CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000107510/1-790 MPAAPVLRPPPPPATPAPPAPSRPAPPIPGHRGPCDHSLKCLSSKISERKLPGPWLPAGR ENSRNOP00000046063/1-807 MPAAPVLRPPPPPATPAPPAPSRPAPAISGHRGPCDHSLKCLSSKISERKLPGSWLPSGR ENSP00000394484/1-648 ------------------------------------------------------------ ENSCPOP00000002071/1-645 ------------------------------------------------------------ XP_004857959.1/1-794 -------------------------FPVVGHRGLCDNSLKYLSSKITERKLQGTWLPAGR ENSMUSP00000107510/1-790 GPLEKPVLGPRGAVMPLFSPQSSLHSVRAEHSPLKPRVVTVVKLGGQPLRKATLLLNRRS ENSRNOP00000046063/1-807 GPLEKPVLGPRGAVMPMFSPQSSLHSVRAEHSPLKPRVVTVVKLGVQPLRKATLLLNRRS ENSP00000394484/1-648 ------------------------------------------------------------ ENSCPOP00000002071/1-645 ------------------------------------------------------------ XP_004857959.1/1-794 GNLEKPLPGSRGSVVPMFSPQNGLQSVHSENSPLKPRVVTVVRLSGQPLRKVTMLLNRRS ENSMUSP00000107510/1-790 VQTFEQLLSDISEALGFPRWKNDRVRKLFTLKGREVKSVSDFFREGDAFIAMGKEPLTLK ENSRNOP00000046063/1-807 VQTFEQLLSDISEALGFPRWKNDRVRKLFTLKGREVKSVSDFFREGDAFIAMGKEPLTLK ENSP00000394484/1-648 ---------------------------------------------------MGKEPLTLK ENSCPOP00000002071/1-645 ---------------------------------------------------MGKEPLTLK XP_004857959.1/1-794 VQTFEQLLADISEALGFPKWKNDRVRKLFNLKGREIRSVSDFFREGDAFIATGKEPLTLK ******** ENSMUSP00000107510/1-790 SIQLAMEELYP-KNRALALAPHSRVPSPRLRSRLPSKLLKGSHRCGEAG---SYSAEMES ENSRNOP00000046063/1-807 SIQLAMEELYP-KNRALALAPHSRVPSPRLRSRLPSKLLKGSHRCGEAG---SYGEVMGN ENSP00000394484/1-648 SIQVAVEELYPNKARALTLAQHSRAPSPRLRSRLFSKALKGDHRCGETETPKSCSEVAGC ENSCPOP00000002071/1-645 NIQMAIEELYPNKNRALTVTQHSRASSPRLRSRLYSKVLKGGHHCGETG---SGTESAQG XP_004857959.1/1-794 NIQMAIEGLYPNKNRALTLTQHSHAPSPRLRSRLYSKVLKGGHHCGEIG---SGSESAQS .**:*:* *** * ***::: **:..******** ** ***.*:*** * ENSMUSP00000107510/1-790 KAVSRHQGKTSTVLAPEDKARAQK-WVRGKQESEPGGPPSPGAATQEETHASGEKHLGVE ENSRNOP00000046063/1-807 KAVIRHQGKTSTELAPEDKARAQKKWVGGKQESENGGLPSPREATQEETHASGEKHLGVE ENSP00000394484/1-648 KAAMRHQGKIPEELSLDDRARTQKKWGRGKWEPEPSSKP-PREATLEERHARGEKHLGVE ENSCPOP00000002071/1-645 KAIIRRQGKSPMEPALQDKVRAQKKWMRGKQKPESGSKL-SRETTLEERHASGEKHLGLE XP_004857959.1/1-794 KAVIRHQGKSPVEPALEDKVRAWKKWVRGKQEPEPGSKL-PKETTLEERHASGEKHLGLE ** *:*** . : :*:.*: * * ** :.* .. . :* ** ** ******:* ENSMUSP00000107510/1-790 IEKTSGEIVRCEKCKRERELQLGLQREPCPLGTSELDLGRAQKRDSEKLVRTKSCRRPSE ENSRNOP00000046063/1-807 IEKTSGEIVRCEKCKRETELQLGLQRGQCPPGTSELDLGRGQKRDSEKLVRTKSCRRASE ENSP00000394484/1-648 IEKTSGEIIRCEKCKRERELQQSLERERLSLGTSELDMGKGPMYDVEKLVRTRSCRRSPE ENSCPOP00000002071/1-645 IEKTSGEIVRCEKCKRERERQQSLQHERLSLGTSELDMGKCQRYEVEKLVRTKSYRRSPE XP_004857959.1/1-794 IEKTSGEIVRCETCRKEQECQQSLQRERLSLGTSELDMGKCQRYDVEKLVRARSCRRSPE ********:***.*::* * * .*:: . ******:*: : *****::* **..* ENSMUSP00000107510/1-790 AKSTDGEEGWKGDSHRGSPRDPPQELRRPNSNSDKKEIRGSESQDSHPQGAPKAQKDLVE ENSRNOP00000046063/1-807 AKSTDGEEGWKGDSHRGSPRDPPQELRRPNNNSDKKESRGSEAQESHPQGVAKAQKDLME ENSP00000394484/1-648 ANPASGEEGWKGDSHRSSPRNPTQELRRPSKSMDKKEDRGPEDQESHAQGAAKAKKDLVE ENSCPOP00000002071/1-645 ANPAHGGEGRKVDSHRSSPRNPTHELHRLSKNTDMKEDRDPEDQASHPQGAARIKKELME XP_004857959.1/1-794 ANPARGGEGWKGDSHWSSPRNPVQELNRPSKNTDKKENRDPENQASHLQGAATTKKELIE *:.: * ** * *** .***:* :**.* ... * ** *..