CLUSTAL W(1.81) multiple sequence alignment ENSP00000451263/1-1118 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAV ENSMUSP00000041819/1-1077 MESSRSLLGCLAS-ATAAPPGDDATGAGAEEEEDEEEAAA------ELGSHAALPYWTAV ENSRNOP00000009693/1-1077 MESSRSLLGCLAS-AAAAPPGEDATGAGAEEEEDEEEAAA------ELGSHATLPYWTAV ENSCPOP00000001631/1-1083 MEPSRALLGGLASAAAAAP-------------------AAVA--PGELGCDAPLPYWTAV XP_004837349.1/1-1078 MEPSRALLGCLASAAAAAQPGEDGSGAAAEEEEEEEEEAAAA--SGELGCTAQLPYWTAV **.**:*** *** *:** ** ***. * ******* ENSP00000451263/1-1118 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR ENSMUSP00000041819/1-1077 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR ENSRNOP00000009693/1-1077 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR ENSCPOP00000001631/1-1083 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR XP_004837349.1/1-1078 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR ************************************************************ ENSP00000451263/1-1118 CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED ENSMUSP00000041819/1-1077 CQPGAEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWAGDEVAVKAARHDPDED ENSRNOP00000009693/1-1077 CQPGTEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWVGDEVAVKAARHDPDED ENSCPOP00000001631/1-1083 CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARYDPDED XP_004837349.1/1-1078 CQPGGEDPSCYPPIQLLEIDFVELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARYDPDED **** ****************.********************* **********:***** ENSP00000451263/1-1118 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD ENSMUSP00000041819/1-1077 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD ENSRNOP00000009693/1-1077 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRVPPD ENSCPOP00000001631/1-1083 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD XP_004837349.1/1-1078 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD ********************************************************:*** ENSP00000451263/1-1118 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE ENSMUSP00000041819/1-1077 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE ENSRNOP00000009693/1-1077 ILVNWAVQIARGMNYLHDEAIVPVIHRDLKSSNILILQKVENGDLSNKTLKITDFGLARE ENSCPOP00000001631/1-1083 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE XP_004837349.1/1-1078 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE ***********************:************************ *********** ENSP00000451263/1-1118 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG ENSMUSP00000041819/1-1077 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG ENSRNOP00000009693/1-1077 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG ENSCPOP00000001631/1-1083 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG XP_004837349.1/1-1078 WHRTTKMSAAGTYAWMAPEVIRSSMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG **********************:************************************* ENSP00000451263/1-1118 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH ENSMUSP00000041819/1-1077 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTSILDQLTTIEESGFFEMPKDSFH ENSRNOP00000009693/1-1077 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFSSILDQLTTIEESGFFEMPKDSFH ENSCPOP00000001631/1-1083 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHLRPSFMSILDQLTTIEESGFFEMPKDSFH XP_004837349.1/1-1078 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHLRPSFTSILDQLTTIEESGFFEMPKDSFH ******************************* **** .********************** ENSP00000451263/1-1118 CLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL ENSMUSP00000041819/1-1077 CLQDDWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL ENSRNOP00000009693/1-1077 CLQDDWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL ENSCPOP00000001631/1-1083 CLQDDWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL XP_004837349.1/1-1078 CLQDDWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL ****:******************************************************* ENSP00000451263/1-1118 ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK ENSMUSP00000041819/1-1077 ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK ENSRNOP00000009693/1-1077 ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK ENSCPOP00000001631/1-1083 ERELNIIIHQLCQEKPRVKKRKGKFRKNRLKLRDGNRISLPSDFQHKFTVQASPTMDKRK XP_004837349.1/1-1078 ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK ***************************.****:*************************** ENSP00000451263/1-1118 SLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG ENSMUSP00000041819/1-1077 SLISNRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG ENSRNOP00000009693/1-1077 SLISNRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG ENSCPOP00000001631/1-1083 SLINSHSSPPASPTIIPRLRAIQLTPGESSKTWGRNSVIPKEEGEEEEKRVPKKKGRTWG XP_004837349.1/1-1078 SLINSHSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVIPKEE-EEEEKRVPKKKGRTWG ***..:*****************************.