CLUSTAL W(1.81) multiple sequence alignment ENSP00000459501/1-750 MEFVSGYRDEFLDFTALLFGWFRKFVAERGAVGTSLEGRCRQLEAQIRRLPQDPALWVLH ENSMUSP00000048816/1-736 MEFVSGYRDEFLDFAALLFGWFRKFVAERGTMGTSLEGRWRQLESQIRRLPQDPALWVLH ENSRNOP00000045805/1-738 MEFVSGYRDEFLDFAALLFGWFRKFVAERGTMGTSLEGRWRQLESQIRRLPQDPALWVLH XP_004857335.1/1-698 MEFVSGYQDEFLDFAALLLGWFHKFVAERGPVGASLEGHWRPLEAQIKRLPQDPALWVLH ENSCPOP00000001675/1-686 MEFVSGYRDEFLDFAALLFGWFHKFVAERGPVGASLEGRWRQMEAQIKRLPQDPALWVLH *******:******:***:***:*******.:*:****: * :*:**:************ ENSP00000459501/1-750 VLPNHSVGISLGQGAEPGPGPGLGTAWLLGDNPPLHLRDLSPYISFVSLEDGEEGEEEEE ENSMUSP00000048816/1-736 VLPNRSVGISLGQGAEPGPGPGLGASRLLGDEPPLHLRDLSPYVSFVSLEDGEEG--EEE ENSRNOP00000045805/1-738 VLPNRSVGISLGQGAEPGPGPGLGASRLLGDEPPLHLRDLSPYVSFVSLEDGEEGEEEEE XP_004857335.1/1-698 VLPNHNVGIILRQGAELGPGCGLGVARLLGDEPLLHLQDLSPYVSFVSLEDGEEG--DQE ENSCPOP00000001675/1-686 VLPNNSVGVSLGQGAEPGPGSGLGAARLLGDEPPLHLRDLSPYVSFVS------------ ****..**: * **** *** ***.: ****:* ***:*****:**** ENSP00000459501/1-750 EDEEEEKREDGGAGSTEKVEPEEDRELAPTSRESPQETNPPGESEEAAREAGGGKDGCRE ENSMUSP00000048816/1-736 EEDEEHG-ERPG---MEKVEPQEGGEPAPPSKRFPQEAKPAPESEVTQQEA-SREEGSRE ENSRNOP00000045805/1-738 EEEEEHGEERPG---TEKVELQEGGEPAPPSKELPQEVKPAQESEVTQQEA-SCDEGCRE XP_004857335.1/1-698 EEDEENGEKTKS---TEKVELQEVREPASTSRESPQEAKPPPEPGEAEQEA-GGEDGCPE ENSCPOP00000001675/1-686 --------SPPR---TEKGEPQEDGEPAPSSRESPPDAKPPLEPGETEQEA-GGEDVCPE . ** * :* * *..*:. * :.:*. *. : :** . .: . * ENSP00000459501/1-750 DRVENETRP---QKRKGQRS-EAAPLHVSCLLLVTDEHGTILGIDLLVDGAQGTASWGSG ENSMUSP00000048816/1-736 ERPEDERAP---EKRKGQKNAEAAPLHLSCLLLVTDEHGTILGIDLLMDGAQGSVGQNPG ENSRNOP00000045805/1-738 ERAEDERAP---EKRKGRKT-EAAPLHLSCLLLVTDEHGTILGIDLLMDGAQGSVGQSPG XP_004857335.1/1-698 DRGEDKMAR---EKRKGQRS-EAGPLHLSCLLLVTDEYGTILGIDLLMDRAQGITDQDSG ENSCPOP00000001675/1-686 NRAESHTAAAALEKRKGRRSAEAGPLHLSCLLLVTDEYGTILGIDLLMDRAPGSADLGSG :* *.. :****::. **.***:*********:*********:* * * .. ..* ENSP00000459501/1-750 TKDLAPWAYALLCHSMACPMGSGDPRKPRQLTVGDARLHRELESLVPRLGVKLAKTPMRT ENSMUSP00000048816/1-736 TENLAPRAYALLCHSMACPMGSGDPRKPRQLTVGDAHLHRELESLVPRLGVKLAKTPMRT ENSRNOP00000045805/1-738 TENLAPRAYALLCHSMACPMGSGDPRKPRQLTVGDAHLHRELESLVPRLGVKLAKTPMRT XP_004857335.1/1-698 TKNLAPRAYTLLCHSMACPMGPGDPRKPRRLTVGDARLHRELESLVSRLGVKLTKTPMRT ENSCPOP00000001675/1-686 TKSLAPRAYILLCHSMACPMGSGDPRKPRQLTVGDVQLHRELESLVSRVKVKLTKTPMRT *:.*** ** ***********.*******:*****.:*********.*: ***:****** ENSP00000459501/1-750 WGPRPGFTFASLRARTCHVCHRHSFEAKLTPCPQCSAVLYCGEACLRADWQRCPDDVSHR ENSMUSP00000048816/1-736 WGPRPGFTFASLRARTCHVCHKHSFEVKLTPCPQCSAVLYCGEACLQADWRRCPDDVSHR ENSRNOP00000045805/1-738 WGPRPGFTFASLRARTCHVCHKHSFEVKLTPCPQCSAVLYCGEACLQADWRRCPDDVSHR XP_004857335.1/1-698 WGPRPDFTFASLRARTCHVCHRHSFEVKLTPCPQCGAVLYCGEACLQTDWRRCPDDVSHR ENSCPOP00000001675/1-686 WGPRPGFTFASLRARTCHVCHRHSFEVKLTPCPQCGAVLYCGEACLRTDWRRCPDDVSHR *****.***************:****.********.**********::**:********* ENSP00000459501/1-750 FWCPRLAAFMERAGELATLPFTYTAEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGF ENSMUSP00000048816/1-736 FWCPRLSAFMERVGELASLPFTYTAEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGA ENSRNOP00000045805/1-738 FWCPRLAAFMERAGELASLPFTYTAEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGA XP_004857335.1/1-698 FWCPKLAAFMKRAGELATLPFTYTAEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGT ENSCPOP00000001675/1-686 FWCPKLAAFMERAGELATLPFTYTAEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGT ****:*:***:*.****:***************************************** ENSP00000459501/1-750 SRHPRGNTPSLSLLRGGDPYQLLQGDGTALMPPVPPHPPRGVFGSWQDYYTWRGLSLDSP ENSMUSP00000048816/1-736 PRYPWGSTSSLSCLLNGDPYQLLQGDGPALMPPVPLEPPRSLFGSWQDYYTWRGLSLDSP ENSRNOP00000045805/1-738 PRNPWGTTPSLSCLLNGDPYQLLQGDGPALMPPVPLDPPRSLFGSWQDYYTWRGLSLDSP XP_004857335.1/1-698 RRIPQGSLPSLS-LVSGDPYQLLQVDGAPLMPPVPSDPPRHPF----------------- ENSCPOP00000001675/1-686 PRTPRGSVPSLS-LLNGDPYQLLQGDGPALMPPVPSDPPRGPFGSWQDYYTWRGLSLDSP * * *. .*** * .******** **..****** .*** * ENSP00000459501/1-750 IAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPH ENSMUSP00000048816/1-736 MAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPH ENSRNOP00000045805/1-738 VAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPH XP_004857335.1/1-698 ----------------------VPELNIQNKQSLKIHVVEAGKEFDLVMVFWEFLVLLPH ENSCPOP00000001675/1-686 LAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPH .******************************:****** ENSP00000459501/1-750 VALELQFVGDGLPPESDEQHFTLQRDSLEVSVRPGSGISARPSSGTKEKGGRRDLQIKVS ENSMUSP00000048816/1-736 VALELQFVGDSLPPESDQQHFTMQRDGPEVSLRPGSGVSARFNSGTKEKGGRRDLQIRVS ENSRNOP00000045805/1-738 VALELQFVGDSLPPESDQQHITMQRDGPEASVRPGSGVSARLSSGTKEKGGRRDLQIRVS XP_004857335.1/1-698 MALELQFVGDGLPLENDQQHFTLQRDAPEVSVRPSSGVSARLSSGVKEKGGRRDLQIKVS ENSCPOP00000001675/1-686 VALELQFVGDDLPLESDQQHFTLQRDGPEVSVRPSCGVSARLNSGTKEKGGRRDLQIKVL :*********.** *.*:**:*:***. *.*:**..*:*** .**.***********:* ENSP00000459501/1-750 ARPYHLFQGPKPDLVIASPSSLSAGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSC ENSMUSP00000048816/1-736 ARPYHLLQGPKPDLVI--------GFNSGFGLKDTWLSSLPRLQSLRVPAFFTESSEYGC ENSRNOP00000045805/1-738 TRPYHLLQGPKPDLVI--------GFNSGFGLKDTWLSSLPRLQSLRVPAFFTESSEYGC XP_004857335.1/1-698 ARPYHLFQGPKPDLVI--------GFNSGFGLKDTWLSSLPRLQSLRVPAFFTESSEYGC ENSCPOP00000001675/1-686 ARPYHLLQGPKPDLVI--------GFNSGFGLKDTWLSSLPRLQSLRVPAFFTESSEYGC :*****:********* ******.****** ********************.* ENSP00000459501/1-750 VMDGQTMAVATGGGTSPPQPNPFRSPFRLRAADNCMSWYCNAFIFHLVYKPAQGSGARPA ENSMUSP00000048816/1-736 VMDDQTMAVATGGGTSSPQPNPFRSPFRLRAADNCMPWYCNAFIFHLVYKPPQGGTVRSA ENSRNOP00000045805/1-738 VMDDQTMAVATGGGTSSPQPNPFRSPFRLRAADNCMPWYCNAFIFHLVYKPPQGGTVRSA XP_004857335.1/1-698 VMDDQTMAVATGGGTSPPQANPFRSPFRLRAADNCMPWYCNAFIFHLVYKPPQGNGTRPA ENSCPOP00000001675/1-686 VMDDQTMAVATGGGTSTPRPNPFRSPFRLRAADNCMPWYCNAFIFHLVYKPAQGNSIRS- ***.************.*:.****************.**************.**. *. ENSP00000459501/1-750 --PGPPPPSPTPSAPPAPTRRRRGEKKPGRGARRRK ENSMUSP00000048816/1-736 --PGPAPRPPTPAAPPVPARRRRGEKKAARGPRRRR ENSRNOP00000045805/1-738 --PGPAPRPPTPAAPPVPARRRRGEKKAARGPRRRR XP_004857335.1/1-698 LCPSPPAPAPAPAAPPAPARRRRGEKKAGRGARWRR ENSCPOP00000001675/1-686 ------------------------------------