CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000089498/1-1254 ------------------------------------------------------------ ENSRNOP00000024704/1-1285 ------------------------------------------------------------ ENSP00000421917/1-1292 ------------------------------------------------------------ ENSCPOP00000002369/1-1490 AALPGRPTTSSNSSLRCPGLLAGSSPSALARPLGVAAHLRLRAGLHAVTHRWLLPVHREV XP_004854468.1/1-1286 ------------------------------------------------------------ ENSMUSP00000089498/1-1254 ------------------------------------------------------------ ENSRNOP00000024704/1-1285 ------------------------------------------------------------ ENSP00000421917/1-1292 ------------------------------------------------------------ ENSCPOP00000002369/1-1490 RRDGSPWRSLERCCCHCCCQCHHRIGVAATLVPLSSLGSPGLDPRGGSSAGVGGNPAERT XP_004854468.1/1-1286 ------------------------------------------------------------ ENSMUSP00000089498/1-1254 ------------------------------------------------------------ ENSRNOP00000024704/1-1285 ------------------------------------------------------------ ENSP00000421917/1-1292 ------------------------------------------------------------ ENSCPOP00000002369/1-1490 CAPALVFHHPPELLRRGERGRLSRPRAVCRPAGPWGRGFSSPRDARASPCFHFLVAGVTT XP_004854468.1/1-1286 ------------------------------------------------------------ ENSMUSP00000089498/1-1254 ------------------------------MDAPYDGAEVTVLMEEIEEAY-YTSPGPPK ENSRNOP00000024704/1-1285 ------------------------------MDAPYDGTEVTVLMEEIEEAY-YTSPGPPK ENSP00000421917/1-1292 ------------------------------MDASYDGTEVTVVMEEIEEAYCYTSPGPPK ENSCPOP00000002369/1-1490 GAASRRQRGARVCWPALPECEPRGCHAPRVMDASYDGTEVTVVMEEIKEVYCYTSPGPPK XP_004854468.1/1-1286 ------------------------------MDASYDGTEVTVVMEEIKEVYCYTSPGPPK ***.***:****:****:*.* ******** ENSMUSP00000089498/1-1254 KKKKYKIHGEKAKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSY ENSRNOP00000024704/1-1285 KKKKYKIHGEKAKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSY ENSP00000421917/1-1292 KKKKYKIHGEKTKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSY ENSCPOP00000002369/1-1490 KKKKYKIHGEKAKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSY XP_004854468.1/1-1286 KKKKYKIHGEKAKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSY ***********:************************************************ ENSMUSP00000089498/1-1254 YLEKAKLEKEGLDPNSKLSALTAVVPDIPGFRKILPRSEYIIIPKSTLQEDRSCPQLELC ENSRNOP00000024704/1-1285 YLEKAKLEKEGLDPNSKLSALTAVVPDIPGFRKILPRSEYIIIPKSTLQEDRSCPQLELC ENSP00000421917/1-1292 YLEKAKLEKEGLDPNSKLSALTAVVPDIPGFRKILPRSDYIIIPKSSLQEDRSCPQLELC ENSCPOP00000002369/1-1490 YLEKAKLEKEGLDPNSKLSTVTAVVPDIPGFRKILPRSEYIIIPKSSLQEDQSCAQLELC XP_004854468.1/1-1286 YLEKAKLEKEGLDPNAKLSTVTAVVPDIPGFRKILPRSEYIIIPKSTLQEEQSCAQLELC ***************:***::*****************:*******:***::**.