CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000001703/1-869 ----------------------MMPPPFMPPPGIPPPFPPMGLPPMSQRPPAIPPMPPGI ENSMUSP00000115869/1-873 ----------------------MMPPPFMPPPGLPPPFPPMGLPPMSQRPPAIPPMPPGI ENSRNOP00000062158/1-867 ----------------------MMPPPFMPPPGLPPPFPPMGLPPMSQRPPAIPPMPPGI ENSP00000448073/1-892 MSVPDSGPRPPAAPAPFPPGPPMMPPPFMPPPGIPPPFPPMGLPPMSQRPPAIPPMPPGI XP_004863082.1/1-890 MSVPDSGPRPPAAPAPFPPGPPMMPPPFMPPPGIPPPFPPMGLPPMSQRPPAIPPMPPGI ***********:************************** ENSCPOP00000001703/1-869 LPPMLPPMGAPPPLTQIPGMVPPMMPGMLMPAVPVTAATAPGADTTSSAVAGTGPPRALW ENSMUSP00000115869/1-873 LPPMLPPMGAPPPLTQIPGMVPPMMPGMLMPAVPVTAATAPGADTASSAVAGTGPPRALW ENSRNOP00000062158/1-867 LPPMLPPMGAPPPLTQIPGMVPPMMPGMLMPAVPVTAATAPGADTASSAVPGTGPPRALW ENSP00000448073/1-892 LPPMLPPMGAPPPLTQIPGMVPPMMPGMLMPAVPVTAATAPGADTASSAVAGTGPPRALW XP_004863082.1/1-890 LPPMLPPMGAPPPLTQIPGMVPPMMPGMLMPAVPVTAATAPGADTASSAVAGTGPPRALW *********************************************:****.********* ENSCPOP00000001703/1-869 SEHVAPDGRIYYYNADDKQSVWEKPSVLKSKAELLLSQSPWKEYKSDTGKPYYYNNQSQE ENSMUSP00000115869/1-873 SEHVAPDGRIYYYNADDKQSVWEKPSVLKSKAELLLSQCPWKEYKSDTGKPYYYNNQSQE ENSRNOP00000062158/1-867 SEHVAPDGRIYYYNADDKQSVWEKPSALKSKAELLLSQCPWKEYKSDTGKPYYYNNQSQE ENSP00000448073/1-892 SEHVAPDGRIYYYNADDKQSVWEKPSVLKSKAELLLSQCPWKEYKSDTGKPYYYNNQSKE XP_004863082.1/1-890 SEHVAPDGRIYYYNADDKQSVWEKPSVLKSKAELLLSQSPWKEYKSDTGKPYYYNNQSQE **************************.***********.*******************:* ENSCPOP00000001703/1-869 SCWTRPKDLDDLEALAKQETAGKQQ-----PQTLQPQPPQPQPDPPPVPPGPTPGPTGLL ENSMUSP00000115869/1-873 SRWTRPKDLDDLEALVKQESAGKQQTQ--QLQTLQPQPPQPQPDPPPIPPGPIPVPMALL ENSRNOP00000062158/1-867 SRWTRPKDLDDLEALVKQESAGKQQTQ--QLQTLQPQP--PQPDPPPIPPGPIPVPMALL ENSP00000448073/1-892 SRWTRPKDLDDLEVLVKQEAAGKQQQQ--LPQTLQPQPPQPQPDPPPVPPGPTPVPTGLL XP_004863082.1/1-890 SRWTRPKDLDDLEALVKQEAAGKQQPQALQPQPPQPQPPQPQPEPPPVPPGPTPGST--- * ***********.*.***:***** *. **** ***:***:**** * . ENSCPOP00000001703/1-869 EPEPDGSEDCDVSEAAQSLEQGFLQQVEEGPSSS-GQHQLPQQEEEESKPEPERSGLSWS ENSMUSP00000115869/1-873 EPEPGRSEDCDVLEAAQPLEQGFLQR-EEGPSSSTGQHRQP-QEEEEAKPEPERSGLSWS ENSRNOP00000062158/1-867 EPEPGRSEDCDVLEAAQPLEQGFLQR-EEGPSSSTGQHRLP-QEEEEAKPEPERSGLSWS ENSP00000448073/1-892 EPEPGGSEDCDVLEATQPLEQGFLQQLEEGPSSS-GQHQ-PQQEEEESKPEPERSGLSWS XP_004863082.1/1-890 --EPDGSEDCDVSEASQPLEQGFLQQVEEGPSSSAGQHHLQQQEEEESKPEPERSGLSWS **. ****** **:*.