVYRKFKYGLLDDDDIDELEYDDESYSYYQ ENSMUSP00000025618/1-1877 TVYRKFKYGLLDETEDDELEYDDESYSYQ- ENSRNOP00000016164/1-915 ------------------------------ ENSCPOP00000002433/1-1147 ------------------------------ XP_004862588.1/1-913 ------------------------------