CLUSTAL W(1.81) multiple sequence alignment ENSP00000388743/1-974 MGDVRKAKEALAEVQIPPPDAGPSPRCKPPPAERLLGPGRRRRGLRRRREAVWFEVVNMD ENSMUSP00000056655/1-913 ----------------------------------------------------------MD ENSRNOP00000045984/1-757 ----------------------------------------------------------MD ENSCPOP00000002090/1-908 ------------------------------------------------------------ XP_004840376.1/1-908 ----------------------------------------------------------MD ENSP00000388743/1-974 FSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLA--T ENSMUSP00000056655/1-913 FSRLHTYTPPQCVPENTGYTYALSSSYSSDALDFETEHKLEPVFDSPRMSRRSLRLV-TT ENSRNOP00000045984/1-757 FSRLHTYTPPQCVPENTGYTYALSSSYSSDALDFETEHRLEPVFDSPRMSRRSLRLITTT ENSCPOP00000002090/1-908 ------YTPPQCVPENTGYTYALSSSYSSDALDFEIEHRLDPVFDSPRMSRRSLRLV--T XP_004840376.1/1-908 FSRLHTYTPPQCVPENTGYTYALSSSYSSDALDFETEHRLDPVFDSPRMSRRSLRLV--T *:*************************** **:*:*************** * ENSP00000388743/1-974 TACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSA-FSINHVSRQVTSSGVSHG ENSMUSP00000056655/1-913 ASYSSGDSQAIDSHISTSRATPAKGRETRTVKQRRSASKPA-FSINHLSGKGLSSSTSHD ENSRNOP00000045984/1-757 AAYSSGDGQTVDTHISTSRATPAKGRETRTVKQ-RSASKPA-FSINHLSGKGLSSSTSHD ENSCPOP00000002090/1-908 AAYSSGDSQAMDTHSCASSTASLRDRASKTVKQRRSTSKQASFSVNHLSGKATSSSISQG XP_004840376.1/1-908 AAYSSGDSQAMDAHSCASSTASFKDRVTRTVKQRRSASKQASFSINHLSGKATSSSVSQG :: : **.:::.:. :* :.. :.* ::*.** **:.* * **:**:* : **. *:. ENSP00000388743/1-974 GTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATA ENSMUSP00000056655/1-913 SSCSLRSATVLRHPVLDESLIREQTKVDHFWGLDDDGDLKGGNKAATQGNGEL-AAEVAS ENSRNOP00000045984/1-757 SSCSLRSATVLRHPVLDESLIREQTKVDHFWGLDDDGDLKGGNKAATQGNGEL-AAEVAS ENSCPOP00000002090/1-908 SSGNLQGAVPLRPPVLDETLIREQTKVDHFWGLDDDGDLKGVNKAATQGNGDL-AADTAA XP_004840376.1/1-908 GSGSLQGTVSLQPPVLDESLIQEQTKVDHFWGLDDDGDLKGGNKAAAQGNGDL-AADTAV .: .*:.:. : *****: *:***.*************** **** ****:: ** .: ENSP00000388743/1-974 HNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQK-CGASFYVNRILWLARYTAS ENSMUSP00000056655/1-913 SNGYTCRDCRMLSARTDALTAHSAIHGTTSRVYSRDRTLKPRGVSFYLDRTLWLAKSTSS ENSRNOP00000045984/1-757 SNGYTCRDCRMLSARTDALTAHSAVHGPTSRVYSRDRTLR-------------------- ENSCPOP00000002090/1-908 HNGYTCRDCSMLSERTDMLTAHPAAHGPASKIYSRDRNLK-RGVSFYLDRTLWLARYTSS XP_004840376.1/1-908 RNGYTCRDCSMLSERTDVLTAHPATHGPSSRIYSRDRNLK-RGVSFYMDRTLWLARYTTS **::* :* *** *.* ****.