CLUSTAL W(1.81) multiple sequence alignment ENSP00000373937/1-1150 MAPPLRPLARLRPPGMLLRALLLLLLLSPL---PGVWCFSELSFVKEPQDVTVTRKDPVV ENSMUSP00000055815/1-1191 MAPPVR-------PGML--PLLLLLLLPPLGSVPGVWSFSELFFMKEPQDATVTRKDPVV ENSRNOP00000036541/1-1193 MAPPVR-------PGML--PLLLLLLLPPLGSVPGVWSFSELFFMKEPQDATVTRKDPVF ENSCPOP00000001549/1-1145 ----------------------------------GVWCFSELFFIREPQDVTVTRKDPVF XP_004835404.1/1-1169 MAPSER-------PPGMRALLPLLLLLPLLGASPGVWCFSELFFVREPQDVTVTRKDPVF ***.**** *::****.********. ENSP00000373937/1-1150 LDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMN ENSMUSP00000055815/1-1191 LDCQAHGEGPIKVTWLKNGAKLSENKRIQVLSNGSLYISEVEGRRGEQSDEGFYQCLAVN ENSRNOP00000036541/1-1193 LDCQAHGEGPIKVTWLKNGAKLSENKRIQVLSNGSLYISEAEGRRGEQSDEGFYQCLAVN ENSCPOP00000001549/1-1145 LDCQAHGEVPIKVTWLKNGAKVSESKRIQVLSNGSLYISEVEGRRGAQSDEGFYQCLAVN XP_004835404.1/1-1169 LDCQAHGEVPIKVTWLKNGAKVSENKRIQVLSNGSLYISEVEGRRGAQSDEGFYQCLAVN ******** ************:**.***:***********.***** ***********:* ENSP00000373937/1-1150 KYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPPAVITWEFNRTTLPM ENSMUSP00000055815/1-1191 KYGAILSQKAHLTLSTISAFEVHPVSTEVHEGGVARFSCKISSTPPAVITWEFNRTALPT ENSRNOP00000036541/1-1193 KYGAILSQKAHLTLSTISAFEVHPVSTEVPEGGVARFSCKISSTPPAVITWEFNRTALPM ENSCPOP00000001549/1-1145 KYGAILSQKAHLALSTISAFEIQPVSTEVQEGGVARFTCKISSNPPAVVTWEFNRTTLPA XP_004835404.1/1-1169 KYGAILSQKAHLTLSTISAFEIQPISMEVQEGGVARFACKISSSPPAVVTWEFNRTALPM ************:********::*:* ** *******:***** ****:*******:** ENSP00000373937/1-1150 TMD-RITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPT ENSMUSP00000055815/1-1191 TMD-RVTALPSGVLQIYDVGPEDAGNYRCVAATIAHKRKSMEASLTIVAANETRSFYMPT ENSRNOP00000036541/1-1193 TMDSRVTALPSGVLQIYDAGPEDAGKYRCVAATHAHKRKSMEASLTIVPANETRSFYMPT ENSCPOP00000001549/1-1145 TTD-RMAALPTGVLQIYDVGPGDMGSYRCVAATMAHRRRSAEAALTVTPAKASKPFNTPT XP_004835404.1/1-1169 MTD-RMAALPTGVLQIYSVGPGDVGSYRCVATTLTHRRRSAEAMLTVTPAKESKPFHAPT * *::***:******... * *.***:*:* :*:*:* ** **: .*: ::.* ** ENSP00000373937/1-1150 IIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRL ENSMUSP00000055815/1-1191 IIASPQNVTASLHQTVVLECMATGYPRPIISWSRLDHKSIDVFNTRVLGNGNLIISDVKL ENSRNOP00000036541/1-1193 IIASPQNVTASLHQTVVLECMATGYPKPIISWSRLDHKSIDVFNTRVLGNGNLIISDVKL ENSCPOP00000001549/1-1145 IVAGPQNVTAALHQTVVLECMATGNPKPIISWSRLDHRSIDVFFTRMLGNGNLLISDVRL XP_004835404.1/1-1169 IVAGPQNVTASLHQTIVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLLISDIRL *:*.