* * ** **.. :*:*:* ENSMUSP00000107510/1-790 GPPAVEEGPIDMRREDRHTCRSKHAAWLRREQQAEPPQLPRTRGEEKQAEHEKKPGGL-- ENSRNOP00000046063/1-807 GLPAVEEGAVDARRDSRHTCRIKHAAWLRREQQAEPPQLPRTRGEEKEAEHEKKSGGL-- ENSP00000394484/1-648 VLPVTEEGLREVKKDTRPMSRSKHGGWLLREHQAGFEKLRRTRGEEKEAEKEKKPCMS-- ENSCPOP00000002071/1-645 VPPETEEGPRDVQKDIRHVCKSKHSISLLREHQPELEKLSKTRREEKEAENEKKPGVS-- XP_004857959.1/1-794 VPPVTEEGPRDMKKDIRHVCKNKHGARLLREHQTELDKLSKTQGEEKEAEKEKKPGVSGV * .*** : ::: * .: **. * **:*. :* :*: ***:**:***. ENSMUSP00000107510/1-790 -GERRA---------PEKESKRKLEEKRPERPSGRKPRPKGIISADVEKHYDIGGVIGDG ENSRNOP00000046063/1-807 -GGRRM---------LEKESKTKPEENRPERPSGRKLRPTGIISADVEKHYDIGRVIGDG ENSP00000394484/1-648 -GGRRMTLRDDQPAKLEKEPKTRPEENKPERPSGRKPRPMGIIAANVEKHYETGRVIGDG ENSCPOP00000002071/1-645 -GARKIAVRDDPPARIEKEPKTRPEENKSKRSTGWKPRPAGIITADVGKHYETGRVIGDG XP_004857959.1/1-794 SGGRRMTVRDDTPARVEKEPKTRPEDSKPERSSSRKLRPTGIIAADVEKHYETGRVIGDG * *: ***.* : *:.:.:*.:. * ** ***:*:* ***: * ***** ENSMUSP00000107510/1-790 NFATVKECRHRETKQAYAMKMIDKSQLKGKEDIVDSEILIIQSLSHPNIVKLHEVYETEA ENSRNOP00000046063/1-807 NFAIVKECKHRETRQAYAMKIIDKSQLKGKEDIVDSEILIIQSLSHPNIVKLHEVYETEA ENSP00000394484/1-648 NFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIVKLHEVYETDM ENSCPOP00000002071/1-645 NFAVVKECRHRETRQAYAMKIIDKSKLKGKEDIIDSEILIIQSLSHPNIVKLHEVYEMEM XP_004857959.1/1-794 NFAVVKECRHRETRQAYAMKIIDKSKLKGKEDIIDSEILIIQSLSHPNIVKLYEVYEMET *** ****:****:******:****:******::******************:**** : ENSMUSP00000107510/1-790 EIYLIMEYVQGGDLFDAIVENVKFPEPEAAVMITDLCKALVHMHDKNIVHRDVKPENLLV ENSRNOP00000046063/1-807 EIYLIMEYVQGGDLFDAIIESVKFPEPDAAVMITDLCKALVHMHDKKIVHRDLKPENLLV ENSP00000394484/1-648 EIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLV ENSCPOP00000002071/1-645 EICLIMEYVQGGDLFDAIIESVKFPEPDAARLIMDLCKALVHMHDKNIVHRDLKPENLLV XP_004857959.1/1-794 EIYLIMEYVQGGDLFDAIIESVKFPEPDAALLIMDLCKALVHMHNKNIVHRDLKPENLLV ** **:************:*.******:** :* **********:*.*****:******* ENSMUSP00000107510/1-790 QRNEDKSITLKLADFGLAKYVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYI ENSRNOP00000046063/1-807 QRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYI ENSP00000394484/1-648 QRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYI ENSCPOP00000002071/1-645 QRNEDKSTTLKLADFGLAKHVVRPVFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYI XP_004857959.1/1-794 QRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYI ******* ***********:****:*********************************** ENSMUSP00000107510/1-790 LLCGFPPFRSPERDQDELFNIIQVGQFEFLSPYWDNISDAAKDLVRNLLEVDPKKRYTAE ENSRNOP00000046063/1-807 LLCGFPPFRSPERDQDELFNIIQLGQFEFLSPYWDNISDAAKDLVRNLLVVDPKKRYTAH ENSP00000394484/1-648 LLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAH ENSCPOP00000002071/1-645 LLCGFPPFRSPERDQDELFNIIQLGNFEFLAPYWDNISDAAKDLVSRLLVVDPKKRYTAH XP_004857959.1/1-794 LLCGFPPFRSPERDQDELFNIIQLGRFEFLAPYWDNISDAAKDLVSRLLVVDPKKRYTAH ***********************:*.****.************** .** *********. ENSMUSP00000107510/1-790 QVLQHPWIEMVGHTNTGNSQKEESPNS---------------- ENSRNOP00000046063/1-807 QVLHHPWIGMVGHPSTVNPQKEESPSSEGRFQSQHKKVAEHVS ENSP00000394484/1-648 QVLQHPWIETAGKTNTVKRQKQVSPSSEGHFRSQHKRVVEQVS ENSCPOP00000002071/1-645 QVLQHPWIETAGKISRVDPQKEVSSSSEGHSWSQHKRIMEQAS XP_004857959.1/1-794 QVLQHPWIETTGKISKVNLQKEVSSSSEGHIRSQHKRVAEQAS ***:**** .*: . . **: *..*