CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000002333/1-1202 LGHPRQSRAHEGCRRKTKARAPPPPGKPALPSMPSEQKPPRDAAIGCHQNLIHQQEALRD XP_004840593.1/1-1079 MEAPQALAARPPSGRKMKAHAPAPPGKPAPLRVPADRTPPGDAALGCPQNLIHQQEALRN ENSP00000378912/1-1343 MDAPRASAAKPPTGRKMKARAPPPPGKAATLHVHSDQKPPHDGALGSQQNLVRMKEALRA ENSMUSP00000045693/1-1337 MDAPRALAAKPPTGRKMKARAPPPPGKPAAQNVHSEQKLPHDATLGSQQSLVYMKEALQN ENSRNOP00000063258/1-1133 ----------------MKARAPPPPGKPAAQNVHSEQKLPHDATLGSQQSLVHLKEALHN **:**.****.* : :::. * *.::*. *.*: :***: ENSCPOP00000002333/1-1202 STLDVTVVLPSGLEKQSVVSGSHAMMDLLVELCLQNHLNPSHHALEIRSAETQQPLSFKP XP_004840593.1/1-1079 STLDVTVVLPSGLEKQSVVSGSHAMMDLLVELCLQNHLNPSHHALEIRSSETQQPLSFKP ENSP00000378912/1-1343 STMDVTVVLPSGLEKRSVLNGSHAMMDLLVELCLQNHLNPSHHALEIRSSETQQPLSFKP ENSMUSP00000045693/1-1337 STLDITVVLPSGLEKQSVVSGSHAMMDLLVELCLQNHLNPSHHVLEIWSSETQQPLSFKP ENSRNOP00000063258/1-1133 STLDITVVLPSGLEKQSVVSGSRAVMDLLVELCLQNHLNPSHHVLEIWSSETQQPLSFKP **:*:**********:**:.**:*:******************.*** *:********** ENSCPOP00000002333/1-1202 NTLVGTLNVHTVFLKEKVPEEKEKPGPRKVPEKSVRLVVNYLRTQKAVVRVSPDVPLRSI XP_004840593.1/1-1079 NTLVGTLNVHTVFLKEKVPEEKAKPGPRKVPEKSVRLVVNYLRTQKAVVRVSPDAPLRSI ENSP00000378912/1-1343 NTLIGTLNVHTVFLKEKVPEEKVKPGPPKVPEKSVRLVVNYLRTQKAVVRVSPEVPLQNI ENSMUSP00000045693/1-1337 NTLIGSLNVHTVLLKEKVPEERVKPGLTKAPEKSVRLVVNYLRTQKAVVRVSPEVPLQNI ENSRNOP00000063258/1-1133 NTLIGSLNAHTVFLKEKVPEEKGKPGLTKAPEKSVRLVVNYLRTQKAVMRVSPEVPLQNI ***:*:**.***:********: *** *.******************:****:.**:.* ENSCPOP00000002333/1-1202 LPLICAKCEVSPEHVVLLRE-AAGEELELSKSLSELGIKELYAWDNRRETFRKSSLGNDE XP_004840593.1/1-1079 LPLICAKCDVRPEHVVLLRDSAAGEELELSKSLSELGVKELYAWDNRRETFRKSSLGNDE ENSP00000378912/1-1343 LPVICAKCEVSPEHVVLLRDNIAGEELELSKSLNELGIKELYAWDNRRETFRKSSLGNDE ENSMUSP00000045693/1-1337 LPVICAKCEVNPEHVILLRDNVAGEELELSKSLNELGIKELYAWDNRREMFRKSSLGNDE ENSRNOP00000063258/1-1133 LPVICAKCEVSPDHVVLLRDNIAGEELELSKSLNELGIKELYAWDNRREMLRKSSLGNDE **:*****:* *:**:***: ***********.***:*********** :********* ENSCPOP00000002333/1-1202 TDAEKKKFLGFLKANKRSNSK-------------------------GCLTTPSSPSEQPR XP_004840593.1/1-1079 TDNEKKKFLGFFKVNKRSNSK-------------------------GCLTMPNSPSAHAR ENSP00000378912/1-1343 TDKEKKKFLGFFKVNKRSNSKAEQLVLSGADSDEDTSRAAPGRGLNGCLTTPNSPSMHSR ENSMUSP00000045693/1-1337 TDKEKKKFLGFFKANKRSNSKAEHLGLSGADSDEDPAKSASGGDLNGCVTTPNSPSLHSR ENSRNOP00000063258/1-1133 TDKEKKKFLGFFKVNKRSNSKAEHLGLSGADSDEDPSKSASGGDLNGCVTTPNSPSLHSR ** ********:*.******* **:* *.*** :.* ENSCPOP00000002333/1-1202 SWSLGPARSLGSLSGASGKSEMKKRQAPPPPGSGPRVQDKTSEKVSLGSQVDLQKKKRR- XP_004840593.1/1-1079 SLSLGPALSLGNISGVSMKSEMKKRRAPPPPGSGPLVQDKTPEKVSLGSQVDLQKKKRRA ENSP00000378912/1-1343 SLTLGPSLSLGSISGVSVKSEMKKRRAPPPPGSGPPVQDKASEKVSLGSQIDLQKKKRRA ENSMUSP00000045693/1-1337 SLTLGPSLSLGNISGVSMKSDMKKRRAPPPPSPKLLGQDKVSEKASLSSQADLQKKKRRA ENSRNOP00000063258/1-1133 SLTLGPSLSLGNISGMSMKSDMKKRRAPPPPSPGLLGQDKVSEKASLSSQADLQKKKRRA * :***: ***.:** * **:****:*****.. ***..**.**.** ******** ENSCPOP00000002333/1-1202 -----------SPLVPNRREDKEENRKSTM------------------------------ XP_004840593.1/1-1079 PAPPPPQPPPPSPLVPNRREDKEENRKSTMGVGRQAPQKPPRGSTRGPPQLV---PPPLP ENSP00000378912/1-1343 PAPPPPQPPPPSPLIPNRTEDKEENRKSTMGGGRQVPQKPPRGTARGPPQLVLPPPPPYP ENSMUSP00000045693/1-1337 PAPPPPQQPPPSPVVPNRKEDKEENRKSTVGVGRQVPQKPPRGTARGPPQLVLPPPPPYP ENSRNOP00000063258/1-1133 PAPPPPQPPPPSPVVPNRKEDKEENRKSTV------------------------------ **::*** **********: ENSCPOP00000002333/1-1202 ---------------------------VSLLLSPGSHSSVDSSPAVTSEAEETISVGSCF XP_004840593.1/1-1079 PPGPDEVEPLGPPGEGAGSEPSELRPELSLPLSPSSHSGVDGILPVPSEAEETASVGSCF ENSP00000378912/1-1343 PPDTDVVEPLSFPGEGAGSEASDPIPKLSLPLGSGSHCSPDGAPQVLSEAEETVSVGSCF ENSMUSP00000045693/1-1337 PPDTDVTEPVTFPGEGAGSETSELRPKLSLPLGPGSHCSMGGVSQVPAESEET------- ENSRNOP00000063258/1-1133 ------------------------------------------------------------ ENSCPOP00000002333/1-1202 ASEDTTEDSGVISSPSDIVSLDSQHDSLKSKDKWATDQEDCSDQDLAGTPELGPPKSPLW XP_004840593.1/1-1079 ASEDTTEDSGVISSPSDIISLDSQHDSLKSKDKWATDQEDCSDQDLAGTPEPGHQKSPSW ENSP00000378912/1-1343 ASEDTTEDSGVMSSPSDIVSLDSQQDSMKYKDKWATDQEDCSDQDLAGTPDLGPQKSPLW ENSMUSP00000045693/1-1337 ASEDTTEDSGVMSSPSDAISLDSQQDSMRSKDKWSTDQEDGSDQDLAGTPELGPQKSPSW ENSRNOP00000063258/1-1133 ------------------------------------------------------------ ENSCPOP00000002333/1-1202 ERPGPRDTCLRSETATV-TSAEEDLFIDAHSRRTLAAPLGGRGPDEMEDSYDTDSSSAAS XP_004840593.1/1-1079 EGSGPAKLCLRSEEAAG-TTDEDNLLVTGRLHSTLAEPDG--GLDGMEGSPGADGSAATQ ENSP00000378912/1-1343 EKNGSENSHLRTEKAVTASNDEEDLLIAGEFRKTLAELDE--DLEEMEDSYETDTSSLTS ENSMUSP00000045693/1-1337 GKSGSGSSILRTEKATMPTNDDEDLFITGHLHQTLAELDE--DLEGMEENYETDTSSLTN ENSRNOP00000063258/1-1133 ---------------------------------------------GMEENYETDTSSLTS ** . :* *: :. ENSCPOP00000002333/1-1202 STDGGWGHCVQDGAM--ADVDTIPVTFIGEVSEEPG--DSGLSSNRNNNAASSTSGGITG XP_004840593.1/1-1079 GRSGAWSPSAQGWA---AGADAVPVTFIGEVSEEPGPEDCGLWPDQSNGAGPSDAGPGAA ENSP00000378912/1-1343 SIHGASNHCPQDAMIPHGDTDAIPVTFIGEVSDDPV--DSGLFSNRNNNAGSFDSEGVAS ENSMUSP00000045693/1-1337 SVNGVSNHSLQEAIIPDSGVDDIPVTFIGEVSDEPF--DSGLFSSRCNNATTFNTGSIAS ENSRNOP00000063258/1-1133 SVNGVSNHSLQEAIIPDSGVDDIPVTFIGEVSDEPF--DSGLFFSGSNNAAALNQGGIAS . * . . * ...* :*********::* *.** . *.* . :. ENSCPOP00000002333/1-1202 RGPCLPPCKAEQDQP--------QGGWSPPQDAGQGDL--------YRKAMGPVPKGASL XP_004840593.1/1-1079 QRGAGAP------------------GW--------------------------------- ENSP00000378912/1-1343 RRDSLAPLQAEHSQPHEKAREEVPALHPASHDVGKGIRVALSNISKDGNLMETAPRVTSF ENSMUSP00000045693/1-1337 QRSHLSPSQTEHSQPFVRTSRKEPDPSPPSQDNRKRNQPTLANTSENENPVETDPTVTSL ENSRNOP00000063258/1-1133 QRSHLPPYQTEQSQPFIRTNRKEPDPSLPSQDYRKRNQPILANTSENENPVGIDPRVTSF : .* ENSCPOP00000002333/1-1202 AVKSPPANPSVKEPGSRHSSAHGERTQAPWG-----TEDQEARQPSSIPGPPAWCRRGHP XP_004840593.1/1-1079 -----------REPGRR------------------------APAPRAVPGPPSWCRRGQP ENSP00000378912/1-1343 ASNLHTDNLNAKVKDKVYGCADGERTQATERVNSQPVNEKDSNDKNAALAPTSWHQRGQN ENSMUSP00000045693/1-1337 VSKLLIDDPKAKDKGKVHGSSHSEKTQAGHGINSLRVNPRDGKDESSNSAPPPWSHHGQA ENSRNOP00000063258/1-1133 VSKPSTDDPKAKDKDKMCGSGPSEKTQTGHRVNSLPVNPRVGEDENSNSALPPWSHHGQA : . . : . ..* ::*: ENSCPOP00000002333/1-1202 AAGSYGLKQGLTTYKIVPPRSEMRCYDRGASLSTGAIEIDELGNLVSPAGASGRTEFPPL XP_004840593.1/1-1079 AAGRCWREPGLTTYTIVPSHAERRPYARGASPPAGALRIDELGNLV---GVPGARAAAPA ENSP00000378912/1-1343 PGKSYRLKHGLTTYKIIPPKSEMRCYDRDVSLSTGAIKIDELGNLVSP-HATGIRIISLS ENSMUSP00000045693/1-1337 LGGSYGLKYGLTTYKIVPPKSEMRCYDRDVSLSTGAIKIDELGNLVSP-HMNGSRTISPP ENSRNOP00000063258/1-1133 SGGSYGLKYGLTTYKIVPPKPEMRCYDRDVSLSTGAIKIDELGNLMSP-HMNGSRTISKP . : *****.*:*.:.* * * *..* .:**:.*******: * . ENSCPOP00000002333/1-1202 TPGVDTEARPLGKVKEFWRRGSSEKPPSQ-PAGCPAARVTPAATTSSVTMAAPIPTLAPS XP_004840593.1/1-1079 APGVDSEEQQPGKVREFWRRGPGAGSAQQAPSPSPAAR------------APPSPASAPA ENSP00000378912/1-1343 SSVPEAESQPIGKVREFWRCNSVEKHLGR-PSESSARG------------PPSTPVPTQT ENSMUSP00000045693/1-1337 SAVVETDTPPIGKVKEFWRRNSMEKYLNG-PAECTIKR------------APSTTITATP ENSRNOP00000063258/1-1133 SAVAETEAPPIGKVKEFWRRNSMEKYLNG-PAECTVKK------------APSTTITATS :. ::: ***:**** .. *: .. ... . : . ENSCPOP00000002333/1-1202 KPPQDST-VTTAPVPATLKQPTVPHAGERPQEDTRSRPPLAVAGQEKVPAVPMGELPFLR XP_004840593.1/1-1079 QPP---------------------------------------------PSAALARAPPLR ENSP00000378912/1-1343 QNPESR--LQADPKPISPQQKSAHHEGRNPLGEGRNQPPTMGMGHVRVPAAHTTEVTFLK ENSMUSP00000045693/1-1337 EKPQQDNGMKAAFTVTTPQQQPASQEYGAHLEEERSRPQSAVSCSVKVPASNPTDITFLK ENSRNOP00000063258/1-1133 EKPQRDE-TKAGFTLTTPEQQPASQEYGAPPEEDRSRPHSAVSCPVKVPAPNPTDITFLK : * *: . *: ENSCPOP00000002333/1-1202 PHRRTSSQHVASAIARRMGSTPAPSDTARPH-SVMEKGPSARRPVSPGQPLPTQGASARG XP_004840593.1/1-1079 PQRRTSSQHVAAAIARRIGA----------------------------GPAGQRDDKARG ENSP00000378912/1-1343 PQRRTSSQYVASAIAKRIGAPKVHADVVRPH-GYAEKGYAGKAPVLAAPPVTVKDDRTSS ENSMUSP00000045693/1-1337 PQRRTSSQYVASAIAKKMGPPKVHADVVRPHKATTEQCH--EEAKLARSPPTRKDDAAPN ENSRNOP00000063258/1-1133 PQRRTSSQYVASAIAKKMGPPKVHADVVRPHKKTAEQGH--EEAKLARPPPAWKDSAVPN *:******:**:***:::*. * :. . . ENSCPOP00000002333/1-1202 LDTEPQGLDTRQPRPGDTSNTQPG---RVADSPQRTAAAT-----DKDSPIAVQGVSCSS XP_004840593.1/1-1079 P---------------------PGSPQPNGGP----------------------RLSSAV ENSP00000378912/1-1343 PHSETQGWKDGAQWPCVTPPNNHGEDLAVGAPPRGEVIGPHRKLSTQDRPAAIHRSSCFS ENSMUSP00000045693/1-1337 LHSEARQHEHGTNQSSVCLPSNPGVQLPAGGHPKVEVNSTYGKSSTQDYPAAVHRNSYFL ENSRNOP00000063258/1-1133 LCSEAGQCEHGTNQGSVRLPSNPGGQLP-ADHPKVEVNSTYGKSATHNSPAAVHRNSYFL * . * ENSCPOP00000002333/1-1202 ASHLPLREPMSARWSCGPQKKP--SDPKASLAPNSVHTLDRVR-PIPTHPAD------VL XP_004840593.1/1-1079 PGRASREEPATLRRGCGPQEEPCTLDLGTSTVPRAPHSPDPAHAPVPHR---------LP ENSP00000378912/1-1343 LVQSSQRDRVSVGQSCGFSGKQSTSSQEASSASEPRRAPDGTD-PPPPHTSDTQACSREL ENSMUSP00000045693/1-1337 PGRSSHRDRVSVGQSCGFNEKQTTSNQKANSTSNFSQALDKAH-PPPLLLAEARDSGRIL ENSRNOP00000063258/1-1133 PGRSSQRDRVSVGQSCGFHEKQTISNQKMNSTSNPSQALDKAH-PAPLLLTEARDSGRIL : . .: : .