***:*::****:******** *:**********:***** **:******:***::* ENSP00000373937/1-1150 QHAGVYVCRATTPGTRNFTVAMATLTVL--APPSFVEWPESLTRPRAGTARFVCQAEGIP ENSMUSP00000055815/1-1191 QHAGVYVCRATTPGTRNFTVAMATLTVL--APPSFVEWPESLTRPRAGTARFVCQAEGIP ENSRNOP00000036541/1-1193 QHAGVYVCRATTPGTRNFTVAMATLTVL--APPSFVEWPESLTRPRAGTARFVCQAEGIP ENSCPOP00000001549/1-1145 HHAGVYVCRATTPGTRNFTVAMATLTVLETAPPSFIEWPESLTRPRAGTARFVCQAEGIP XP_004835404.1/1-1169 HHAGVHVCRATTPGTRNFTVAMATLTVL--APPSFTERPESLTRPRAGTARLVCQAEGIP :****:********************** ***** * *************:******** ENSP00000373937/1-1150 SPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVM ENSMUSP00000055815/1-1191 SPKMSWLKNGRRIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSVLSRARLTVVM ENSRNOP00000036541/1-1193 SPKMSWLKNGRRIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSVLSRARLTVVM ENSCPOP00000001549/1-1145 TPKMSWLKNGRKMHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENTQGSVLSRARLTVVM XP_004835404.1/1-1169 APKMSWLKNGRKMHSNGRIKMYSSKLVINQIIPEDDAIYQCMAENTLGSVLSQARLTVVM :**********::*********.**********************: **:**:******* ENSP00000373937/1-1150 SEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGND ENSMUSP00000055815/1-1191 SEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVLGND ENSRNOP00000036541/1-1193 SEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVLGND ENSCPOP00000001549/1-1145 SEDRPSAPCNVHAETVSSSAILLAWDRPLYNADKVIAYSVHYMKAEGLNNEEYQVVLGND XP_004835404.1/1-1169 SEDRPSAPCNVHAETVSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVLGND ******** ******:*********:*****:************************:*** ENSP00000373937/1-1150 TTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDIL ENSMUSP00000055815/1-1191 TTHYIIDDLEPDSNYTFYIVAYMPLGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDIL ENSRNOP00000036541/1-1193 TTHYIIDDLEPDSNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDIL ENSCPOP00000001549/1-1145 TTHYVIDDLEPASNYSFYIVAYMPMGASQMSDHVTQSTLEDVPLRPPEISLTSRSPTDIL XP_004835404.1/1-1169 TTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQSTLEDVPLRPPEISLTSRSPTDIL ****:****** ***:********:***********.*********************** ENSP00000373937/1-1150 ISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAA ENSMUSP00000055815/1-1191 VSWLPIPAKYRRGQVVLYRLSFRLSTENAIQVVELPGTVHEYLLEGLKPDSVYLVRITAA ENSRNOP00000036541/1-1193 ISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVVELPGTVHEYLLEGLEPDSVYLVRITAA ENSCPOP00000001549/1-1145 ISWLPIPAKYRRGRVVLYRLSFRLSTDSTVQVLELPGTSHEHLLQGLRPDSVYLVRITAA XP_004835404.1/1-1169 VSWLPIPAKYRRGRVVLYRLSFRLSTDSAVQVLELPGTSHEHLLQGLRPDSIYLVRITAA :************:************:.::**:***** **:**:**.