CLUSTAL W(1.81) multiple sequence alignment ENSP00000273814/1-942 MAAAAEPGARAWLGGGSPRPGSPACSPVLGSGGRARPGPGPGPGPERAGVRAPGPAAAPG ENSMUSP00000057859/1-934 MAAAAEPGARTWPGSGSPRLGSPAGSPVLGISGRTRPGSGPERTSRAIG------SAAPG ENSRNOP00000036466/1-937 MATAAESGARTWPGSGSPRLGSPAGSPVLGISGRARPGSGPERTGRAIG------SVAPG ENSCPOP00000002100/1-917 MAAAAEPGTRAWLGDGSS-----------GAGGRARAGD------TASG------PAVPS XP_004847522.1/1-896 ------------------------------------------------------------ ENSP00000273814/1-942 HSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKHVRIPCTSVAPSLVRVPV ENSMUSP00000057859/1-934 HSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKQVKTPCTSIAPSLVRVPV ENSRNOP00000036466/1-937 HSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKQVKTPCTSIAPSLVRVPV ENSCPOP00000002100/1-917 HSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLRHVKTPCAGVAPSLVRVPV XP_004847522.1/1-896 ----------------------------------MSHEKCLRHVKTACACVAPSLVRVPV *******::*: .*: :********* ENSP00000273814/1-942 AHCFGPRGLHKRKFCAVCRKVLEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQDHD ENSMUSP00000057859/1-934 AHCFGSLGLYKRKFCVVCRKSLEVPAFRCEVCELHVHPDCVPFACSDCRQCHQDGQQDYD ENSRNOP00000036466/1-937 AHCFGSLGLYKRKFCVVCRKSLEVPAFRCEVCELHVHPDCVPFACSDCRQCHQDGQHDYD ENSCPOP00000002100/1-917 AHCFGPPGLYKRKFCAVCRKVLETPAFRCEVCELHIHADCVPFACSDCRQCHQDGHHDHD XP_004847522.1/1-896 AHCFGPRGLYKRKFCAVCRKGLEAPALRCEVCELHIHADCVPFACSDCRQCHQDGHHDHD *****. **:*****.**** **.**::*******:*.*****************::*:* ENSP00000273814/1-942 THHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLR ENSMUSP00000057859/1-934 TYHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSVCSTALAPECTFGRLR ENSRNOP00000036466/1-937 TYHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSVCSTALTPECTFGRLR ENSCPOP00000002100/1-917 TYHHHWREGNLPLGGRCEICRKTCGSSDVLAGVRCEWCGVQAHSLCSAMLAPECTFGRLR XP_004847522.1/1-896 TYHHHWREGNLPLGARCEVCRKTCGSSDVLAGVRCGWCGIQAHSLCSSVLAPECTFGQLR *:********** *.***:**************** ***:****:**: *:*** **:** ENSP00000273814/1-942 SLVLPPACVRLLPGGFSKTQSFRIVEAAEP--GEGGDGADGSAAVGPGRETQATPESGKQ ENSMUSP00000057859/1-934 SMVLPPSCVRLLSRNFSKMHCFRIPETMVLELGDGDDGVDGSAAIGTGREVLTATESTKQ ENSRNOP00000036466/1-937 SMVLPPSCVRLLSRNFSKMHCFRIPETMVLELGDGDDGLDGSAAVGTGREVSAATESTKQ ENSCPOP00000002100/1-917 TMVLPPGCVRLLSRNFSKMHCFRIAETTAPELGDRDDGMDGSAALGPGRDMPAAPESSKQ XP_004847522.1/1-896 SMVLPPGCVRLLSRNFSKMHCFRIAETAALELGDRDDGVDGSAASGPGRDAPATPESSKQ ::****.*****. .*** :.*** *: *: .** ***** *.**: ::.** ** ENSP00000273814/1-942 TLKIFDGDDAVRRSQFRLVTVSRLAGAEEVLEAALRAHHIPEDPGHLELCRLPPSSQACD ENSMUSP00000057859/1-934 TLKIFDGNDSMRKNQFRLVTVSRLARNEEVMEAALRAYYISEDPKDFQLQALPL---SGN ENSRNOP00000036466/1-937 TLKIFDGNDSMRKNQFRLVTVSRLARNEEVMEAALRAYYINEDPKDFQLQALPLTLLSGN ENSCPOP00000002100/1-917 TLKIFDGNDTMKRNHFRLVTVPRLARSEEVLEAALRAYYVSEDAGNFELQEFPLPSPAAD XP_004847522.1/1-896 TLEIFDGNDTVRRNRFRLVTVPRLASSEEVLEAALRVYYVSEDPGDFELQELPLPSLAAV **:****:*::::.:******.