**:**** ******.********* ENSP00000451263/1-1118 PGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGP ENSMUSP00000041819/1-1077 PGTLGQKELTSGDE-----------------------GLKSLVDGYKQWSSSAPNLGKGP ENSRNOP00000009693/1-1077 PGTLGQKELTSGDE-----------------------GLKSLVDGYKQWSSSAPNLGKGP ENSCPOP00000001631/1-1083 PGTLGQKELSSGDEGSPQRRERANGLSTPSESPHFHLGLKSLVDGYRQWSSSAPNLGKGP XP_004837349.1/1-1078 PGTLGQKELTSGDE-----------------------GLKSLVDGYRQWSSSAPNLGKGP *********:**** *********:********* *** ENSP00000451263/1-1118 RSSPALPGFTSLMEMALLAASWVVPIDIEEDEDSEGPGSGESRLQHSPSQSYLCIPFPRG ENSMUSP00000041819/1-1077 RSSPALPGFTSLMEI--------------EDEDSEGPGSGENHQQHSPNQSYLCIPFPRG ENSRNOP00000009693/1-1077 RSSPALPGFTSLMEI--------------EDEDSEGPGSGENHLQHSPNQSYLCIPFPRG ENSCPOP00000001631/1-1083 RNSPALPGFTSLMEM--------------EDEDSEGLRSGENRLQHSPNQPYLCIPFPRG XP_004837349.1/1-1078 RSSPALPGFTSLMEM--------------EDEDSEGPRGGENRLQPSPSQSYLCTPFPRG *.************: ******* .**.: * **.*.*** ***** ENSP00000451263/1-1118 EDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLG ENSMUSP00000041819/1-1077 EDGDGPSSDGVHEEPTPVNSATSTPQLTPTNSLKRGGTHHRRCEVALLGCGAVLAATGLG ENSRNOP00000009693/1-1077 EDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRSGTHHRRCEVALLGCGAVLAATGLG ENSCPOP00000001631/1-1083 EDGDGPPGDGVHEEPTPVNSATSTPQLTPTNSLKRSGTHQRRCEMALLGCGAVLAATGLG XP_004837349.1/1-1078 EDGDGPPSDGVHEEPTPVNSATSTPQLTPTNSLKRSGTHHRRCEMALLGCGAVLAATGLG ******..**:************************.*:*:****:*************** ENSP00000451263/1-1118 FDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLG ENSMUSP00000041819/1-1077 FDLLEAGKCQLLPPEEPEPPAREEKKRREGLFQRASRPRRSTSPPSRKLFKKEEPMTLLG ENSRNOP00000009693/1-1077 FDLLEAGKCQLLPPEEPEPPAREEKKRREGLFQRASRPRRSTSPPSRKLFKKEEPMTLLG ENSCPOP00000001631/1-1083 FDLLEAGRCQLVPPEEPEPPVREEKKRREGLFQRASRPRRSTSPPSRKLFKKEEPTLLLG XP_004837349.1/1-1078 FDLLEAGRCQLLPAEEPEAPVREEKKKREGLFQRASRPRRSTSPPSRKLFKREEPVLLLG *******:***:* ****.*.*****:*******:****************:*** *** ENSP00000451263/1-1118 DPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVE ENSMUSP00000041819/1-1077 DPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLTQCTHNPLVNVRVE ENSRNOP00000009693/1-1077 DPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLTQCTQNPLVNVRVE ENSCPOP00000001631/1-1083 DPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPPTPCTHNPLVNVRVE XP_004837349.1/1-1078 DPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVQAPPRTPCTHNPLVNVRVE *****************************************:*** : **:********* ENSP00000451263/1-1118 RFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPET---LLASRSPSSNGLSPSPGA ENSMUSP00000041819/1-1077 RFKRDPNQSLTPTHVTLTAPTQPSGHRRTPSDGALKPTAAPAVLGSRSPSSNGMSPSPGT ENSRNOP00000009693/1-1077 RFKRDPNQSLTPTHVTLTAPTQPSGHRRTPSDGALKPASVPPALGSRSPSSNGVSPGPGA ENSCPOP00000001631/1-1083 RFKRDPNQSLTPTHVTLTAPTQPSGHRRTPSDGALKPAA---PVASQSPSSNGLSPSHGA XP_004837349.1/1-1078 RFKRDPNQSLTPTHVTLTAPAQLSGHRRTPSDGALTPAA---LLASRSPSSNGLSPSRGS ******************:*:* *.**********.* : :.*:******:**. *: ENSP00000451263/1-1118 GMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQR ENSMUSP00000041819/1-1077 GMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQRDSTLERPKTLEFLPRPRPSANRQR ENSRNOP00000009693/1-1077 GMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQRDSTLERPKTLEFLPRPRPSANRQR ENSCPOP00000001631/1-1083 GVPKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQR XP_004837349.1/1-1078 GMLKTPSPSRDPGEFPRLPDPNMVFPPTPRRWHTQQDSALERPKTLEFLPRPRPSANRQR *: *******************:*********:**:**:********************* ENSP00000451263/1-1118 LDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPT ENSMUSP00000041819/1-1077 LDPWWFVSPSHARSASPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPLQAGPLLPA ENSRNOP00000009693/1-1077 LDPWWFVSPSHARSASPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPLQAGPLPPA ENSCPOP00000001631/1-1083 LDPWWFVSPSHARSASPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQPGPLPDT XP_004837349.1/1-1078 LDPWWFVSPSRARSASPANSSSTETPSNLDSCFASSSSTVEERPGLPALLSFQAGPLPPA **********:***:***********************************.:*.*** : ENSP00000451263/1-1118 ERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS ENSMUSP00000041819/1-1077 ERTLLDLDAEGQSQDSTVPLCRAELNAHGPSPYEIQQEFWS ENSRNOP00000009693/1-1077 ERTLLDLDAEGQSQDSTVPLCRAELNAHGPSPYEIQQEFWS ENSCPOP00000001631/1-1083 ERTLLDLDAEGQSQDSTVPLCRAEMNTHRSTPYEIQQEFWS XP_004837349.1/1-1078 ERTLLDLDAEGQSQDSTVPLCRAELNTHRPTPYEIQQEFWS ************************:*:* .:**********