CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000020846/1-1134 MDELAFGEAALEQTLAEMCELDTAVLNDI------------------------------E ENSRNOP00000050057/1-1134 MDELPFGEAALEQALAEVCEMDAALLTDI------------------------------E ENSP00000348069/1-1177 MDEPPFSEAALEQALGEPCDLDAALLTDIEGEVGAGRGRANGLDAPRAGADRGAMDCTFE ENSCPOP00000002221/1-1126 MDEQPFSEAALEQALAEPCELDAALLTDI------------------------------E XP_004868769.1/1-1129 MD----------------CTF--------------------------------------E ** * : * ENSMUSP00000020846/1-1134 DMLQLINNQDSDFPGLFDAPYAGGETGDTGPSSPGANSPE-SFS--SASLASSLEAFLGG ENSRNOP00000050057/1-1134 DMLQLINNQDSDFPGLFDAPYAGGETGDTGPSSPGASSPE-SFS-SPASLGSSLEAFLGG ENSP00000348069/1-1177 DMLQLINNQDSDFPGLFDPPYAGSGAGGTDPASPDTSSPG-SLSPPPATLSSSLEAFLSG ENSCPOP00000002221/1-1126 DMLQLINNQDSDFPGLFDPPYAGGGAGDADPASPGACSPGSSLSPPPASLNSPLEAFLGG XP_004868769.1/1-1129 DMLQLINNQNSDFPGLFDPPYAGAGAGDTDPASPGACSPS-SLS-PPLSLSSPLEALLGG *********:********.****. :*.:.*:**.: ** *:* . :* *.***:*.* ENSMUSP00000020846/1-1134 PKVTPAPLSPPPSAPAALKMYPSVSPFSPGPGIKEEPVPLTILQPAA----------PQP ENSRNOP00000050057/1-1134 PKVTPAPLSPPPSAPTAVKMYPSVPPFSPGPGIKEEPVPLTILQPPA----------PQP ENSP00000348069/1-1177 PQAAPSPLSPPQPAPTPLKMYPSMPAFSPGPGIKEESVPLSILQTPT----------PQP ENSCPOP00000002221/1-1126 SKATPPPSSPPQSVLTPLKMFSPVPPFSPGHGIKEEPVPLTILQPPT------------- XP_004868769.1/1-1129 SKATPPPSSPPQSVLTPLKMFSSVSPFSPGHGIKEELVPLTILQPPTLPSPARQPPIPQP .:.:*.* *** .. :.:**:..:..**** ***** ***:***..: ENSMUSP00000020846/1-1134 SPGTLLPPSFPAP-PVQLSPAPVLGYSSLPSGF-SGTLPGNTQQPPSSLPLAPAPGVLPT ENSRNOP00000050057/1-1134 SPGTLLPPSFPPP-PVQLSPAPVLGYSSLPSGF-SGTLPGNTQQTPSSLPLGSTPGISPT ENSP00000348069/1-1177 LPGALLPQSFPAPAPPQFSSTPVLGYPSPPGGFSTGSPPGNTQQPLPGLPLASPPGVPPV ENSCPOP00000002221/1-1126 ------LPSFPTPAPPQFSSTPVIGYSSSPGGFVAGTPLGSTQQPLPSLPLASPPGVTPA XP_004868769.1/1-1129 LP-PLLPQSFPAPAPPQFNSTPVLGYSSSPGGFVAETPSGSAQPPLLGLPLASPTGVIPT ***.* * *:..:**:**.* *.** : : *.:* . .***....*: *. ENSMUSP00000020846/1-1134 PALHTQVQSLASQQPLPASAAPR----TNTVTSQVQQVPVVLQPHFIKADSLLLTAVKTD ENSRNOP00000050057/1-1134 P-LHTQVQSSAAQQPPPASAAPR----MSTVASQIQQVPVVLQPHFIKADSLLLTAVKTD ENSP00000348069/1-1177 S-LHTQVQSVVPQQLLTVTAAPTAAPVTTTVTSQIQQVPVLLQPHFIKADSLLLTAMKTD ENSCPOP00000002221/1-1126 S-LHTPVQSVAPQQLLTATAAPG----TTTVTSQIQQVPVLLQPHFIKADSLLLTTMKTD XP_004868769.1/1-1129 S-FHAPVQSMAPQQLLTATAAPG----TTTVTSQIQQVPVLLQPHFIKADSLLLTTMKTD . :*: *** ..** ..:*** .