CLUSTAL W(1.81) multiple sequence alignment ENSP00000262794/1-1211 MLSLAAKLVAFFWRTADTPREEAGQLEPELAEGDTKLKTVRGVVTRYCSDYGMIDDMIYF ENSMUSP00000118437/1-1239 MLRLAAKLVSFFWRKEDIPEEEVGQPGRELSEGDTRLKTVQGVVTRYCSDYGMIDDLIYF ENSRNOP00000039486/1-1239 MLRLAAKLVSFFWRREDIPEEEVGQPRQELSEGDTRLKTVQGVVTRYCSDYGMIDDLIYF ENSCPOP00000001821/1-1185 MLRLAAKLVAFFWRREDASEEKDRSSGQELVEGDTRLKTVQGVVTRYCSDYGMIDDLIYF XP_004845408.1/1-1186 MLRLAAKLVSFFWRREDAREEEARHPGEKLVEGDTRLKTIQGVVTRYCSDYGMIDDLIYF ** ******:**** * .*: :* ****:***::***************:*** ENSP00000262794/1-1211 SSDAVTSRVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWEDDSRNHGSP-SDCGPRV ENSMUSP00000118437/1-1239 SNDAVTSKVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWEDDSKNSSKGLSDSSPRV ENSRNOP00000039486/1-1239 SNDAVTSKVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWEDDNRNSSKGLSDSSPRV ENSCPOP00000001821/1-1185 SSEAVTGSVVLNVGQEVVALVEENKVSNGLKAIRVEAISDKWEDDSKNHGRELTDSRPRV XP_004845408.1/1-1186 SNEAVTGNVVLNVGQEVIALVEENKVSNGLKAIRVEAVSDKWEDDSKDNGRQLTGSSPRV *.:***. *:*******:*:*****************:*******.:: . :.. *** ENSP00000262794/1-1211 LIGCVTSLVEGAGCISQTTYFSLESVCEGFEPCKGDWVEAEYRIRPGTWSSEATSVKPLR ENSMUSP00000118437/1-1239 LIGCVTSMLEGAGYISQTTYFSLESVCEGFHPCKGDWVEAEYWIRPGTWSSEAISVKPLR ENSRNOP00000039486/1-1239 LIGCVTSMLEGAGYISQTTYFSLESVCEGFHPCKGDWVEAEYWIRPGTWSSEAISVKPLR ENSCPOP00000001821/1-1185 LIGCVTSLMKGAGYINQTTYFSLENVCEGFQPCKGDWVEAEYRIRPGTWSSEAITVKPLR XP_004845408.1/1-1186 LIGCVTSLMEGAGYINQTTYFSLENVCKGFQPCKGDWVEAEYWIRPGSWNSEALTVKPLR *******:::*** *.********.**:**.*********** ****:*.*** :***** ENSP00000262794/1-1211 YKRVDKVCISSLCGRNGVLEESIFFTLDSLKLPDGYTPRRGDVVNAVVVESSQSCYVWRA ENSMUSP00000118437/1-1239 YKRVDKVCISSLCGRNGVIEDSIFFSLDSLKLPEGYIPRRHDIVNAVVVESSQSCYIWRA ENSRNOP00000039486/1-1239 YKRVDKVCISSLCGRNGVIEDSIFFSLDSLKLPEGYTPRRHDIVNAVVVESSQSCYIWRA ENSCPOP00000001821/1-1185 YKRVDKVCISSLCGRNGVIEDSIFFSLDSLKLPKGYTPRRHDIVNTVVVESSQSCYVWRA XP_004845408.1/1-1186 YKRVDQVCISSLCGRNGVIEDSIFFSLDSLKLPEGYAPRRYDIVNAMVVESSQSCYIWRA *****:************:*:****:*******.** *** *:**::*********:*** ENSP00000262794/1-1211 LCMTLVKR-RDAAPVHEATH-FYGTILLKNKGDIEVTQVTHFGTLKEGRSKTMVIWIENK ENSMUSP00000118437/1-1239 LCMTPVK--RD-ATLGEAPQEPYGALLLKNKGDIEVTRMTSFGTLKEGESKSIVIWIENK ENSRNOP00000039486/1-1239 LCMTPVK--RE-AIIGEAPQEPYGALLLKNKGDVEVTRTTSFGTLKEGESKAVVIWIENK ENSCPOP00000001821/1-1185 LCITPVRSFRDSATGGEAPREACGTHLLKNKGGVEVTRMTDFGTLKEGGSKTMVIWIENK XP_004845408.1/1-1186 LCITPVR--RDSASVGEAPEESYGTHLLKNKGGIEVTRMTHFGTLKEGGSKTMVIWIENK **:* *: *: * **.. *: ******.:***: * ******* **::******* ENSP00000262794/1-1211 GDIPQNLVSCKLAGWDKSKQFRFQMLDKDQMCPVVSFVSVPE-KENSSDENINSLNSHTK ENSMUSP00000118437/1-1239 GKVSRELVSCRLANWDKAHQFRFETQGRSKSCPGAAAGSVPE------GENVNSLNHHRE ENSRNOP00000039486/1-1239 GEISQDLVSCRLAGWDKAHQFRFEAQGRGQACAGVAAVAVSE------GENVNSLNHHRE ENSCPOP00000001821/1-1185 GDVPQDLISCKLAGWDRTQQFRFQRPDLGQACPAAS--SVPEEKQIFSDENVNSLNIDNK XP_004845408.1/1-1186 GDIPQDLISCKLAGWDRAQQFGFQTADVGQAYPEASFVSIPEKKQLFSDENFNSLNSDRK *.:.::*:**:**.