CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000021201/1-1377 MASGRDERPPWRLGRLRLLPPPPLLLLLLLLRSSAQAAHIKKAEATTTTVG-GSEAAEGQ ENSRNOP00000005262/1-1378 MASGWDERPPWRLESLRLLPPPPLLLLLLLLRSSAQAAHIKKAEATTTTVG-GSEAAEGQ ENSP00000225719/1-1380 MASGRDERPPWRLGRLLLLMC------LLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQ ENSCPOP00000001972/1-1333 MASGRDSRPPWRLERLP-------------PRSPAWAAHIKKAEATTTTSA----GA--- XP_004857142.1/1-1376 MASGWDARPPWRLRRLPLLLCLLLLCLLLLLRSPTRAAHIKKAEATTTTSA----GAEGQ **** * ****** * *.: ************* . .* ENSMUSP00000021201/1-1377 FDHYYHEAALGEALEAAAAAGPPGLARLFSIGSSVEGRPLWVLRLTAGLGPPPT------ ENSRNOP00000005262/1-1378 FDHYYHEAALGEALEAAAAAGPPGLARLFSIGNSVEGRPLWVLRLTAGLGPPPTP----- ENSP00000225719/1-1380 FDRYYHEEELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDAGP ENSCPOP00000001972/1-1333 -----RRAQFGPL---TITKKEPGQGRCFSIGRSVEGRPLWVLRLTAGLGPLLPD----- XP_004857142.1/1-1376 FDRYYHEEELGKALREAAAAGTPGLARLFSIGRSVEGRPLWVLRLTAGLGPLPPDG---- :. : : : ** .* **** *****************. . ENSMUSP00000021201/1-1377 AAAGLDAAGPLLPGRPQVKLVGNMHGDETVSRQVLVYLARELASGYRRGDPRLVRLLNTT ENSRNOP00000005262/1-1378 AAVGLDAAGPLLPGRPQVKLVGNMHGDETVSRQVLVYLARELASGYRRGDPRLVRLLNTT ENSP00000225719/1-1380 DAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTT ENSCPOP00000001972/1-1333 ----------LVPGRPQVKLVGNMHGDETVSRQVLVYLARELAAGYRRGDPRLVRLLNTT XP_004857142.1/1-1376 DAAGSDAAGPLVPGRPQVKLVGNMHGDETVSRQVLVYLARELASGYRRGDPRLVRLLNTT *:***********************:*******:**************** ENSMUSP00000021201/1-1377 DVYLLPSLNPDGFERAREGDCGLGDSGPPGTSGRDNSRGRDLNRSFPDQFSTGEPPSLDE ENSRNOP00000005262/1-1378 DVYLLPSLNPDGFERAREGDCGLGDSGPPGTSGRDNSRGRDLNRSFPDQFSTGEPPSLDE ENSP00000225719/1-1380 DVYLLPSLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDE ENSCPOP00000001972/1-1333 DVYVLPSLNPDGFERSREGDC--------GTSGRDNSRGRDLNRSFPDQFSTGEPPSLDE XP_004857142.1/1-1376 DVYVLPSLNPDGFERSREGDCGLGDSGPPGTSGRDNSRGRDLNRSFPDQFSTGEPPSLDE ***:***********:***** *:*************************:*** ENSMUSP00000021201/1-1377 VPEVRALIDWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKTTGLYSKTSDDEVFRYLAKA ENSRNOP00000005262/1-1378 VPEVRALIDWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKTTGIYSKTSDDEVFRYLAKA ENSP00000225719/1-1380 VPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKA ENSCPOP00000001972/1-1333 VPEVRALIDWIRRNKFVLSGNLHGGSVVASYPFDDSPEHQATGIYSKTSDDEVFKYLAKA XP_004857142.1/1-1376 VPEVRALIDWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKA ********:******************************::**:**********:***** ENSMUSP00000021201/1-1377 YASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCC ENSRNOP00000005262/1-1378 YASNHPIMRTGEPHCPGDEEETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCC ENSP00000225719/1-1380 YASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCC ENSCPOP00000001972/1-1333 YASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCC XP_004857142.1/1-1376 YASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCC ********:**********:**************************************** ENSMUSP00000021201/1-1377 KYPPASQLRQEWENNRESLITLIEKVHIGIKGFVKDSVTGSGLENATISVAGINHNITTG ENSRNOP00000005262/1-1378 KYPPASQLRQEWENNRESLITLIEKVHIGIKGFVKDSVTGSGLENATISVAGINHNITTG ENSP00000225719/1-1380 KYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTG ENSCPOP00000001972/1-1333 KYPPASQLRQEWENNRESLITLIEKVHIGIKGFVKDSVTGSGLENATISVAGINHNITTG XP_004857142.1/1-1376 KYPPASQLRQEWENNRESLITLIEKVHIGIKGFIKDSVTGSGLENATISVAGINHNITTG *****************************:***:***:********************** ENSMUSP00000021201/1-1377 RFGDFHRLLVPGTYNLTALSTGYMPLTINNIMVKEGPATEMDFSLRPTVMSVMPGSTEAV ENSRNOP00000005262/1-1378 RFGDFHRLLIPGSYNLTAVSPGYMPLTINNIVVKEGPATEMDFSLQPTVMSVVPDSTEAV ENSP00000225719/1-1380 RFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAV ENSCPOP00000001972/1-1333 RFGDFHRLLIPGTYNLTALSTGYMPLTIHNIIVKEGPATEVDFSLRPTATSVIPDATEVL XP_004857142.1/1-1376 RFGDFHRLLVPGIYNLTALSTGYMPLTINNIIVKEGPATEVDFSLRPTTTSVVPDTTEVL *****:***:** ****.: .