CLUSTAL W(1.81) multiple sequence alignment ENSP00000304226/1-1215 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS ENSCPOP00000001881/1-1217 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTCVNGRNFGNSYPPTKGS XP_004852126.1/1-1211 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPWTYVNGRNFGNSHPPAKGS ENSMUSP00000106754/1-1213 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSGCVFQERTYPQIHVNGRNFGNSHPSTKGS ENSRNOP00000015775/1-1191 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSGCVFQERACPQIHVNGRHFGNPLPSTKGS *******************************.****** * ****:***. *.:*** ENSP00000304226/1-1215 AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE ENSCPOP00000001881/1-1217 AFQTKVPFSRLRGHNFSLQTSAVVLKNTAGATKVIAAQARPAQVEAPQIGAWRQRLQFLE XP_004852126.1/1-1211 AFQTKIPFSRLRGHNFSLQTSAVVLKNTAGATKVIAAQGQPAPVEAPQIGVWRQRLHFLE ENSMUSP00000106754/1-1213 AFQTKIPFTKPRGHSFSLQAGAIVVKDTAGATKVLAAQAQQAGVEAPRAVVWRNRLHFLE ENSRNOP00000015775/1-1191 AFQTKIPFSKPRGHSFSLQAGAIVVKDTAGATKVIAAQAQQAGVEAPRAVVWRNRLHFLG *****:**.: ***.****:.*:*:*:*******:***.: * *:**: .**:**:** ENSP00000304226/1-1215 GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG ENSCPOP00000001881/1-1217 GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTTTTGSKQNCTTGEG XP_004852126.1/1-1211 GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTTTAGSKQNCTTGEG ENSMUSP00000106754/1-1213 GPQRCGLKRKSEELENHSGAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTSGEG ENSRNOP00000015775/1-1191 GPQRCGLKRKSEELDNHSGAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTSGEG **************:***.***************************:*:*******:*** ENSP00000304226/1-1215 DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI ENSCPOP00000001881/1-1217 DYQLVQHEVLCSLKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI XP_004852126.1/1-1211 DYQLVQHEVLCSLKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI ENSMUSP00000106754/1-1213 DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI ENSRNOP00000015775/1-1191 DYQLVQHEVLCSVKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI ************:*********************************************** ENSP00000304226/1-1215 EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR ENSCPOP00000001881/1-1217 EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR XP_004852126.1/1-1211 EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR ENSMUSP00000106754/1-1213 EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR ENSRNOP00000015775/1-1191 EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR ************************************************************ ENSP00000304226/1-1215 PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL ENSCPOP00000001881/1-1217 PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL XP_004852126.1/1-1211 PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL ENSMUSP00000106754/1-1213 PVLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL ENSRNOP00000015775/1-1191 PVLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL *:********************************************************** ENSP00000304226/1-1215 QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE ENSCPOP00000001881/1-1217 QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE XP_004852126.1/1-1211 QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE ENSMUSP00000106754/1-1213 QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE ENSRNOP00000015775/1-1191 QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE ************************************************************ ENSP00000304226/1-1215 QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV ENSCPOP00000001881/1-1217 QLLNVGTKSTRFFCRETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDIAHVNTV XP_004852126.1/1-1211 QLLNVGTKSTRFFCRETDMSHPGWRLKTLEEHEAETGMKSKEARKYIFNSLDDIAHVNTV ENSMUSP00000106754/1-1213 QLLNVGTKSTRFFCRETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDIVHVNTV ENSRNOP00000015775/1-1191 QLLNVGTKSTRFFCRETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDIVHVNTV **************:******.