CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000001810/1-1138 ------------------------------------------------------------ ENSMUSP00000105191/1-1231 MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQP ENSRNOP00000012131/1-1227 MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQP ENSP00000263991/1-1231 MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQP XP_004850046.1/1-1192 MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQP ENSCPOP00000001810/1-1138 ------------------------------DDRERKLWTGMMSQESLSGRRKALATSCIN ENSMUSP00000105191/1-1231 GIKNPYRGVVVWPVPENIEITVTLFKDPHAEEFEDKEWTFVIENESPSGRRKALATSSIN ENSRNOP00000012131/1-1227 GIKNPYRGVVVWPVPENIEITVTLFKDPHAEEFEDKEWTFVIENESPSGRRKALATSNIN ENSP00000263991/1-1231 GIKNPYRGVVVWPVPENIEITVTLFKDPHAEEFEDKEWTFVIENESPSGRRKALATSSIN XP_004850046.1/1-1192 GIKNPYRGVVVWPVPENIEITVTLFKDPHAEEFEDKEWTFVIENESPSGRRKALATSSIN :: * * ** ::.:** ********** ** ENSCPOP00000001810/1-1138 MKQYASPMPTQTDVKLKFKPLSKKVVSATLQFSLSCIFLREGKATSEDELTLVNLQGLKY ENSMUSP00000105191/1-1231 MKQYASPMPTQTDVKLKFKPLSKKVVSATLQFSLSCIFLREGKATDEDMQSLASLMSMKQ ENSRNOP00000012131/1-1227 MKQYASPMPTQTDVKLKLKPLSKKVVSATLQFSLSCIFLREGKATDEDMQSLASLMSMKQ ENSP00000263991/1-1231 MKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMSMKQ XP_004850046.1/1-1192 MKQYASPMPTQTDVKLKFKPLSKKVVSATLQFSLSCIFLREGKATDEDMQSLASLMSMKQ *****************:**********:****************.** :*..* .:* ENSCPOP00000001810/1-1138 EEIKHCEEFKKNNQIEHISLIEKNKSAARFIEIVNQLNALSSLDEDQDDCIKQANMPSAK ENSMUSP00000105191/1-1231 ADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANVPSAK ENSRNOP00000012131/1-1227 ADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDHDDCVKQAAMPSAK ENSP00000263991/1-1231 ADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMRSAK XP_004850046.1/1-1192 ADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMPSAK :* : ::*:::*: :. . :::::.**:: ***************:***:*** : *** ENSCPOP00000001810/1-1138 SASSSEELISKLNFLDEAEKDLATVNSNPFDDPDVSELNPFGDPDAEEPITETALVKKTE ENSMUSP00000105191/1-1231 SASSSEELINTLNFLDEAQKDLATVNTNPFDEPDVTELNPFGDPDSEEPITETTSPKKPE ENSRNOP00000012131/1-1227 SASSSEELINTLNFLDEAQKDLATVNTNPFDEPDVTELNPFGDPDSEESITETSSPRKAE ENSP00000263991/1-1231 SASSSEELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTE XP_004850046.1/1-1192 SASSSEELISKLNFLDEAEKDLATVNSNPFDEPDVPELNPFGDPDLEEPITETALPKKAE *********..*******:*******:****:**..********* **.****: :*.* ENSCPOP00000001810/1-1138 ESFYNDSYNPFKDVHTPQYLNPFDEPEAFVTMKESPPQSTKRKNIRPVDMSKYLYADSSK ENSMUSP00000105191/1-1231 ESFYNNSCNPFKGVQTPQYLNPFDEPETFVMIKDSPPQSTRRKNLRPVDMSKYLYADSSK ENSRNOP00000012131/1-1227 ESFYNNSCNPFKGVQTPQHLNPLDEPETFVMIKDSPPQSTRRRNPRPVDMSKYLYADSSK ENSP00000263991/1-1231 DSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSK XP_004850046.1/1-1192 DSFYN-SYNPFKDVHTPQYLNPFGEPETFVTVKESPPQCAKRKNIRPVDMSKYLYADSSK :**** * **** *:***:***:.***:** :*:****.::*:* *************** ENSCPOP00000001810/1-1138 T-EEELDESNPFYEPKPTLPTNNLLNPVQELETEKRVKRKAPAPP------------VLS ENSMUSP00000105191/1-1231 S-EEELDESNPFYEPKPTSP-NNLVNTVQEGETERRVKRRAPAPPAPLAPPAPPAPPALT ENSRNOP00000012131/1-1227 S-EEELDESNPFYEPKPTSP-NNLVNTVQEGETERRVKRRAPAPP---VPPAPPALPALA ENSP00000263991/1-1231 TEEEELDESNPFYEPKSTPPPNNLVNPVQELETERRVKRKAPAPP------------VLS XP_004850046.1/1-1192 T-EEELDESNPFYEPKPTLPVNNLVNSVQELETERKMKRKAPAPP------------VLS : **************.* * ***:*.*** ***:::**:***** .