***:******** ENSP00000373937/1-1150 TRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLY ENSMUSP00000055815/1-1191 TRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWLQDTEDPAAIRGYKLF ENSRNOP00000036541/1-1193 TRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWLQDTEDPAAIRGYKLF ENSCPOP00000001549/1-1145 TRVGLGESSVWTSHKTPKATSVQVPRSPELHLEPLNCTTISVRWQRDAEDPAAIQGYKLF XP_004835404.1/1-1169 THVGLGEASVWTSHQTPKATSMQAPRSPELHLEPLNCTTIAVRWQCDAKDPAAIQGYKLF *:*****:******:******::.*:**************:*** *.:*.***:****: ENSP00000373937/1-1150 YKEEGQQENGPIFLDTKDLLYTLSGL-DPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVS ENSMUSP00000055815/1-1191 YKEEGQQEHGPIFLDTGDLLYTLSGL-DPRRKYHVRLLAYNNMEEGYQADQTVSTPGCVS ENSRNOP00000036541/1-1193 YKEEGQQEHGPIFLDTGDLLYTLSGL-DPRRKYHVRLLAYNNLEDGYQADQTVSTPGCVS ENSCPOP00000001549/1-1145 YKEEGQQEHGPIILAPSELLHTLSGLVDPRRKYHVRLLAYSNIEDGYQADQTVSTPGCVS XP_004835404.1/1-1169 YKEEGQQEHGPIVLAPREHLHTLSGL-DPRRKYHVRLLAYSSIEEGYQADQTVSTPGCVS ********:***.* . : *:***** *************..:::*************** ENSP00000373937/1-1150 VRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYL ENSMUSP00000055815/1-1191 VRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTTAQVINYTIRCNPVGLQNASLVLYL ENSRNOP00000036541/1-1193 VRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTTAQVINYTIRCNPVGLQNASLVLYL ENSCPOP00000001549/1-1145 VRDRLVPPPPPPHHLYAKANGSFAVFLHWRRPAFTAAQTINYTIRCNPVGLQNASLVLYL XP_004835404.1/1-1169 VRDRVVPPPPPPHHLYASANSSSCVFLHWRRPAFTAAHAVNYTIRCNPVGLQNASLVLYL ****:************.** * .:**********:*: :******************** ENSP00000373937/1-1150 QTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIED ENSMUSP00000055815/1-1191 QTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPTGPPVGVKVTLIED ENSRNOP00000036541/1-1193 QTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHTTLPEAPTGPPVGVKVTLIED ENSCPOP00000001549/1-1145 QTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYQATLPEAPAGPPVGVKVTLIED XP_004835404.1/1-1169 QTSETHMLVQGLEPNTKYEFAVRLHVEQLSSPWSPVVYHATLPEAPAGPPVGVKVTLIED **************************:***********::******:************* ENSP00000373937/1-1150 DTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIV ENSMUSP00000055815/1-1191 DTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIV ENSRNOP00000036541/1-1193 DTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIV ENSCPOP00000001549/1-1145 DTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHRGGAITMALLENLVAGDVYIV XP_004835404.1/1-1169 DTALVSWKPPDGPETVITRYTILYASRKAWVAGKWQVLHREGAITMALLENLVVGDVYIV ****************:*************:**:****** ************.