*******************************:.***** ENSP00000304226/1-1215 MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK ENSCPOP00000001881/1-1217 MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPVETLNHPFVNMKHLLDFPHSNHVK XP_004852126.1/1-1211 MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK ENSMUSP00000106754/1-1213 MDLEGGDLLAEKADRREFVNLLKKMLLIDADLRITPIETLNHPFVNMKHLLDFPHSNHVK ENSRNOP00000015775/1-1191 MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPIETLNHPFVSMKHLLDFPHSSHVK *****.*************.**************** ********.**********.*** ENSP00000304226/1-1215 SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRS-QALTTSAHS ENSCPOP00000001881/1-1217 SCFHIMDICKSHPNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQQALTTSAHS XP_004852126.1/1-1211 SCFHIMDICKSHPNSCDTNNHNKTSLLRPVASSGTTTLTANFTKIGTLRS-QALTTSAHS ENSMUSP00000106754/1-1213 SCFHIMDICKS-PSSCETNNHSKMSLLRPVASNGTAALAANFTKVGTLRS-QALTTSAHS ENSRNOP00000015775/1-1191 SCFHIMDICKS-PSSCETNNHSKMSLLRPVASNGTAALAANFTKVGTLRS-QALTTSAHS *********** .**:****.* ********..*::*:*****:***** ********* ENSP00000304226/1-1215 VVHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAP ENSCPOP00000001881/1-1217 VVHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPAAHGKPTSFSIRVDNTVPLVTQAP XP_004852126.1/1-1211 VVHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQAP ENSMUSP00000106754/1-1213 VVHHGIPLQAGTAQFGCGDAFHQTLIICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQAP ENSRNOP00000015775/1-1191 VVHHGIPLQAGTAQFGCGDAFHQTLIICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQAP *********************:***************:******:*************** ENSP00000304226/1-1215 AVQPLQIRPGVLS-QTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMI ENSCPOP00000001881/1-1217 -VQPLQIRPGVLSQQTWSGRTQQMLVPAWQQVTPMAPATATLTSEGVAGSQRLGDWGKMI XP_004852126.1/1-1211 AVQPLQIRPGVLSQQTWSGRTQQMLVPTWQQVTPMVPATATLTSEGVAGSQRLGDWGKMI ENSMUSP00000106754/1-1213 AVQPLQIRPGVLSQQTWSGRTQQMLIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWGKMI ENSRNOP00000015775/1-1191 AVQPLQIRPGVLS-QTWSGRTQQMLIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWGKMI ************ ***********:*:******:.**::*****.:***:********* ENSP00000304226/1-1215 SCSNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEW ENSCPOP00000001881/1-1217 SHSNHYNSMMPQPLLTNQITLSAPQPISVGIAHVVWPQPASTKKNKLCHNRGILVKLMEW XP_004852126.1/1-1211 SHSNHYNSVIPQPLLTNQITLSAPQPISVGIAHVVWPQPATTKKNKLCHNRGILVKLMEW ENSMUSP00000106754/1-1213 PHSNHYNSVMPPPLLTNQITLSAPQPISVGIAHVVWPQPATTKKNKLCQNRGILVRLMEW ENSRNOP00000015775/1-1191 PHSNHYNSVMPPPLLTNQITLSAPQPISVGIAHVVWPQPATTKKNKLCQNR--------- . ******::* **************:*************:***** *:** ENSP00000304226/1-1215 EPGREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCE ENSCPOP00000001881/1-1217 EPGREEINAFSWSNSLQNTNIPHSAFISPKITNGKDVEEVNCVETQDNHNSEGETRNCCE XP_004852126.1/1-1211 EPGREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCVETQDNHNSEGETRNCCE ENSMUSP00000106754/1-1213 EPGREEINAFRWSNSLQNTNIPHSAFISPKIISGKEVEEVSCVDTQDNHTSEGEAGTCRE ENSRNOP00000015775/1-1191 ------------SNSLQNTNVPHSAFISPKIISGKEVEEVSCVETQDNHTSEGEARTCHE ********:********** .