*******: ******* ***: *****:************ ENSCPOP00000001703/1-869 NREKAKQAFKELLRDKAVPSNASWEQAMKMVVTDPRYSALPKLSEKKQAFNAYKAQREKE ENSMUSP00000115869/1-873 NREKAKQAFKELLRDKAVPSNASWEQAMKMVVTDPRYSALPKLSEKKQAFNAYKAQREKE ENSRNOP00000062158/1-867 NREKAKQAFKELLRDKAVPSNASWEQAMKMVVTDPRYSALPKLSEKKQAFNAYKAQREKE ENSP00000448073/1-892 NREKAKQAFKELLRDKAVPSNASWEQAMKMVVTDPRYSALPKLSEKKQAFNAYKAQREKE XP_004863082.1/1-890 NREKAKQAFKELLRDKAVPSNASWEQAMKMVVTDPRYSALPKLSEKKQAFNAYKAQREKE ************************************************************ ENSCPOP00000001703/1-869 EKEEARLRAKEAKQTLQHFLEQHERMTSTTRYRRAEQTFGELEVWAVVPERDRKEVYDDV ENSMUSP00000115869/1-873 EKEEARLRAKEAKQTLQHFLEQHERMTSTTRYRRAEQTFGDLEVWAVVPERERKEVYDDV ENSRNOP00000062158/1-867 EKEEARLRAKEAKQTLQHFLEQHERMTSTTRYRRAEQTFGDLEVWAVVPERDRKEVYDDV ENSP00000448073/1-892 EKEEARLRAKEAKQTLQHFLEQHERMTSTTRYRRAEQTFGELEVWAVVPERDRKEVYDDV XP_004863082.1/1-890 EKEEARLRAKEAKQTLQHFLEQHERMTSTTRYRRAEQTFGELEVWAVVPERDRKEVYDDV ****************************************:**********:******** ENSCPOP00000001703/1-869 LFFLAKKEKEQAKQLRRRNIQALKSILDGMSSVNFQTTWSQAQQYLMDNPSFAQDHQLQN ENSMUSP00000115869/1-873 LFFLAKKEKEQAKQLRRRNIQALKSILDGMSSVNFQTTWSQAQQYLMDNPSFAQDQQLQN ENSRNOP00000062158/1-867 LFFLAKKEKEQAKQLRRRNIQALKSILDGMSSVNFQTTWSQAQQYLMDNPSFAQDQQLQN ENSP00000448073/1-892 LFFLAKKEKEQAKQLRRRNIQALKSILDGMSSVNFQTTWSQAQQYLMDNPSFAQDHQLQN XP_004863082.1/1-890 LFFLAKKEKEQAKQLRRRNIQALKSILDGMSSVNFQTTWSQAQQYLMDNPSFAQDHQLQN *******************************************************:**** ENSCPOP00000001703/1-869 MDKEDALICFEEHIRALEREEEEERERARLRERRQQRKNREAFQTFLDELHETGQLHSMS ENSMUSP00000115869/1-873 MDKEDALICFEEHIRALEREEEEERERARLRERRQQRKNREAFQSFLDELHETGQLHSMS ENSRNOP00000062158/1-867 MDKEDALICFEEHIRALEREEEEERERARLRERRQQRKNREAFQTFLDELHETGQLHSMS ENSP00000448073/1-892 MDKEDALICFEEHIRALEREEEEERERARLRERRQQRKNREAFQTFLDELHETGQLHSMS XP_004863082.1/1-890 MDKEDALICFEEHIRALEREEEEERERSRLRERRQQRKNREAFQTFLDELHETGQLHSMS ***************************:****************:*************** ENSCPOP00000001703/1-869 TWMELYPAVSTDIRFANMLGQPGSTPLDLFKFYVEELKARFHDEKKIIKDILKDRGFCVE ENSMUSP00000115869/1-873 TWMELYPAVSTDVRFANMLGQPGSTPLDLFKFYVEELKARFHDEKKIIKDILKDRGFCVE ENSRNOP00000062158/1-867 TWMELYPAVSTDVRFANMLGQPGSTPLDLFKFYVEELKARFHDEKKIIKDILKDRGFCVE ENSP00000448073/1-892 TWMELYPAVSTDVRFANMLGQPGSTPLDLFKFYVEELKARFHDEKKIIKDILKDRGFCVE XP_004863082.1/1-890 TWMELYPAVSTDVRFANMLGQPGSTPLDLFKFYVEELKARFHDEKKIIKDILKDRGFCVE ************:*********************************************** ENSCPOP00000001703/1-869 VNTAFEDFAHVISFDKRAAALDAGNIKLTFNSLLEKAEARDREREKEEARRMRRREAAFR