*: ENSCPOP00000001810/1-1138 PKTGGVNENTVLSAGRDLSTSPKLSPIPSPVLRRKPNASQSLLVWCKEVTKNYRGVKITN ENSMUSP00000105191/1-1231 PKTG-VNENTVVSAGKDLSTSPKPSPIPSPVLGQKPNASQSLLAWCREVTKNYRGVKITN ENSRNOP00000012131/1-1227 PKT---NESTVVSAGKDLSTSPKPSPIPSPVLGQKPNASQSLLAWCKEVTKNYRGVKITN ENSP00000263991/1-1231 PKTGVLNENTV-SAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKEVTKNYRGVKITN XP_004850046.1/1-1192 PKTGGVKESTVVSTGRDLSTSPKPSPIPSPILGQKPNASQSLLVWCKEVTKNYRGVKITN *** :*.** *:*:******* ******:* :*********.**:************* ENSCPOP00000001810/1-1138 FTTSWRNGLAFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVL ENSMUSP00000105191/1-1231 FTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVL ENSRNOP00000012131/1-1227 FTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVL ENSP00000263991/1-1231 FTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVL XP_004850046.1/1-1192 FTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVL *********:************************************************** ENSCPOP00000001810/1-1138 LAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAE ENSMUSP00000105191/1-1231 LAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAE ENSRNOP00000012131/1-1227 LAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAE ENSP00000263991/1-1231 LAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAE XP_004850046.1/1-1192 LAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAE ************************************************************ ENSCPOP00000001810/1-1138 LSDLKREPELQAPTSGAVDFL-SQDDSVFVNDSGVGESESEHQTPDDHLSPSIASPYYRR ENSMUSP00000105191/1-1231 LSDLKREPEPHQPARGAVDLL-SQDDSVFVTDSGVGESESEHQTPDDHLSPSTASPYYRR ENSRNOP00000012131/1-1227 LSDLK--PASQQPASGAVDLL-SQDDSVFVTDSGVGESESERQTPDDHLSPSTASPYCRR ENSP00000263991/1-1231 LSDLKREPELQQPISGAVDFL-SQDDSVFVNDSGVGESESEHQTPDDHLSPSTASPYCRR XP_004850046.1/1-1192 LSDLKQEPELQQPTSGAVDFLSSQEDSVFVNDSGVGESESEHQTPDDHLSPSTASPYCRR ***** * : * ****:* **:*****.**********:********** **** ** ENSCPOP00000001810/1-1138 TKSDTEPQKSQQSSGRTSGSDDTGICSNTESFQAQVLLGKKRVLKAETLELSDLYVSGKK ENSMUSP00000105191/1-1231 TKSDTEPQKSQQSSARTSGSDDPGLSSSTDSAQALASLGKKR-LKAENLELSDLCVSDKK ENSRNOP00000012131/1-1227 TKSDTEPQKSQQSSGRTSGSDDPGLSSSTDSAQALILLGKKRLPKAEDLELRDLYVSGKK ENSP00000263991/1-1231 TKSDTEPQKSQQSSGRTSGSDDPGICSNTDSTQAQVLLGKKRLLKAETLELSDLYVSDKK XP_004850046.1/1-1192 TKSDTEPQKFQQSSGRTSGSNEPGVCSNTESVQAQALLSNKRVLKAETLELNDLYVSDKK ********* ****.*****::.*:.*.*:* ** *.:** *** *** ** **.** ENSCPOP00000001810/1-1138 KEESLSFVCEETDQQKLPTLN-CSNLQEEKLENSRPLECRSDAESPI-KTSLSPTSKPGY ENSMUSP00000105191/1-1231 KDVSPLSAYE----QKLQTVHASSDMEQGKMEKSRSLECRLDGELAITKPNVSSPSKLGY ENSRNOP00000012131/1-1227 KDVSLPSTYE----QKLQPVNPRSDVEQEKIENSRSLECRLDGELAIQKPRLSPPSKLGY ENSP00000263991/1-1231 KDMSPPFICEETDEQKLQTLDIGSNLEKEKLENSRSLECRSDPESPIKKTSLSPTSKLGY XP_004850046.1/1-1192 KEESPSCICEETDQQKLQILN-SSDLEEEKLENSKPLECKSEAESPIKKTSLSPTSKPGY *: * * *** :. *:::: *:*:*:.***: : * .* *. :*..** ** ENSCPOP00000001810/1-1138 SYNRDADLAKKIPTSLRQMESDPDAEKTTLNHADHSTKTVQHRMLSRQEELKERARVLLE ENSMUSP00000105191/1-1231 --NRDTDFTKKPCASLRQIESDPDADKSTLNHADHPNKAVQHRMLSRQEELKERARVLLE ENSRNOP00000012131/1-1227 SYNRDTDFTNKPCASLRQIESDPDADKSTLNHADHASKPVQHRMLSRQEELKERARVLLE ENSP00000263991/1-1231 SYSRDLDLAKKKHASLRQTESDPDADRTTLNHADHSSKIVQHRLLSRQEELKERARVLLE XP_004850046.1/1-1192 SCSRDADLAKKTHTSLRQTESDPDADRTTLNHTDHSAKTVQHRMLSRQEELKERARVLLE .