**:::** *: . .: . .: ::.* .**.**** . : ENSP00000262794/1-1211 NKTSQMSESSLVNNRGISPGDCTCKGENGEKDNILSRKQMTEPEPGGLVPPGGKTFIVVI ENSMUSP00000118437/1-1239 DKTDEIPESRLANSTEISPDGCACKEESREKGNTPEKQ---EPEPGGLIPPGEKTHIVVT ENSRNOP00000039486/1-1239 DKPDPIPESSLENNTEISPDGCACTEESREKGDTAEKQ---EPEPGGLIPPGEKTSIVVT ENSCPOP00000001821/1-1185 NKTSETLESRVMNNVEDCADDCDYEARSSEKENTPSEKQEAEPKPGGLLPPGGRTFIAVT XP_004845408.1/1-1186 NKTKERLEGRLVNNIEDSPDDCAYEGKSPEKENTPSQKQLTDPKPGGPLPPGGRTFIVVT :*.. *. : *. ....* .. ** : ..: :*:*** :*** :* *.* ENSP00000262794/1-1211 CDGKNPGRCKELLLLCFSDFLIGRYLEVNVISGEESLIAAREPFSWKKLKSSQALTSAKT ENSMUSP00000118437/1-1239 CSAKNPGRCKELLLLCFSDFLIGRHLEVSVVSSEEALIAVREPFSWKKPKSSQTLVSAKT ENSRNOP00000039486/1-1239 CNAKNPGRCKELLLLCFSNFLIGRHLEVNVVSSEEALIAVREPFSWKKPKSSQTIVSAKT ENSCPOP00000001821/1-1185 CNARTSGRCKELLLFCFSNFLIGRYLEVTVVSVEEALIAVREPFSWKKPRSSQAVPSHKT XP_004845408.1/1-1186 CDARTSGRCKELLLLCFSDFVIGRFLEVTVVSGEEALIAVREPFSWKKPRSSQAVTATKT *..:..********:***:*:***.***.*:* **:***.******** :***:: : ** ENSP00000262794/1-1211 TVVVTAQKRNSRRQLPSFLPQYPIPDRLRKCVEQKIDILTFQPLLAELLNMSNYKEKFST ENSMUSP00000118437/1-1239 TVVVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILTFQPLLAELLNMSNYKEKFST ENSRNOP00000039486/1-1239 TVVVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILTFQPLLAELLNMSNYKEKFST ENSCPOP00000001821/1-1185 T-VVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILTFQPLLAELLNMSNYKEKFST XP_004845408.1/1-1186 T-VVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILTFQPLLAELLNMSNYKEKFST * ***:**********************:******************************* ENSP00000262794/1-1211 LLWLEEIYAEMELKEYNMSGIILRRNGDLLVLEVPGLAEGRPSLYAGDKLILKTQEYNGH ENSMUSP00000118437/1-1239 LLWLEEIHAEIELKEYNMSRVVLKRKGDLLVLEVPGLAESRPSLYAGDKLILKSQEYNGH ENSRNOP00000039486/1-1239 LLWLEEIHAEIELKEYNMSGVVLKRKGELLVLEVPGLAESRPSLYAGDKLILKSQEYNGH ENSCPOP00000001821/1-1185 LLWLEEIHAEMELKDYSMSGVTLKRNGDLLVLEVPGLAESRPSLYTGDKLILKTQEYNGH XP_004845408.1/1-1186 LLWLEEIHAEMELKDYSMSGVTLKRNGDLLVLEVPGLAESRPSLYTGDKLILKSQEYNGH *******:**:***:*.** : *:*:*:***********.*****:*******:****** ENSP00000262794/1-1211 AIEYISYVTEIHEEDVTLKINPEFEQAYNFEPMDVEFTYNRTTSRRCHFALEHVIHLGVK ENSMUSP00000118437/1-1239 VIEYIGYVMEIHEEDVTLKLNPGFEQMYNFEPMDVEFTYNRTTSRRCHYALEQVIHLGVK ENSRNOP00000039486/1-1239 VIEYIGYVMEIHEEDVTLKLNPGFEQMYNFEPMDVEFTYNRTTSRRCHYALEQVIHLGVK ENSCPOP00000001821/1-1185 VVEYIGYVMEIHEEDVTLKLNTEFEQTYNSEPMDVEFTYNRTTSRRCHFALEQAIHLGVK XP_004845408.1/1-1186 VVEYISYVMEIHEEDVTLKLNTEFEQAYNSEPMDVEFTYNRTTSRRCHFALEQAIHLGVK .:***.** **********:*. *** ** ******************:***:.****** ENSP00000262794/1-1211 VLFPEEIILQSPQVTGNWNHAQDTKSSGQSTSK--------------------------- ENSMUSP00000118437/1-1239 VLFPEEIILQSPQVTGNWSLAQDTKNDGQSITNITRNDGQSMTKVTRNDSQSITNIIRND ENSRNOP00000039486/1-1239 VLFPEEIILQSPQVTGNWSLAQDTKNDGQSITNITKNDGQSITKVTKNDGQSITNITKND ENSCPOP00000001821/1-1185 VLFPEEVILQSPQVTDNWNHAQQIKSDEQSITK--------------------------- XP_004845408.1/1-1186 VLFPEEVILQSPQVTGSWSHAQHTKSDEQFTTK--------------------------- ******:********..*. **. *.. * :: ENSP00000262794/1-1211 --------------------------------------KNRKTMTDQAEHGTEERRVGDK ENSMUSP00000118437/1-1239 GQSITNVTRNDGQPITKVTRNNSQSITNITRNDGQPITKNKKTVKDQTKHTTEERHVGTT ENSRNOP00000039486/1-1239 GQSITSITKNGGQSINKVTRNDGQSITNITRNDGQSITKNKKTVKDQTKNTTKERHLSTT ENSCPOP00000001821/1-1185 --------------------------------------KNIKTIKNQTRHSTKERSSGTK XP_004845408.1/1-1186 --------------------------------------VNRKTTKDQIRHSTKEKSVGAK * ** .:* .: *:*: . . ENSP00000262794/1-1211 DLPVLAPFTAEMSDWVDEIQTPKARKMEFFNPVLNENQKLAVKRILSGDCRPLPYILFGP ENSMUSP00000118437/1-1239 DQPEKASSTAET---MDEIQIPKARDKEFFNPVLNENQKLAVRRILSGDCRPLPYILFGP ENSRNOP00000039486/1-1239 DQPEKTASTAET---MDEIQIPRARDKEFFNPVLNENQKLAVRRILSGDCRPLPYILFGP ENSCPOP00000001821/1-1185 DLPGTVTAAAEMSDSVDEAHTPKGRDAEFFNVLLNENQKLAVRRILSGDCRPLPYILFGP XP_004845408.1/1-1186 DLPRMVTSTAEISDLVDETHTPKARDTEFFNPLLNENQKLAVRRILSGDCRPLPYILFGP * * .. :** :** : *:.*. **** :*********:***************** ENSP00000262794/1-1211 PGTGKTVTIIEAVLQVHFALPDSRILVCAPSNSAADLVCLRLHESKVLQPATMVRVNATC ENSMUSP00000118437/1-1239 PGTGKTVTIIEAVLQVHYALPDSRILVCAPSNSAADLVCLRLHESKVLKPAAMVRVNATC ENSRNOP00000039486/1-1239 PGTGKTVTIIEAVLQVHYALPDSRILVCAPSNSAADLVCLRLHESKVLKPAAMVRVNATC ENSCPOP00000001821/1-1185 PGTGKTMTIIEAVLQVHHALQDSRILVCAPSNSAADLVCLRLHESRVLRPASMVRVNATC XP_004845408.1/1-1186 PGTGKTMTIIEAVLQVHHALQDSRILVCAPSNSAADLVCLRLHESKVLRPASMVRVNATC ******:**********.** ************************:**:**:******** ENSP00000262794/1-1211 RFEEIVIDAVKPYCRDGEDIWKASRFRIIITTCSSSGLFYQIGVRVGHFTHVFVDEAGQA ENSMUSP00000118437/1-1239 RFEETIIDAIKPYCRDGEDIWRASRFRIIITTCSSAGLFYQIGVRVGYFTHVFVDEAGQA ENSRNOP00000039486/1-1239 RFEETIIEAIKPYCRDGEDIWRASRFRIIITTCSSAGLFYQIGVRVGYFTHVFVDEAGQA ENSCPOP00000001821/1-1185 RFEETIIDAIKPYCRDGEDIWRASRFRIIITTCSSAGLFYQIGVRVGHFTHVFVDEAGQA XP_004845408.1/1-1186 RFEETIIDAVKPYCTDGEDIWRASRFRIIITTCSSAGLFYQIGVRVGHFTHVFVDEAGQA **** :*:*:**** ******:*************:***********:************ ENSP00000262794/1-1211 SEPECLIPLGLMSDISGQIVLAGDPMQLGPVIKSRLAMAYGLNVSFLERLMSRPAYQRDE ENSMUSP00000118437/1-1239 SEPECLIPLGLISDINGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLMSRPAYLRDE ENSRNOP00000039486/1-1239 SEPECLIPLGLISDINGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLMSRPAYLRDE ENSCPOP00000001821/1-1185 SEPECLIPLGLISDVSGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLMLRPVYQRDE XP_004845408.1/1-1186 SEPECLIPLGLISDVSGQIVLAGDPMQLGPVIKSRLAMAFGLNMSMLERLMSRAVYLRDE ***********:**:.