**:****.*::****:.****: .* * ENSP00000304226/1-1215 TSIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQ-RHSLRECKGSLDCE ENSCPOP00000001881/1-1217 SSIRQDSESSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSSLRHSLRECKGSLDCE XP_004852126.1/1-1211 ASIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSP-RHSLRECKGSLDCE ENSMUSP00000106754/1-1213 ASVRQD--SSVSDKQRQTIIIADSPSPAVSVITISSDSDDEETSP-RPSLRECKGSLDCE ENSRNOP00000015775/1-1191 ASVRQD--SSVSDKQRQTIIIADSPSPAVSVITISSDTDDEETSP-RPSLRECKGSLDCE :*:*** *****************************:*:**** * ************ ENSP00000304226/1-1215 ACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDS ENSCPOP00000001881/1-1217 ACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESGCDTVDGSPTSDS XP_004852126.1/1-1211 ACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESGCDTVDGSPTSES ENSMUSP00000106754/1-1213 ACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDDEQESGCETVDGSPTSDS ENSRNOP00000015775/1-1191 ACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDDEQESGCETVDGSPTSDS ******************************************:****.*:********:* ENSP00000304226/1-1215 SGHDSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSI ENSCPOP00000001881/1-1217 SGHDSPFAESSFVEDSHQNTELVTSADTETKPAVCTVVVPPMGIENGLNADEHMANTDST XP_004852126.1/1-1211 SGHDSPFAESSFVEDTHQNTELVTSADTETKPAVCTVVVPPMGIENGLNADEHMANIDSS ENSMUSP00000106754/1-1213 SGHDSPFAENSFVEDAHQNTELGTCAGPEAKPAVGTAVEPPVGRESGLSVDEHMANTDST ENSRNOP00000015775/1-1191 SGHDSPFAESSFVEDTPQNPELGTCAGTEAKPALSTAVEPPVGTERGLNVDAHMANTDST *********.:****: :*.** :.*..*:***: :.* **: * **..* **** ** ENSP00000304226/1-1215 CQPLIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQ ENSCPOP00000001881/1-1217 CQPLIKGRSAPGRLHQPSAVGNRQQKLPSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQ XP_004852126.1/1-1211 CQPLIKGRSAPGRLHQPSAAGNRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQ ENSMUSP00000106754/1-1213 CQPLRKGQPAPGKLHQPPALGARQQKPAAAFPQQHLNLSQVQHFGTGHQEWNGNFGHRRQ ENSRNOP00000015775/1-1191 CQPLTKGQPAPGKLNQPSASAARQQKPTSAFQQQHLNLSQVQHFGTGHQEWNGNLGHRRQ **** **:.***:*:**.* . **** .:** *****:*******:********:***** ENSP00000304226/1-1215 QAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLL ENSCPOP00000001881/1-1217 QAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLL XP_004852126.1/1-1211 QAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGSTHLGGQPTLLPYP-----SSAAPVAHLL ENSMUSP00000106754/1-1213 QAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGSTHLGGQPTLLPYPSSASLSSAAPVAHLL ENSRNOP00000015775/1-1191 QAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGSAHLGGQPTLLPYPPSTALSSAAPVAHLL *******************************.:************ ********** ENSP00000304226/1-1215 ASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASP ENSCPOP00000001881/1-1217 ASPCTSRPMLQHPTYNISHPSGIVHQVPVGINPRLLPSPTIHQTQYKPIFPPHSYIAASP XP_004852126.1/1-1211 ASPCTSRPMLQHPTYNISHPSGIVHQVPVGINPRLLPSPTIHQTQYKPIFPPHSYIAASP ENSMUSP00000106754/1-1213 ASPCTSRPMLQHPTYNISHPSGIVHQVPVGINPRLLPSPTIHQTQYKPIFPPHSYIAASP ENSRNOP00000015775/1-1191 ASPCTSRPMLQHPTYNISHPSGIVHQVPVGINPRLLPSPTIHQTQYKPIFPPHSYIAASP ******************************:***************************** ENSP00000304226/1-1215 AYTGFPLSPTKLSQYPYM ENSCPOP00000001881/1-1217 AYTGFPLSPTKLSQYPYM XP_004852126.1/1-1211 AYTGFPLSPTKLSQYPYL ENSMUSP00000106754/1-1213 AYTGFPLSPTKLSQYPYM ENSRNOP00000015775/1-1191 AYTGFPLSPTKLSQYPYM *****************: