CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000042028/1-942 MDFLRLRLPGLHQALRGALDSFSAFVSYLVGDTVPTVERQTQAAEELGEVTEG---KVVG ENSRNOP00000023555/1-788 MDFLRLRLPGLHQALRGALDSFSAFVSYLIGDTVPTVERQPQAAEELGEVTEG---KVVG ENSP00000457539/1-1097 MDFLRLYLPGLHQALRGALDSLGTFVSYLLGDAVPTVEREAQAAEELGVVAVGKTGKIVE ENSCPOP00000002240/1-908 MDFLRLHLPGLHQALRGALDSLSTFVSYLMGDAVLTVEREVR---ELGEVAAGKPEKTVE XP_004856121.1/1-883 MDFLRQHLPGLHQALRGALDSLSTFVSYLMGDEVPTVEREAQAAEELGEVAARGPEKI-- ***** **************:.:*****:** * ****: : *** *: * ENSMUSP00000042028/1-942 EEAQEVLEGLRSGQSEGVEA---PEETRRCQEGSLAGEQTWGWRADSSARPQAERQDTGS ENSRNOP00000023555/1-788 EETQEVLDGLRSGQSERVGA---PEESIRCQEGSLAGEQTWEWRADSSTRPRAERQDTGS ENSP00000457539/1-1097 EEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGA ENSCPOP00000002240/1-908 EEAQEALHSLRDGPSERAGVLRGTGEAGGGQEERSAAEQVWGWGEGSSCRSQAGRQNSGA XP_004856121.1/1-883 -EAQEALHSLRGGQSQGVGALRGPAEAEGCQEQSSAAEQVWGWGEGSSCRSQTGRRDSGT *:** *..**.. .: . . : : * **.* * .** .:: *:::*: ENSMUSP00000042028/1-942 WKAAEDARGQEPSVPLK----PEAEPGTHRDRSSNTAQEIWEHGEEEASSGEPLRTCEQK ENSRNOP00000023555/1-788 RKAAEGARGQEPSVSLK----PEAERGTLRDRSSDIAQELWEHGEEEASNGELLRTCKQK ENSP00000457539/1-1097 GETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQ-AQERQESHEQEVNREERLRSWEQE ENSCPOP00000002240/1-908 WGAGTAAKSPEPSVLLKAEKTSEAESRTHRDESSQ-AKKRQES----------------- XP_004856121.1/1-883 WGAVTAARVPEPSVLLKAKKTSEAESGPHRDRSSQ-AKERQESEEQEVNRGDTLRTWEQE : *: ***. *: .:* . :*.*.: *:: * ENSMUSP00000042028/1-942 EEEE----EVVRAAESGMAEGVESQPTWHSEPGGNAGTEGQHVTEDSKEIDWVAKDM-VA ENSRNOP00000023555/1-788 EEEEVVKAEVVKATEPGMARGVESQPTWHSKPEESAGTEGQNVTDDRKEIDCVAKDV-VA ENSP00000457539/1-1097 EEE-----EEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAG ENSCPOP00000002240/1-908 --------EEVGARGAGMARGVESEQPWHGELQGKAGVEREKVARDC----GVVRVA-VA XP_004856121.1/1-883 EEE-----EEVRAREPGMARGVESEQPWHWEPEAEAGAEREEVARDTVETRPVVREA-VA * * * .***.*.**: .** : .**. ..: * .: .. ENSMUSP00000042028/1-942 EIEWFGAKGIDKEEERMVPMRDGERARAQGTQCPGAESED---QAMLSR----------- ENSRNOP00000023555/1-788 EVEWFGAKGADKEEERMVPTRNGQSARAQGTQCPGAESED---WAMLSR----------- ENSP00000457539/1-1097 ETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPED---WGILGREEARTTPGREE ENSCPOP00000002240/1-908 ETEVSGAKRPWRKEGEVVGVRADQSTRAQETQGPGPESEDQATW---------------- XP_004856121.1/1-883 ETEVSGATGPRREEGEVVEARTGQSTRVQGTHGPGAESED-------------------- * * ** : * :* : : :*. * **.*.** ENSMUSP00000042028/1-942 ------------------------------------------------------------ ENSRNOP00000023555/1-788 ------------------------------------------------------------ ENSP00000457539/1-1097 ARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGG ENSCPOP00000002240/1-908 ------------------------------------------------------------ XP_004856121.1/1-883 ------------------------------------------------------------ ENSMUSP00000042028/1-942 -------------------EAWTVSDREGADSLGVQGTEYGSDPGDNFPGTTGRVWVLEE ENSRNOP00000023555/1-788 -------------------EAWTVSGREEADNLGIQEAEYGSDPGDNIPEATGRVWVLEE ENSP00000457539/1-1097 EEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEE ENSCPOP00000002240/1-908 ----------------HKEEARATLGKEADDLPGIRETEDGLVTADRILEAASSIRILEK XP_004856121.1/1-883 ---------------------WTASAREEADLLGVRGTEDGLVPGDRRPKATSSIRIPEE :. :* * *:: :* * ..:. ::. : : *: ENSMUSP00000042028/1-942 ADKGDQQDEVDEKREAEVR-FPIQTLE--AERTGEMTEGHIAEEEAMGEQ----ETEGSF ENSRNOP00000023555/1-788 AGKGDQQDEVDEKREAEAR-LLIQTWE--AERTGEMTEGQIARSGAVGDQ----ETGDSF ENSP00000457539/1-1097 EG--------DEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQ----EAGESF ENSCPOP00000002240/1-908 ASNRDQEEEPDEKREDKVKVFSKQPWALVTEAIEDAAEGQKAKREAAGAQESEEEAGEHF XP_004856121.1/1-883 ASNGDQEEEPEEKTADEVKVFPKQPWALVTEAIEEAAEGQKTRQGAAGAQEPEEEAGEHF . :*: :. : *. :* : :*.: : * * * *: * ENSMUSP00000042028/1-942 ED---------EERQDLAIRDNGVSLEEEVRAEESSREKRNSWATEPTLVLDTEAKDEPD ENSRNOP00000023555/1-788 ED---------EERQDLATRDNGVSLEEEVQAKESSREKRSHWATEAILVSDTGVKDEPD ENSP00000457539/1-1097 EGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTAD ENSCPOP00000002240/1-908 EGKTDEYTKEACSGPNSEIKADDGASPWEVPAEEPQEKKETCCALEAELVPGKEVEGEAD XP_004856121.1/1-883 EGKTGLYRTEAHGRQNSESRADGTRPREEAPTEEPQEKKGSRRAPEAELAPDKEAEGEVD *. : : : . ::*...:: . . * . .:. * ENSMUSP00000042028/1-942 WEDSPEVSTEELFVGERSEAAQMTPEVLRVK-------VTEGQDPELVRHSQALTKQLEE ENSRNOP00000023555/1-788 REDSPGAKTEELFVGEKSEAVQMTP----------------------------------- ENSP00000457539/1-1097 LEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEE ENSCPOP00000002240/1-908 SEAALEARPEE-FMWEKDQEYQTSQEALGVEWSIPKHGVPEDQGLKLVEDAQTPEESPKE XP_004856121.1/1-883 SEAALEARPEEEFLWERGQEDQMSQGALGVEW----------------GDAQAPAEPPEE * : . .** : *..: * : ENSMUSP00000042028/1-942 GQKGQEETSGAPDLSPERV-LSLKEYPGPVGFAGPELEA-----WGNWSRG-VDRRNSQE ENSRNOP00000023555/1-788 ------------------------------------------------------------ ENSP00000457539/1-1097 REAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQE ENSCPOP00000002240/1-908 GQGGQEEHCQDQGLSREEAGTGVREQPRHLG--PPEVPETEG--WELWRVGDPESKITQE XP_004856121.1/1-883 GQGGQGAHRRGPGLSKEETESREKEQPRHVGSLPPEVLEAEP--WELWWRGDTESKVTQR ENSMUSP00000042028/1-942 VKADAEA-GKEQTATEQAVEIRAEGGQEAQQPEVFG------------SGGEEALTSVAL ENSRNOP00000023555/1-788 ---------------------------------------------------EESRVKVAE ENSP00000457539/1-1097 DAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSE ENSCPOP00000002240/1-908 GKSDAEE-GEEEAAGGQALEAEAEGSWGSEPPEVLD------------CGMEEGETSVVD XP_004856121.1/1-883 EKADAEE-GDEEAAGG----------WESGLPESPE------------WGMEEGDTSVEE **. ..* ENSMUSP00000042028/1-942 NPELEGSQGAEAGTEESVEESKPTENEAAEEEAVVPWEADGTCRKR-RLEEVTLSLQDSE ENSRNOP00000023555/1-788 GQELE------------------------------------------------------- ENSP00000457539/1-1097 NQELDGSTGADAGPCPSLGEAYARETEDEEA------EADRTSRRGWRLQAVAVGLPDRE ENSCPOP00000002240/1-908 NQELQANKGTEAEPGQALGESEAGETTDKVVEITVPWEADRIPRWGWRLEGAALSLQDSE XP_004856121.1/1-883 NQELQGNQGAEAGTGQALGQPEARETKDYVADIPAPREAARVPREGWRPREAALSLQNSE . **: ENSMUSP00000042028/1-942 DTETSYLAEEIIVGI---RAVDTEEGPKWE-AGLAPETELGKAWCSEGRGEAGRGTELEE ENSRNOP00000023555/1-788 --------LEIIVGT---RTVDAEEGPRWE-GGLAPDMELGKAWYSEGREEAGRDTELEE ENSP00000457539/1-1097 DAQTGSVAAGIMGGDVVPHISAAGAGEALE-GVL------GQGWDSKEKEEAAAG----- ENSCPOP00000002240/1-908 DTQTSSLATEVVEDQ----AVLAGEGLQGEAGGAWSSEELGRGWDSEEREEAEGG----- XP_004856121.1/1-883 DTGTSPLPAEMVEGQ--------AEGQP------------GQGWGSEEGQEAGGG----- :: . * *:.* *: ** . ENSMUSP00000042028/1-942 TTEKQSGQEVGLVGSA-EKVSGYDIQ-----EIDGTEEGEQAEMETSVMAEDIRGTDGVT ENSRNOP00000023555/1-788 ATEKQSGQEVGLEDSAEEKVSGYDTQ-----ETDGMGEGEQVQMETSVMAEGIRGADGVT ENSP00000457539/1-1097 --EHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPA- ENSCPOP00000002240/1-908 --------------------------------------AGQIEAA--------------- XP_004856121.1/1-883 --------------------------------------AEQVEAV--------------- . : : ENSMUSP00000042028/1-942 LGSQAERAEGSITPMETEGLLRDQMLLEEEAGG-GQSREQKVHNSE--------GEIQ-- ENSRNOP00000023555/1-788 LGSQAERAEGSKTTMETEQLLRDQILLKEEAGG-GQSREPKGHISE--------GEIQKL ENSP00000457539/1-1097 -GSQTARAEGMGAMVEAGGLLEKWTLLEEEAVG-WQEREQREDSEGRCGDYHPEGEAPRL ENSCPOP00000002240/1-908 -----------------------QALLEEETGE-WHIGEQRGDSERQDEDRHPEGQAERP XP_004856121.1/1-883 -----------------------QVLLEEESSGKWHVGEQRGHRERQCGGRHPEGEARRP **:**: : * : . . *: ENSMUSP00000042028/1-942 ----------------------TLDDSSDQEGQQTHQIPTVAVP---GPLESAEATAGAP ENSRNOP00000023555/1-788 QEEEDARI-GAQRTEIQETYP-GLDDSSGQEGQQTLQIPTVAMP---GPSESAEATAGAP ENSP00000457539/1-1097 LDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSAR ENSCPOP00000002240/1-908 PEVDDVKVTGGQRTEAEGTAPEDLEDVQGQEGQPTYQPPVETAP---GPSETAEAVGSDT XP_004856121.1/1-883 LGVDTAAGTDGWRTEAEGAAPEDLEAVQGQEGQPAHQPPVETAP---GPSATAEAMGSDR *: .** * : * *. : * * :*** .. ENSMUSP00000042028/1-942 GDVHSNWNEALLPGSRLDVSVPRSRVLLSRSSSRRRSRPSFHRISVPEPQ-CDPPSPQ-P ENSRNOP00000023555/1-788 GDVHSNWNEAPLPGSRLDVSVPRSRVLLSRSSSRRRSRPSFRRISVPEPQ-WDPPSPQ-P ENSP00000457539/1-1097 GGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQ-EEPPAPNPP ENSCPOP00000002240/1-908 GDTHSSWSKALLPGSRLDVSVSRSRVLLSRSSWKRRSRPSSWRKTSPEQQQEDPPSPQ-P XP_004856121.1/1-883 GDTHSHWSEVLLPGSRLDVSVSRSRALLSRNSSKRRSRPSFWRASASEQQ--DPPSPQ-L *.. . *.:. **** *****.***. ***.* :****** * . * * :**:*: ENSMUSP00000042028/1-942 QAERPVPEQSSLQLEETPELSATKPEGTPVPARRKMLGRGFGFAHPGMMQELQARLSQPK ENSRNOP00000023555/1-788 QEELPFPEQSPPRLEETPELSATKPEGTPVPVRRKVLGQGFGFAHPGMMQELQARLSQPK ENSP00000457539/1-1097 EEELSAPEQRPLQLEEPLEPSPLRHDGTPVPARRRPLGHGFGLAHPGMMQELQARLGRPK ENSCPOP00000002240/1-908 DEGLSTPEQRPLQLEEAPEPSPLQSGGTSEPVKRKLLGHGFGPMHPGMMQELQARLVQRK XP_004856121.1/1-883 EEELPTPEQSLLQLEEAPEPSPLRPGGTPELAGRKLLGHGFGLAHPGMMQELQARLSQRK : . *** :***. * *. : **. . *: **:*** ************ : * ENSMUSP00000042028/1-942 PQ ENSRNOP00000023555/1-788 PQ ENSP00000457539/1-1097 PQ ENSCPOP00000002240/1-908 PQ XP_004856121.1/1-883 PQ **