***** ENSMUSP00000089498/1-1254 VAQNQMSPKGSTLMSNASPDVVASHAGMAEQCLAVEALAEEVGALPQPGTVQEIATSEIL ENSRNOP00000024704/1-1285 VAQNQMSPKGSTLMPNASPEVVASHAGMAEQCLAVEALAEEVGALSQPGAMQEIATSEIL ENSP00000421917/1-1292 VAQNQMSPKGPPLVSNTAPETVPSHAGMAEQCLAVEALAEEVGALTQSGAVQEIATSEIL ENSCPOP00000002369/1-1490 VAQNQMSPKGPSVVSSTAPETVPGHAGIAEQSLAEETLAEEVGALAQPGAVQEITTSEIL XP_004854468.1/1-1286 VAQNQMSPKGSSLVSNTAPETVPSHVGVAEQCLAEETLAEEVGALAQPGAVQEIATSEIL **********..::..::*:.*..*.*:***.** *:********.*.*::***:***** ENSMUSP00000089498/1-1254 SHDMLLEEASLEVGESHQPYQTSLVIEETLVNGSSDLPTGSLAVPHSQVGESLSVVTVMR ENSRNOP00000024704/1-1285 SHDVLLEEASLEVGESHQPYQTSLVIEETLVNGSSDLPTGSLAVPHSQVGESLSVVTVMR ENSP00000421917/1-1292 SQDVLLEDASLEVGESHQPYQTSLVIEETLVNGSPDLPTGSLAVPHPQVGESVSVVTVMR ENSCPOP00000002369/1-1490 TQEVLLEEASLEVGESQQPYQTNLVIEETLLNSSSEPPSGNLTMPRTQVGESVSVVTVMR XP_004854468.1/1-1286 TQDVLLEEASLEVGESHQPYQTNLVIEETLLNGSSELPTGNLAVPRTQVGESVSVVTVMR ::::***:********:*****.*******:*.*.: *:*.*::*:.*****:******* ENSMUSP00000089498/1-1254 DSSESSPSAPATQFIMLPLPAYSVVENPSSIKLTTTYTRRGHGTCTSPGCSFTYVTRHKP ENSRNOP00000024704/1-1285 DSSENNPSAPTTQFIMLPLPAYSVVENPSSIKLTTTYTRRGHGTCTSPGCSFTYVTRHKP ENSP00000421917/1-1292 DSSESSSSAPATQFIMLPLPAYSVVENPTSIKLTTTYTRRGHGTCTSPGCSFTYVTRHKP ENSCPOP00000002369/1-1490 DSSESSSSAPATQFIMLPVPTYSVVENPSPIKLTTTYTRRGHGTCTSPGCSFTYVTRHKP XP_004854468.1/1-1286 DSNESSSCAPTTQFIMLPVPTYSVVENPSPIKLTTTYTRRGHGTCTSPGCSFTYVTRHKP **.*....**:*******:*:*******:.****************************** ENSMUSP00000089498/1-1254 PKCPTCGNFLGGKWIPKEKPAKVKVELASGVSSKGSVIKRNQQSVTTEQNPSKENASKLT ENSRNOP00000024704/1-1285 PKCPTCGNFLGGKWIPKEKPAKVKVELASGVSSKGSVIKRNQQSVTTEQNPSKENASKLT ENSP00000421917/1-1292 PKCPTCGNFLGGKWIPKEKPAKVKVELASGVSSKGSVVKRNQQPVTTEQNSSKENASKLT ENSCPOP00000002369/1-1490 PKCPACGNFLGGKWIPKEKPARVKVELASGISSKGSVIKRNHPP---EQNSSKENACKLI XP_004854468.1/1-1286 PKCPTCGNFLGGKWIPKEKPARVKVELASGVSSKGSVIKRNQQP---EQNSSKENACKLT ****:****************:********:******:***: . ***.*****.