**:**:*****:**************::*** ENSMUSP00000020846/1-1134 AGATVKTAGISTLAPGTAVQAGPLQTLVSGGTILATVPLVVDTDKLPIHRLAAGSKALGS ENSRNOP00000050057/1-1134 TGATMKTAGINTLAPGTAVQAGPLQTLVSGGTILATVPLVVDTDKLPIHRLAAGGKALGS ENSP00000348069/1-1177 -GATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATVPLVVDAEKLPINRLAAGSKAPAS ENSCPOP00000002221/1-1126 MGATVKAAGISSLTPGTAVQTGPLQTLVSGGTILATVPLVVDADKLPINRLTAGSKTPGS XP_004868769.1/1-1129 VGATVKATGISSLAPGTAVQTGPLQTLVSGGTILATVPLVVDADKLPINRLAAGSKAPGS ***:*::*:..*..**:**:*** *****************::****:**:**.*: .* ENSMUSP00000020846/1-1134 AQSRGEKRTAHNAIEKRYRSSINDKIVELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSN ENSRNOP00000050057/1-1134 AQSRGEKRTAHNAIEKRYRSSINDKIVELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSN ENSP00000348069/1-1177 AQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSN ENSCPOP00000002221/1-1126 AQSRGEKRTAHNAIEKRYRSSINDKIVELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSN XP_004868769.1/1-1129 AQSRGEKRTAHNAIEKRYRSSINDKIVELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSN **************************:********************************* ENSMUSP00000020846/1-1134 QKLKQENLTLRSA-HKSKSLKDLVSACGSGGGTDVSMEGMKPEVVETLTPPPSDAGSPSQ ENSRNOP00000050057/1-1134 QKLKQENLTLRSA-HKSKSLKDLVSACGSGGGTDVSMEGMKPEVVETLTPPPSDAGSPSQ ENSP00000348069/1-1177 QKLKQENLSLRTAVHKSKSLKDLVSACGSGGNTDVLMEGVKTEVEDTLTPPPSDAGSPFQ ENSCPOP00000002221/1-1126 QKLKQENLSLRSAVHKSKSRKDLVSDCGGGGNVDVAMEGVKSEVVDTLTPPPSDAGSPSQ XP_004868769.1/1-1129 QKLKQENLSLRSAVHKSKSLKDLVSDCGSGENADVAMEGVKSEVVDTLTPPPSDAGSPSQ ********:**:* ***** ***** **.* ..** ***:*.** :************ * ENSMUSP00000020846/1-1134 SSPLSFGSRASSSGG--SDSEPDSPAFEDSQVKAQRLPS-HSRGMLDRSRLALCVLAFLC ENSRNOP00000050057/1-1134 SSPLSLGSRGSSSGG--SDSEPDSPAFEDNQVKAQRLPS-HSRGMLDRSRLALCVLVFLC ENSP00000348069/1-1177 SSPLSLGSRGSGSGGSGSDSEPDSPVFEDSKAKPEQRPSLHSRGMLDRSRLALCTLVFLC ENSCPOP00000002221/1-1126 SSPLS------------RDSEPDSPVIEDSQMKPEQLPSPHSRGMVDRSRLALCALAFLC XP_004868769.1/1-1129 SSPLSLSSRSSGSGGSGSDSEPDSPVIEDSQVKPEQLPSPHSRGMLDRSRLALCALVFLC ***** *******.:**.: *.:: ** *****:********.*.*** ENSMUSP00000020846/1-1134 LTCNPLASLFG-WGILTPSDATGTHRSSGRSMLEAESRDGSNWTQWLLPPLVWLANGLLV ENSRNOP00000050057/1-1134 LTCNPLASLFG-WGILTPSDASGVHRSSGRSMLEAESRDGSNWTQWLLPPLVWLANGLLV ENSP00000348069/1-1177 LSCNPLASLLGARGLPSPSDTTSVYHSPGRNVLGTESRDGPGWAQWLLPPVVWLLNGLLV ENSCPOP00000002221/1-1126 LTYNPWASLLSSWGLPSPLDASGITHSPGRTMLGAEGRDGPGWAQWLLPPLVWLGNGLLV XP_004868769.1/1-1129 VFYNPLASLLSGRGLPSPLDATSVHHSPGRAMLGAEGRDGPGWAQWLLPPLVWLGNGLLV : ** ***:. *: :* *::. :*.