ENSMUSP00000115869/1-873 VNTAFEDFAHVISFDKRAAALDAGNIKLTFNSLLEKAEAREREREKEEARRMRRREAAFR ENSRNOP00000062158/1-867 VNTAFEDFAHVISFDKRAAALDAGNIKLTFNSLLEKAEAREREREKEEARRMRRREAAFR ENSP00000448073/1-892 VNTAFEDFAHVISFDKRAAALDAGNIKLTFNSLLEKAEAREREREKEEARRMRRREAAFR XP_004863082.1/1-890 VNTAFEDFAHVISFDKRAAALDAGNIKLTFNSLLEKAEAREREREKEEARRMRRREAAFR ****************************************:******************* ENSCPOP00000001703/1-869 SMLRQAVPALELGTAWEEVRERFVCDSAFEQITLESERIRLFREFLQVLEQTECQHLHTK ENSMUSP00000115869/1-873 SMLRQAVPALELGTAWEEVRERFVCDSAFEQITLESERIRLFREFLQVLE-TECQHLHTK ENSRNOP00000062158/1-867 SMLRQAVPALELGTAWEEVRERFVCDSAFEQITLESERIRLFREFLQVLE-TECQHLHTK ENSP00000448073/1-892 SMLRQAVPALELGTAWEEVRERFVCDSAFEQITLESERIRLFREFLQVLE-TECQHLHTK XP_004863082.1/1-890 SMLRQAVPALELGTAWEEVRERFVCDSAFEQITLESERIRLFREFLQVLE-TECQHLHTK ************************************************** ********* ENSCPOP00000001703/1-869 GRKHSRKGKKHHRKRSHSPS----GSESEEEELPPPSLRPPKRKRRNPSESGSEPSSSLD ENSMUSP00000115869/1-873 GRKHGRKGKKHHRKRSHSPSVSRQGSESDEEELPPPSLRPPKRRRRNPSESGSEPSSSLD ENSRNOP00000062158/1-867 GRKHGRKGRKHHRKRSHTPS----GSESDEEELPPPSLRPPKRRRRNPSESGSEPSSSLD ENSP00000448073/1-892 GRKHGRKGKKHHHKRSHSPS----GSESEEEELPPPSLRPPKRRRRNPSESGSEPSSSLD XP_004863082.1/1-890 GRKHGRKGKKHHHKHSHSPS----GSESEEEELPPPSLRPPKRKRRNPSESGSEPSSSLD ****.***:***:*:**:** ****:**************:**************** ENSCPOP00000001703/1-869 SVESGGAALGGRGSPSSN-LLVSDCCLRPAKNEQRGLWQRRHKSNSPESETDPEEKAGKE ENSMUSP00000115869/1-873 SVESGGAALGGPGSPSSHLLLGSDHGLRKTKKPKKKTKKRRHKSTSPDSETDPEDKAGKE ENSRNOP00000062158/1-867 SVESGGAALGGPGSPSSHLLLGSDHGLRKTKKPKKKTKKRRHKSTSPDSETDPEDKAGKE ENSP00000448073/1-892 SVESGGAALGGRGSPSSH-LLGADHGLRKAKKPKKKTKKRRHKSNSPESETDPEEKAGKE XP_004863082.1/1-890 SVESGGAALGGRGSPSSHLLLASDHGLRKVKKPKKKTRKRRHKSNSPESETDPEEKAGKE *********** *****: ** :* ** .*: :: :*****.**:******:***** ENSCPOP00000001703/1-869 SEEKEQEQDKDRELQQAELSNRSPGFGVKKEKTGWDTSESELSEGELERRRRTLLQQLDD ENSMUSP00000115869/1-873 SEDREQEQ--DREPRQAELPNRSPGFGIKKEKTGWDTSESELSEGELERRRRTLLQQLDD ENSRNOP00000062158/1-867 SEDREQEQ--DREPRQAELPNRSPGFGIKKEKTGWDTSESELSEGELERRRRTLLQQLDD ENSP00000448073/1-892 SDEKEQEQDKDRELQQAELPNRSPGFGIKKEKTGWDTSESELSEGELERRRRTLLQQLDD XP_004863082.1/1-890 SEEREQEQ--DRELRHVELPNRSPGFGVKKEKTGWDTSESELSEGELERRRRTLLQQLDD *:::**** *** ::.**.*******:******************************** ENSCPOP00000001703/1-869 HQ ENSMUSP00000115869/1-873 HQ ENSRNOP00000062158/1-867 HQ ENSP00000448073/1-892 HQ XP_004863082.1/1-890 HQ **