CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000035203/1-1378 -----------------------MGLPLPLLQSSLLLMLLLRLSA-ASTNLNWQCPRIPY ENSRNOP00000063136/1-1372 -----------------------MGLLLPLLQASLLLMLLLRLPE-ASTNLDWQCPRIPF ENSP00000296474/1-1400 -----------------------MELLPPLPQSFLLLLL---LPAKPAAGEDWQCPRTPY ENSCPOP00000002118/1-1381 ---------------------KGCDWPRWSSFRSLLLLLLLRLSAMTSIDQDWRCPRTPY XP_004834122.1/1-1376 MGFQNRRFTLFPAKPAPAGSLRASGWSRWSSPWSLLLLLLLRLSAVSSTEKDWQCPRTPY ***:* *. .: :*:*** *: ENSMUSP00000035203/1-1378 AASRDFSVKYVVPSFSAGGRVQATAAYEDSTN-SAVFVATRNHLHVLGPDLQFIENLTTG ENSRNOP00000063136/1-1372 AASRDFSVKYVVPSFSAGGRVQATAVYEDSKN-SAVFVAIRNRLHVLGPDLQYIESLTTG ENSP00000296474/1-1400 AASRDFDVKYVVPSFSAGGLVQAMVTYEGDRNESAVFVAIRNRLHVLGPDLKSVQSLATG ENSCPOP00000002118/1-1381 AATRDFNVRYVVPFFSAGSPVQAVVTYEDGQDGSAVFVATRNRLHVLGPELQIVQSLATG XP_004834122.1/1-1376 ATAHDFDVRYVVPRFSAAGPVQAVLTYEGGPDGNAVFVATRNRLHVLGPDLQFVESVATG *:::**.*:**** ***.. *** .**.. : .***** **:******:*: ::.::** ENSMUSP00000035203/1-1378 PIGNPGCQTCASCGPGPHGPPKDTDTLVLVMEPGLPALVSCGSTLQGRCFLHELEPRGKA ENSRNOP00000063136/1-1372 PIGDPGCQTCASCGPGPHGPPNDTDTLVLVMEPGLPALVSCGSTLQGRCFLHELEPQGEA ENSP00000296474/1-1400 PAGDPGCQTCAACGPGPHGPPGDTDTKVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTA ENSCPOP00000002118/1-1381 PAGDPSCQTCAACGPGPHGPPGDTDTLVLVLEPGLPALVSCGSSLQGRCFLHELEPHGTA XP_004834122.1/1-1376 PAGDPSCQTCVTCGPGPHGPPGDTDTLVLVLEPGLPALVSCGSSLQGRCFLHELEPQETA * *:*.****.:********* **** ***::*.*********:********:***: * ENSMUSP00000035203/1-1378 LHLAAPACLFSANNNKPEACTDCVASPLGTRVTVVEQGHASYFYVASSLDPELAASFSPR ENSRNOP00000063136/1-1372 LHLAAPACLFSASNNKPEACTDCVASHLGTRVTVVEQGHASYFYVASSLDPELAASFSPR ENSP00000296474/1-1400 VHLAAPACLFSAHHNRPDDCPDCVASPLGTRVTVVEQGQASYFYVASSLDAAVAASFSPR ENSCPOP00000002118/1-1381 LHLAAPACLFSADRNLPEDCPDCVASSLGTRVTVVEQGQASYLYVASSLNATVAASFSPR XP_004834122.1/1-1376 LHLVAPACLFSALGNLPEDCPDCVASPLGTRVTVVEQGQASYFYVASSLNTTVAASFSPR :**.******** * *: *.***** ***********:***:******:. :******* ENSMUSP00000035203/1-1378 SVSIRRLKSDTSGFQPGFPSLSVLPKYLASYLIKYVYSFHSGDFVYFLTVQPISVTSPPS ENSRNOP00000063136/1-1372 SVSIRRLKSDTSGFQPGFPSLSVLPKYLASYLIKYVHSFHSGDFVYFLTVQPMDVRSPPS ENSP00000296474/1-1400 SVSIRRLKADASGFAPGFVALSVLPKHLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPS ENSCPOP00000002118/1-1381 SVSIRRLRADASGFEPGFAALSVLPKYLDSYHIEYVHSFHSGAFVYFLTVQPASVTDTPG XP_004834122.1/1-1376 SVSIRRLKADASGFETGFSALSVLPKYLDSYHIKYVHSFHSGAFVYFLTVQPASVTDTPG *******::*:*** .