** :* :*.***..*:******:*** ***** ENSMUSP00000020846/1-1134 LACLALLFVYGEPVTRPHSGPAVHFWRHRKQADLDLARGDFPQAAQQLWLALQALGRPLP ENSRNOP00000050057/1-1134 LACLALLFVYGEPVTRPHSGPAVHFWRHRKQADLDLARGDFAQAAQQLWLALQALGRPLP ENSP00000348069/1-1177 LVSLVLLFVYGEPVTRPHSGPAVYFWRHRKQADLDLARGDFAQAAQQLWLALRALGRPLP ENSCPOP00000002221/1-1126 MASLALLFVYGEPVTRPHSGPAVHFWRHRKQADLDLAQGDFAQASQQLWLALRALGRPLP XP_004868769.1/1-1129 LLSLAFLFVYGEPVTRPHSGPAVHFWRHRKQADLDLARGDFAQAAQQLWLALRALGRPLP : .*.:*****************:*************:***.**:*******:******* ENSMUSP00000020846/1-1134 TSNLDLACSLLWNLIRHLLQRLWVGRWLAGQAGGLLRDRGLRKDARASARDAAVVYHKLH ENSRNOP00000050057/1-1134 TSNLDLACSLLWNLVRHLLQRLWVGRWLAGQAGGLQRDYRLRKDARASARDAAVVYHKLH ENSP00000348069/1-1177 TSHLDLACSLLWNLIRHLLQRLWVGRWLAGRAGGLQQDCALRVDASASARDAALVYHKLH ENSCPOP00000002221/1-1126 TSHLDLACSLLWNLIRHLLQRLWVGRWLASCAGGLQRDGALKADVRASARDAALVYHKLH XP_004868769.1/1-1129 TSHLDLACSLLWNLIRHLLQRFWVGRWLAGRAGGLQRDCALRADVRASARDAALVYHKLH **:***********:******:*******. **** :* *: *. *******:****** ENSMUSP00000020846/1-1134 QLHAMGKYTGGHLAASNLALSALNLAECAGDAISMATLAEIYVAAALRVKTSLPRALHFL ENSRNOP00000050057/1-1134 QLHAMGKYTGGHLVASNLALSALNLAECAGDAISMATLAEIYVAAALRVKTSLPRALHFL ENSP00000348069/1-1177 QLHTMGKHTGGHLTATNLALSALNLAECAGDAVSVATLAEIYVAAALRVKTSLPRALHFL ENSCPOP00000002221/1-1126 QLHAMGKYTGGHLTATNLALSALNLAECAGDTVSMATMVEIYVAAALRVKTSLPRALHFL XP_004868769.1/1-1129 QLHAMGKYTGGHLTAANLALSALNLAECAGDTVSMATMAEIYVAAALRVKTSLPRALHFL ***:***:*****.*:***************::*:**:.********************* ENSMUSP00000020846/1-1134 TRFFLSSARQACLAQSGSVPLAMQWLCHPVGHRFFVDGDWAVHGAPPESLYSVAGNPVDP ENSRNOP00000050057/1-1134 TRFFLSSARQACLAQSGAVPLAMQWLCHPVGHRFFVDGDWAVHGAPQESLYSVAGNPVDP ENSP00000348069/1-1177 TRFFLSSARQACLAQSGSVPPAMQWLCHPVGHRFFVDGDWSVLSTPWESLYSLAGNPVDP ENSCPOP00000002221/1-1126 TRFFLSSARQACLAQSGSVPLAMQWLCHPVGHRFFVDGDWAVRSAPRESLYSLTGNPVDP XP_004868769.1/1-1129 TRFFLSGARQACLAQSSSVPLTMQWLCHPVGHRFFVDGDWAVCSAPRESLYSLAGNPVDP ******.*********.:** :******************:* .:* *****::****** ENSMUSP00000020846/1-1134 LAQVTRLFREHLLERALNCIAQP----SPGAADGDREFSDALGYLQLLNSCSDAAGAPAC ENSRNOP00000050057/1-1134 LAQVTRLFCEHLLERALNCIAQP----SPGAADGDREFSDALGYLQLLNSCSDAVGAPAC ENSP00000348069/1-1177 LAQVTQLFREHLLERALNCVTQP--NPSPGSADGDKEFSDALGYLQLLNSCSDAAGAPAY ENSCPOP00000002221/1-1126 LAQVTQLFREHLLERALNCVAQPSLSPSAGSADGDREFSDALSYLQLLNSCSDAAGTPAC XP_004868769.1/1-1129 LAQVTQLFREHLLERALNCVAQPSLSPSPGSADGDREFSDALSYLQLLNSCSDAAGTPAC *****:** **********::** *.*:****:******.