******: *::********:****:**. **:*.:**.: ENSMUSP00000021201/1-1377 TTPGTVAVPNIPPGTPSSHQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVE ENSRNOP00000005262/1-1378 TTPGTVAVPNIPPGTPSSHQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVE ENSP00000225719/1-1380 STASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVE ENSCPOP00000001972/1-1333 ATASTVVLPNVSPGTLSSHQPIQPKDFHHHHFPDMEIFLRRFANDYPNITRLYSLGKSVE XP_004857142.1/1-1376 ATTSTVILPNIPPGTSSSHQPIQPKDFHHHHFPDMEIFLRKFANDYPNITHLYSLGKSVE :*..** :**: .** **:*********************:***:*****:********* ENSMUSP00000021201/1-1377 SRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDL ENSRNOP00000005262/1-1378 SRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDL ENSP00000225719/1-1380 SRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDL ENSCPOP00000001972/1-1333 SRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDL XP_004857142.1/1-1376 SRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDSEVTDL ******************************************************.***** ENSMUSP00000021201/1-1377 VRSTRIHLMPSMNPDGYEKSQEGDSISVVGRNNSNNFDLNRNFPDQFVPITEPTQPETIA ENSRNOP00000005262/1-1378 VRSTRIHLMPSMNPDGYEKSQEGDSISVVGRNNSNNFDLNRNFPDQFVPITDPTQPETIA ENSP00000225719/1-1380 VHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIA ENSCPOP00000001972/1-1333 VRSTRIHLMPSMNPDGYEKSQEGDSVSVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIA XP_004857142.1/1-1376 VRSTRIHLMPSMNPDGYEKSQEGDAVSVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIA *:.*********************::**:******************* **:******** ENSMUSP00000021201/1-1377 VMSWVKAYPFVLSANLHGGSLVVNYPYDDNEQGVATYSKSPDDAVFQQIALSYSKENSQM ENSRNOP00000005262/1-1378 VMSWVKAYPFVLSANLHGGSLVVNYPYDDNEQGVATYSKSPDDAVFQQIALSYSKENSQM ENSP00000225719/1-1380 VMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQM ENSCPOP00000001972/1-1333 VMSWMKAYPFVLSANLHGGSLVVNYPFDNDEQGLAIYSKSPDDAVFQQLALSYSKENSQM XP_004857142.1/1-1376 VMSWMKAYPFVLSANLHGGSLVVNYPFDDDEQGLALYSKSPDDAVFQQIALSYSKENPQM ****:*:*******************:*::***:* ************:********.** ENSMUSP00000021201/1-1377 FQGRPCKDMYLNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPFENEL ENSRNOP00000005262/1-1378 FQGRPCKDMYLNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPFEKEL ENSP00000225719/1-1380 FQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKEL ENSCPOP00000001972/1-1333 FQGRPCKNMYPNEYFPHGITNGANWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPFEKDL XP_004857142.1/1-1376 FQGRPCKNMYPNEYFHHGITNGANWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPFEKDL *******:** **** *******.*******************************:*::* ENSMUSP00000021201/1-1377 PKYWEQNRRSLIQFMKQVHQGVKGFVLDATDGRGILNATLSVAEINHPVTTYKAGDYWRL ENSRNOP00000005262/1-1378 PKYWEQNRRSLIQFMKQVHQGVKGFVLDATDGRGILNATLSVAEINHPVTTYKAGDYWRL ENSP00000225719/1-1380 PNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRL ENSCPOP00000001972/1-1333 PMFWEQNRRSLIQFMKQVHQGVKGFVLDATDGRGILNASISVAEINHPVTTYKTGDYWRL XP_004857142.1/1-1376 PKFWEQNRRSLIQFMKQVHQGVKGFVLDATDGRGILNATISVAEINHPVTTYKAGDYWRL * :*******************:***************::*************:****** ENSMUSP00000021201/1-1377 LVPGTYKITASARGYNPVTKNVTVRSEGAVQVNFTLVRSSADANNESKKGRGHSTSTDDT ENSRNOP00000005262/1-1378 LVPGTYKITASARGYNPVTKNVTVRSEGAIQVNFTLVRSSTDANNESKKGKGHSTSTDDT ENSP00000225719/1-1380 LVPGTYKITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDA ENSCPOP00000001972/1-1333 LVPGTYKITASARGYNPVTKNVTVKSEGAIQVNFTLNRSSTDANSDSKKGKGDSTSTDDT XP_004857142.1/1-1376 LVPGTYKITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDANNKSKKGKGDSTSTDDA ************************:****:****** ***:*:*..****:* *:**:*: ENSMUSP00000021201/1-1377 SDPTSKEFEALIKHLSAENGLEGFMLSSSSD--LALYRYHSYKDLSEFLRGLVMNYPHIT ENSRNOP00000005262/1-1378 SDPTSKEFEALIKHLSAENGLEGFMLSSSSD--LALYRYHSYKDLSEFLRGLVMNYPHIT ENSP00000225719/1-1380 SDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHIT ENSCPOP00000001972/1-1333 SDPTAKKFEALIKDLSAENGLEGIMLSSSSN--LALYRYHSYKDLSEFLRGLVMNYPLIT XP_004857142.1/1-1376 SDPTTKEFEALIKDLSAENGLEGIMLSSSSN--LALYRYHSYKDLSEFLRGLVMNYPLVT ****:*:**:***.********.:** ***: ************************ :* ENSMUSP00000021201/1-1377 NLTTLGQSVEYRHIWSLEISNKPNISEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLN ENSRNOP00000005262/1-1378 NLTTLGQSVEYRHIWSLEISNKPNISEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLN ENSP00000225719/1-1380 NLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLN ENSCPOP00000001972/1-1333 NLTTLGQSAEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLN XP_004857142.1/1-1376 NLTTLGQSAEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLN ***.****.***************:*********************************** ENSMUSP00000021201/1-1377 YKRNPVVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKTGHTNAHGKDLDTDFTSNASQP ENSRNOP00000005262/1-1378 YKKNPVVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKTGHTNARGRDLDTDFTSNASQP ENSP00000225719/1-1380 YKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQP ENSCPOP00000001972/1-1333 YKKNPAVSQLIDRTRIVIVPSLNPDGRERAQEKDCTSNTGQTNARGKDLDTDFTNNASQP XP_004857142.1/1-1376 YKKNPAVTQLIDRTRIVIVPSLNPDGRERAQEKDCTSKIGQANARGKDLDTDFTNNASQP **:**.*:**:**************************: *::**:*:*******.***** ENSMUSP00000021201/1-1377 ETKAIIENLIQKQDFSLSIALDGGSVLVTYPYDKPVQTVENKETLKHLASLYANNHPSMH ENSRNOP00000005262/1-1378 ETKAIIENLIQKQDFSLSIALDGGSVLVTYPYDKPVQTVENKETLKHLASLYANNHPSMH ENSP00000225719/1-1380 ETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMH ENSCPOP00000001972/1-1333 ETKAIIENLIQKQDFSLSVALDGGSVLVTYPYDKPVQTVENKETLKHLASLYANNHPSMH XP_004857142.1/1-1376 ETKAIIENLIQKQDFSLSVALDGGSVLVTYPYDKPVQTVENKETLKHLASLYANNHPSMH ******************:******:********************************** ENSMUSP00000021201/1-1377 MGQPSCPNNSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAAQLP ENSRNOP00000005262/1-1378 MGQPSCPNNSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAAQLP ENSP00000225719/1-1380 MGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLP ENSCPOP00000001972/1-1333 MGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAAQLP XP_004857142.1/1-1376 MGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSGTYGHCPEITVYTSCCYFPSAAQLP ********:************************** *********************:** ENSMUSP00000021201/1-1377 ALWAENKKSLLSMLVEVHKGVHGLVKDKAGKPISKAVIVLNEGIKVYTKEGGYFHVLLAP ENSRNOP00000005262/1-1378 ALWAENKKSLLSMLVEVHKGVHGLVKDKTGKPISKAVIVLNEGIRVHTKEGGYFHVLLAP ENSP00000225719/1-1380 SLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAP ENSCPOP00000001972/1-1333 SLWAENKKSLLSMLVEVHKGVHGLVKDKTGKPISKAVIVLNEGIKVHTKEGGYFHVLLAP XP_004857142.1/1-1376 SLWAENKKSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVYTKEGGYFHVLLAP :***:**:***************:****:***************:* ************* ENSMUSP00000021201/1-1377 GVHNINAIADGYQQQHTQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALIL ENSRNOP00000005262/1-1378 GVHNINAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALIL ENSP00000225719/1-1380 GVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALIL ENSCPOP00000001972/1-1333 GVHNINAIAEGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTISGATMSALIL XP_004857142.1/1-1376 GVHNINAIAEGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTISGATMSALIL ***** ***:******:********************************:********** ENSMUSP00000021201/1-1377 TACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEET ENSRNOP00000005262/1-1378 TACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEET ENSP00000225719/1-1380 TACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEET ENSCPOP00000001972/1-1333 TACIIWCICSIKSNRHKDGFHRLRQHHDDYEDEIRLMSTGSKKSLLSHEFQDETDTEEET XP_004857142.1/1-1376 TTCIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRLMSTGSKKSLLSHEFQDETDTEEET *:**************************:******:************************ ENSMUSP00000021201/1-1377 LYSSKH ENSRNOP00000005262/1-1378 LYSSKH ENSP00000225719/1-1380 LYSSKH ENSCPOP00000001972/1-1333 LYSSKH XP_004857142.1/1-1376 LYSSKH ******