** ENSMUSP00000089498/1-1254 LENSEA--------------------------------EVPGNRGTAVTKMPVVKSGAQA ENSRNOP00000024704/1-1285 LENSEAVSQLLNVAPPREGGEDSEWEEVIVSDAHVLVKEVPGNCNTAVTKMPVVKSGIQA ENSP00000421917/1-1292 LENSEAVSQLLNVAPPREVGEESEWEEVIISDAHVLVKEAPGNCGTAVTKTPVVKSGVQP ENSCPOP00000002369/1-1490 LENSEAVSQLLNVAPPREVGEEKEWEEAITSDAHILVKEAPGICGTAVTKTPVVK----P XP_004854468.1/1-1286 LENSEAVSQLLNVAPPREVGDENEWEEVIVSDAHILVKEAPGICGTAVTKMSVVK----P ****** *.** .***** .*** . ENSMUSP00000089498/1-1254 EISLGTTENDSPGPDILP-SAEGTSSSSLLQAHKKSPGVDLFTTGPKAPELKGRARGKPS ENSRNOP00000024704/1-1285 EVSLGTTENDSPGPDIPP-SAEGTSTSSLLQAHKKSSGVDLFTTGPKAPELKGRARGKPS ENSP00000421917/1-1292 EVTLGTTDNDSPGADVPT-PSEGTSTSSPLPAPKKPTGADLLTPGSRAPELKGRARGKPS ENSCPOP00000002369/1-1490 EATLGTTEKDSCGVEIPPAAAEGTSTSTQLPAPKKPTGVDLFTTRPRTPELKSRARGKPS XP_004854468.1/1-1286 EVTLGTTENDSSGLEIPPPPAEGTSTSTQLPGPKKPTGVDLLTTGPRTPELKGRARGKPS * :****::** * :: . .:****:*: * . **..*.**:*. .::****.******* ENSMUSP00000089498/1-1254 LLAAARPMRAILPAPTSVGRGSGVGLPRARQAFPL-DKTPSVRTCGLKPSTLKQLGQPIQ ENSRNOP00000024704/1-1285 LLAAARPMRAILPAPTSVGRGSSMGLPRARQAFPL-DKTPPVRTCGLKPSTLKQLGQPIQ ENSP00000421917/1-1292 LLAAARPMRAILPAPVNVGRGSSMGLPRARQAFSLSDKTPSVRTCGLKPSTLKQLGQPIQ ENSCPOP00000002369/1-1490 LLAAARPMRAILPAPANVGRGSSVGLPRGRQAFSLSDKTSSVRTCGLKPSTLKQLGQPMQ XP_004854468.1/1-1286 LLAAARPMRAILPAPSNVGRGSSMGLPRARQAFSLSDKTSSVRTCGLKPSTLKQLGQPVQ *************** .*****.:****.****.* ***..*****************:* ENSMUSP00000089498/1-1254 QPPSTGEVKLSNCASSRTPQLKIVEVKPDLFPPYKYSCTVTLDLGLATSRGRGKCKNPSC ENSRNOP00000024704/1-1285 QPPSTGEVKLSSCASSRTPQLKIVEVKPDMFPPYKYSCTVTLDLGLATSRGRGKCKNPSC ENSP00000421917/1-1292 QPSGPGEVKLPSGPSNRTSQVKVVEVKPDMFPPYKYSCTVTLDLGLATSRGRGKCKNPSC ENSCPOP00000002369/1-1490 QSSSTSEVKLPSGPNNRTSQVKVVEVKPDMFPPYKYSCTVTLDLGLATSRGRGKCKNPSC XP_004854468.1/1-1286 QPSSTGEVKLPSGPNNRTSQVKVVEVKPDMFPPYKYSCTVTLDLGLATSRGRGKCKNPSC *.....****.. ...**.*:*:******:****************************** ENSMUSP00000089498/1-1254 SYVYTNRHKPRICPSCGFNLAKDRTEKTPKAIEASSPHPDVPSTTEALNPTQREVQRQST ENSRNOP00000024704/1-1285 SYVYTNRHKPRICPSCGFNLAKDRTEKTTKAIEASSPHPDVPSTTEPLNAAQREIQRQST ENSP00000421917/1-1292 SYVYTNRHKPRICPSCGVNLAKDRTEKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQST ENSCPOP00000002369/1-1490 SYVYTNRHKPRICPSCGFNLAKDRTEKTTKTLEVSSPLPDG------LSAAQREIQRQST XP_004854468.1/1-1286 SYVYTNRHKPRICPSCGFNLAKDRTEKTTKTIEMSSPLPDGLSATEPLSATQREIQRQST *****************.**********.