***********.*:** ENSMUSP00000020846/1-1134 SFSVSSSMAATTGPDPVAKWWASLTAVVIHWLRRDEEAAERLYPLVEHIPQVLQDTERPL ENSRNOP00000050057/1-1134 SFSVSSSMATTTGTDPVAKWWASLTAVVIHWLRRDEEAAERLYPLVEHIPQVLQETERPL ENSP00000348069/1-1177 SFSISSSMATTTGVDPVAKWWASLTAVVIHWLRRDEEAAERLCPLVEHLPRVLQESERPL ENSCPOP00000002221/1-1126 SFSISSSMAATTGTDPVAKWWASLTAVVIHWLRRDEEAAERLYPLVEHLPRALQETEKPL XP_004868769.1/1-1129 SFSISSSMAATTGTDPVAKWWASLTAVVIHWLRRDEEAAERLYPLVEQLPRALQETERPL ***:*****:*** **************************** ****::*:.**::*:** ENSMUSP00000020846/1-1134 PRAALYSFKAARALLDHRKVESSPASLAICEKASGYLRDSLASTPTGSSIDKAMQLLLCD ENSRNOP00000050057/1-1134 PRAALYSFKAARALLDHRKVESSPASLAICEKASGYLRDSLASTSTASSIDKAMQLLLCD ENSP00000348069/1-1177 PRAALHSFKAARALLGCAKAESGPASLTICEKASGYLQDSLATTPASSSIDKAVQLFLCD ENSCPOP00000002221/1-1126 PRAALHSFKAVRALLGHGKAESGLASLAICEKASGYLQESLATTPTSSSIDKAVQLLLCD XP_004868769.1/1-1129 PRAALHSFKAVRALLGCGKSESGLASLAICEKASGYLQDSLATTSTGSSIDKAVQLLLCD *****:****.****. * **. ***:*********::***:*.:.******:**:*** ENSMUSP00000020846/1-1134 LLLVARTSLWQRQQSPASVQVAHGTSNGPQASALELRGFQHDLSSLRRLAQSFRPAMRRV ENSRNOP00000050057/1-1134 LLLVARTSLWRRQQSAASAQGAHGTSNGPQASALELRGFQHDLSSLRRLAQSFRPAMRRV ENSP00000348069/1-1177 LLLVVRTSLWRQQQPPAPAPAAQGTSSRPQASALELRGFQRDLSSLRRLAQSFRPAMRRV ENSCPOP00000002221/1-1126 LLLVARTNLWRQQQPPTSAQVAQSVNSGPQASALELRGFQRDLSGLRRLAQSFRPAMRRV XP_004868769.1/1-1129 LLLVARTSLWQQQQPPTSAQVAQGASSGPQASALELRGFQRDLSGLRRLAQSFRPAMRRV ****.**.**::**..:.. *:.... ************:***.*************** ENSMUSP00000020846/1-1134 FLHEATARLMAGASPARTHQLLDRSLRRRAGSSGKGGTTAELEPRPTWREHTEALLLASC ENSRNOP00000050057/1-1134 FLHEATARLMAGASPARTHQLLDRSLRRRAGSSGKGGAAAELEPRPTWREHTEALLLASC ENSP00000348069/1-1177 FLHEATARLMAGASPTRTHQLLDRSLRRRAGPGGKGGAVAELEPRPTRREHAEALLLASC ENSCPOP00000002221/1-1126 FLHEATARLMAGASPTRTHQLLDRSLRRRTGPGGKGGGAAELEPRPTRREHAEALLLASC XP_004868769.1/1-1129 FLHEATARLMAGASPTRTHQLLDRSLRRRAGPGSK-GGAAELEPRPTRREHAEALLLASC ***************:*************:*...* * .******** ***:******** ENSMUSP00000020846/1-1134 YLPPAFLSAPGQRMSMLAEAARTVEKLGDHRLLLDCQQMLLRLGGGTTVTSS ENSRNOP00000050057/1-1134 YLPPAFLSAPGQRVSMLAEAARTVEKLGDHRLLLDCQQMLLRLGGGTTVTSS ENSP00000348069/1-1177 YLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLGGGTTVTSS ENSCPOP00000002221/1-1126 YLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLGGGTTVTSS XP_004868769.1/1-1129 YLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLGGGTTVTSS ****.********:.********:*****:*** ******:***********