*:**** ENSP00000373937/1-1150 KISASNEVGEGPFSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAV ENSMUSP00000055815/1-1191 KISASNEVGEGPFSNSVELAVLPKDASESNQRPKRLDSSNAKVYSGYYHLDQKSMTGIAV ENSRNOP00000036541/1-1193 KISASNEVGEGPFSNSVELAVLPKDASESNQRPKRLDSSDAKVYSGYYHLDQKSMTGIAV ENSCPOP00000001549/1-1145 KISASNEVGEGPFSNSVELAVLPKDPSGSNQRPKRLDSADAKVYSGYYHLDRKSMTGIAV XP_004835404.1/1-1169 KISASNEVGEGPFSNSVELTVLPKDPSGSNQRPKRLDAADARVYSGYYHLDRKSMTGITV *******************:****:.* *********:::*:*********:******:* ENSP00000373937/1-1150 GVGIALTCILICVLILIYRSKARKSSASKTAQNGTQQLPRTSASLASGNEVGKNLEGAVG ENSMUSP00000055815/1-1191 GVGIALTCILICVLILIYRSKARKSSASKTAQSGTQPLSQASASVAAGSDMGKNLERATE ENSRNOP00000036541/1-1193 GVGIALTCILICVLILIYRSKARKSSASKTTQSGTQPLSRASASVAAGSDMGKNLERATE ENSCPOP00000001549/1-1145 GVGIALTCILVCVLILICRSKARKSSASKTAQNGTQPLPLPGAPGSPGDERGKKLSRVIG XP_004835404.1/1-1169 GVGIALTCILVCVLILICRSKARKSSACKTAQNGSRQLPHAGASPTPVNEAGKKLDRAIE **********:****** *********.**:*.*:: *. ..*. :. .: **:*. . ENSP00000373937/1-1150 NEESLMPMIMPNSFIDAKGGTDLIINSYGPIIKNNSKKKWFFFQDSKKIQVEQPQ-RRFT ENSMUSP00000055815/1-1191 TAESLVPMM-PSSFIDAKGGTDLIINSYGPIIKNNTKKKWLFFQDTKKIKVEQTQ-RRFT ENSRNOP00000036541/1-1193 NEESSVPMM-PSCFIDAKGGTDLIINSYGPIIKNNPKKKWRFFQDTKKIKVEQTQ-RRIT ENSCPOP00000001549/1-1145 SQESSVPVTMPCSFIDAKGGSDLIINSYGPIIKNNSKKKWLFFQDSKRMRAEQPQSQKFP XP_004835404.1/1-1169 NQESSVPVMVPHSFIDAKGGSDLIINSYGPVIKNNSKKKWLFFQDAKRMRAEQPQ-RRFP . ** :*: * .*******:*********:****.**** ****:*:::.**.* :::. ENSP00000373937/1-1150 PAVC-FYQPGTTVLISDEDSPSSPGQTTSFSRPFGVAA-DTEHSANSEGSHETGDSGRFS ENSMUSP00000055815/1-1191 QAVC-FYQPGTTVLISDEDSPGSPGQTASFPRPFGATALDTEHSANSEGSHETGDSGRFS ENSRNOP00000036541/1-1193 QTVC-FYQPGTTVLISDEDSPSSPGQTTSFPRPFGPTTLDTEHSANSEGSHETGDSGRFS ENSCPOP00000001549/1-1145 PAAARFRQPDPAVLI------GSPARAPALPGLSGAAT-DTEHSAHSEGSQDTGDSGRFS XP_004835404.1/1-1169 PATH-FYQPGTTVLVSSQDSPSSLDPATAF---LGAAV-DTEHSTQSEGSQDTGDSGRFS :. * **..:**: .* :.:: * :. *****::****::******** ENSP00000373937/1-1150 HESNDEIHLSSVISTTPPNL---------------------------------------- ENSMUSP00000055815/1-1191 HESNDEIHLSSVISSTPPTSNPLAGGDSDGDAAPKKHG-DPAQPLPAEQTSAPQ-TSAGL ENSRNOP00000036541/1-1193 HESNDEIHLSSVISSTPPTSNSLTCGDSDGDAAPKKHG-DPAQPLPAEQTSAPQPTPAGL ENSCPOP00000001549/1-1145 HESSAELRLSAALSGSPWSSGALAGGAAVANQAPPAQGAGPAGPLAA------------- XP_004835404.1/1-1169 HESSAELRLSAALSSSPPSSSSLAGGEVAGNHVPGQDE-GPAGRARL------------- ***. *::**:.:* :* . ENSP00000373937/1-1150 --------- ENSMUSP00000055815/1-1191 RYAAEGFPV ENSRNOP00000036541/1-1193 RHAAESVPV ENSCPOP00000001549/1-1145 --------- XP_004835404.1/1-1169 ---------