*::* *** ** *..:***:***** ENSMUSP00000089498/1-1254 LQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQC ENSRNOP00000024704/1-1285 LQLLRKVMQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQC ENSP00000421917/1-1292 LQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQC ENSCPOP00000002369/1-1490 LQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQC XP_004854468.1/1-1286 LQLLRKVLQIPENESELAEVFTLIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSMQC *******:*************:*********************************** ** ENSMUSP00000089498/1-1254 LLCSSPLFKGGHNSLAGPQECWLLTANRLQVVTAQVKMCLNPHCLALHSFTDIYTGLFNV ENSRNOP00000024704/1-1285 LLCSSPLFKGGQNSLAGPQECWLLTANRLQVVTAQVKMCLNPHCLALHSFMDIYTGLFNV ENSP00000421917/1-1292 LLCSSPLFKGGQNSLAGPQECWLLTASRLQTVTAQVKMCLNPHCLALHSFIDIYTGLFNV ENSCPOP00000002369/1-1490 LLCSSPLFKGGQNSLAGPQECWLLTANRLQVVTAQVKMCLNPHCLALHSFMDIYTGLFNV XP_004854468.1/1-1286 LLCSSPLFKGGQNSLAGPQECWLLTANRLQVVTAQVKMCLNPHCLALHSFMDIYTGLFNV ***********:**************.***.******************* ********* ENSMUSP00000089498/1-1254 GNKLLVSLDLLFAIRNQIKLGEDPRVSVGVVLKSVQEQTEKTLTSEELSQLQELLCNGYW ENSRNOP00000024704/1-1285 GNKLLVSLDLLFAIRNQIKLGEDPRVSVGVVLKSVQEQTEKTLTSEELSQLQDLLCNGYW ENSP00000421917/1-1292 GNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTSEELSQLQELLCNGYW ENSCPOP00000002369/1-1490 GNKLLVSLDLLFAIRNQIKLGEDPRVSVSVVLKSVQEQTEKTVTSEELSQLQELLCNGYW XP_004854468.1/1-1286 GNKLLVSLDLLFAIRNQIKLGEDPRVSVSVVLKSVQEQTEKTLISEELSQLQELLCNGYW ***************************:.*************: ********:******* ENSMUSP00000089498/1-1254 AFECLTVRDYNDMICGICGVAPKVEMAQRNEENVLALKSVEFTWPEFLGSSEVNVEDFWT ENSRNOP00000024704/1-1285 AFECLTVRDYNDMICGICGVAPKVEMAQRNEENVLALKSVEFTWPEFLGSSEVNVEDFWT ENSP00000421917/1-1292 AFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWPEFLGSNEVNVEDFWA ENSCPOP00000002369/1-1490 AFECLTVRDYNDMICGICGVAPKVELAQRSEENVLALKSVEFTWPEFLSSSEVNVEGFWA XP_004854468.1/1-1286 AFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWPEFLGSSEVNVEDFWA *************************:***.******************.*.*****.**: ENSMUSP00000089498/1-1254 TMETEVIEQVAFPASIPITKFDASVIAPFFPPLMRGAVVVNTEKDKTQDMQPVPGNGSAL ENSRNOP00000024704/1-1285 TMETEVIEQVAFPASIPITKFDASVIAPFFPPLMRGAVVVNTEKDKNLDVQPVPGNGSAL ENSP00000421917/1-1292 TMETEVIEQVAFPASIPITKFDASVIAPFFPPLMRGAVVVNTEKDKNLDVQPVPGSGSAL ENSCPOP00000002369/1-1490 TMETEVIEQVAFPASIPITKFDASVIAPFFPPLMRGAVVVNTEKDKNLDVQPVPGNGSAL XP_004854468.1/1-1286 TMETEVIEQVAFPASIPITKFDASVIAPFFPPLMRGAVVVNTEKDKNLVVQPVPGNGSVL **********************************************. :*****.**.