* *. *::*****. : ENSP00000388743/1-974 SFSSFLVQLFQVVLMKLSYESENYKLKTHESKDCESESYKSKSHESKAHASYYGRMNVRE ENSMUSP00000056655/1-913 SFASFIVQLFQVVLMKLNFET--YKLKGYESRAYESQSYETKSHESEAHLGHCGRMTAGE ENSRNOP00000045984/1-757 ------------------------------------------------------------ ENSCPOP00000002090/1-908 SFSSFLVQLFQVVLMKLYCESNNYKLKNFFPSSFSPPNNAFKVFNMKAHRSYCGRMTVTE XP_004840376.1/1-908 SFASFLAQLFQVVLMKLNYESDNYKLKNYESKDCESES---------SHRSYCGRKTVTE ENSP00000388743/1-974 VLRED-GHLSVNGEALCDDCKGKRHLDAHTAAHSQSPRLPGRAGTLWHIWACAGYFLLQI ENSMUSP00000056655/1-913 LSRVD-------GESLCDDCKGKKHLEIHTATHSQLPQPHRVAGAMGRLCIYTGDLLVQA ENSRNOP00000045984/1-757 ------------------------------------------------------------ ENSCPOP00000002090/1-908 LPREDPDRPSVHGELLCDDCKGKKHLETHTAARWQPSKLHRVVGAMGHLCTRAGYFLMQT XP_004840376.1/1-908 LPRED-GRPSVHGESLCDDCKGKKHLETHTAARWQPSRPHRVVGAMGHLCTFAGYFLMQM ENSP00000388743/1-974 LRRIGAVGQAVSRTAWSALWLAVVAP-GKAASGVFWWLGIGWYQFVTLISWLNVFLLTRC ENSMUSP00000056655/1-913 LRRTRAAGWSVAEAVWSVLWLAVSAP-GKAASGTFWWLGSGWYQFVTLISWLNVFLLTRC ENSRNOP00000045984/1-757 -------------------------P-RKAASGTFWWLGSGWYQFVTLISWLNVFLLTRC ENSCPOP00000002090/1-908 LGRVRAAGWLVSKTVWSVLWLAIVAP-GKVASGVFSWLGIGWYQFVTLISWLNVFLLTRC XP_004840376.1/1-908 LRRARAAGWFVAETVWSVLWLATVAPGGKVASGALWWFGIGWYQFATLISWLNVFLLTRC * *.***.: *:* *****.************** ENSP00000388743/1-974 LRNICKFLVLLIPLFLLL-AGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVFKPTTS ENSMUSP00000056655/1-913 LRNICKVFVLLLPLLLLLGAGVSLWGQGNFFSLLPVLNWTAMQPTQRVDDSKGMHRPGPL ENSRNOP00000045984/1-757 LRNICKVFVLLLPLLLLLGAGFSLWGQGNFFSLLPMLNWTAMQPAQRVDNPKDMHRPGPL ENSCPOP00000002090/1-908 LRNICKFLILLIPLLLLVGVGLSLWGQSDFFSFLPVLNWTDVRTVERVEDPKDTFRPGSS XP_004840376.1/1-908 LRNTCKFLILLIPLLLLLGAGLSLWGQSDFFSLLPVLNWTDMRTAERVDDPKDTFRPGSS *** **.::**:**:**: .*.** **.:***:**:***: :: .:**::.:. .:* . ENSP00000388743/1-974 RLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQMEGGA ENSMUSP00000056655/1-913 PPSPPPKVDHKASQWPQESDMGQKVASLSAQCHNHDERLAELTVLLQKLQIRVDQVDDGR ENSRNOP00000045984/1-757 SPSPPLKVDPMASQWPQESDMGQKIASLSAQCHNHDERLAELTVLLQKLQIRVDQVDDGR ENSCPOP00000002090/1-908 QL-QVLKDKEEASWWLQENDGRQQVTSFSAQCHNHEEKLGELTVLLQKLQARVDQIDDGR XP_004840376.1/1-908 HL----QVDGQASWWLWENDMRQQVASFSTQCHNHEEKLRELTVLLQKLQLRVDQMDEGR : . * * .. *:::*:* ***:* *.* ***.****** ****:: * ENSP00000388743/1-974 AGPSASVRDAVGQPPRE----------TDFMAFHQEHEVRMSHLEDILGKLREKSEAIQK ENSMUSP00000056655/1-913 EGLSLWVKNVVGQHLQEMGTIEPPDAKTDFMTFHHDHEVRLSNLEDVLRKLTEKSEAIQK ENSRNOP00000045984/1-757 EGLSLWVKDMVGQHLQEIGSIEPPDAKTDFLTLHHDHEVRLSSLEDVLRKLTEKSEAIQK ENSCPOP00000002090/1-908 EGLSLQVKDVVGQHLQE----------TDIMTFHHEHEVRLSKLEDIFRKLTEKSEAIHK XP_004840376.1/1-908 EGLLLWMKDVVGQHLQEMSAAGFRGTKTDFMTYHHENEVRLSNMEDILRKLTEKSEAIQK * ::: *** :* **::: *:::***:* :**:: ** ******:* ENSP00000388743/1-974 ELEQTKQKTISAVGEQ-LLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQV ENSMUSP00000056655/1-913 ELEETKLKAGSRDEEQPLLDRVQHLELELNLLKSQLSDWQHLKTSCEQ-------AGARI ENSRNOP00000045984/1-757 ELEETKLRAGSRDEEQPLLDRVQHLELELNLLKSQLSDWQHLRSSCEQ-------ADARI ENSCPOP00000002090/1-908 ELEQTKLRTISGAEEQ-LLPRVERLEEELSLLRSQLSDWQQLKASCEQVGAAQSLVDAQV XP_004840376.1/1-908 ELEHMKLRTTSGAEEQPLLLRMERLEQELGLLRSQLSGWQQLKAGCEK-------VDAQV ***. * :: * ** ** :::*: **. *:*:**.