** :******:* ** *:**:***:* ********* .* . *. ENSMUSP00000035203/1-1378 ALHTRLVRLNAVEPEIGDYRELVLDCHFAPKRRRR-GAPEGTQPYPVLQAAHSAPVDAKL ENSRNOP00000063136/1-1372 ALQTRLVRLNAIEPEIGDYRELVLDCHFAPKRRRRSGAPKSLQAYQVLQAAHSAPVDAKL ENSP00000296474/1-1400 ALHTRLARLSATEPELGDYRELVLDCRFAPKRRRR-GAPEGGQPYPVLRVAHSAPVGAQL ENSCPOP00000002118/1-1381 ALQTRLVRLNALEPELDDYRELILDCDFAPKRRRR--APEGRHSYPVLQAAHSAHVGAQF XP_004834122.1/1-1376 ALQTRLARLNALEPELSDYRELILDCYFAPKRRRR--TPEGRQSYPVLQAAHSAYVGAQL **:***.**.* ***:.*****:*** ******** :*:. :.* **:.**** *.*:: ENSMUSP00000035203/1-1378 AVELSISEGQEVLFGVFVTVKDGGSGMGPNSVVCAFPIYHLNILIEEGVEYCCHSSNSSS ENSRNOP00000063136/1-1372 ALDLSISEGQEVLFGVFVAVKDSSSG--PNSVVCAFPINHLDNLIEEGVERCCHPSNSSL ENSP00000296474/1-1400 ATELSIAEGQEVLFGVFVTGKDGGPGVGPNSVVCAFPIDLLDTLIDEGVERCCESPVHPG ENSCPOP00000002118/1-1381 ASELNIAEGHEVLFGAFVTGRAGDSGMGPNSVVCAFPIDQLNTLIGEGVERCCGSSVISG XP_004834122.1/1-1376 ATELSIPEGREVLFGVFVTGRGGGPGMGPNSVVCAFPIDLLNTLIDEGVERCCESPVIPG * :*.*.**:*****.**: : ...* ********** *: ** **** ** .. . ENSMUSP00000035203/1-1378 LL-SRGLDFFQTPSFCPNPPGGEASGPSSRCHYFPLMVHASFTRVDLFNGLLGSVKVTAL ENSRNOP00000063136/1-1372 LTRRRGLDFFQTPSFCPNPPG----APSSRCHYFPLMVHDSFTRVDLFNGLLGSVKVTAL ENSP00000296474/1-1400 L--RRGLDFFQSPSFCPNPPGLEALSPNTSCRHFPLLVSSSFSRVDLFNGLLGPVQVTAL ENSCPOP00000002118/1-1381 P--RRGLEFFQTLSFCPNLPFPEAPSPNISCHYFPLLVSGSFSRVDLFNGLLGPAQITAL XP_004834122.1/1-1376 L--RRGLDFFQTPSFCPNPPVPEAPSPNISCHYFPLRVSSSFQRVDLFNGLLGPMQITAL ***:***: ***** * .*. *::*** * ** **********. ::*** ENSMUSP00000035203/1-1378 HVTRLGNVTVAHMGTVDGRVLQVEIARSLNYLLYVSNFSLGSSGQPVHRDVSRLGNDLLF ENSRNOP00000063136/1-1372 HVTRLGNVTVAHMGTEDGRILQVEIARSLNYLLYVSNFSLGSSGQPVHQDVSRLGNDLLF ENSP00000296474/1-1400 YVTRLDNVTVAHMGTMDGRILQVELVRSLNYLLYVSNFSLGDSGQPVQRDVSRLGDHLLF ENSCPOP00000002118/1-1381 YVTRFDNVTVAHMGTADGRILQVELARSLNYLLYVSNFSLGSSGQPIRRDVSRLRDDLLF XP_004834122.1/1-1376 YVTRLGNVTVAHMGTTDGRILQVELARSLNYLLYVSNFSLGSSRQPIQRDVSRLGGHLFF :***:.********* ***:****:.***************.* **:::***** ..