* ENSMUSP00000089498/1-1254 VRLLQEGTCKLEELGSYSGEELQYLLEQCDIPFSPEDSRDQLCFSLLALYESVQNGARAR ENSRNOP00000024704/1-1285 VRLLQEGTCKLEELGSYGGEELQFLLEQCDIPFGPEDSRDQLCFSLLALYESVQNGARAR ENSP00000421917/1-1292 VRLLQEGTCKLDEIGSYSEEKLQHLLRQCGIPFGAEDSKDQLCFSLLALYESVQNGARAI ENSCPOP00000002369/1-1490 VRLLQEGTCRIEEIGSYSEEELRHLLGQCDIPFTAEDCRDQLCFSLLALYESVQNGARAR XP_004854468.1/1-1286 VRLLQEGTCKLEEIGSYSEEELQHLLGQCDIPFKAEDCRDQLCFSLLALYESVQNGARAR *********:::*:***. *:*:.** **.*** .**.:******************** ENSMUSP00000089498/1-1254 PPPAHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATPVALC ENSRNOP00000024704/1-1285 PPP-HFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATPVALC ENSP00000421917/1-1292 RPPRHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATSVALC ENSCPOP00000002369/1-1490 QTPPHLTGGKIYKMCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATPVALC XP_004854468.1/1-1286 QPPPHLTGGKIFKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATPVALC .* *:*****:*:*****************************************.**** ENSMUSP00000089498/1-1254 ADLCYPELTSQMWGKNQGCFSNPTEPVVSVSCPELLDQHYSVDVTEAENSVQHPVTKSAT ENSRNOP00000024704/1-1285 ADLCYPELTSQMWGKNQGCFSNPTEPVVSVSCPELLDQHYSVDVTEAENSVQHPVTKTAT ENSP00000421917/1-1292 ADLCYPELTNQMWGRNQGCFSSPTEPPVSVSCPELLDQHYTVDMTETEHSIQHPVTKTAT ENSCPOP00000002369/1-1490 ADLCYPELTSQMWGKNQGCFSSPTEPPVTVSCPELLDQHNSVDVTEAEHSVQHPVTKSVM XP_004854468.1/1-1286 ADLCYPELTSQMWGKNQGCFSSPTEPPMTVSCPELLDQHNSVDTTEAEHAVQHPVTKSAT *********.****:******.**** ::********** :** **:*:::******:. ENSMUSP00000089498/1-1254 RRIVHANTKPDPSDPSAGHRSLSLCPELAPY----ASTTDSKLSSVRQRPIAFDNATHYY ENSRNOP00000024704/1-1285 RRIIHANTKPDPSDPSAGHRSLSLCPELAPY----ASTTDSKLSSIRQRPIAFDNATHYY ENSP00000421917/1-1292 RRIVHAGLQPNPGDPSAGHHSLALCPELAPYATILASIVDSKPNGVRQRPIAFDNATHYY ENSCPOP00000002369/1-1490 RRIVHAGTQPSPGDPSAGHHSLSLCPELAPYTSILASITDSKSNSVRQRPIAFDNATHYY XP_004854468.1/1-1286 RRIVHAGTQPSPGDPSAGHHSLSLCPELAPYASILASIMDSKSNNVRQRPIAFDNATHYY ***:**. :*.*.******:**:******** ** *** ..:************** ENSMUSP00000089498/1-1254 LYNRLMDFLTSREIVNRQIHDIVQSCQPGEVVIRDTLYRLGVAQIKTEAQEEGEEEEVAS ENSRNOP00000024704/1-1285 LYNRLMDFLTSREIVNRQIHDIVQSCQPGEVVIRDTLYRLGVAQIKTETQEDGEEEEVPS ENSP00000421917/1-1292 LYNRLMDFLTSREIVNRQIHDIVQSCQPGEVVIRDTLYRLGVAQIKTETEEEGEEEEVAA ENSCPOP00000002369/1-1490 LYNRLMDFLTSREIVNRQIHDIVQNCQPGEVVIRDTLYRLGVAQIKTEPEEEMEEEEATS XP_004854468.1/1-1286 LYNRLMDFLTSREIVNRQIHDIVQNCQPGEVVIRDTLYRLGVAQIKTEPEEEGEEEEAAT ************************.***********************.:*: ****..: ENSMUSP00000089498/1-1254 VVE ENSRNOP00000024704/1-1285 VVE ENSP00000421917/1-1292 VAE ENSCPOP00000002369/1-1490 AAE XP_004854468.1/1-1286 VAE ..*