** : . . ... :: * . * * ENSCPOP00000002333/1-1202 TNGSAWDP---EPPLCPQVSSTHSHSTLETGERPRPFPEARGDGDSSFPASIFGPKKKFK XP_004840593.1/1-1079 ATGSAQAPTR-EPPSCPRVPGA-----LEAEAQPCPAPAARH-ADCSLPTGIFGPKKKFR ENSP00000378912/1-1343 VNGSVRAPGHGEPSHPPGGSGTESHILLEREEKPSVFSTDGNETDSIWPPSIFGPKKKFK ENSMUSP00000045693/1-1337 MNGSARTPGNCEPPHSPKESTLTSYIILQTEEKPSSLSTDGQDADDTLPSSIFGPKKKFK ENSRNOP00000063258/1-1133 VNGSAQTPGNCEPPHSQKESTLTSYIILQTEEKPSPLSADGQNSDDALPSSIFGPKKKFK .**. * **. . *: :* . * *..********: ENSCPOP00000002333/1-1202 PVVQRPVPKDTCLHSVLMEAIQAAGGKDGLRKTAEPSTERGPRTLSYTEADSERSALMAA XP_004840593.1/1-1079 PVAQKPVRKDTCLHSALMDAIHAAGGKDKLRKTAEPPEERGPRTLSYTEADSERSALLAA ENSP00000378912/1-1343 PVVQRPVPKDTSLHSALMEAIHSAGGKDRLRKTAEHTGEGRPAKLSYTEAEGERSALLAA ENSMUSP00000045693/1-1337 PVIQRPLPKDVSLHSALMEAIHSSGGREKLRKTAEQTSEGRPKKPSYVEAESERSALLAA ENSRNOP00000063258/1-1133 PVVQRPLPKDISLHSALMEAIHTSGGRDKLRKTAEQASEGRPKKPSYVEAESERSALLAA ** *:*: ** .***.**:**:::**:: ****** . * * . **.**:.*****:** ENSCPOP00000002333/1-1202 IRGHSGTRSLRKVSSSASAELQGCRNTA------------------PPQVPQPP-PGPCA XP_004840593.1/1-1079 IRGHSGTRSLRKVSSSASAELWGCWAAV------------------PPEAPGPL-PMPQA ENSP00000378912/1-1343 IRGHSGTCSLRKVASSASEELQSFRDAALSAQGSESPLLEDLGLLSPPAIPPPPPPPSQA ENSMUSP00000045693/1-1337 IRGHSGTLSLRKVSSLASEELQSFRNAALGAPGLDKPQQEDLGLPPPPALPPPPAPAPQA ENSRNOP00000063258/1-1133 IRGHSGTLSLRKVSSLASEELQSFRDAALMAPGVDKPQQEDRGLPPPPALPPPSTPASQV ******* *****:* ** ** . :. ** * * * . . ENSCPOP00000002333/1-1202 PPAPPVAPGLGAGPLSETVDARQALLDAIRSGSGAARLKKVSEQQ XP_004840593.1/1-1079 PPAPMTAPRTSSGPLGDAVDARQALLDAIRSGSGAARLKKVPLLV ENSP00000378912/1-1343 LSAPRTASRFSTGTLSNTADARQALMDAIRSGTGAARLRKVPLLV ENSMUSP00000045693/1-1337 PSASVTVSRFSTGTPSNSVNARQALMDAIRSGTGAARLRKVPLLV ENSRNOP00000063258/1-1133 PSASIPVSRFSIGTLSNPVNARQALMDAIRSGTGAARLRKVPLLV .*. .. . *. .:..:*****:******:*****:**.