*:::::.** ...:: ENSP00000388743/1-974 REMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLP ENSMUSP00000056655/1-913 QETVQLMFSEDQQGGSLEWLLEKLSSRFVSKDELQVLLHDLELKLLQNITHHITVTGQAP ENSRNOP00000045984/1-757 QETVQLMFSEDQPGGSLEWLLQKLSSRFVSKDELQVLLHDLELKLLQNITHHITVTGQAP ENSCPOP00000002090/1-908 KETPRLMFTEDQQGSSLEWLIQRLSSHYVSRDDLQTLLRDLELQVLKNITHHLVVTGQKP XP_004840376.1/1-908 KETVRLMFSEDQQGGSLEWLLQKLSSHYVSRDDLQVLLRDLELQVLKNITHHLVVTGQKL :* :*:*:*** *.*** *::::**::**:.:**.:*:**:*::*:*:***: ** * ENSP00000388743/1-974 TSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSET ENSMUSP00000056655/1-913 TSEAIVSAVNQAGISGITEAQAHIIVNNALKLYSQDKTGMVDFALESGGGSILSTRCSET ENSRNOP00000045984/1-757 TSEAIVSAMSQAGISGITEAQAHIIVNNALRLYSQDKTGMVDFALESGGGSILSTRCSET ENSCPOP00000002090/1-908 TSETVVSAVSEAGISGITEEQARVIVNNALKLYSQDKTGMVDFALESGGGSILSTRCSET XP_004840376.1/1-908 TSETVVSAVSGAGISGITEAQARVIVNNALKLYSQDKTGMVDFALESGGGSILSTRCSET ***::***:. ** ***** **: ***.**:***************************** ENSP00000388743/1-974 YETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTL ENSMUSP00000056655/1-913 YETKTALLSLFGVPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMKIYPTTFTM ENSRNOP00000045984/1-757 YETKTALLSLFGVPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMKIYPTTFTM ENSCPOP00000002090/1-908 YETKTALLSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMKIHLTMFTM XP_004840376.1/1-908 YETKTALLSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMKIHPTMFTV *******:****:************************************** *: : **: ENSP00000388743/1-974 EHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDT ENSMUSP00000056655/1-913 EHIPKTLSPTGNISSAPKDFAVYGLETEYQEEGQPLGRFTYDQEGDSLQMFHTLERPDQ- ENSRNOP00000045984/1-757 EHIPKTLSPTGNISSAPRDFAVYGLETEYQEEGQPLGRFTYDQEGDSLQMFHTLERPDQ- ENSCPOP00000002090/1-908 EHIPKTLSPMGNISSAPKDFAVYGLENEYQEEGQPLGQFTYDQEGESLQMFPALEIPDR- XP_004840376.1/1-908 EHIPKTLSPMGNISSAPKDFAVYGLENEYQEEGQPLGQFTYDQEGESLQMFQALERPDK- ********* *******:********.******* **:*****:*:***** :*: ** ENSP00000388743/1-974 AFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK ENSMUSP00000056655/1-913 AFQIVELRVLSNWGHPEYTCLYRFRVHGEPIQ ENSRNOP00000045984/1-757 GFQIVELRVLSNWGHPEYTCLYRFRVHGEPIQ ENSCPOP00000002090/1-908 AFQIVELRILSNWGHLEYTCLYRFRVHGQPAH XP_004840376.1/1-908 AFQIVELRILSNWGHPEYTCLYRFRVHGQPAQ .*******::***** ************:* :