** *:::* :**** ******:::****:**. * ****:**************** ENSCPOP00000001810/1-1138 QARRDAALKAGNKQNTGAAAPLCGGQISDQQDEERRRQLRERARQLIAEARSGVKMSELP ENSMUSP00000105191/1-1231 QARRDAAFKVGSKHGGSAAPALCSRQLNDQQDEERRRQLRERARQLIAEARCGVKMSELP ENSRNOP00000012131/1-1227 QARRDAAFKAGSKHGGSTAPALCSRQLNDRQDEERRRQLRERARQLIAEARCGVKMSELP ENSP00000263991/1-1231 QARRDAALKAGNKHNTNTATPFCNRQLSDQQDEERRRQLRERARQLIAEARSGVKMSELP XP_004850046.1/1-1192 QARRDAALKAGNKQNTNTATPLCNRQISDQQDEERRRQLRERARQLIAEARSGVKMSELP *******:*.*.*:. .:*..:*. *:.*:*********************.******** ENSCPOP00000001810/1-1138 SYGEMAAEKLKERSKASGDENDNIEIDTNEEIAEGFVVGGGDELTNLENDLDTPEQNSKL ENSMUSP00000105191/1-1231 SYGEMAAEKLKERSKASGDENDNIEIDTNEEIPEGFVVGGGDELTNIESDLDNPEQNSKV ENSRNOP00000012131/1-1227 SYGEMAAEKLKERSKASGDENDNIEIDTNEESPEGFVVGGGDELTNIESDLDTPEQNSKL ENSP00000263991/1-1231 SYGEMAAEKLKERSKASGDENDNIEIDTNEEIPEGFVVGGGDELTNLENDLDTPEQNSKL XP_004850046.1/1-1192 SYGEMAAEKLKERSKASG------------------------------------EQNSKL ****************** *****: ENSCPOP00000001810/1-1138 MDLKLKKFLEAQPQVA--LSGASQKAVAESSEQDIKNGTEDLRTERLQKATEGFRNPVVF ENSMUSP00000105191/1-1231 VDLRLKKLLEAQPQVANLLPSAAQKAVTEASEQGEKSGVEDLRTERLQKATERFRNPVVF ENSRNOP00000012131/1-1227 VDLRLKKLLDAQPQVANSLSSAAQKAATDTSEQGEKNGMEDLRTERLQKATERFRNPVVF ENSP00000263991/1-1231 VDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDMKSGTEDLRTERLQKTTERFRNPVVF XP_004850046.1/1-1192 MDLKLKKFLEAQPQVA--LSGTAQKAVAESSEQDIKNGTEDLRTERLQKATEGFRNPVVF :**:***:*:.***** ..::***.:::***. *.* **********:** ******* ENSCPOP00000001810/1-1138 SKDSTVRKTQLQSFSQYVENRPEEMKRQRSIQEDTKKGNEEKAAITETQRKPSEDEVLNK ENSMUSP00000105191/1-1231 NKDSTVRKTQLQSFSQYVENRP-EMKRQRSIQEDTKRGTEEKAEITETQRKPSEDE---K ENSRNOP00000012131/1-1227 NKDSTVRKTQLQSFSQYVENRP-EMKRQRSIQEDTERGDEEKAMITEAQRKPSEDE---K ENSP00000263991/1-1231 SKDSTVRKTQLQSFSQYIENRP-EMKRQRSIQEDTKKGNEEKAAITETQRKPSEDEVLNK XP_004850046.1/1-1192 SKDSTVRKTQLQSFSQYVENRP-EMKRQRSIQEDTKKGNEEKAAITETQRKPSEDEVLNK .****************:**** ************::* **** ***:******** * ENSCPOP00000001810/1-1138 GFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNK ENSMUSP00000105191/1-1231 GFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNK ENSRNOP00000012131/1-1227 GFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNK ENSP00000263991/1-1231 GFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNK XP_004850046.1/1-1192 GFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNK ************************************************************ ENSCPOP00000001810/1-1138 KNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVAL ENSMUSP00000105191/1-1231 KNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVAL ENSRNOP00000012131/1-1227 KNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVAL ENSP00000263991/1-1231 KNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVAL XP_004850046.1/1-1192 KNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVTL **********************************************************:* ENSCPOP00000001810/1-1138 VNKRDALVRDLDAQEKQAEEEDEHLERTLEQNKGKMAKKEEKCVLQ ENSMUSP00000105191/1-1231 VDKRDALVRDLDAQEKQAEEEDEHLERTLEQNKGKMAKKEEKCALQ ENSRNOP00000012131/1-1227 VDKRDALVRDLDAQEKQAEEEDEHLERTLEQNKGKMAKKEEKCTLQ ENSP00000263991/1-1231 VNKRDALVRDLDAQEKQAEEEDEHLERTLEQNKGKMAKKEEKCVLQ XP_004850046.1/1-1192 VNKRDALVRDLDAQEKQAEEEDEHLERTLEQNKGKMAKKEEKCVLQ *:*****************************************.**