*** ***:*****.::: **. .::* :* : ENSP00000273814/1-942 AWAGGKAGSAVISEEGRSPGSGEAT--PEAWVIRALPRAQEVLKIYPGWLKVGVAYVSVR ENSMUSP00000057859/1-934 AQALGKAGT---TEEEASKGSCPRDSVPEAWVIRSLPRTQEILKIYPGWLKVGVAYVSIR ENSRNOP00000036466/1-937 AQALGKAGT---TEEETSKDSGPGDSVPEAWVIRSLPRTQEILKIYPDWLKVGVAYVSIR ENSCPOP00000002100/1-917 AQAPGKAGSGGSAEEDSSRGSGARE--PEAWVIRARPRTQEVLKIYPGWLKVGVAYVSIR XP_004847522.1/1-896 AQTPGKAGSGGLAEEDSTRGSGSHE--PEAWVIRARPRAQEVLKIYPGWLKVGVAYVSIR * : ****: :** : .* *******: **:**:*****.**********:* ENSP00000273814/1-942 VTPKSTARSVVLEVLPLLGRQAESPESFQLVEVAMGCRHVQRTMLMDEQPLLDRLQDIRQ ENSMUSP00000057859/1-934 VNSQSTARSVVQEVLPLFGQQVEDKERFQLIEVLMSSRQVQRTVLADEEPLLDRLWDIRQ ENSRNOP00000036466/1-937 VNSQSTARSVVQEVLPLFGRQVEDQERFQLIEVLMSSRQVQRTVLVDEEPLLDRLRDIRQ ENSCPOP00000002100/1-917 VTSQSTAHSVVLEVLPLLGRQAEGPESFHLVEVLMGSRQVQRMVLADEESLLQRLRDIRQ XP_004847522.1/1-896 VTSQSTVRTVVLEVLPLLGRQAEDPENFQLMEVLMGSRQVQRMVLADEELLLERLWDIRQ *..:**.::** *****:*:*.*. * *:*:** *..*:*** :* **: **:** **** ENSP00000273814/1-942 MSVRQVSQTRFYVAESRDVAPHVSLFVGGLPPGLSPEEYSSLLHEAGATKATVVSVSHIY ENSMUSP00000057859/1-934 TSVRQVSQTRFYVAETRATAPRVSLFVGGLPPGLSPQDYSNLLHEAMATKAAVVSVSHVY ENSRNOP00000036466/1-937 TSVRQASQTRFYVAEARAVTPHVSLFVGGLPPGLSPQDYSNLLHEAMATKAAVVSVSHVY ENSCPOP00000002100/1-917 TSLRQASQTRFYVVESRAVAPHISLFVSGLPPGLSPQEYGSLLHEAMATKAAAVSVSHVY XP_004847522.1/1-896 TSLRQASRTRFYVVESRAVAPRVSLFVGGLPPGLSPRAYGDLLHEAMATKAAVVSVSHVY *:**.*:*****.*:* .:*::****.********. *..***** ****:.*****:* ENSP00000273814/1-942 SSQGAVVLDVACFAEAERLYMLLKDMAVRGRLLTALVLPDLLHAKLPPDSCPLLVFVNPK ENSMUSP00000057859/1-934 SLQGAVILDVTCFAEAERLYMLARDTAVHGRPLTALVLPDVLHTKLPPDCCPLLVFVNPK ENSRNOP00000036466/1-937 SLQGAVVLDVTCFAEAERLYMLARDTAVHGRPLTALVLPDVLHTKLPPDCCPLLVFVNPK ENSCPOP00000002100/1-917 S-QGAVVLDVTCFAEAERLYMLARDTAVHGRPLTTLVLPDVLHTKLPPDCCPLLVFVNPR XP_004847522.1/1-896 S-QGAVVLDVTCFAEAERLYMLGRDTAVHGQPLTTLVLPDVLHTKLPPDCCPLLVFVNPK * ****:***:*********** :* **:*: **:*****:**:*****.*********: ENSP00000273814/1-942 SGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLVCGGDGTVGWVLGA ENSMUSP00000057859/1-934 SGGLKGRELLCSFRKLLNPHQVFELTNGGPLPGFHLFSQVPSFRVLVCGGDGTVGWVLAA ENSRNOP00000036466/1-937 SGGLKGRELLCSFRKLLNPHQVFELTNGGPLPGFHLFSQVPCFRVLVCGGDGTVGWVLAA ENSCPOP00000002100/1-917 SGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGFHLFSQVPCFRVLVCGGDGTVGWVLTA XP_004847522.1/1-896 SGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGFHLFAQVPCFRVLVCGGDGTVGWVLTA *******:***************:*********:***:***.**************** * ENSP00000273814/1-942 LEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLSVDEADAVLMDRWT ENSMUSP00000057859/1-934 LEETRRHLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLVSVDEADAVLMDRWT ENSRNOP00000036466/1-937 LEETRRHLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLVSVDEADAVLMDRWT ENSCPOP00000002100/1-917 LEETRHHLACQEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSMLVSVDEADAVLVDRWT XP_004847522.1/1-896 LEETRHRLTCQEPSVAILPLGTGNDLGRVLRWGAGYSGEDPLSMLVSVDEADAVLVDRWT ***** :*:* ******************************:*:*:*********:**** ENSP00000273814/1-942 ILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNK ENSMUSP00000057859/1-934 ILLDAHEIDSTENNVVETEPPKIVQMNNYCGIGIDAELSLDFHQAREEEPGKFTSRFHNK ENSRNOP00000036466/1-937 ILLDAHEIDSTENNVVETEPPKIVQMNNYCGIGIDAELSLDFHQAREEEPGKFTSRFHNK ENSCPOP00000002100/1-917 ILLDAHGAAGAENSVLDAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRFHNK XP_004847522.1/1-896 ILLDAHKATGTGNNAVDTEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRFHNK ****** .: *.. ::********.*****************************:*** ENSP00000273814/1-942 GVYVRVGLQKISHSRSLHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLWGSDSDTR ENSMUSP00000057859/1-934 GVYVRVGLQKISHSRSLHKEIRLQVEQQEVELPSIEGLIFINIPSWGSGADLWGSDNDSR ENSRNOP00000036466/1-937 GVYVRVGLQKISHSRSLHKEIRLQVEQQEVELPSIEGLIFINIPSWGSGADLWGSDSDSR ENSCPOP00000002100/1-917 GVYVRVGLQKISHSRGLHKEIRLQVEQREVELPSIEGLIFINIPSWGSGADLWGSDSDSR XP_004847522.1/1-896 GVYVRVGLQKISHSRGLHKEIRLQVEQREVELPSIEGLIFINIPSWGSGADLWGSDSDSR ***************.***:******::****************************.*:* ENSP00000273814/1-942 FEKPRMDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQ ENSMUSP00000057859/1-934 FEKPRIDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQ ENSRNOP00000036466/1-937 FEKPRIDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWIQ ENSCPOP00000002100/1-917 FEKPRMDDGLLEVVGVTGVMHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQ XP_004847522.1/1-896 FEKPRMDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQ *****:*************:**************************************:* ENSP00000273814/1-942 APGHMIISAAGPKV--HMLRKAKQKPRRAGTTRDARADAAPAPESDPR------------ ENSMUSP00000057859/1-934 APGHMIISATAPKV--HMLRKAKQKPRKAGANRDTRVDTLPAPEGNPL------------ ENSRNOP00000036466/1-937 APGHMIISATAPKV--HMLRKAKQKPRKAGAIRDTRVDTLPAPEGNPL------------ ENSCPOP00000002100/1-917 APGHMIISAAGPKV--HMLRKAKQKPRKPAAIRG---DAVPAPEGSAK------------ XP_004847522.1/1-896 APGHMIISVAGPKVCWWLTAQARWMEQVATAKRWLGWPCCPGGPGPPVNREATGTDVGRQ ********.:.*** : :*: : . : * *. . . ENSP00000273814/1-942 --------------------------------- ENSMUSP00000057859/1-934 --------------------------------- ENSRNOP00000036466/1-937 --------------------------------- ENSCPOP00000002100/1-917 --------------------------------- XP_004847522.1/1-896 LFKPCAPQCRHLGLWKRAWGKGSARRAAASPCF