***********************:***:*:***** *..* *** ENSP00000262794/1-1211 NAFGACGAHNPLLVTKLVKNYRSHEALLMLPSRLFYHRELEVCADPTVVTSLLGWEKLPK ENSMUSP00000118437/1-1239 NAFGACGAYNPLLVTKLVKNYRSHSALLALPSRLFYHRELEVCADPKVVTSLLGWEKLPR ENSRNOP00000039486/1-1239 NAFGACGAYNPLLVTKLVKNYRSHSALLALPSRLFYHRELEVCADPKVVTSLLGWEKLPR ENSCPOP00000001821/1-1185 HAFGACGAYNPLLVTKLVKNYRSHSALLALPSRLFYHKELEVCADPKVVTLLLGWEKLPK XP_004845408.1/1-1186 NAFGACGAYNPLLVTKLVKNYRSHSALLALPSRLFYHRELEVCADSKVVTSLLGWEKLPK :*******:***************.*** ********:*******..*** ********: ENSP00000262794/1-1211 KGFPLIFHGVRGSEAREGKSPSWFNPAEAVQVLRYCCLLAHSISSQVSASDIGVITPYRK ENSMUSP00000118437/1-1239 KGFPLIFHGVRGNEAREGRSPSWFSPAEAVQVMRYCCLLARSVSSQVSSKDIGVITPYRK ENSRNOP00000039486/1-1239 KGFPLIFHGVRGNEAREGRSPSWFSPAEAVQVMRYCCLLARNVSSQVSSKDIGVITPYRK ENSCPOP00000001821/1-1185 KGFPLVFHGVRGMEAREGRSPSWFNPAEAVQVMRYCCLLANSMSSQVSSRDIGVITPYRK XP_004845408.1/1-1186 KGFPLIFHGVRGSEAREGRSPSWFNPAEAVQVMRYCCLLAQSMSNQVSAKDIGVITPYRK *****:****** *****:*****.*******:*******..:*.***: ********** ENSP00000262794/1-1211 QVEKIRILLRNVDLMDIKVGSVEEFQGQEYLVIIISTVRSNEDRFEDDRYFLGFLSNSKR ENSMUSP00000118437/1-1239 QVEKIKILLRNVDLTDIKVGSVEEFQGQEYLVIVISTVRSNEDRFEDDRYFLGFLSNSKR ENSRNOP00000039486/1-1239 QVEKIKILLRNVDLTDIKVGSVEEFQGQEYLVIVISTVRSNEDRFEDDRYFLGFLSNSKR ENSCPOP00000001821/1-1185 QVEKIKILLQNVDLMDIKVGSVEEFQGQEYLVIIISTVRSSEDRFEDDRYFLGFLSNSKR XP_004845408.1/1-1186 QVEKIKILLRNVDLMDIKVGSVEEFQGQEYLVIIISTVRSSEDRFEDDRYFLGFLSNSKR *****:***:**** ******************:******.******************* ENSP00000262794/1-1211 FNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYMGCDLPPALQSLQNCGEGVA ENSMUSP00000118437/1-1239 FNVAITRPKALLIILGNPHVLVRDPCFGALLEYSVSNGVYTGCDLPPELQALQK------ ENSRNOP00000039486/1-1239 FNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSVTNGVYTGCDLPPELQALQK------ ENSCPOP00000001821/1-1185 FNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYTGCDLPPELQALQ------- XP_004845408.1/1-1186 FNVAITRPKALLIVLGNPHVLIRDPCFGALLEYSVANGVYTGCDLPPELQALQK------ *************:*******:************::**** ****** **:** ENSP00000262794/1-1211 DPSYPVVPESTGPEKHQEPS ENSMUSP00000118437/1-1239 -------------------- ENSRNOP00000039486/1-1239 -------------------- ENSCPOP00000001821/1-1185 -------------------- XP_004845408.1/1-1186 --------------------