*:* ENSMUSP00000035203/1-1378 ASGDQVFKVPIQGPGCRHFLTCWRCLRAQRFMGCGWCGDRCDRQKECPGSWQQDHCPPEI ENSRNOP00000063136/1-1372 ASGDQVFKVPIQGPGCGHFLTCWRCLRAQRFMGCGWCGDRCGRQKECPGSWQQDYCPPEI ENSP00000296474/1-1400 ASGDQVFQVPIQGPGCRHFLTCGRCLRAWHFMGCGWCGNMCGQQKECPGSWQQDHCPPKL ENSCPOP00000002118/1-1381 TSGDQVRKVPIRGPGCRHFLTCRGCLRTQRFMGCGWCGDVCGRQEECPGSWQRDHCPPIL XP_004834122.1/1-1376 ASGDQVFQVPIRGPGCRHFLTCRGCLQTQRFMGCGWCGDICGRQEECPGSWQQDHCPPKL :***** :***:**** ***** **:: :********: *.:*:*******:*:*** : ENSMUSP00000035203/1-1378 SEFYPHSGPLRGTTRLTLCGSNFYLRPDDVVPEGTHQITVGQSPCRLLPKDSSSPRPGSL ENSRNOP00000063136/1-1372 TEFHPHSGPLRGTTRLTLCGSNFYLRPDGVVPEGTHQITVGQSPCRLLPKDSSTRRSGSQ ENSP00000296474/1-1400 TEFHPHSGPLRGSTRLTLCGSNFYLHPSGLVPEGTHQVTVGQSPCRPLPKDSSKLRPVPR ENSCPOP00000002118/1-1381 TEFYPHSGPRRGSTRLTLCGSNFYLRPDSPVPEGTHQVTVGQSPCQLLPQDTSSLRPVLQ XP_004834122.1/1-1376 TQFYPHSGPLRGSTRLTLCGSNFYRHPDSLVPEGTYQITVGQSPCQLLPQDASNLSPAPQ ::*:***** **:*********** :*.. *****:*:*******: **:*:*. . ENSMUSP00000035203/1-1378 KEFIQELECELEPLVTQAVGTTNISLVITNMPAGKHFRVEGISVQEGFSFVEPVLTSIKP ENSRNOP00000063136/1-1372 KEFIEELECELEPLETQAVGTTNISLLITNMPAGKHFRVEGVSVREDFSFMEPMLTSIKP ENSP00000296474/1-1400 KDFVEEFECELEPLGTQAVGPTNVSLTVTNMPPGKHFRVDGTSVLRGFSFMEPVLIAVQP ENSCPOP00000002118/1-1381 KDFVEELECELEPSHTQAAGTTNVSLSVTNTLPSRHFRIDGTSMLGGFSFMEPVLTAVQP XP_004834122.1/1-1376 KDFVEELECELEPLHGQTAGTTNVSLTVTNMLPGRHFRVDGTSMLGGFSFMEPVLTAVRP *:*::*:****** *:.*.**:** :** ..:***::* *: .***:**:* :::* ENSMUSP00000035203/1-1378 DFGPRAGGTYLTLEGQSLSVGTSRAVLVNGTQCRLEQVNEEQILCVTPPGAGTARVPLHL ENSRNOP00000063136/1-1372 DFGPRAGGTYLTLEGQSLSVGTSRAVLVNGTQCRLEQVSEEKILCVTPPGAGTASVPLRL ENSP00000296474/1-1400 LFGPRAGGTCLTLEGQSLSVGTSRAVLVNGTECLLARVSEGQLLCATPPGATVASVPLSL ENSCPOP00000002118/1-1381 LFGPRAGGTRVTLEGQGLSIGTSRAVLINGTQCQLEQVSEVQIVCATPPAAATASVPLGL XP_004834122.1/1-1376 LFGPRAGGTRVTLEGQGLSVGTSRAVLINGTQCQLKQVSEGQIVCATPPGASTASVPLGL ******** :*****.**:*******:***:* * :*.* :::*.***.* .* *** * ENSMUSP00000035203/1-1378 QIGGAEVPGSWTFHYKEDPIVLDISPKCGYSGSHIMIHGQHLTSAWHFTLSFHDGQSTVE ENSRNOP00000063136/1-1372 -IGGAEVRGSRTFHYKEDPIVLDISPKCGYSGSHVMVHGQHLTSAWHLTVSFNDGQSIVE ENSP00000296474/1-1400 QVGGAQVPGSWTFQYREDPVVLSISPNCGYINSHITICGQHLTSAWHLVLSFHDGLRAVE ENSCPOP00000002118/1-1381 QIGGAEVPGSWTFHYREDPIVLGISPNCGYAGSHVTIHGQHLTSTWHLKLSFHDGQRAIE XP_004834122.1/1-1376 QVGGAEVPGSWTFHYQEDPIVLGITPNCGYIGSHVTIHGQHLTSAWHLLLSFHDGQREVE :***:* ** **:*:***:**.*:*:*** .**: : ******:**: :**:** :* ENSMUSP00000035203/1-1378 SRCAGQFVEQQQRRCRLPEYVVRNPQGWATGNLSVWGDGAAGFTLPGFRFLPPPSPLRAG ENSRNOP00000063136/1-1372 SRCAGQFLEQQH-QCRLPEYMVRNPQGWATGNLSLWGDGAAGFTLPGFRFLPPPSLPRTG ENSP00000296474/1-1400 SRCERQLPEQQ--LCRLPEYVVRDPQGWVAGNLSARGDGAAGFTLPGFRFLPPPHPPSAN ENSCPOP00000002118/1-1381 NRCEGPFPEQH--RCRLPEYMVRDPRGWVIGNLSVQGDGAAHFTLPSFRFLPPPRPPSAD XP_004834122.1/1-1376 NRCDGPLPEQH--RCRLPEYVIRDPRGWVIGNLSVQGDGAAGFTLPSFRFLPPPRPPSAD .** : **: ******::*:*:**. **** ***** ****.******* :. ENSMUSP00000035203/1-1378 LVELKPEEHSVKVEYVGLGAVADCVTVNMTVGGEVCQHELRGDVVICPLPPSLQLGKDGV ENSRNOP00000063136/1-1372 PVLLKPEEHSVKVEYIGLGAVADCVTVNVTVGGEVCQHELRGDVVICPLPPSLQLGKDGV ENSP00000296474/1-1400 LVPLKPEEHAIKFEYIGLGAVADCVGINVTVGGESCQHEFRGDMVVCPLPPSLQLGQDGA ENSCPOP00000002118/1-1381 LVPLKPEEHAVKFQYIGLDAVTDCVGVNVTVGGKRCQYEFRGDVVVCPLPPSVQLSKDGT XP_004834122.1/1-1376 LAPLKPEEHAVKF----------------------------------------------- . ******::*. ENSMUSP00000035203/1-1378 PLQVCVDGGCHILSQVVRSSPGRASQRILLIALLVLILLVAVLAVALIFNSRRRKKQL-- ENSRNOP00000063136/1-1372 PLQVCVDGGCHILGQVVRSGPGRASQRTLLIALLALILLVAGLAIALVCNSRRRKKQL-- ENSP00000296474/1-1400 PLQVCVDGECHILGRVVRPGPDGVPQSTLLGILLPLLLLVAALATALVFSYWWRRKQLVL ENSCPOP00000002118/1-1381 PLKVCVDGDCHTVGRVVRAAPGGIPQNILLIVLLGLFLLVVLLAAALVFN-WWRRKQQ-- XP_004834122.1/1-1376 --QVCVDGDCHILGRVVRPGPGGIPQNILLVVLLGLLLLVVLLAAALVFNYQWRRKQLVL :***** ** :.:***..*. .* ** ** *:***. ** **: . *:** ENSMUSP00000035203/1-1378 ------------------------GAHSLSPTTLSDINDTASGAPNHEES-SESRDGTSV ENSRNOP00000063136/1-1372 ------------------------GAYSLSPTTLSDFDNTASRPPNHEES-SEGQDGTSV ENSP00000296474/1-1400 PPNLNDLASLDQTAGATPLPILYSGSDYRSGLALPAIDGLDSTTCVHGASFSDSEDESCV ENSCPOP00000002118/1-1381 ------------------GPHHSTNSHAFSSTVLPALDGLHSPTGLHGGSYSE--EASHV XP_004834122.1/1-1376 SPSLDELASLDQTAGAMLLPVLYSGSDYRNDVALSALDVPHSPTGVHGESFSGSKEGSCV .: . .*. :: * . * * * : : * ENSMUSP00000035203/1-1378 PLLRTESIRLQDLDRMLLAEVKDVLIPHEQVVIHTDQVIGKGHFGVVYHGEYTDGAQNQT ENSRNOP00000063136/1-1372 PLLRTDSIRLQDLDKMLLAEVKDVLIPHEQVVIHTDQVIGKGHFGVVYHGEYTDEAQNQI ENSP00000296474/1-1400 PLLRKESIQLRDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRI ENSCPOP00000002118/1-1381 PLLRTESIRLRDLNSALLAEVKDVLIPHEQVIIHSDQVIGKGHFGVVYHGEYTDEAQNQI XP_004834122.1/1-1376 PLLRTESIRLRDLNSALVAEVKDILIPHERVITHSDQVIGKGHFGVVYHGEYTDKDQNQI ****.:**:*:**: *:*****:*****:*: *:*:*************** * **: ENSMUSP00000035203/1-1378 HCAIKSLSRITEVQEVEAFLREGLLMRGLHHPNILALIGIMLPPEGLPRVLLPYMRHGDL ENSRNOP00000063136/1-1372 HCAIKSLSRITEVQEVEAFLREGLIMRGLHHPNILALIGIMLPPEGLPRVLLPYMRHGDL ENSP00000296474/1-1400 QCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDL ENSCPOP00000002118/1-1381 HCAIKSLSRITEAQEVEAFLREGLLMRGLHHPNVLALIGILLPPEGLPRVLLPYMRHGDL XP_004834122.1/1-1376 HCAIKSLSRITEVQEVEAFLREGLLMRGLHHPNVLALIGIMLPPEGLPRVLLPYMRHGDL :*********** *:*********:****:***:******:*******:****** **** ENSMUSP00000035203/1-1378 LHFIRSPQRNPTVKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGL ENSRNOP00000063136/1-1372 LRFIRSPQRNPTVKDLISFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGL ENSP00000296474/1-1400 LQFIRSPQRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGL ENSCPOP00000002118/1-1381 LHFIRSPQRNPTVKDLISFGLQVARGMEYLAGQKFVHRDLAARNCMLDESFVVKVADFGL XP_004834122.1/1-1376 LHFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFIVKVADFGL *:**************:******* .***** ******************* ******** ENSMUSP00000035203/1-1378 ARGVLDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYP ENSRNOP00000063136/1-1372 ARGILDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYP ENSP00000296474/1-1400 ARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYR ENSCPOP00000002118/1-1381 ARDVLDKEYYSVRQHRHACLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYP XP_004834122.1/1-1376 ARDILDKDYYSVRQQRHACLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYP **.:**::****:*:*** **************************************** ENSMUSP00000035203/1-1378 HIDPFDLSHFLAQGRRLPQPEYCPDSLYHVMLRCWEADPAARPTFRALVLEVKQVVASLL ENSRNOP00000063136/1-1372 HIDPFDLSHFLVQGRRLPQPEYCPDSLYQVMLRCWEADPAARPTFRALVLEVEQVASSLL ENSP00000296474/1-1400 HIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALL ENSCPOP00000002118/1-1381 HIDPFDLIYFLAQGRRLPQPEYCPNSLYQVMERCWEADPAARPTFRALVVEVEQVVASLL XP_004834122.1/1-1376 HIDPFDLIYFLAQGRRLPQPEYCPNSLYQVMERCWEADPAARPTFRALVIEMEQVVASLL ******* :**.************:***:** :*******.*****.** *::*:.::** ENSMUSP00000035203/1-1378 GDHYVQLTAAYVNVGPRAVDDGSVPPEQVQPSPQHCRSTSKPRPLSEPPLPT ENSRNOP00000063136/1-1372 GDHYVQLTAAYVNVGPGAVDDGSVFPEQGQSSPLHHRSTSRPRPLSEPPLPT ENSP00000296474/1-1400 GDHYVQLPATYMNLGPSTSHEMNVRPEQPQFSPMP-GNVRRPRPLSEPPRPT ENSCPOP00000002118/1-1381 GDHYVQLSAAYVNLGPGTMDKGNVLLEHPQSSPLH-RSMSWSRPLSEPPLPT XP_004834122.1/1-1376 GEHYVQLSTAYVNLGPGTLNEVNVLSEHPRSSPVH-RSMSRPRPLSEPPLPT *:*****.::*:*:** : .. .* *: : ** . .******* **